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Search Results for " soft "

Targets Recommended: Others

36

抑制剂 & 化合物

5

天然产物

2

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T16949	Sucrose octaacetate	Others	Others
	Sucrose octaacetate 是蔗糖的乙酰化衍生物，具有强烈的苦味，可用作苦味替代品。它可用作食品添加剂，还可用作粘合剂和增塑剂。它也可用作软模板，以合成聚苯胺纳米纤维。它还用于许多农药，杀虫剂和其他有毒产品中，以防止意外中毒。
T4502	BISMUTH SUBGALLATE 次没食子酸铋,Dermatol Puder,Bismuth Gallate	Others	Others
	Bismuth subgallate (Dermatol Puder) 是一种止血剂，可作用于凝血因子 XII ，促使凝血级联的激活，改善纤维蛋白凝块的早期形成。
T12242	Norvancomycin hydrochloride Desmethyl-vancomycin hydrochloride,盐酸去甲万古霉素	Antibacterial	Microbiology/Virology
	Norvancomycin hydrochloride (Desmethyl-vancomycin hydrochloride) 可用于葡萄球菌所致的心内膜炎、骨髓炎、肺炎、败血症或软组织感染。
T7902	Ozenoxacin 奥泽沙星,T-3912	Antibacterial	Microbiology/Virology
	Ozenoxacin (T-3912) 是一种非氟喹诺酮抗菌剂，对大多数从在皮肤和软组织感染中分离的微生物有活性。
T8133	SulfadiMethoxine sodium	Anti-infection; Antibacterial; Antibiotic	Microbiology/Virology
	SulfadiMethoxine sodium 是一种磺胺类抗生素，可研究由多种感染引起的疾病。
T76761	Olaratumab LY3012207,IMC-3G3	PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Olaratumab(IMC-3G3) 是一种人源抗血小板衍生生长因子受体α (PDGFRα)单克隆 IgG1 抗体，具有抗肿瘤作用，可用于研究晚期软组织肉瘤。
T3280	Clodronate disodium tetrahydrate clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,氯屈膦酸二钠(四水合物),Clodronate disodium	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Clodronate disodium tetrahydrate (Clastoban) 是一种选择性、高效的，可逆、Cl-竞争性的囊泡核苷酸转运体阻滞剂(IC50:15.6 nM)。是一种双膦酸盐，具有抗骨质疏松、抗炎作用，可用于缓解疼痛的研究。它可抑制神经元释放囊泡 ATP，缓解慢性神经病理性疼痛和炎症性疼痛。
T60197	UNC 1025	Others	Others
	UNC1062 is a highly selective tyrosine kinase inhibitor that specifically targets MERTK. This compound effectively suppresses MERTK-mediated downstream signaling, induces apoptosis in cell cultures, reduces colony formation in soft agar, and inhibits invasion of melanoma cells. Notably, UNC1062 demonstrates potent inhibition of MERTK kinase activity, with an IC50 of 1.1 nM and a Morrison Ki of 0.33 nM. It also displays specificity within the TAM family, exhibiting IC50 values of 60 nM for TYRO3 ...
T9657	FiVe1	Others	Others
	FiVe1是一种波形蛋白结合小分子，在中期促进波形蛋白解体和磷酸化，导致有丝分裂灾难，多核化和癌细胞干性丧失；选择性地和不可逆地抑制间充质转化的乳腺癌细胞（FOXC2-HMLER 细胞IC50=234nM）和不同组织学亚型的软组织肉瘤的生长。
T34528	Sarcosterol	Others	Others
	Sarcosterol is a marine sterol from the soft coral Sinularia mayi.
T71312	Litophynin C	Others	Others
	Litophynin C is an Insect Growth Inhibitory Diterpenoid from a Soft Coral Litophyton sp.
T34863	Thurfyl Salicylate Tetrahydrofurfuryl salicylate	Others	Others
	Thurfyl Salicylate (tetrahydrofurfuryl Salicylate) is a redness preparation used for the treatment of musculoskeletal, joint, periarticular, and soft tissue pain.
T32835	Lobomichaolide	Others	Others
	Lobomichaolide is a cembranolide from the soft coral, Lobophytum michaelae.
T34527	Sarcophytoxide	Others	Others
	Sarcophytoxide is a polyoxygenated cembranoid from the soft coral Sarcophyton ehrenbergi.
T26367L	Reltecimod sodium AB 103 sodium,AB-103 sodium,AB103 sodium	Others	Others
	Reltecimod sodium, a CD28 antigen inhibitor, is used potentially for the treatment of necrotizing soft tissue infection.
T0183L	Pramiracetam Sulfate CNS-1879,CI879,CI-879,CI 879,Pramiracetam	Others	Others
	Thurfyl salicylate is a reddening agent for the treatment of musculoskeletal, joint, periarticular, and soft tissue pain.
T71414	Litophynin A	Others	Others
	Litophynin A is an insect Growth Inhibitory Diterpenoids from the Soft Coral Litophyton sp.
T34526	Sarcophytol B Sarcophytol-B	Others	Others
	Sarcophytol B is a cembrane-type diterpene isolated from a soft coral, Sarcophyton glaucum.
T26367	Reltecimod NSC-37096,P2TA,AB-103,AB103,P-2TA
	Reltecimod, a CD28 antigen inhibitor, is used potentially for the treatment of necrotizing soft tissue infection.
T27573	Ibuproxam Ibuproxamum,G-277	Others	Others
	Ibuproxam, a nonsteroidal antiinflammatory drug (NSAID), is used for the treatment of musculoskeletal pain, arthritis, and soft-tissue disorders.
T25658	Lemnalol	Others	Others
	Lemnalol is a natural marine compound from the Formosan soft coral Lemnalia cervicorni. It exhibits anti-inflammatory and analgesic effects in carrageenan-injected rats.
T1120L2	Dacarbazine citrate DTIC citrate	Others	Others
	Dacarbazine citrate is an alkylating agent used to treat cancers of the lymphatic system and malignant melanoma (a type of skin cancer) in patients with certain conditions: islet cell carcinoma (part of the pancreas) Soft tissue sarcoma (cancer of muscles
T71561	LEO-29102	Others	Others
