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Search Results for " tetramer "

Targets Recommended: Others

7

抑制剂 & 化合物

2

天然产物

58

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T61098	RUNX1/ETO tetramerization-IN-1	Others	Others
	RUNX1/ETO tetramerization-IN-1 is a small-molecule inhibitor that specifically targets NHR2 of RUNX1/ETO, effectively inhibiting the tetramerization process. With an EC50 value of 0.25 μM, this compound successfully restores gene expression that has been down-regulated by RUNX1/ETO. Furthermore, RUNX1/ETO tetramerization-IN-1 demonstrates promising anti-leukemic activity by inhibiting the proliferation of SKNO-1 cells dependent on RUNX1/ETO and significantly reducing RUNX1/ETO-associated tumor g...
T9108	BI-0115	Lipoxygenase	Metabolism
	BI-0115 是LOX-1的选择性抑制剂，其IC50值为 5.4 µM，可以阻止细胞摄取氧化低密度脂蛋白。它通过形成同源二聚体配体结合域的二聚体来触发受体抑制。
T40132	Insulin β Chain Peptide (15-23)
	Insulin β Chain Peptide (15-23), also referred to as INS, is an insulin-derived peptide that is specifically recognized by islet-associated T cells. The tetramer of Insulin β Chain Peptide (15-23) effectively stained the INS-reactive CTL clone G9C8; however, neither this tetramer nor the negative control tetramer (TUM) exhibited staining on the splenic CD8+ T cells obtained from NOD or 8.3-TCRαβ transgenic NOD mice.
T21318	Efaproxiral RSR13,Efaproxyn,RSR 13,RSR-13	Others	Others
	Efaproxiral is a synthetic small molecule with radiosensitizing activity. Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity, increasing tumor
T71785	GUN35758	Others	Others
	GUN35758, also known as 4'-Carboxybenzo-18C6, is a novel transthyretin (ttr) amyloidogenesis inhibitor, stabilizing the ttr tetramer by binding to the allosteric sites on the molecular surface of the ttr tetramer. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
T68986	ZINC08383544	Others	Others
	ZINC08383544 is a specific pyruvate kinase M2 activator which promotes the formation of PKM2 tetramer. ZINC08383544 effectively blocks PKM2 nuclear translocation, and inhibits the growth of tumor.
T79286	TRAP1-IN-2	HSP	Cytoskeletal Signaling; Metabolism
	TRAP1-IN-2（化合物36）作为TRAP1下游蛋白的选择性降解剂，不会对Hsp90的胞质下游蛋白产生影响。同时，该化合物还能抑制OXPHOS，导致细胞糖酵解代谢的变化。此外，TRAP1-IN-2会破坏TRAP1四聚体的稳定性，并影响线粒体膜电位。

化合物

RUNX1/ETO tetramerization-IN-1

Cat.No: T61098

Target: Others

Cat.No: T9108

Target: Lipoxygenase

Insulin β Chain Peptide (15-23)

Cat.No: T40132

Cat.No: T21318

Synonym: RSR13,Efaproxyn,RSR 13,RSR-13

Target: Others

Cat.No: T71785

Target: Others

Cat.No: T68986

Target: Others

Cat.No: T79286

Target: HSP

Cat. No.	Product Name	Target	Signaling Pathways
T20793	Magnesium Lithospermate B 丹參酸B鎂,Monomethyl lithospermate B,丹参酸 B 镁,Lithospermate B	Others	Others
	Magnesium Lithospermate B 是一种咖啡酸四聚体的衍生物，从Salviae miltiorrhizae 中提取得到。它能够抑制神经炎症并减轻神经变性。它被广泛用于心血管疾病的研究，并且可以防止葡萄糖引起的细胞内氧化损伤。
TN6218	Vitisin A (+)-Vitisin A	Apoptosis; Antioxidant	Apoptosis; oxidation-reduction
	Vitisin A ((+)-Vitisin A) 是一种可从 Vitis vinifera 根中分离出来的白藜芦醇四聚体，具有抗氧化、抗癌、抗细胞凋亡、神经保护和抗炎活性，可改善东莨菪碱诱导的失忆 ICR 小鼠的学习和记忆功能受损，可用于研究退行性疾病。

