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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13396 |
Zinc Protoporphyrin
Zinc Protoporphyrin-9,锌原卟啉,ZnPP,Zn(II)-protoporphyrin IX |
Apoptosis; Reactive Oxygen Species; Endogenous Metabolite | Apoptosis; Immunology/Inflammation; Metabolism; NF-κB |
Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) 是一种具有口服活性的,竞争性血红素加氧酶-1 抑制剂,显著减弱间苯三酚对 H2O2 的保护作用,具有抗癌活性。它用于评估人群铁状态与血红蛋白浓度的组合,也可用作个体孕妇和儿童缺铁的筛查标志物。 | |||
T36113 |
Cobaltic Protoporphyrin IX chloride
Protoporphyrin IX cobaltic chloride |
Autophagy | Autophagy |
Cobaltic Protoporphyrin IX chloride (CoPP)是一种有效的血红素加氧酶 1(HO-1)诱导剂,具有抗病毒活性,通过诱导 I 型 IFN 反应来抑制甲型流感病毒(IAV)感染。 | |||
T13161 |
Tin-protoporphyrin IX dichloride
SnPPIX,SnPPIX dichloride |
Virus Protease; Autophagy | Autophagy; Microbiology/Virology |
Tin-protoporphyrin IX dichloride (SnPPIX dichloride) 是血红素加氧酶-1 (HO-1) 抑制剂,具有抗病毒活性,抑制登革热和黄热病病毒,可改善肝部分切除术后的肝脏再生。 | |||
T83663 |
Mn(III) Protoporphyrin IX Chloride
Manganese(III) Protoporphyrin IX Chloride |
Others | Others |
Mn(III) protoporphyrin IX chloride是一种金属卟啉,当浓度为10 µM时,能在鸡胚肝细胞中诱导δ-氨基酮戊二酸合成酶和血红素加氧酶(HO)基因的mRNA表达,这些酶分别催化血红素生物合成和降解的限速步骤。Mn(III) protoporphyrin IX chloride含纳米仿生物已被用于体外纤维蛋白凝块的磁共振成像(MRI)研究。此外,它还被用于Mn(III) protoporphyrin IX-6(7)-甘氨酰-甘氨酰-L-组氨酸甲酯(MnGGH)的合成,MnGGH是一种具有微过氧化物酶活性的金属卟啉衍生物。 | |||
T38935 |
Cu(II) protoporphyrin IX
|
Others | Others |
Cu (II) Protoporphyrin IX functions as a negative control for Zn (II) Protoporphyrin, a heme oxygenase inhibitor. Heme oxygenase is involved in tumor cell resistance to chemotherapy and the regulation of free radical formation, inflammation, and vascular repair. | |||
T38980 |
Mg(II) protoporphyrin IX
|
Others | Others |
Mg(II) protoporphyrin IX is a crucial compound in the synthesis of chlorophyll in Chlorella. It also serves as a negative regulator of nuclear photosynthetic gene expression. Additionally, Mg(II) protoporphyrin IX is employed as a valuable research tool for investigating the signaling molecule involved in plastid-to-nucleus communication. | |||
T39026 |
Ni(II) protoporphyrin IX
|
Others | Others |
Ni(II) protoporphyrin IX is a metalloporphyrin compound characterized by its limited propensity for axial ligation and its distortion upon binding to ferrochelatase. | |||
T39603 |
Mn(II) protoporphyrin IX
|
Others | Others |
Mn(II) protoporphyrin IX is a potent intravenous paramagnetic magnetic resonance contrast agent, known for its strong paramagnetic properties. | |||
T39700 |
Ga(III) protoporphyrin IX
|
Others | Others |
Ga(III)protoporphyrin-IX, a model for interporphyrin interactions in malaria pigment, possesses potent antibacterial effects against gram-negative, gram-positive, and acid-fast bacteria. It exhibits high solubility in methanol (MeOH) and serves as a malarial pigment analogue for drug development, as well as a potential antibacterial agent. | |||
T78623 |
Cobalt protoporphyrin IX
|
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Cobalt protoporphyrin IX 作为一种特异性的血红素加氧酶-1 (HO-1) 诱导剂,表现出对甲型流感病毒 (IAV) 的广谱抗病毒活性。 | |||
T19147 |
5-ALA benzyl ester hydrochloride
Benzyl-ALA hydrochloride |
Others; Endogenous Metabolite | Metabolism; Others |
5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) 是一种原卟啉前体,可用作光检测器。5-ALA benzyl ester hydrochloride 在结肠癌细胞系中可以诱导原卟啉 IX (PPIX) 的积聚。 | |||
T41281 |
N-Methylprotoporphyrin IX
|
Others | Others |
N-Methylprotoporphyrin IX 是有效的肝铁螯合酶 (ferrochelatase enzyme) 抑制剂。 | |||
T40588 |
Acifluorfen
|
Others | Others |
Acifluorfen 是一种除草剂。Acifluorfen 是一种原卟啉原氧化酶抑制剂,可促进原卟啉 IX 的积累,并诱导啮齿动物肝脏发生肿瘤。它会引起敏感植物物种中的色素和脂质强烈的光氧化破坏。 | |||
T84999 |
CP94
CGP 46700 |
Others | Others |
CP94, an iron chelator, enhances protoporphyrin IX photobleaching and reduces the viability of A431 squamous epithelial carcinoma cells at a 150 µM concentration with photodynamic therapy (PDT) using protoporphyrin IX precursors such as aminolevulinic acid (ALA), methyl aminolevulinate (MAL), or hexylaminolevulinate (HAL). Additionally, CP94 (2 mg/ml in drinking water) lowers hepatic non-heme and ferritin-bound iron levels while increasing hepatic protoporphyrin levels in mice. It also counterac... | |||
T19421 |
Methyl aminolevulinate
|
Others | Others |
Methyl aminolevulinate is a prodrug that can be metabolized to Protoporphyrin IX. Methyl aminolevulinate is an agent used as a sensitizer in photodynamic therapy (PDT). | |||
T84736 |
Biliverdin
NSC 62793 |
Others | Others |
胆绿素是通过胆红素氧化得到的化合物,可经由谷氨酸棒杆菌的非原卟啉途径进行合成。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1192 |
Protoporphyrin IX
PPIX,原卟啉,原卟啉IX |
Others; Endogenous Metabolite | Metabolism; Others |
Protoporphyrin IX (PPIX) 是一种四吡咯,是血红素、细胞色素 c 和叶绿素的代谢前体。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01332 |
Ferrochelatase Protein, Human, Recombinant (His & Myc)
Ferrochelatase, mitochondrial,Heme synthase,Protoheme ferro-... |
Human | E. coli |
Catalyzes the ferrous insertion into protoporphyrin IX. Ferrochelatase Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 49.6 kDa and the accession number is P22830. | |||
TMPH-00265 |
Ferrochelatase, mitochondrial Protein, Bovine, Recombinant (His & Myc & SUMO)
Ferrochelatase, mitochondrial,Protoheme ferro-lyase,FECH,Hem... |
Bovine | E. coli |
Catalyzes the ferrous insertion into protoporphyrin IX. Ferrochelatase, mitochondrial Protein, Bovine, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Mycd tag. The predicted molecular weight is 58.1 kDa and the accession number is P22600. | |||
TMPH-03128 |
TSPO Protein, Pig, Recombinant (His & Myc & SUMO)
TSPO,Peripheral-type benzodiazepine receptor,Translocator pr... |
Sus scrofa (Pig) | E. coli |
Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides. TSPO Protein, Pig, Recombinant (His & Myc & SUMO) is expressed in E. coli e... |