	LEO-29102 is a potent, selective, and soft-drug phosphodiesterase 4 (PDE4) inhibitor, which may be potentially useful for treatment of dermatological diseases. LEO 29102 shows properties suitable for patient-friendly formulations giving efficient drug delivery to the skin. LEO-29102 has reached phase 2 and demonstrated clinically relevant efficacy in the treatment of atopic dermatitis.
T38002	LEO 39652	Others	Others
	LEO 39652 is a dual-soft PDE4 inhibitor with IC50s of 1.2 nM, 1.2 nM, 3.0 nM and 3.8 nM for PDE4A, PDE4B, PDE4C and PDE4D, respectively. LEO 39652 also inhibits TNF-α with an IC50 value of 6.0 nM. LEO 39652 is used for topical research of Atopic dermatitis (AD) [1]. LEO 39652 shows unbound in vitro potency when measured as LPS induced TNF-α release in human peripheral blood mononuclear cells (PBMC), incubated in serum free medium. LEO 39652 shows a relatively high binding to human serum albumin...
T68999	Cefonicid (free base)	Others	Others
	Cefonicid (free base) is a second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.
T68817	Cefonicid monosodium	Others	Others
	Cefonicid monosodium is the salt form of Cefonicid (free base), a second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.
T15734	Lenampicillin hydrochloride 盐酸仑氨苄西林,KBT 1585 hydrochloride	Antibacterial	Microbiology/Virology
	Lenampicillin hydrochloride is an orally active prodrug of Ampicillin. Lenampicillin hydrochloride is an effective beta-lactam antibacterial agent that inhibits bacterial penicillin-binding proteins. It is applied in the investigation of suppurative skin
T36441	Contezolid acefosamil sodium	Others	Others
	Contezolid acefosamil sodium (MRX-4) is a novel orally active oxazolidinone antibiotic under investigation for the treatment of complicated skin and soft tissue infections (cSSTI) caused by drug-resistant Gram-positive bacteria. It possesses strong efficacy against these pathogens while significantly minimizing the risks of myelosuppression and monoamine oxidase inhibition (MAOI) [1][2].
T84617	15-epi Prostaglandin A1 15-epi PGA1	Others	Others
	15-epiProstaglandin A1 (15-epiPGA1) is an R-stereoisomer of PGA1, belonging to the A-series prostaglandins derived from gorgonian soft corals. PGA1 is known for its effects on renal vasodilation, promoting sodium excretion through urine, and reducing arterial pressure in hypertensive individuals. However, the specific biological activities of 15-epiPGA1 have not yet been documented in published reports.
T63227	Hydrocortisone phosphate sodium	Others	Others
	Hydrocortisone phosphate (sodium) (Hydrocortisone 21-phosphate (sodium)) 是一种具有较弱抗炎作用的软类固醇，作用时间短，能够用于研究几种眼部疾病和胃溃疡。
T37612	IBTP (iodide)	Others	Others
	IBTP is a lipophilic cation that is accumulated in mitochondria and forms stable thioether adducts in a thiol-specific manner. As a result, mitochondrial proteins that have changed thiol redox state following oxidative stress are selectively tagged with IBTP and can be separated by two-dimensional electrophoresis and isolated. IBTP-tagged proteins can also be evaluated by immunoblotting using an antibody directed against the triphenylphosphonium moiety of the IBTP molecule. IBTP has also been us...
T81522	Pendetide GYK-DTPA
	Pendetide为一种能与铟(111In)结合的螯合剂，当与Capromab（卡普罗单抗）偶联后，形成Capromab pendetide，此显像剂已获得FDA批准，用于探测前列腺软组织的转移情况。
T70287	BMS-186511	Others	Others
	BMS-186511 is a Farnesyltransferase (FT) inhibitor with potential anticancer activity. BMS-186511 is a bisubstrate analogue inhibitor of FT, would inhibit the malignant growth properties of a cell line established from malignant schwannoma of an NF1 patient. Following treatment with BMS-186511 , ST88-14 cells became flat, nonrefractile, were contact-inhibited, and lost their ability to grow in soft agar. BMS-186511 was found to specifically inhibit FT, but not geranylgeranyltransferase I, a clos...
T63554	TGR5 Receptor Agonist 3	Others	Others
	TGR5 Receptor Agonist 3 是一种 G 蛋白偶联胆汁酸受体 1（GPBAR1，TGR5）激动剂软药化合物，能够降低胆囊充盈，表现出良好的胆囊安全性，能够作用于 hTGR5 (EC50: 16.4 nM) 和 mTGR5 (EC50: 209 nM)。
T69682	AEW541 HCl	Others	Others
	AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP- AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. Note: AEW541 has a Cis-configuration on the cyclobutane ring. Its CAS# is 475489-16-8. Many vendors and Sc-finder sc...
T78107	Reltecimod TFA AB-103 TFA	Others	Others
	Reltecimod (AB-103) TFA 是一款针对 T 细胞特异性表面糖蛋白CD28(TP44) 的拮抗剂。该化合物能够有效抵御各类细菌感染、细菌产生的外毒素和内毒素，以及电离辐射。其通过特异性目标定位并调节 CD28/B7-2 共刺激通路以减弱炎症反应，但并不完全抑制该通路。Reltecimod TFA 主要用于坏死性软组织感染(NSTIs)的研究。

