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Search Results for " self-assembly "

Targets Recommended: 5-HT Receptor AChE

15

抑制剂 & 化合物

1

天然产物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T0204	Protriptyline hydrochloride 盐酸普罗替林,Protriptyline HCl	5-HT Receptor; AChE	GPCR/G Protein; Neuroscience
	Protriptyline hydrochloride (Protriptyline HCl) 是一种含有一个仲胺的三环结构抗抑郁试剂，可以用于抑郁和 ADHD 的相关研究。它使动物精力充沛起激励作用，并且有时用于嗜睡症的相关研究。
TP1159L	Boc-Gly-Gly-Phe-Gly-OH acetate Boc-Gly-Gly-Phe-Gly-OH acetate(187794-49-6 free base),GGFG acetate
	Boc-Gly-Gly-Phe-Gly-OH acetate (GGFG acetate)(187794-49-6 free base) 是 N 和 C 保护的四肽的自组装体。
T28860	ST-148 ST148	Others	Others
	ST-148 is a potent inhibitor for Dengue virus capsid. ST-148-enhanced capsid protein self-interaction perturbs assembly and disassembly of DV nucleocapsids, probably by inducing structural rigidity.
T29198	Z060228 Z 060228,Z-060228	Others	Others
	Z060228 is an potent anti-HBV inhibitor. The HBV DNA replication was effectively inhibited by Z060228 in the supernatants of the HepG2.2.15 cells. Z060228 exhibited effects on the self-assembly of Cp149. SEC data revealed that Z060228 altered the equilibr
TP1495	Boc-Gly-Gly-Phe-Gly-OH TFA(187794-49-6,free) Boc-Gly-Gly-Phe-Gly-OH TFA
	Boc-Gly-Gly-Phe-Gly-OH TFA is a self-assembly of N-protected and C-protected tetrapeptides and is a protease cleaved connector for antibody-drug binding (ADC).
TP1159	Boc-Gly-Gly-Phe-Gly-OH GGFG	ADC Linker	Antibody-drug Conjugate/ADC Related
	Boc-Gly-Gly-Phe-Gly-OH is a self-assembly of N- and C-protected tetrapeptide.
T70941	CLR01 sodium	Others	Others
	CLR01 is a molecular tweezer. CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy. CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS. CLR01 inhibits Ebola and Zika virus infection. CLR01 Stabilizes a Disordered Protein-Protein Interface. CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity.
T76652	PHF6
	PHF6 (VQIVYK) 为一自组装序列，能启动全长tau蛋白聚集，其定位于tau蛋白第三个微管结合重复区。
T60430	Protriptyline	Others	Others
	Protriptyline 是有效的抗抑郁剂，抑制AChE 活性(IC50 =.06 mM)，并可抑制 Aβ 自组装。Protriptyline 具有用于抑郁症和阿尔茨海默病的研究潜力。
T79224	Ara-SH	Apoptosis	Apoptosis
	Ara-SH为Cytarabine巯基丙酸取代的衍生物，应用于通过自组装技术制造携带Cytarabine和Venetoclax的智能共负载纳米颗粒(AV-NP)的触发器。在体外和体内实验中，Ara-SH展现出显著的协同抗白血病效果。
T73533	ADH-6	Others	Others
	ADH-6，一种三吡啶酰胺化合物，消除突变p53 DBD聚集成核亚结构域的自组装，并靶向解离人类癌细胞中的突变p53聚集体。通过此过程，ADH-6恢复p53的转录活性，导致细胞周期停滞与细胞凋亡(apoptosis)，展示了其研究癌症疾病的潜力。
T80362	Human α-Defensin 6
	Human α-Defensin 6，含32个半胱氨酸残基的抗菌肽，能够阻止细菌入侵，促进粘膜免疫。该肽通过自组装形成有序的原纤维和纳米网，能随机结合细菌表面蛋白，进而围绕并缠绕细菌。此外，Human α-Defensin 6抑制C. albicans生物膜的形成。
T74443	ADH-6 TFA	Others	Others
	ADH-6 TFA为三吡啶酰胺类化合物，通过靶向并解离人类癌细胞中突变p53聚集体，阻止突变p53 DBD聚集成核亚结构域的自组装，从而恢复p53的转录活性。这一过程导致细胞周期停滞和细胞凋亡(apoptosis)，显示出其在研究癌症疾病中的应用潜力。
T37105	2',3'-O-Isopropylideneguanosine	Others	Others
	2',3'-O-Isopropylideneguanosine is an alkylated guanosine building block.1,2It has been used in the synthesis of ordered honeycomb microporous films and mRNA cap analogs. 1.Gao, Y.-F., Huang, Y.-J., Xu, S.-Y., et al.Ordered honeycomb microporous films from self-assembly of alkylated guanosine derivativesLangmuir27(6)2958-2964(2011) 2.Kore, A.R., Shanmugasundaram, M., and Vlassov, A.V.Synthesis and application of a new 2',3'-isopropylidene guanosine substituted cap analogBioorg. Med. Chem. Lett.1...
T36929	Pal-KTTKS (acetate)	Others	Others
	Pal-KTTKS is a lipidated pentapeptide consisting of a fragment of the type I collagen C-terminal propeptide conjugated to palmitic acid .1 It increases collagen production in human corneal and dermal fibroblasts when used at concentrations of 0.002, 0.004, and 0.008 wt%.2 Following topical administration, pal-KTTKS (50 μg/cm2) is found in the stratum corneum, epidermis, and dermis of isolated hairless mouse skin.1 It can self-assemble into flat tapes and extended fibrillar structures.3 Pal-KTTKS...

