27
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7736 |
2-Chloroadenosine
|
Adenosine Receptor | GPCR/G Protein; Neuroscience |
2-Chloroadenosine 是腺苷类似物,可防止大鼠海马缺血细胞长期丢失。它是尿苷内流 (Ki:33 μM) 的竞争性抑制剂,高亲和力与硝基苄基硫肌苷结合 (Ki:0.18 mM)。它是一种人红细胞核苷转运体的转运渗透剂。 | |||
T21627 |
Hoechst 33342 trihydrochloride
HOE 33342 trihydrochloride,bisBenzimide H 33342 trihydrochloride,bisBenzimide H 33342 trihydrochloride;HOE 33342 trihydrochloride,Hoechst 33342 |
Others; Autophagy | Autophagy; Others |
Hoechst 33342 trihydrochloride (bisBenzimide H 33342 trihydrochloride;HOE 33342 trihydrochloride) 是一种可透过膜的蓝色荧光 DNA 染料。 | |||
T12205 |
Ned 19
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Ned 19 is a selective membrane-permeant non competitive antagonist of NAADP and strongly inhibits tumor growth and vascularization as well as lung metastases in mice. | |||
T17109 |
TMRM Perchlorate
四甲基若丹明甲酯酸铵,T668 |
Others | Others |
TMRM Perchlorate (T668) 是细胞渗透性的阳离子亲脂性红色荧光染料 (λex=530 nm, λem=592 nm)。 | |||
T2449 |
D4476
D 4476,Casein Kinase I Inhibitor |
Apoptosis; Casein Kinase; ALK; Autophagy | Angiogenesis; Apoptosis; Autophagy; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors |
D4476 (Casein Kinase I Inhibitor) 是一种选择性和细胞渗透性的CK1抑制剂,在体外实验的IC50值为0.3 μM。 | |||
T6573 |
E 64c
阿洛司他丁酸,NSC 694279,EP 475,Loxistatin Acid |
SARS-CoV; Cysteine Protease | Microbiology/Virology; Proteases/Proteasome |
E 64c (EP 475) 是一种不可逆且可透过膜的半胱氨酸蛋白酶抑制剂,是 E-64 的衍生物。它也是钙离子激活中性蛋白酶抑制剂和组织蛋白酶 C 弱不可逆抑制剂,可抑制 MERS-CoV。 | |||
T14048 |
5-CFDA
5-羧基荧光素二乙酸酯,5-Carboxyfluorescein diacetate |
Others | Others |
5-CFDA (5-Carboxyfluorescein diacetate) 是可透过细胞屏障并被水解为5-carboxyfluorescein,可标记人椎间盘细胞,以便体外荧光显微镜观察。 | |||
T2606 |
KN-93 Phosphate
|
CaMK | Neuroscience |
KN-93可以竞争性阻断钙调蛋白与对应激酶的结合,是一种钙离子/钙调蛋白依赖激酶 II(CaMKII)抑制剂,Ki 为370 nM。 | |||
T9807 |
CPDS
|
Others | Others |
CPDS 是一种非渗透性硫醇剂,可影响多种线粒体功能。在大鼠肝线粒体中,它仅抑制 Pi/OH- 载体。它和丙二酸正丁酯都是完全抑制 Pi 进入所必需的。 | |||
T7658 |
Dimethyl DL-Glutamate (hydrochloride)
|
Others | Others |
Dimethyl DL-Glutamate (hydrochloride) 是一种细胞渗透性谷氨酸衍生物,可在孤立的胰岛和糖尿病动物模型中增强胰岛素释放以响应葡萄糖。 | |||
T18894 |
5(6)-CFDA
CFDA,5-(6)-Carboxyfluorescein diacetate,5(6)-羧基荧光素二乙酸酯 |
Others | Others |
5(6)-CFDA (5-(6)-Carboxyfluorescein diacetate) 是具有细胞渗透性的胺反应型绿色荧光探针(λex: 492 nm; λem: 517 nm),可用于细胞染色分析。 | |||
T13884 |
Shield-1
|
Others | Others |
Shield-1 是 FK506 结合蛋白 12 (FKBP) 的特异性、高亲和力和细胞渗透性配体,通过与突变的 FKBP (mtFKBP) 结合来逆转不稳定性,允许 mtFKBP 融合蛋白的条件表达。它可以稳定整个融合蛋白。 | |||
TP1907L1 |
Dynamin inhibitory peptide, myristoylated acetate
Dynamin inhibitory peptide, myristoylated acetate(251634-22-7 free base) |
Dynamin | Cytoskeletal Signaling |
Dynamin inhibitory peptide, myristoylated acetate(251634-22-7 free base) 是一种 DynaMin 抑制剂,可干扰两性霉素与 dynamin 的结合。 DynaMin 抑制肽,肉豆蔻酰化 TFA 是肽的膜渗透形式,可防止内吞作用。 | |||
T34706 |
SRI-29132
SRI29132,SRI 29132,TPZ-11,TPZ 11,TPZ11 |
Others | Others |
