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重组蛋白 细胞因子和生长因子 •   细胞因子 •   生长因子 受体蛋白 •   Fc 受体 •   细胞因子和生长因子受体 •   受体酪氨酸激酶 CD 蛋白 •   T 细胞 CD 蛋白 •   B 细胞 CD 蛋白 免疫检查点蛋白 •   抑制性免疫检查点蛋白 •   刺激性免疫检查点蛋白 CAR-T 细胞治疗靶点蛋白 •   血液恶性肿瘤靶点蛋白 •   实体瘤靶点蛋白
信号通路 血管生成 凋亡 自噬 细胞周期 表观遗传 细胞骨架
DNA损伤和修复 内分泌与激素 G蛋白偶联受体 免疫与炎症 JAK/STAT信号通路 MAPK信号通路 离子通道
代谢 微生物学 神经科学 NF-κB信号通路 氧化还原 PI3K/Akt/mTOR信号通路 蛋白酶体
干细胞 蛋白酪氨酸激酶 泛素化 PROTAC 其他
活性化合物库 上市药物库 临床期小分子药物库 已知活性化合物库 FDA上市及药典收录分子库 抗癌药物库 抗病毒库 铁死亡化合物库
天然产物库 高通量筛选天然产物库 Ro5类药天然产物库 中药单体化合物库 糖类及苷类化合物库 稀有天然产物库 天然产物衍生物库 天然产物单体化合物库
Fragment片段库 高溶解性片段库 精选片段库 高溶解性多官能团片段化合物库 高溶解性卤化片段化合物库 药物片段库 Mini片段亲电杂环化合物库 高溶解性微型片段化合物库
类药性化合物库 多样性核心库Part2 多样性核心库Part1 药物靶点库 多样性核心预制库 Golden骨架库 Mini骨架库 化合物库深度定制
TargetMol Compound Library
天然产物库 高通量筛选天然产物库 特色天然产物库 天然产物衍生物库 虚拟筛选天然产物库
结构类型 萜类 类固醇 类黄酮 醌类 香豆素 木脂素 多糖和糖苷
苯丙烷 生物碱 酚类 其他
植物来源 列当科 水龙骨科 南洋杉科 报春花科 海金沙科 商陆科 买麻藤科
萝藦科 肉豆蔻科 鸭跖草科 交让木科 三白草科 海桐花科 五味子科 红厚壳科
莲叶桐科 胡桃科 石杉科 桔梗科 百合科 忍冬科 漆树科
计算机辅助药物设计 虚拟筛选 分子对接 反向找靶 分子动力学模拟
基于靶点筛选实体化合物活性筛选 分子结合&互作检测 酶学靶点活性检测 核受体靶点活性检测 GPCR靶点活性检测
基于表型筛选实体化合物活性筛选 细胞增殖检测 细胞周期检测 细胞凋亡检测 药代动力学研究
药物设计和结构优化 化合物定制合成 分子砌块 网络药理学平台 软件平台
细胞因子和生长因子 •   细胞因子 •   生长因子 受体蛋白 •   Fc 受体 •   细胞因子和生长因子受体
CD 蛋白 •   T 细胞 CD 蛋白 •   B 细胞 CD 蛋白 免疫检查点蛋白 •   抑制性免疫检查点蛋白 •   刺激性免疫检查点蛋白
CAR-T 细胞治疗靶点蛋白 •   血液恶性肿瘤靶点蛋白 •   实体瘤靶点蛋白 酶 •   氧化还原酶 •   转移酶
病毒蛋白 •   冠状病毒蛋白 •   流感病毒蛋白 荧光蛋白 其他蛋白

搜索结果

Search Results for " synapse "
Targets Recommended: transporter

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抑制剂 & 化合物

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天然产物

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重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T9347 EAAT2 activator 1

3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine

 transporter Metabolism
EAAT2 activator 1 (3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine) 是兴奋性氨基酸转运蛋白 2(EAAT2) 的有效激活剂，以剂量依赖性方式增加 EAAT2 蛋白水平。
T9379 L-Threonic acid magnesium salt

