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Targets Recommended: Ferroptosis Lipoxygenase Autophagy

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T7530	PD146176 NSC168807	Ferroptosis; Lipoxygenase; Autophagy	Apoptosis; Autophagy; Metabolism
	PD146176 (NSC-168807) 是一种 15-脂氧合酶(15-LO)抑制剂，抑制兔网织红细胞 15-LO，Ki 为 197 nM，IC50 为 0.54 μM。它通过刺激老年三重转基因小鼠的自噬来逆转认知障碍、脑淀粉样变性和 tau 病理学。
T19065	Thiazole Orange	Others	Others
	Thiazole Orange 是不对称的花青素染料，能够与寡核苷酸偶联，制备荧光杂交探针。它可用于分析网织红细胞。
T82456	EPO mimetic peptide-1 EMP-1
	EPO mimetic peptide-1 (EMP-1)为含20个氨基酸的多肽，该化合物具有促进细胞增殖、影响细胞周期以及诱导网织细胞产生的作用。
T84565	9-OxoODE 9-KODE	Others	Others
	9-OxoODE, formed through the oxidation of the allylic hydroxyl group in both 9(S)-HODE and 9(R)-HODE, is present in rabbit reticulocyte plasma and mitochondrial membranes as both 9- and 13-oxoODEs, constituting approximately 2% of the total linoleate residues. The majority of these oxidized linoleate residues are esterified to membrane lipids.
T83774	Shepherdin TFA Lys-His-Ser-Ser-Gly-Cys-Ala-Phe-Leu-OH,Survivin (79-87)
	Shepherdin是人体survivin的79-87氨基酸对应的合成肽，也是survivin与heat shock protein 90 (Hsp90)之间蛋白质-蛋白质相互作用的抑制剂。它以浓度依赖的方式与Hsp90的N末端结构域结合，并在150 µM的浓度下抑制了在分离的人源网状红细胞提取物中重组人survivin与Hsp90之间的相互作用。结合了穿膜肽penetratin或HIV Tat序列的Shepherdin肽结合物，体内外具有抗癌活性。

化合物

PD146176

Cat.No: T7530

Synonym: NSC168807

Target: Ferroptosis, Lipoxygenase, Autophagy

EPO mimetic peptide-1

Synonym: Lys-His-Ser-Ser-Gly-Cys-Ala-Phe-Leu-OH,Survivin (79-87)

Target:

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03143	PFD0110w Protein, Plasmodium falciparum, Recombinant Normocyte-binding protein 1,Reticulocyte-binding pr...	Plasmodium falciparum	E. coli
	PFD0110w Protein, Plasmodium falciparum, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 30.1 kDa and the accession number is P86148.