天然产物

Magnesium Lithospermate B

Cat.No: T20793

Synonym: 丹參酸B鎂,Monomethyl lithospermate B,丹参酸 B 镁,Lithospermate B

Target: Others

Cat.No: TN6218

Synonym: (+)-Vitisin A

Target: Apoptosis, Antioxidant

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01510	HLA-A03:01&B2M&KRAS WT (VVVGAGGVGK) Tetramer* Protein, Human, MHC (His & Avi) NS,NS3,KRAS2,RASK2,MHC,RALD,K-Ras 2,K-RAS4B,C-K-RAS,KI-RAS,K...	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target.
TMPK-01493	HLA-A01:01&B2M&MAGE-A3 (EVDPIGHLY) Tetramer* Protein, Human, MHC (His & Avi) MZ2-D,Melanoma-associated antigen 3,MAGE-3,CT1.3,MZ2D	Human	HEK293 Cells
	Melanoma antigen gene A3 (MAGE-A3) is one of the most immunogenic cancer testis antigens and is common in various types of cancers. MAGE-A3 can be considered as a predictor for poor prognosis and an option for vaccine immunotherapy in patients with PCa.
TMPK-01519	HLA-A02:01&B2M&AFP (FMNKFIYEI) Tetramer* Protein, Human, MHC (His & Avi) MHC,FETA,AFP,Alpha-feto,AFPD,Alpha-1-fetoprotein,HPAFP,Alpha...	Human	HEK293 Cells
	Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response.
TMPK-01520	HLA-A02:01&B2M&AFP (PLFQVPEPV) Tetramer* Protein, Human, MHC (His & Avi) Alpha-1-fetoprotein,AFP,HPAFP,FETA,AFPD,MHC,Alpha-fetoprotei...	Human	HEK293 Cells
	Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response.
TMPK-01501	HLA-A02:01&B2M&HBV (FLLTRILTI) Tetramer* Protein, Human, MHC (His & Avi) MHC,Hepatitis B virus,HBV	Human	HEK293 Cells
	Hepatitis B virus (HBV), is the leading cause of liver diseases infecting an estimated 240 million persons worldwide. The HBV prevalence rates are variables between different countries, with an high level of endemicity in the south-eastern part of Europe. Seven main HBV-D subgenotypes have been described until now (D1-D7).
TMPK-01482	HLA-A02:03&B2M&AFP (FMNKFIYEI) Tetramer* Protein, Human, MHC (His & Avi) MHC,AFPD,Alpha-fetoprotein,FETA,Alpha-1-fetoprotein,AFP,HPAF...	Human	HEK293 Cells
	Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response.
TMPK-01494	HLA-A01:01&B2M&CT83 (NTDNNLAVY) Tetramer* Protein, Human, MHC (His & Avi) HLA-A,HLA-A*0101,HLA class I,MHC,MHC HLA-A alpha,CT83,MHC cl...	Human	HEK293 Cells
	Cancer/testis antigens 83 (CT83), also called KK-LC-1 or CXorf61, recognized by cytotoxic T lymphocytes (CTL), has become a promising target for immunotherapy.
TMPK-01518	HLA-A11:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer* Protein, Human, MHC (His & Avi) MHC,NS,KRAS1,K-RAS2A,GTPase Kras,KRAS,RALD,KRAS2,RASK2,C-K-R...	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
TMPK-01433	HLA-A11:01&B2M&KRAS G12C (VVVGACGVGK) Tetramer* Protein, Human, MHC (His & Avi) GTPase Kras,NS3,K-Ras 2,K-RAS2B,RALD,MHC,RASK2,K-RAS4A,CFC2,...	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
TMPK-01504	HLA-A02:01&B2M&HPV16 E7 (YMLDLQPET) Tetramer* Protein, Human, MHC (His & Avi) MHC,HPV16,E7	Human	HEK293 Cells
	HPV16 E7 protein, one of the primary target proteins in molecular targeted therapy for HPV-induced cervical cancer. The affitoxin, ZHPV16E7 affitoxin384 was generated by fusing the modified Pseudomonas Exotoxin A (PE38KDEL) to the HPV16 E7-specific affibody.