Others Others
L-Threonic acid magnesium salt 可增加老年大鼠和晚期阿尔茨海默病 (AD) 模型小鼠的突触密度和记忆能力。
T26408 A 21960

Ethyl 2-chloroacetoacetate,A21960,A-21960

 Others Others
A 21960 (Ethyl 2-chloroacetoacetate) 能抑制 resolvase 与两个直接重复的 res 位点之间的突触形成，阻断位点特异性重组反应，可用于研究细菌感染。
TP1223L Apamin acetate

Apamine acetate,Apamin acetate(24345-16-2 Free base)

 Potassium Channel Membrane transporter/Ion channel
Apamin acetate (Apamine acetate) 是一种具有选择性的 Ca2+ 激活的 K+ (SK) 通道的阻断剂，是在蜂毒素中发现的一种 18 个氨基酸的肽类神经毒素。Apamin acetate 可增强皮质神经元撕裂损伤后的神经突生长和再生。Apamin acetate 具有抗炎和抗纤维化的作用。
T26407 A 20832

A-20832,A20832

 Others Others
A-20832 inhibits resolvase-promoted site-specific recombination postsynaptically at strand cleavage. It does not inhibit resolvase binding to res, as measured by filter binding, or synapse formation. DNase I analysis in the presence of A-20832 indicates t
T76998 Cevostamab

Cevostamab（BFCR4350A; RG6160; RO7187797）为一种人源化IgG1基型双特异性抗体（BsAb），特异性结合多发性骨髓瘤（MM）细胞表面FcRH5的近膜端胞外结构域及T细胞CD3，促进高效的免疫突触形成，增强T细胞对MM肿瘤细胞的杀伤能力。
T35436 (-)-L-threo-PDMP (hydrochloride)

Others Others
(-)-L-threo-PDMP is an enhancer of ganglioside biosynthesis. The (-)-L-threo-PDMP (1S,2S) isomer is the active stimulatory component of DL-threo-PDMP in contrast to (+)-D-threo-PDMP , which is an inhibitor of glucosylceramide synthetase. (-)-L-threo-PDMP upregulates GM3, GD3, and GQ1b synthase levels, which are glycosyltransferases involved in ganglioside biosynthesis, and increases ganglioside levels in cells. It increases neurite outgrowth and synapse formation in vitro and improves retention ...
T76221 Leptin (116-130)

Leptin(116-130)是一种生物活性的瘦素片段，能促进AMPA受体运输至突触并加强活动依赖性的海马突触可塑性。此外，Leptin(116-130)在抗淀粉样蛋白毒性模型中有效阻止海马突触损伤和神经元细胞死亡，显示出对研究阿尔茨海默病(AD)具有重要潜力。
T35892 Q134R

Q134R

 Others Others
Q134R, a neuroprotective hydroxyquinoline derivative that suppresses nuclear factor of activated T cell (NFAT) signaling. Q134R can across blood-brain barrier. Q134R has the potential for Alzheimer’s disease (AD) and aging-related disorders research[1]. Q134R (1-10 μM) suppresses NFAT signaling, without inhibiting calcineurin activity. Q134R partially inhibits NFAT activity in primary rat astrocytes, but does not prevent calcineurin-mediated dephosphorylation of a non-NFAT target, either in vivo...

化合物

EAAT2 activator 1
Cat.No: T9347
Synonym: 3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine
Target: transporter
L-Threonic acid magnesium salt
Cat.No: T9379
Synonym:
Target: Others
A 21960
Cat.No: T26408
Synonym: Ethyl 2-chloroacetoacetate,A21960,A-21960
Target: Others
Apamin acetate
Cat.No: TP1223L
Synonym: Apamine acetate,Apamin acetate(24345-16-2 Free base)
Target: Potassium Channel
A 20832
Cat.No: T26407
Synonym: A-20832,A20832
Target: Others
Cevostamab
Cat.No: T76998
Synonym:
Target:
(-)-L-threo-PDMP (hydrochloride)
Cat.No: T35436
Synonym:
Target: Others
Leptin (116-130)
Cat.No: T76221
Synonym:
Target:
Q134R
Cat.No: T35892
Synonym: Q134R
Target: Others
Cat. No. Product Name Target Signaling Pathways
TN2100 Pratensein