SRI-29132 is potent; highly permeant of the blood-brain barrier; and selective for LRRK2 kinase activity, therefore effective in attenuating pro-inflammatory responses in macrophages and in rescuing neurite retraction phenotypes in neurons. | |||
T17109L |
TMRM
|
Others | Others |
TMRM is a cell-permeant cationic lipophilic red fluorescent dye (λex: 530 nm, λem: 592 nm). | |||
T69514 |
CLE-030
|
Others | Others |
CLE-030 is a KCNQ2 agonist. CLE030 stably binds to the central cavity. Functional analysis, molecular dynamics simulations, and calculations of the potential of mean force revealed that the carbonyl oxygen of CLE030 influences permeant ions in the central cavity to contribute to its activation effects. | |||
T37477 |
L-858,051 (hydrochloride)
|
Others | Others |
L-858,051 is a water-soluble analog of forskolin , a cell-permeant activator of adenylate cyclase. L-858,051 activates adenylate cyclase (EC50 = 3 μM), inhibits glucose transport, and blocks cytochalasin B binding in rat adipocyte membranes. L-858,051 is used to activate adenylate cyclase and initiate signaling through elevated cAMP synthesis in a variety of cell types in culture. | |||
T37607 |
Rhodamine B isothiocyanate (mixed isomers)
|
||
Rhodamine B isothiocyanate (RITC) is a cell-permeant fluorogenic dye most often used as a conjugate to antibodies and proteins for fluorescence detection in microscopy. It displays excitation/emission maxima of 570/595 nm, respectively, and can be used in conjunction with immunohistochemistry for multi-labeling studies. It has also been used as an anterograde and retrograde tracer in neurons and in nanoparticles to detect apoptosis. | |||
T36388 |
Rhod-5N AM
|
||
Rhod-5N AM is a cell-permeant acetoxymethyl ester of the fluorescent calcium indicator rhod-5N . As rhod-5N AM enters cells, it is hydrolyzed by intracellular esterases to produce rhod-5N. Rhod-5N displays a low affinity for calcium (Kd = 19 μM). Low affinity calcium indicators are particularly useful for studying compartments with high concentrations of calcium, such as endoplasmic reticulum, where high affinity dyes will be insensitive to luminal fluctuations. Rhod-5N has excitation/emission m... | |||
T37320 |
Rhod-FF AM
|
||
Rhod-FF AM is a cell-permeant acetoxymethyl ester of the fluorescent calcium indicator rhod-FF . As rhod-FF AM enters cells, it is hydrolyzed by intracellular esterases to produce rhod-FF. Rhod-FF is a difluorinated analog of the cell-impermeant calcium indicator rhod-2. It has a very low affinity for calcium (Kd = 320 μM). Low affinity calcium indicators are particularly useful for studying compartments with high concentrations of calcium, such as endoplasmic reticulum, where high affinity dyes... | |||
T37473 |
SBFI AM
Sodium-binding Benzofuran Isophthalate Acetoxymethyl ester |
||