TMPK-01444	HLA-A02:01&B2M&MAGE-A1 (KVLEYVIKV) Tetramer* Protein, Human, MHC (His & Avi) MZ2-E,MAGE1A,MAGE-1 antigen,MAGE A1,MAGE-A1,MAGE-1,MAGE1,CT1...	Human	HEK293 Cells
	MAGE-A1 belongs to the chromosome X-clustered genes of cancer-testis antigen family and is normally expressed in the human germ line but is also overexpressed in various tumors.
TMPK-01540	HLA-A02:01&B2M&GP100 (YLEPGPVTA) Tetramer* Protein, Human, MHC (His & Avi) HLA0201,P100,MHC I,gp100,Glycoprotein 100,ME20-M	Human	HEK293 Cells
	Glycoprotein 100, gp100 or Melanocyte protein PMEL is 661 amino acids long and is a type I transmembrane glycoprotein enriched in melanosomes, which are the melanin-producing organelles in melanocytes. This protein is involved in melanosome maturation. The Human HLA-A0201 gp100 (YLEPGPVTA) complex Protein is a complex of HLA-A0201 of the MHC Class I, B2M and YLEPGPVTA peptide of the gp100.
TMPK-01544	HLA-E01:03&B2M&Peptide (VMAPRTLVL) Tetramer* Protein, Human, MHC (His & Avi) MHC class I antigen E,HLAE,sHLA-E,QA1,MHC HLA-E alpha-2.1,MH...	Human	HEK293 Cells
	HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ...
TMPK-01472	HLA-A24:02&B2M&MAGE-A3 (IMPKAGLLI) Tetramer* Protein, Human, MHC (His & Avi) MAGE-3,CT1.3,Melanoma-associated antigen 3,MZ2D,MZ2-D,HLA-A*...	Human	HEK293 Cells
	Melanoma antigen gene A3 (MAGE-A3) is one of the most immunogenic cancer testis antigens and is common in various types of cancers. MAGE-A3 can be considered as a predictor for poor prognosis and an option for vaccine immunotherapy in patients with PCa.
TMPK-01489	HLA-A11:01&B2M&KRAS WT (VVVGAGGVGK) Tetramer* Protein, Human, MHC (His & Avi) K-RAS2A,NS3,KRAS1,KRAS2,MHC,NS,K-RAS2B,K-RAS4A,KRAS,CFC2,RAS...	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target.
TMPK-01454	HLA-A02:01&B2M&PRAME (SLLQHLIGL) Tetramer* Protein, Human, MHC (His & Avi) MAPE,OIP4,OIP-4,PRAME	Human	HEK293 Cells
	PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen expressed in cutaneous and ocular melanomas and some other malignant neoplasms, while its expression in normal tissue and benign tumors is limited.
TMPK-01516	HLA-A02:01&B2M&Survivin (LMLGEFLKL) Tetramer* Protein, Human, MHC (His & Avi) IAP4,survivin variant 3 alpha,BIRC5,Survivin,EPR-1,API4,MHC ...	Human	HEK293 Cells
	Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all cancers; consequently, it has received significant attention as a potential oncotherapeutic target.
TMPK-01468	HLA-A02:01&B2M&MART-1 (ELAGIGILTV) Tetramer* Protein, Human, MHC (His & Avi) SK29-AA,MLANA,LB39-AA,Melan-A,MART1	Human	HEK293 Cells
	Melanoma antigen recognized by T cell-1 (Mart-1), one of the melanosome-specific proteins, also recognized by cytotoxicity T lymphocytes as a marker. Mart-1 is considered to play a critical role in the immunotherapy for melanoma.
TMPK-01542	HLA-A02:01&B2M&LMP2 (CLGGLLTMV) Tetramer* Protein, Human, MHC (His & Avi) RMF,PSMB9,Proteasome chain 7,RING12,LMP2,LMP-2,MHC,Macropain...	Human	HEK293 Cells
	The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma...
