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Search Results for " spores "

Targets Recommended: Antibacterial Antibiotic Antifungal

5

抑制剂 & 化合物

5

天然产物

3

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T0901	Chlorobutanol Chlortran,Chloretone,YM-57158,三氯叔丁醇,Chlorbutol,Chloreton	Antibacterial; Antibiotic; Antifungal	Microbiology/Virology
	Chlorobutanol (Chlortran) 是一种药物防腐剂，对多种革兰氏阳性和革兰氏阴性细菌以及几种霉菌孢子和真菌具有抗性。它广泛用于食品和化妆品工业，有促进安定、睡眠的作用。
T36075	Cholic Acid anilide	Others	Others
	Cholic acid anilide is a synthetic bile acid and derivative of cholic acid that inhibits the germination of C. difficile strain R20291 spores in vitro (IC50 = 1.8 μM).1 \|1. Sharma, S.K., Yip, C., Esposito, E.X., et al. The design, synthesis, and characterizations of spore germination inhibitors effective against an epidemic strain of Clostridium difficile. J. Med. Chem. 61(15), 6759-6778 (2018).
T80372	P1
	P1是一种具有抗革兰氏阳性菌与抗革兰氏阴性菌能力的广谱抗菌肽，有效针对B. anthracis、耐碳青霉烯类细菌A. baumannii和K. pneumoniae。
T79545	Antifungal agent 66	Others	Others
	Antifungalagent 66（compound 10）是一种具备广谱抗真菌活性的化合物。它对七种植物病原真菌菌丝体显示出有效抑制作用，并对B. cinerea孢子表现出显著的抑制活性，其IC50为47.7 μg/mL。
T38151	Germicidin A	Others	Others
	Germicidin A is a pyranone originally derived from S. viridochromogenes that acts as a reversible, autoregulative inhibitor of spore germination and hyphal elongation in the genus Streptomyces at concentrations as low as 200 pM. During germination, spores of Streptomyces excrete germicidin A along with other germicidin homologs, which inhibit germination of its own arthrospores. At higher concentrations, germicidin A can inhibit the porcine Na+/K+-activated ATPase (ID50 = 100 μM) and prevent the...

化合物

Cat.No: T0901

Synonym: Chlortran,Chloretone,YM-57158,三氯叔丁醇,Chlorbutol,Chloreton

Target: Antibacterial, Antibiotic, Antifungal

Cholic Acid anilide

Cat.No: T36075

Target: Others

Cat.No: T80372

Antifungal agent 66

Cat.No: T79545

Target: Others

Cat.No: T38151

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T15001	Corypalmine	Others; Antifungal	Microbiology/Virology; Others
	Corypalmine 是一种来自黄连、紫瑾的生物碱，对植物病原孢子萌发和腐生真菌具有抑制作用。
TN4509	Medicarpin 3-O-glucoside	Others	Others
	Medicarpin-3-O-glucoside, a phytoalexin, inhibits the germination of G. intraradices spores and hyphal elongation.
T31913	Ganosporeric acid A
	Ganosporeric acid A is a natural compound extracted from the spores of Ganoderma lucidum karst.
T13764	Lycopodine	Lipoxygenase; Caspase	Apoptosis; Metabolism; Proteases/Proteasome
	Lycopodine, a bioactive compound derived from Lycopodium clavatum spores, effectively inhibits the proliferation of HeLa cells through the induction of apoptosis. This process is mediated by caspase-3 activation. In refractory prostate cancer cells, Lycopodine triggers apoptosis by modulating 5-lipoxygenase and depolarizing the mitochondrial membrane potential, without altering p53 activity.
TN5153	Torilin	MMP; ERK; IκB/IKK; p38 MAPK; NF-κB; Tyrosinase; Reductase; DNA/RNA Synthesis; JNK	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Endocrinology/Hormones; MAPK; Metabolism; NF-κB; Proteases/Proteasome
	Torilin 是一种睾酮5α还原酶抑制剂，它（IC50=31.7+/-4.23μM）对5α还原酶的抑制作用强于α-亚麻酸（IC50=160.3+/-24.62μM），但弱于非那雄胺（IC50=0.38+/-0.06μM）。Torilin 具有免疫调节、肝脏保护和抗炎特性，它通过限制 TAK1介导的 MAP 激酶和 NF-βB 活化来抑制炎症，它可以减轻关节炎的严重程度，改变 dLN 或关节中的白细胞活化，并恢复血清和脾细胞细胞因子失衡。托利林抑制α-黑素细胞刺激激素激活的 B16黑色素瘤细胞中的黑色素生成，IC（50）值为25μM。Torilin 对枯草芽孢杆菌 ATCC 6633孢子和营养细胞表现出优异的抗菌活性。Torilin 在体内和体外都具有强大的抗血管生成活性，它可能通过抑制肿瘤侵袭来抑制肿瘤发生，逆转癌细胞的多药耐药性，它可以增强阿霉素、长春碱、紫杉醇和秋水仙碱对多药耐药 KB-V1和 MCF7/ADR 细胞的细胞毒性。