SBFI AM is a membrane-permeant, fluorescent Na+ indicator dye. It is selective for Na+ over K+ with Kd values of 20 and 120 mM for these ions, respectively. [1]Increasing concentration of Na+ increases the ratio of excitation efficiency at 330-345 nm to that at 370-390 nm with emission collected at 450-550 nm. [1] Therefore, ratio fluorometry and imaging can be performed with the same wavelengths. SBF AM is suitable for single intracellular dye injection and is typically used for high-resolutio... | |||
T36327 |
Calcein Red™ AM
|
||
Calcein Red AM is a fluorogenic dye that is used to assess cell viability. As the acetoxymethyl ester, Calcein Red AM is non-fluorescent but cell-permeant and is hydrolyzed to the fluorescent probe Calcein Red by intracellular esterases. Calcein Red is retained by living cells and displays excitation/emission maxima of 560/574 nm, respectively. Calcein Red AM is a red-emitting variant of the green fluorophore calcein AM , which has been used to evaluate cell viability and cytotoxicity. | |||
TD0048 |
5-(and-6)-Carboxy SNARF-1, Acetoxymethyl Ester, Acetate
|
||
The cell-permeant pH indicator, carboxy SNARF-1, acetoxymethyl ester, acetate (CAS #126208-13-7) has a pKa of ~7.5 after de-esterification, thus is useful for measuring pH changes between pH 7 and pH 8. Carboxy-SNARF-1 exhibits a significant pH-dependent | |||
T76242 |
MMI-0100
|
||
MMI-0100 是一种细胞渗透性肽抑制剂,抑制丝裂原活化蛋白激酶活化蛋白激酶 II (MK2)。MMI-0100 在体内外减少内膜增生。MMI-0100 抑制IL-6表达而不影响IL-8表达。MMI-0100 抑制纤维化过程,例如静脉移植疾病。 | |||
T76069 |
Tat-NR2Baa TFA
|
||
Tat-NR2BAA TFA 是 Tat-NR2B9c 的对照肽 (control peptide),没有活性。Tat-NR2BAA TFA 的序列与 Tat-NR2B9c 相似,但在 COOH 末端 tSXV 基序中有一个双点突变,这使得它无法结合 PSD-95。Tat-NR2B9c TFA 是一种可通透细胞膜的多肽,破坏 PSD-95/NMDAR 的结合。 | |||
T35568 |
BODIPY-aminoacetaldehyde diethyl acetal
|
Others | Others |
BODIPY-aminoacetaldehyde diethyl acetal (BAAA-DA) is a stable precursor to BODIPY-aminoacetaldehyde, a cell-permeable fluorescent substrate for aldehyde dehydrogenase (ALDH).1,2BODIPY-aminoacetaldehyde diethyl acetal is converted under acidic conditions to BODIPY-aminoacetaldehyde (BAAA).2BAAA is cell-permeant and is converted intracellularly by ALDH to BODIPY aminoacetate (BAA), which is retained by cells and can be used to identify cells with high ALDH activity.1BAA is a substrate for the effl... | |||
T36805 |
TPC2-A1-N
TPC2-A1-N |
Others | Others |
TPC2-A1-N is a novel, lipophilic, membrane permeable isoform-selective small molecule agonist of two-pore channel 2 (TPC2). TPC2-A1-N plays its role by mimicking the physiological actions of NAADP and PI(3,5)P2 through independent binding sites. TPC2-A1-N has inverse effects on key lysosomal activities and increases the pH in the lysosomal lumen in a TPC2-dependent manner[1]. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02905 |
TRPC1 Protein, Mouse, Recombinant (His)
Transient receptor protein 1,Short transient receptor potent... |
Mouse | E. coli |
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. TRPC1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 94.0 kDa and the accession number is Q61056. |