TMPK-01498	HLA-A11:01&B2M&LMP2 (SSCSSCPLTK) Tetramer* Protein, Human, MHC (His & Avi) Proteasome chain 7,MHC,RING12,RMF,LMP2,LMP-2,PSMB9,Macropain...	Human	HEK293 Cells
	The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma...
TMPK-01546	HLA-A02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer* Protein, Human, MHC (His & Avi) MHC,CT6.1,CTAG1,MY-ESO-1,ESO1CTAG,CTAG1B,NY-ESO-1,LAGE-2,LAG...	Human	HEK293 Cells
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPK-01541	HLA-E01:03&B2M&Peptide (VMAPRTLVL) Tetramer* Protein, Human, MHC (His & Avi), Biotinylated QA1,MHC HLA-E alpha-2.1,MHC,HLAE,MHC class I antigen E,MHC H...	Human	HEK293 Cells
	HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ...
TMPK-01434	HLA-A11:01&B2M&KRAS G12R (VVVGARGVGK) Tetramer* Protein, Human, MHC (His & Avi) RASK2,CFC2,GTPase Kras,KRAS,K-RAS2B,MHC,K-RAS2A,K-RAS4A,KRAS...	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
TMPK-01526	HLA-A03:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer* Protein, Human, MHC (His & Avi) KRAS,NS3,GTPase Kras,RASK2,K-RAS2B,C-K-RAS,MHC,KRAS2,KI-RAS,...	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
TMPK-01431	HLA-A11:01&B2M&KRAS G12S (VVVGASGVGK) Tetramer* Protein, Human, MHC (His & Avi) RALD,C-K-RAS,MHC,K-RAS2A,GTPase Kras,KRAS,NS,RASK2,K-RAS4B,K...	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
TMPK-01417	HLA-A02:03&B2M&AFP (FMNKFIYEI) Tetramer* Protein, Human, MHC (His & Avi), PE-Labeled Alpha-1-fetoprotein,HPAFP,AFPD,AFP,Alpha-feto,MHC,FETA,Alpha...	Human	HEK293 Cells
	Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response.
TMPK-01442	HLA-A02:01&B2M&P53 WT (HMTEVVRRC) Tetramer* Protein, Human, MHC (His & Avi), PE-Labeled HLA-A,P53,TP53,LFS1,MHC,BCC7,TRP53,FLJ92943,Antigen NY-CO-13	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein. p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
TMPK-01554	HLA-A02:01&B2M&WT-1 (RMFPNAPYL) Tetramer* Protein, Human, MHC (His & Avi) WT1,WT33,WIT-2,NPHS4GUD,AWT1,GUD,WAGR,MHC,RMF	Human	HEK293 Cells
	The WT1 protein plays a role in cell growth, the process by which cells mature to perform specific functions (differentiation), and the self-destruction of cells (apoptosis). WT1 is differentially expressed in serous, endometrioid, clear cell, and mucinous carcinomas of the peritoneum, fallopian tube, ovary, and endometrium.The Human HLA-A0201 WT-1 (RMFPNAPYL) complex Protein is a complex of HLA-A0201 of the MHC Class I, B2M and RMFPNAPYL peptide of the WT-1.
TMPK-01524	HLA-A02:01&B2M&MAGE-A4 (GVYDGREHTV) Tetramer* Protein, Human, MHC (His & Avi) CT1.4,MAGE-A4,MAGE4A,HLA0201,MAGE4B,MHC I,MAGE-X2,member 4	Human	HEK293 Cells
	Melanoma-associated antigen 4 is a protein that in humans is encoded by the MAGEA4 gene.The MAGE- A4 antigen is among the most commonly expressed cancer testis antigens. The Human HLA-A0201 MAGE-A4 (GVYDGREHTV) complex Protein is a complex of HLA-A0201 of the MHC Class I, B2M and GVYDGREHTV peptide of the MAGE-A4.
TMPK-01499	HLA-A02:01&B2M&NY-ESO-1 (SLLMWITQV) Tetramer* Protein, Human, MHC (His & Avi) ESO1CTAG,LAGE-2,CTAG1B,LAGE2A,MY-ESO-1,CT6.1,NY-ESO-1,CTAG1,...	Human	HEK293 Cells