化合物

Protriptyline hydrochloride

Cat.No: T0204

Synonym: 盐酸普罗替林,Protriptyline HCl

Target: 5-HT Receptor, AChE

Boc-Gly-Gly-Phe-Gly-OH acetate

Cat.No: TP1159L

Synonym: Boc-Gly-Gly-Phe-Gly-OH acetate(187794-49-6 free base),GGFG acetate

Cat.No: T28860

Synonym: ST148

Target: Others

Cat.No: T29198

Synonym: Z 060228,Z-060228

Target: Others

Boc-Gly-Gly-Phe-Gly-OH TFA(187794-49-6,free)

Cat.No: TP1495

Synonym: Boc-Gly-Gly-Phe-Gly-OH TFA

Boc-Gly-Gly-Phe-Gly-OH

Cat.No: TP1159

Synonym: GGFG

Target: ADC Linker

Cat.No: T70941

Target: Others

Cat.No: T76652

Cat.No: T60430

Target: Others

Cat.No: T79224

Target: Apoptosis

Cat.No: T73533

Target: Others

Human α-Defensin 6

Cat.No: T80362

Cat.No: T74443

Target: Others

2',3'-O-Isopropylideneguanosine

Cat.No: T37105

Target: Others

Pal-KTTKS (acetate)

Cat.No: T36929

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2773	Vindoline 文朵灵,文多灵	Microtubule Associated	Cytoskeletal Signaling
	Vindoline 是从长春花叶片中提取的一种生物碱，通过抑制微管组装而表现出抗有丝分裂活性。

天然产物

Cat.No: T2773

Synonym: 文朵灵,文多灵

Target: Microtubule Associated

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00175	YuaB Protein, Bacillus subtilis, Recombinant (His & SUMO) Biofilm-surface layer protein A,bslA,ORF-1	Bacillus subtilis	E. coli
	Involved in biofilm formation. Self-polymerizes and forms a layer on the surface of biofilms that confers hydrophobicity to the biofilm. The layer is stable and capable of resistance to high mechanical force compression. Required for complex colony architecture. May function synergistically with exopolysaccharides and TasA amyloid fibers to facilitate the assembly of the biofilm matrix. YuaB Protein, Bacillus subtilis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xH...
TMPH-01256	Dystonin Protein, Human, Recombinant (His & SUMO) DT,DST,BPAG1,BP240,BP230,KIAA0728,Dystonin,DMH	Human	E. coli
	Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transpo...
TMPH-01257	Dystonin Protein, Human, Recombinant (His) DT,BP230,Dystonin,BP240,DST,DMH,BPAG1,KIAA0728	Human	P. pastoris (Yeast)
	Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transpo...
TMPH-01642	MELK Protein, Human, Recombinant (His & Myc) Protein kinase Eg3,Tyrosine-protein kinase MELK,Protein kina...	Human	E. coli
	Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. ...
TMPY-01816	Pentraxin 3 Protein, Human, Recombinant (His) TNFAIP5,pentraxin 3,PTX3,TSG-14	Human	HEK293 Cells
	Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cycl...
TMPH-02632	TRIM21 Protein, Mouse, Recombinant (E. coli, His) Trim21,52 kDa ribonucleoprotein autoantigen Ro/SS-A,Triparti...	Mouse	E. coli
	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr...
TMPH-02633	TRIM21 Protein, Mouse, Recombinant (His) Tripartite motif-containing protein 21,E3 ubiquitin-protein ...	Mouse	Baculovirus Insect Cells
	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr...

重组蛋白

YuaB Protein, Bacillus subtilis, Recombinant (His & SUMO)

Cat.No: TMPH-00175

Species: Bacillus subtilis

Expression System: E. coli

Dystonin Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01256

Species: Human

Expression System: E. coli

Dystonin Protein, Human, Recombinant (His)

Cat.No: TMPH-01257

Species: Human

Expression System: P. pastoris (Yeast)

MELK Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01642

Species: Human

Expression System: E. coli

Pentraxin 3 Protein, Human, Recombinant (His)

Cat.No: TMPY-01816

Species: Human

Expression System: HEK293 Cells

TRIM21 Protein, Mouse, Recombinant (E. coli, His)

Cat.No: TMPH-02632

Species: Mouse

Expression System: E. coli

TRIM21 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02633

Species: Mouse

Expression System: Baculovirus Insect Cells

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