红车轴草素,三叶草

 Others; NF-κB NF-κB; Others
Pratensein 是黄酮类化合物，能够减少氧化损伤和恢复突触和 BDNF 水平，改善 β-淀粉样蛋白诱导的大鼠认知障碍。

天然产物

Pratensein
Cat.No: TN2100
Synonym: 红车轴草素,三叶草
Target: Others, NF-κB
Species：
Human (11)
Mouse (9)
Rat (1)
Expression System：
HEK293 Cells (8)
E. coli (7)
Baculovirus Insect Cells (5)
P. pastoris (Yeast) (1)
Tag：
C-His (5)
N-6xHis (5)
C-6xHis (2)
C-hFc (2)
His, GST (2)
N-10xHis, C-Myc (2)
N-10xHis-SUMO, C-Myc (1)
N-His (1)
N-mFc (1)
Cat. No. Product Name Species Expression System
TMPY-06815 SYAP1 Protein, Human, Recombinant (His)

PRO3113,synapse associated protein 1

 Human Baculovirus Insect Cells
Synapse-associated protein 1 (SYAP1), also known as PRO3113 and BSTA, belongs to the synapse-associated BSD domain family, featuring three α-helices and two conserved tryptophan and phenylalanine residues located at the C-terminus. Expressed near neuronal Golgi and synaptic regions of cerebellar Purkinje cells, SYAP1 has been linked to intact sensorimotor control and general vesicular trafficking in neurons. SYAP1-deficient mice display impaired locomotor activity. In cultured adipocytes, SYAP1 ...
TMPJ-00652 PSD-95 Protein, Rat, Recombinant (His)

PSD95,SAP90,Disks large homolog 4,SAP-90,PSD-95,Postsynaptic...

 Rat E. coli
Disks large homolog 4(DLG4) is a cell membrane protein and it is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains 1 guanylate kinase-like domain，3 PDZ (DHR) domains and 1 SH3 domain. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. DLG4 is the be...
TMPH-01876 Plexin-B1 Protein, Human, Recombinant (mFc)

Plexin-B1,Semaphorin receptor SEP,PLXNB1

 Human HEK293 Cells
Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Plexin-B1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with N-mFc tag. The predicted molecular weight is 83.2 kDa and the accession number is O43157.
TMPH-02807 NPTXR Protein, Mouse, Recombinant (His & Myc)

Neuronal pentraxin receptor,Nptxr

 Mouse Baculovirus Insect Cells
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.
TMPH-02162 Synaptotagmin-1 Protein, Human, Recombinant (His)

SYT1,Synaptotagmin-1,p65,Synaptotagmin I

 Human E. coli
Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at leas...
TMPH-01875 Plexin-B1 Protein, Human, Recombinant (His)

Semaphorin receptor SEP,PLXNB1,Plexin-B1

 Human E. coli
Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Plexin-B1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 56.4 kDa and the accession number is O43157.
TMPH-02528 SLC7A10 Protein, Mouse, Recombinant (His & SUMOstar)

Slc7a10,Solute carrier family 7 member 10,Asc-type amino aci...

 Mouse P. pastoris (Yeast)
Sodium-independent, high affinity transport of small neutral D- and L-amino acids and amino acid-related compounds. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse. SLC7A10 Protein, Mouse, Recombinant (His & SUMOstar) is expressed in yeast with N-His tag. The predicted molecular weight is 22.5 kDa and the accession number is P63115.
TMPH-01844 Paralemmin-1/PALM Protein, Human, Recombinant (His)

Paralemmin,PALM,Paralemmin-1

 Human E. coli
Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. Paralemmin-1/PALM Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 45.7 kDa and the accession number is O75781.
TMPH-02808 NPTX1 Protein, Mouse, Recombinant (His)

Nptx1,Neuronal pentraxin-1,Neuronal pentraxin I

 Mouse E. coli
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.
TMPK-00621 CSPG5 Protein, Human, Recombinant (His)