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPK-01415	APC-equivalent Peptide Ready HLA-A02:01&B2M Tetramer* Protein, Human, MHC (His) Peptide Ready,HLA-A*02:01,MHC	Human	HEK293 Cells
	Peptide Ready HLA-A02:01&B2M Tetramer* is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A02:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramer*ized and loaded with peptides of choice in a high-throughput manner.
TMPK-01508	HLA-A02:01&B2M&P53 WT (HMTEVVRRC) Tetramer* Protein, Human, MHC (His & Avi) TP53,Antigen NY-CO-13,P53,MHC,HLA-A,BCC7,LFS1,FLJ92943,TRP53	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein. p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
TMPK-01406	HLA-A02:01&B2M&PRAME (SLLQHLIGL) Tetramer* Protein, Human, MHC (His & Avi), PE-Labeled MAPE,OIP4,OIP-4,PRAME	Human	HEK293 Cells
	PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen expressed in cutaneous and ocular melanomas and some other malignant neoplasms, while its expression in normal tissue and benign tumors is limited.
TMPK-01436	HLA-A02:01&B2M&AFP (FMNKFIYEI) Tetramer* Protein, Human, MHC (His & Avi), PE-Labeled Alpha-1-fetoprotein,FETA,MHC,Alpha-feto,AFPD,Alpha-fetoprote...	Human	HEK293 Cells
	Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response.
TMPK-01531	HLA-A02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer* Protein, Human, MHC (His & Avi) Antigen NY-CO-13,MHC,FLJ92943,TRP53,HLA-A,BCC7,TP53,LFS1,P53	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
TMPK-01432	HLA-A11:01&B2M&KRAS G12A (VVVGAAGVGK) Tetramer* Protein, Human, MHC (His & Avi) RASK2,K-RAS4A,K-RAS4B,KRAS2,CFC2,MHC,KRAS,KI-RAS,K-RAS2B,C-K...	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
TMPK-01486	HLA-A24:02&B2M&Survivin 2B (AYACNTSTL) Tetramer* Protein, Human, MHC (His & Avi) svn-2B,Survivin-2B,svn 2B	Human	HEK293 Cells
	Survivin-2B, a known splice variant of survivin, has been reported to promote cell death in some cancer cells, although it keeps prosurvival function in others.survivin-2B promoted autophagy and further regulated cell death by accumulating and stabilizing IKK alpha in the nucleus.
TMPK-01466	HLA-A02:01&B2M&HPV 16 E6 (KLPQLCTEL) Tetramer* Protein, Human, MHC (His & Avi) Human papillomavirus type 16,E6,HPV16	Human	HEK293 Cells
	Human papillomavirus (HPV) 16 infection is a necessary condition for the pathogenesis and development of cervical cancer. The E6 protein is expressed by the HPV16 E6 gene and promotes malignant phenotype transformation, which is an important mechanism for the occurrence and development of cervical cancer.
TMPK-01507	HLA-A11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer* Protein, Human, MHC (His & Avi) K-RAS2A,K-RAS4B,KI-RAS,RALD,C-K-RAS,RASK2,NS,MHC,NS3,K-RAS4A...	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
TMPK-01456	HLA-C03:04&B2M&KRAS G12D (GADGVGKSAL) Tetramer* Protein, Human, MHC (His & Avi) KRAS2,NS,MHC,C-K-RAS,KRAS1,K-RAS2A,K-RAS2B,KI-RAS,K-Ras 2,RA...	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
TMPK-01535	Chimeric HLA-A02:01 (mα3) &B2M&LMP2 (CLGGLLTMV) Tetramer* Protein, Human&Mouse, MHC (His & Avi) Macropain chain 7,LMP2,Proteasome chain 7,RING12,PSMB9,MHC,R...	Human & Mouse	HEK293 Cells
