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Search Results for " renal inflammation "

Targets Recommended: Cannabinoid Receptor

7

抑制剂 & 化合物

4

天然产物

6

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10696	CB2 modulator 1	Cannabinoid Receptor	GPCR/G Protein
	CB2 modulator 1 是一种有效的 CB2 调节剂。可用于免疫疾病、骨质疏松症、炎症、肾缺血的研究。
T4583	PFI-2 hydrochloride (R)-PFI-2 hydrochloride,PFI-2 HCl	Histone Methyltransferase	Chromatin/Epigenetic
	PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) 是一种有效的、高度选择性的、具有细胞活性的 SETD7 甲基转移酶抑制剂，IC50值为2nM，活性是 (S)-PFI-2 的 500 倍。
T1987	PFI-2 PFI2,PFI 2,(R)-PFI-2	Histone Methyltransferase	Chromatin/Epigenetic
	PFI-2 是一种有效、特异性和细胞活性的赖氨酸甲基转移酶 SETD7 抑制剂，Ki 和 IC50值分别为 0.33 和 2 nM。
T21610	Bradykinin (acetate)	Bradykinin Receptor	GPCR/G Protein
	Bradykinin (acetate) 是一种由激肽释放酶-激肽系统产生的活性肽。它是一种炎症介质，也被认为是多种血管和肾功能的神经介质和调节剂。它由血液中的 kallidin 酶促产生，是一种强大的血管扩张剂，可引起平滑肌收缩，并可能介导炎症。它具有作为人血清代谢物和血管扩张剂的作用。它是缓激肽 (2+) 的互变异构体。
T79516	BT424	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	BT424是一种特异性HCK抑制剂，能够调节体外巨噬细胞的活化及自噬，并在UUO模型中改善炎症和肾纤维化。
T38384	Nexinhib20	Others	Others
	Nexinhib20 is an inhibitor of the protein-protein interaction between the small GTPase Rab27a and its effector JFC1 (IC50 = 2.6 μM).[1] It inhibits myeloperoxidase (MPO) secretion induced by granulocyte macrophage colony-stimulating factor (GM-CSF) and fMLP in isolated human neutrophils (IC50 = 0.33 μM). Nexinhib20 (30 mg/kg) reduces LPS-induced increases in plasma MPO levels, as well as LPS-induced hepatic and renal neutrophil infiltration in a mouse model of endotoxin-induced systemic inflamma...
T61949	Evogliptin	Others	Others
	Evogliptin (DA-1229) 是具有口服活性的DPP4抑制剂。Evogliptin 在小鼠模型中具有显著而持久的降糖效果。Evogliptin 通过诱导自噬抑制肝细胞的纤维化和炎症信号的产生。Evogliptin 可用于 2 型糖尿病、慢性肝脏炎症，骨质疏松症及肾功能损害的研究。

化合物

CB2 modulator 1

Cat.No: T10696

Target: Cannabinoid Receptor

PFI-2 hydrochloride

Cat.No: T4583

Synonym: (R)-PFI-2 hydrochloride,PFI-2 HCl

Target: Histone Methyltransferase

Cat.No: T1987

Synonym: PFI2,PFI 2,(R)-PFI-2

Target: Histone Methyltransferase

Bradykinin (acetate)

Cat.No: T21610

Target: Bradykinin Receptor

Cat.No: T79516

Target: Src

Cat.No: T38384

Target: Others

Cat.No: T61949

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3033	Deoxycorticosterone acetate 醋酸去氧皮质酮,DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate,醋酸脱氧皮质酮	Glucocorticoid Receptor; Endogenous Metabolite; Adrenergic Receptor	Endocrinology/Hormones; GPCR/G Protein; Metabolism; Neuroscience
	Deoxycorticosterone acetate (Cortexone acetate) 是肾上腺产生的类固醇激素，具有盐皮质激素活性，并作为醛固酮的前体。
TQ0119	Cirsimaritin	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Cirsimaritin 具有抗菌、抗炎、抗肿瘤、抗氧化特性和肾脏保护作用。 Cirsimaritin 与 GABAA 受体上的苯二氮卓位点结合较弱。
T3005	4-Hydroxychalcone P-Cinnamoylphenol,4-羟基查尔酮	Others; NF-κB	NF-κB; Others
	4-Hydroxychalcone (P-Cinnamoylphenol) 是一种查尔酮代谢物，具有抗血管生成和消炎作用。它抑制 TNF-α 诱导的 NF-κB 途径活化并激活 BMP 信号传导，通过减轻小鼠的醛固酮过多症和肾脏损伤来降低抵抗性高血压。它通过抑制生长因子途径抑制血管生成，无细胞毒性迹象。
T4904	1-Methylguanidine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	1-Methylguanidine hydrochloride 是内源性代谢产物的一种。