CALEB,NGC,MGC44034,Neuroglycan C

 Human HEK293 Cells
Chondroitin sulfate proteoglycan 5 (CSPG-5), also known as neuroglycan C, has been previously associated to differentiation since it shapes neurite growth and synapse forming. CSPG-5 expression shifts in brain areas of the default mode network of suicide victims, which may reflect an impact in the pathogenesis of psychiatric diseases or support diagnostic power.
TMPK-00697 CD6 Protein, Human, Recombinant (His)

CD6,TP120,T12

 Human HEK293 Cells
The cell surface glycoprotein CD6 is expressed on leukocytes and mediates T cell trafficking across endothelial cell barriers. CD6 is a lymphocyte surface co-receptor physically associated with the T-cell receptor (TCR)/CD3 complex at the center of the immunological synapse.
TMPH-02923 SRPX2 Protein, Mouse, Recombinant (His & Myc & SUMO)

Srpx2,Sushi repeat-containing protein SRPX2

 Mouse E. coli
Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. Required for ultrasonic vocalizations. SRPX2 Protein, Mouse, Recombinant (His & Myc & SUMO) is expressed in E. coli expression syste...
TMPK-00612 CSPG5 Protein, Mouse, Recombinant (His)

MGC44034,Chondroitin sulfate proteoglycan 5,Neuroglycan C,Ca...

 Mouse HEK293 Cells
CALEB also known as chondroitin sulfate proteoglycan (CSPG)5 or neuroglycan C, is a neural chondroitin sulfate-containing and epidermal growth factor (EGF)-domain-containing transmembrane protein that is implicated in synaptic maturation. An involvement of CALEB in the presynaptic differentiation of cerebellar GABAergic synapses and revealed a new role for CALEB in synapse elimination in Purkinje cells.
TMPH-02687 Granzyme A/GZMA Protein, Mouse, Recombinant (His)

CTLA-3,Granzyme A,Autocrine thymic lymphoma granzyme-like se...

 Mouse E. coli
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. Granz...
TMPJ-01130 NPTX1 Protein, Human, Recombinant (His)

Neuronal pentraxin-1,NPTX1,NP1

 Human HEK293 Cells
Neuronal Pentraxin (NPTX1, NP1) is a secreted glycoprotein within the Pentraxin family. NPTX1 is co‑expressed and forms heteromultimers with the related secreted protein, NPTX2/NARP, NPTXR (Neuronal Pentraxin Receptor) at excitatory synapses. Mature human NPTX1 shares 97% aa sequence identity with mouse, and rat NPTX1. It is produced by hippocampal, cerebral and cerebellar neurons, retinal ganglia and the inner nuclear layer of the retina. It is enriched on presynaptic axonal membranes where it ...
TMPH-02922 SRPX2 Protein, Mouse, Recombinant (His & Myc)

Sushi repeat-containing protein SRPX2,Srpx2

 Mouse Baculovirus Insect Cells
Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. Required for ultrasonic vocalizations. SRPX2 Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N...
TMPY-01842 Neuroligin-3/NLGN3 Protein, Human, Recombinant (His)

neuroligin 3,HNL3

 Human HEK293 Cells
Neuroligin 3 (NLGN3) is a member of the type-B carboxylesterase/lipase family. Neuroligins (NLGNs) are a family of presumptive postsynaptic cell adhesion molecules. Neuroligins (NLs) constitute a family of cell-surface proteins that interact with neurexins (beta-Nxs), another class of neuronal cell-surface proteins, one of each class functioning together in synapse formation. Neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons. NL...
TMPY-04414 MUSK Protein, Human, Recombinant (aa 433-783, His & GST)

FADS,CMS9,muscle, skeletal, receptor tyrosine kinase

 Human Baculovirus Insect Cells
Muscle, skeletal receptor tyrosine-protein kinase, also known as Muscle-specific tyrosine-protein kinase receptor, Muscle-specific kinase receptor, and MUSK, is a single-pass type I membrane protein that belongs to the protein kinase superfamily and tyr protein kinase family. MUSK contains one FZ (frizzled) domain, three Ig-like C2-type (immunoglobulin-like) domains, and one protein kinase domain. This protein is a muscle-specific tyrosine kinase receptor and it may play a role in clustering of ...
TMPJ-00339 ALCAM Protein, Mouse, Recombinant (hFc)

CD6 ligand,CD166 antigen,CD6L,activated leucocyte cell adhes...