	The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma...
TMPK-01448	HLA-A02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer* Protein, Human, MHC (E. coli, His & Avi) MHC,LAGE-2,NY-ESO-1,ESO1CTAG,MY-ESO-1,CTAG1B,CTAG1,CT6.1,LAG...	Human	E. coli
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPK-01439	HLA-A11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer* Protein, Human, MHC (His & Avi), PE-Labeled KRAS,GTPase Kras,K-RAS2A,K-RAS4A,NS,CFC2,RALD,MHC,C-K-RAS,NS...	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
TMPK-01522	Chimeric HLA-A02:01 (mα3) &B2M&WT-1 (RMFPNAPYL) Tetramer* Protein, Human&Mouse, MHC (His & Avi) RMF,WT33,WIT-2,MHC,WAGR,AWT1,GUD,WT1,NPHS4GUD	Human & Mouse	HEK293 Cells
	The WT1 protein plays a role in cell growth, the process by which cells mature to perform specific functions (differentiation), and the self-destruction of cells (apoptosis). WT1 is differentially expressed in serous, endometrioid, clear cell, and mucinous carcinomas of the peritoneum, fallopian tube, ovary, and endometrium.The Human HLA-A0201 WT-1 (RMFPNAPYL) complex Protein is a complex of HLA-A0201 of the MHC Class I, B2M and RMFPNAPYL peptide of the WT-1.
TMPK-01497	HLA-A02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer* Protein, Human, MHC (His & Avi), PE-Labeled MY-ESO-1,MHC,ESO1CTAG,NY-ESO-1,CTAG1,LAGE2A,LAGE-2,CT6.1,CTA...	Human	HEK293 Cells
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPK-01438	HLA-A11:01&B2M&KRAS WT (VVVGAGGVGK) Tetramer* Protein, Human, MHC (His & Avi), PE-Labeled RASK2,KRAS2,KRAS1,MHC,C-K-RAS,KI-RAS,K-RAS4B,RALD,K-RAS4A,NS...	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target.
TMPK-01437	HLA-A02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer* Protein, Human, MHC (His & Avi), PE-Labeled FLJ92943,HLA-A,TP53,Antigen NY-CO-13,TRP53,MHC,BCC7,P53,LFS1	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
TMPK-01440	HLA-A11:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer* Protein, Human, MHC (His & Avi), PE-Labeled RASK2,KI-RAS,C-K-RAS,KRAS,MHC,NS,K-RAS4A,K-RAS2B,CFC2,K-Ras ...	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
TMPK-01435	HLA-A03:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer* Protein, Human, MHC (His & Avi), PE-Labeled KRAS2,NS3,RASK2,KI-RAS,RALD,K-RAS2B,K-RAS4B,GTPase Kras,C-K-...	Human	HEK293 Cells
	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
TMPJ-00542	TPSB2 Protein, Human, Recombinant (His) Tryptase-2,Tryptase Beta-2,TPS2,TPSB2,Tryptase II,Tryptase β...	Human	HEK293 Cells
	Tryptases are Trypsin-like Serine Proteases. β-Tryptases are the main isoenzymes in mast cells. Βtryptases form active tetramers with heparin proteoglycan. In the tetramer, the unique arrangement of the active sites facing a narrow central pore, β-Tryptases are resistant to macromolecule protease inhibitors . When mast cells are activated, β-Tryptases are released and participate in provoking inflammatory conditions . β-Tryptases have been implicated as mediators in the pathogenesis of asthma an...
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重组蛋白