天然产物

Cat.No: T15001

Target: Others, Antifungal

Medicarpin 3-O-glucoside

Cat.No: TN4509

Target: Others

Ganosporeric acid A

Cat.No: T31913

Cat.No: T13764

Target: Lipoxygenase, Caspase

Cat.No: TN5153

Target: MMP, ERK, IκB/IKK, p38 MAPK, NF-κB, Tyrosinase, Reductase, DNA/RNA Synthesis, JNK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02337	Hydrophobin-1 Protein, Hypocrea jecorina, Recombinant (His & SUMO) hfb1,Hydrophobin-1,Hydrophobin I	Hypocrea jecorina	E. coli
	Contributes to surface hydrophobicity, which is important for processes such as association of hyphae in reproductive structures, dispersal of aerial spores and adhesion of pathogens to host structures. Hydrophobin-1 Protein, Hypocrea jecorina, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 23.5 kDa and the accession number is P52754.
TMPY-05009	Asp f 1 Protein, Neosartorya fumigata, Recombinant (His)	Neosartorya fumigata	HEK293 Cells
	Asp f 1 (Aspergillus fumigatus allergen 1) is a major allergen produced by the mycelia of Aspergillus fumigatus. It is not present in spores and can be used as a specific marker for the detection of germination of this fungus. Allergic bronchopulmonary aspergillosis (ABPA) is an immunologically complex allergic disorder caused by the fungal pathogen Aspergillus fumigatus.
TMPH-00035	Polyphenol oxidase 2 Protein, Agaricus bisporus, Recombinant (His) Tyrosinase 2,Cresolase 2,PPO2,Polyphenol oxidase 2	Agaricus bisporus	Baculovirus Insect Cells
	Copper-containing oxidase that catalyzes both the o-hydroxylation of monophenols and the subsequent oxidation of the resulting o-diphenols into reactive o-quinones, which evolve spontaneously to produce intermediates, which associate in dark brown pigments. Involved in the initial step of melanin synthesis. Melanins constitute a mechanism of defense and resistance to stress such as UV radiations, free radicals, gamma rays, dehydratation and extreme temperatures, and contribute to the fungal cell...

重组蛋白

Hydrophobin-1 Protein, Hypocrea jecorina, Recombinant (His & SUMO)

Cat.No: TMPH-02337

Species: Hypocrea jecorina

Expression System: E. coli

Asp f 1 Protein, Neosartorya fumigata, Recombinant (His)

Cat.No: TMPY-05009

Species: Neosartorya fumigata

Expression System: HEK293 Cells

Polyphenol oxidase 2 Protein, Agaricus bisporus, Recombinant (His)

Cat.No: TMPH-00035

Species: Agaricus bisporus

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0347	Phenol-d6
	Phenol-d6 是 Phenol 的氘代化合物。Phenol 的 CAS 号为 108-95-2。Phenol 是一种有毒的无色结晶固体，具有类似医院气味的甜焦油气味。它通常用作防腐剂和消毒剂。它对包括一些真菌和病毒在内的多种微生物有活性，但对孢子只有缓慢的效果。它已被用于消毒皮肤和缓解瘙痒。苯酚还用于制备化妆品，包括防晒霜、染发剂和亮肤制剂。它还用于生产药物（它是工业生产阿司匹林的原料）、除草剂和合成树脂。
TMIJ-0416	Phenol-d5 (2,3,4,5,6-d5)
	Phenol-d5 (2,3,4,5,6-d5) 是 Phenol 的氘代化合物。Phenol 的 CAS 号为 108-95-2。Phenol 是一种有毒的无色结晶固体，具有类似医院气味的甜焦油气味。它通常用作防腐剂和消毒剂。它对包括一些真菌和病毒在内的多种微生物有活性，但对孢子只有缓慢的效果。它已被用于消毒皮肤和缓解瘙痒。苯酚还用于制备化妆品，包括防晒霜、染发剂和亮肤制剂。它还用于生产药物（它是工业生产阿司匹林的原料）、除草剂和合成树脂。

同位素标记化合物

Cat.No: TMIJ-0347

Phenol-d5 (2,3,4,5,6-d5)

Cat.No: TMIJ-0416

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