Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T24730 |
Roslin 2 bromide
Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2 |
FAK; p53 | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Roslin 2 bromide (Benzylhexamethylenetetramine bromide) 是一种 p53 再激活剂,可破坏 FAK 和 p53 的结合。 Roslin 2 bromide 具有抗癌作用。 | |||
T1111 |
Pralidoxime Chloride
2-PAM chloride,吡啶醛肟甲氯,2-Pyridinealdoxime methochloride,2-PAM (chloride) |
AChE | Neuroscience |
Pralidoxime Chloride (2-PAM chloride) 是一种肟类化合物,对中毒乙酰胆碱酯酶具有恢复作用,可用于有机磷中毒的研究。 | |||
T6954 |
PRIMA-1
2,2-Bis(hydroxymethyl)-3-quinuclidinone,NSC-281668,PRIMA 1 |
Apoptosis; Others; Ferroptosis; Autophagy | Apoptosis; Autophagy; Others |
PRIMA-1 (NSC-281668) 是一种突变型 p53复活剂,可恢复 TP53 突变型甲状腺癌细胞对组蛋白甲基化抑制剂 3-Deazaneplanocin A 的敏感性。 | |||
T2464 |
ZMC1
|
p53 | Apoptosis |
NSC-319726 (ZMC1)是一种突变型 p53R175 再激活剂,可抑制表达 p53R175 突变的成纤维细胞的生长,IC50值为8nM。 | |||
T70692 |
ST7612AA1
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
ST7612AA1 是一种新型有效且可口服的 HDAC 抑制剂,作为作为HIV-1潜伏期再激活剂。ST7612AA1 在体内外实验中低浓度显示出显著的抗肿瘤活性。ST7612AA1 具有潜在的抗癌活性,可用于研究疟疾。 | |||
T41068 |
P53R3
|
p53 | Apoptosis |
P53R3是一种有效的 p53再激活剂。P53R3可恢复 p53热点突变体的序列特异性 DNA 结合,包括p53 R175H、p53 R248W 和p53 R273H。P53R3特异性诱导p53依赖性抗增殖作用,其特异性比PRIMA-1高得多的。P53R3增强野生型p53和p53 M237I 向靶基因启动子的募集。P53R3强烈增强死亡受体死亡受体5(DR5)的mRNA、总蛋白和细胞表面的水平。P53R3用于癌症研究。 | |||
T68770 |
Obidoxime thiocyanate
|
Others | Others |
Obidoxime thiocyanate is an AChE reactivator. | |||
T70461 |
Pralidoxime mesylate
|
Others | Others |
Pralidoxime mesylate is a Cholinesterase Reactivator | |||
T70236 |
Isonitrosoacetone
|
Others | Others |
Isonitrosoacetone is an acetylcholinesterase reactivator. | |||
T21219 |
Isatin-O
Isatin-3-oxime |
Others | Others |
Isatin-O acts as a neutral BBB crossing reactivator for acetylcholinesterase inhibited by paraoxon and is also an anticonvulsant. | |||
T27611 |
Ingenol 3-Hexanoate
|
Others | Others |
Ingenol 3-Hexanoate is a novel potent reactivator of latent HIV-1. | |||
T69271 |
Diethyxime
|
Others | Others |
Diethyxime is a a non-quaternarv Cholinesterase reactivator | |||
T70641 |
Asoxime dimethanesulfonate
|
Others | Others |
Asoxime dimethanesulfonate is an oxime reactivator used for counteracting intoxication by nerve agents. It is able to reactivate acetylcholinesterase (AChE) inhibited by cytotoxic nerve agents such as sarin or soman. | |||
T69079 |
Trimedoxime bromide
|
Others | Others |
Trimedoxime bromide is a cholinesterase reactivator used as an antidote in alkyl phosphate poisoning. | |||
T62857 |
K203
|
Others | Others |
K203 是一种有效的 tabun 抑制的 AChE 再激活剂,是一种重要的有机磷中毒解毒剂。 | |||
T68624 |
Asoxime chloride monohydrate
|
Others | Others |
Asoxime chloride monohydrate is an oxime reactivator used for counteracting intoxication by nerve agents. It is able to reactivate acetylcholinesterase (AChE) inhibited by cytotoxic nerve agents such as sarin or soman. | |||
T81998 |
K1833
|
Others | Others |
K1833是一种同时具备抑制和重激活特性的hrAChE抑制剂,其IC50值为58μM。对hrBChE亦有高度抑制活性(IC50=0.57μM),但再激活能力较弱。 | |||
T79013 |
SLMP53-2
|
Others | Others |
SLMP53-2是一种可以重建p53转录活性的突变p53再激活因子。该化合物通过促进mutp53-Y220C与Hsp70之间的作用,恢复了mutp53-Y220C的野生型构象和其DNA结合能力。此外,SLMP53-2能够诱导细胞周期停滞、细胞凋亡以及ER应激,展现出了其抗肿瘤的潜力。 |