天然产物

Deoxycorticosterone acetate

Cat.No: T3033

Synonym: 醋酸去氧皮质酮,DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate,醋酸脱氧皮质酮

Target: Glucocorticoid Receptor, Endogenous Metabolite, Adrenergic Receptor

Cat.No: TQ0119

Target: GABA Receptor

4-Hydroxychalcone

Cat.No: T3005

Synonym: P-Cinnamoylphenol,4-羟基查尔酮

Target: Others, NF-κB

1-Methylguanidine hydrochloride

Cat.No: T4904

Target: Others, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00138	CXCL16 Protein, Mouse, Recombinant (hFc) SR-PSOX,SCYB16,SRPSOX,CXCLG16,CXCL16	Mouse	HEK293 Cells
	CXC chemokine ligand 16 (CXCL16) is a CXC soluble chemokine, an adhesion molecule and a cell surface scavenger receptor. CXCL16 regulates inflammation, tissue injury and fibrosis. Parenchymal renal cells, vascular wall cells, leukocytes and platelets express and/or release CXCL16 under the regulation of inflammatory mediators. CXCL16 expression is increased in experimental and human nephropathies. Targeting CXCL16 protected from experimental glomerular injury or interstitial fibrosis. CXCL16 Pro...
TMPK-00469	CXCL16 Protein, Human, Recombinant (hFc) SR-PSOX,SCYB16,CXCL16,CXCLG16,SRPSOX	Human	HEK293 Cells
	CXC chemokine ligand 16 (CXCL16) is a CXC soluble chemokine, an adhesion molecule and a cell surface scavenger receptor. CXCL16 regulates inflammation, tissue injury and fibrosis. Parenchymal renal cells, vascular wall cells, leukocytes and platelets express and/or release CXCL16 under the regulation of inflammatory mediators. CXCL16 expression is increased in experimental and human nephropathies. Targeting CXCL16 protected from experimental glomerular injury or interstitial fibrosis. CXCL16 Pro...
TMPJ-00379	AOC3 Protein, Human, Recombinant (hFc) SSAO,AOC3,Membrane primary amine oxidase,Copper amine oxidas...	Human	HEK293 Cells
	Membrane primary amine oxidase(AOC3), also known as vascular adhesion protein (VAP-1) and HPAO, this protein is a member of the semicarbazide-sensitive amine oxidase (SSAO) family. VAP-1 is a type 1 membrane-bound glycoprotein that has a distal adhesion domain and an enzymatically active amine oxidase site outside of the membrane, VAP-1 has adhesive properties, functional monoamine oxidase activity, and possibly plays a role in glucose handling, leukocyte trafficking, and migration during inflam...
TMPJ-00082	NGAL/Lipocalin-2 Protein, Mouse, Recombinant (hFc) Lipocalin-2,SV-40-induced 24P3 protein,Siderocalin LCN2,LCN2...	Mouse	HEK293 Cells
	Lipocalin-2, also known as Neutrophil Gelatinase-Associated Lipocalin (NGAL), is a secretory protein of the lipocalin superfamily. Lipocalin-2 contains a signal peptide that enables it to be secreted and form complexes with matrix metalloproteinase-9 (MMP-9) through disulfide bonds. Similar to other lipocalin family members, Lipocalin-2 is involved in diverse cellular processes, including the transport of small hydrophobic molecules, protection of MMP-9 from proteolytic degradation, and cell sig...
TMPJ-00299	LIMPII/SR-B2 Protein, Mouse, Recombinant (hFc) LIMP II,Lysosome membrane protein II,SCARB2,85 kDa lysosomal...	Mouse	HEK293 Cells
	Lysosome membrane protein II (LIMPII)，also known as SCARB2, is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junc...
TMPJ-00298	CD36 Protein, Human, Recombinant (aa 27-432, His) LGP85,Scavenger Receptor Class B Member 2,CD36,Lysosome Memb...	Human	HEK293 Cells
	Scavenger Receptor Class B Member 2 (SCARB2) is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstructio...

重组蛋白

CXCL16 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00138

Species: Mouse

Expression System: HEK293 Cells

CXCL16 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00469

Species: Human

Expression System: HEK293 Cells

AOC3 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00379

Species: Human

Expression System: HEK293 Cells

NGAL/Lipocalin-2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00082

Species: Mouse

Expression System: HEK293 Cells

LIMPII/SR-B2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00299

Species: Mouse

Expression System: HEK293 Cells

CD36 Protein, Human, Recombinant (aa 27-432, His)

Cat.No: TMPJ-00298

Species: Human

Expression System: HEK293 Cells

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