 Mouse HEK293 Cells
Activated leukocyte cell adhesion molecule (ALCAM), also named as CD166 and MEMD, is a typeI transmembrane glycoprotein of immunoglobulin superfamily, which mediates homotypic and heterotypic interactions between cells. ALCAM interacts with high affinity with CD6 molecule but weaker homotypic (ALCAM–ALCAM) interactions have also been described. ALCAM–CD6 interactions play an important role in the maintenance of T cell activation, proliferation as well as in formation of immune synapse between an...
TMPJ-00281 CADM1 Protein, Mouse, Recombinant (hFc)

IgSF4,NECL-2,Nectin-like protein 2,Immunoglobulin superfamil...

 Mouse HEK293 Cells
Cell adhesion molecule 1(CADM1) is a single-pass type I membrane protein and belongs to the nectin family. It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in...
TMPY-04408 CAMKII beta/CAMK2B Protein, Human, Recombinant (His & GST)

calcium/calmodulin-dependent protein kinase II beta,CAM2,CAM...

 Human Baculovirus Insect Cells
Calcium/calmodulin-dependent protein kinase II beta (CAMK2B) is a member of the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. CaMKII is an important player in prostate cancer cells ability to escape apoptosis under androgen ablation and facilitate the progression of prostate cancer cells to an androgen independent state. As a multifunctional protein kinase, the loss of activity may play a critical role in initiating the changes leading to...

重组蛋白

SYAP1 Protein, Human, Recombinant (His)
Cat.No: TMPY-06815
Species: Human
Expression System: Baculovirus Insect Cells
PSD-95 Protein, Rat, Recombinant (His)
Cat.No: TMPJ-00652
Species: Rat
Expression System: E. coli
Plexin-B1 Protein, Human, Recombinant (mFc)
Cat.No: TMPH-01876
Species: Human
Expression System: HEK293 Cells
NPTXR Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02807
Species: Mouse
Expression System: Baculovirus Insect Cells
Synaptotagmin-1 Protein, Human, Recombinant (His)
Cat.No: TMPH-02162
Species: Human
Expression System: E. coli
Plexin-B1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01875
Species: Human
Expression System: E. coli
SLC7A10 Protein, Mouse, Recombinant (His & SUMOstar)
Cat.No: TMPH-02528
Species: Mouse
Expression System: P. pastoris (Yeast)
Paralemmin-1/PALM Protein, Human, Recombinant (His)
Cat.No: TMPH-01844
Species: Human
Expression System: E. coli
NPTX1 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02808
Species: Mouse
Expression System: E. coli
CSPG5 Protein, Human, Recombinant (His)
Cat.No: TMPK-00621
Species: Human
Expression System: HEK293 Cells
CD6 Protein, Human, Recombinant (His)
Cat.No: TMPK-00697
Species: Human
Expression System: HEK293 Cells
SRPX2 Protein, Mouse, Recombinant (His & Myc & SUMO)
Cat.No: TMPH-02923
Species: Mouse
Expression System: E. coli
CSPG5 Protein, Mouse, Recombinant (His)
Cat.No: TMPK-00612
Species: Mouse
Expression System: HEK293 Cells
Granzyme A/GZMA Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02687
Species: Mouse
Expression System: E. coli
NPTX1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01130
Species: Human
Expression System: HEK293 Cells
SRPX2 Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02922
Species: Mouse
Expression System: Baculovirus Insect Cells
Neuroligin-3/NLGN3 Protein, Human, Recombinant (His)
Cat.No: TMPY-01842
Species: Human
Expression System: HEK293 Cells
MUSK Protein, Human, Recombinant (aa 433-783, His & GST)
Cat.No: TMPY-04414
Species: Human
Expression System: Baculovirus Insect Cells
ALCAM Protein, Mouse, Recombinant (hFc)
Cat.No: TMPJ-00339
Species: Mouse
Expression System: HEK293 Cells
CADM1 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPJ-00281
Species: Mouse
Expression System: HEK293 Cells
CAMKII beta/CAMK2B Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-04408
Species: Human
Expression System: Baculovirus Insect Cells
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