HLA-A*03:01&B2M&KRAS WT (VVVGAGGVGK) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01510

Species: Human

Expression System: HEK293 Cells

HLA-A*01:01&B2M&MAGE-A3 (EVDPIGHLY) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01493

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01519

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&AFP (PLFQVPEPV) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01520

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&HBV (FLLTRILTI) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01501

Species: Human

Expression System: HEK293 Cells

HLA-A*02:03&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01482

Species: Human

Expression System: HEK293 Cells

HLA-A*01:01&B2M&CT83 (NTDNNLAVY) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01494

Species: Human

Expression System: HEK293 Cells

HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01518

Species: Human

Expression System: HEK293 Cells

HLA-A*11:01&B2M&KRAS G12C (VVVGACGVGK) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01433

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&HPV16 E7 (YMLDLQPET) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01504

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&MAGE-A1 (KVLEYVIKV) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01444

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&GP100 (YLEPGPVTA) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01540

Species: Human

Expression System: HEK293 Cells

HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01544

Species: Human

Expression System: HEK293 Cells

HLA-A*24:02&B2M&MAGE-A3 (IMPKAGLLI) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01472

Species: Human

Expression System: HEK293 Cells

HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01489

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01454

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&Survivin (LMLGEFLKL) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01516

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&MART-1 (ELAGIGILTV) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01468

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01542

Species: Human

Expression System: HEK293 Cells

HLA-A*11:01&B2M&LMP2 (SSCSSCPLTK) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01498

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01546

Species: Human

Expression System: HEK293 Cells

HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Tetramer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01541

Species: Human

Expression System: HEK293 Cells

HLA-A*11:01&B2M&KRAS G12R (VVVGARGVGK) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01434

Species: Human

Expression System: HEK293 Cells

HLA-A*03:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01526

Species: Human

Expression System: HEK293 Cells

HLA-A*11:01&B2M&KRAS G12S (VVVGASGVGK) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01431

Species: Human

Expression System: HEK293 Cells

HLA-A*02:03&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

Cat.No: TMPK-01417

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

Cat.No: TMPK-01442

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&WT-1 (RMFPNAPYL) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01554

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&MAGE-A4 (GVYDGREHTV) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01524

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01499

Species: Human

Expression System: HEK293 Cells

APC-equivalent Peptide Ready HLA-A*02:01&B2M Tetramer Protein, Human, MHC (His)

Cat.No: TMPK-01415

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01508

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

Cat.No: TMPK-01406

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

Cat.No: TMPK-01436

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01531

Species: Human

Expression System: HEK293 Cells

HLA-A*11:01&B2M&KRAS G12A (VVVGAAGVGK) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01432

Species: Human

Expression System: HEK293 Cells

HLA-A*24:02&B2M&Survivin 2B (AYACNTSTL) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01486

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&HPV 16 E6 (KLPQLCTEL) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01466

Species: Human

Expression System: HEK293 Cells

HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01507

Species: Human

Expression System: HEK293 Cells

HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01456

Species: Human

Expression System: HEK293 Cells

Chimeric HLA-A*02:01 (mα3) &B2M&LMP2 (CLGGLLTMV) Tetramer Protein, Human&Mouse, MHC (His & Avi)

Cat.No: TMPK-01535

Species: Human & Mouse

Expression System: HEK293 Cells

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (E. coli, His & Avi)

Cat.No: TMPK-01448

Species: Human

Expression System: E. coli

HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

Cat.No: TMPK-01439

Species: Human

Expression System: HEK293 Cells

Chimeric HLA-A*02:01 (mα3) &B2M&WT-1 (RMFPNAPYL) Tetramer Protein, Human&Mouse, MHC (His & Avi)

Cat.No: TMPK-01522

Species: Human & Mouse

Expression System: HEK293 Cells

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

Cat.No: TMPK-01497

Species: Human

Expression System: HEK293 Cells

HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

Cat.No: TMPK-01438

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

Cat.No: TMPK-01437

Species: Human

Expression System: HEK293 Cells

HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

Cat.No: TMPK-01440

Species: Human

Expression System: HEK293 Cells

HLA-A*03:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

Cat.No: TMPK-01435

Species: Human

Expression System: HEK293 Cells

TPSB2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00542

Species: Human

Expression System: HEK293 Cells

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