化合物

Sucrose octaacetate

Cat.No: T16949

Target: Others

BISMUTH SUBGALLATE

Cat.No: T4502

Synonym: 次没食子酸铋,Dermatol Puder,Bismuth Gallate

Target: Others

Norvancomycin hydrochloride

Cat.No: T12242

Synonym: Desmethyl-vancomycin hydrochloride,盐酸去甲万古霉素

Target: Antibacterial

Cat.No: T7902

Synonym: 奥泽沙星,T-3912

Target: Antibacterial

SulfadiMethoxine sodium

Cat.No: T8133

Target: Anti-infection, Antibacterial, Antibiotic

Cat.No: T76761

Synonym: LY3012207,IMC-3G3

Target: PDGFR

Clodronate disodium tetrahydrate

Cat.No: T3280

Synonym: clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,氯屈膦酸二钠(四水合物),Clodronate disodium

Target: IL Receptor, TNF

Cat.No: T60197

Target: Others

Cat.No: T9657

Target: Others

Cat.No: T34528

Target: Others

Cat.No: T71312

Target: Others

Thurfyl Salicylate

Cat.No: T34863

Synonym: Tetrahydrofurfuryl salicylate

Target: Others

Cat.No: T32835

Target: Others

Cat.No: T34527

Target: Others

Reltecimod sodium

Cat.No: T26367L

Synonym: AB 103 sodium,AB-103 sodium,AB103 sodium

Target: Others

Pramiracetam Sulfate

Cat.No: T0183L

Synonym: CNS-1879,CI879,CI-879,CI 879,Pramiracetam

Target: Others

Cat.No: T71414

Target: Others

Cat.No: T34526

Synonym: Sarcophytol-B

Target: Others

Cat.No: T26367

Synonym: NSC-37096,P2TA,AB-103,AB103,P-2TA

Cat.No: T27573

Synonym: Ibuproxamum,G-277

Target: Others

Cat.No: T25658

Target: Others

Dacarbazine citrate

Cat.No: T1120L2

Synonym: DTIC citrate

Target: Others

Cat.No: T71561

Target: Others

Cat.No: T38002

Target: Others

Cefonicid (free base)

Cat.No: T68999

Target: Others

Cefonicid monosodium

Cat.No: T68817

Target: Others

Lenampicillin hydrochloride

Cat.No: T15734

Synonym: 盐酸仑氨苄西林,KBT 1585 hydrochloride

Target: Antibacterial

Contezolid acefosamil sodium

Cat.No: T36441

Target: Others

15-epi Prostaglandin A1

Cat.No: T84617

Synonym: 15-epi PGA1

Target: Others

Hydrocortisone phosphate sodium

Cat.No: T63227

Target: Others

Cat.No: T37612

Target: Others

Cat.No: T81522

Synonym: GYK-DTPA

Cat.No: T70287

Target: Others

TGR5 Receptor Agonist 3

Cat.No: T63554

Target: Others

Cat.No: T69682

Target: Others

Cat.No: T78107

Synonym: AB-103 TFA

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T7047	Dipalmitin 二棕榈酸甘油酯,1,3-Dipalmitin	Others	Others
	Dipalmitin (1,3-Dipalmitin) 对软棕榈中间部分晶体具有模板作用。
TN2269	Tetramethylcurcumin	Apoptosis; STAT	Apoptosis; JAK/STAT signaling; Stem Cells
	Tetramethylcurcumin 是一种新型姜黄素类似物，是一种有效的 STAT3 磷酸化、DNA 结合活性和体外反式激活抑制剂。它具有抗炎和抗癌作用。
T17155	Trabectedin Ecteinascidin 743,曲贝替定,ET-743	Apoptosis; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	Trabectedin (Ecteinascidin 743) 是一种四氢异喹啉生物碱，有抗肿瘤的活性，通过与 DNA 的小沟结合，阻断应激诱导的蛋白质的转录，诱导 DNA 骨架裂解和癌细胞凋亡，并增加 MCF-7 和 MDA-MB-453 细胞中 ROS 的生成。Trabectedin 在软组织肉瘤和卵巢癌中具有的研究价值。
T34525	Sarcophine Sarcophin,Sarcophin A	Others	Others
	Sarcophine is a natural cembranoid from the Red Sea soft coral Sarcophyton glaucum.
T74761	Eleutherobin	Others	Others
	Eleutherobin 是一种有效的 β 微管蛋白 (β-microtubule)，IC50为 2 μM。Eleutherobin 可从海洋软珊瑚中提取。Eleutherobin 对癌细胞的细胞毒活性具有与紫杉醇 (Paclitaxel)) 相似的效力。具有抗癌活性。

天然产物

Cat.No: T7047

Synonym: 二棕榈酸甘油酯,1,3-Dipalmitin

Target: Others

Tetramethylcurcumin

Cat.No: TN2269

Target: Apoptosis, STAT

Cat.No: T17155

Synonym: Ecteinascidin 743,曲贝替定,ET-743

Target: Apoptosis, Reactive Oxygen Species

Cat.No: T34525

Synonym: Sarcophin,Sarcophin A

Target: Others

Cat.No: T74761

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01201	BPIFA1/LUNX Protein, Human, Recombinant Lung-specific protein X,BPI fold-containing family A member ...	Human	E. coli
	Bactericidal/permeability-increasing fold containing family A, member 1 (BPIFA1) is a secretory protein found in human upper aerodigestive tract mucosa. This innate material is secreted in mucosal fluid or found in submucosal tissue in the human soft palate, lung, uvula, and nasal cavity. BPIFA1 is a critical component of the innate immune response that prevents upper airway diseases.
TMPY-01344	MAP1D Protein, Human, Recombinant (His) MetAP 1D,Metap1l,MAP 1D,methionyl aminopeptidase type 1D (mi...	Human	Baculovirus Insect Cells
	Methionine aminopeptidase 1D, also known as MAP1D, is a member of the peptidase M24A family. N-terminal methionine removal is an important cellular process required for proper biological activity, subcellular localization, and eventual degradation of many proteins. The enzymes that catalyze this reaction are called Methionine aminopeptidases (MAPs). MAP1D is overexpressed in colon cancer cell lines and colon tumors as compared to normal tissues (at protein level). Downregulation of MAP1D express...

重组蛋白

BPIFA1/LUNX Protein, Human, Recombinant

Cat.No: TMPK-01201

Species: Human

Expression System: E. coli

MAP1D Protein, Human, Recombinant (His)

Cat.No: TMPY-01344

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0418	Ozenoxacin-d3
	Ozenoxacin-d3 是 Ozenoxacin 的氘代化合物。Ozenoxacin 的 CAS 号为 245765-41-7。Ozenoxacin是一种新型喹诺酮类抗生素，能够抵抗大多数从在皮肤和软组织感染中分离的微生物。

同位素标记化合物

Cat.No: TMIH-0418

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