opener

Rilmakalim 是一种钾通道开放剂。 Rilmakalim 显示抗血管收缩作用。

1-((3R,4S)-3-hydroxy-2,2-dimethyl-6-(phenylsulfonyl)chroman-4-yl)pyrrolidin-2-one 是 Rilmakalim 的异构体，Rilmakalim 是一种钾通道打开剂 (PCO)，可以激活心脏或其它组织中 ATP-敏感 K+ 通道

Aprikalim (RP 52891) 是一种三磷酸腺苷钾通道（KATP）开启剂，可保护脊髓缺血兔模型中的神经受到损伤。Aprikalim 抑制血管收缩，抑制心肌麻痹期间 [Ca2+]i 升高，可以用于研究心血管疾病。

Flupirtine maleate (Katadolon maleate) 是可透过血脑屏障的、具有口服活性的非阿片类化合物。它是间接 NMDAR 拮抗剂，可用于缓解疼痛的研究，具有神经保护特性。

SG 209是nicorandil的类似物，可作为K+通道开放剂和无硝酸盐的冠状血管扩张剂。

PCO 400 是一种 comakalim 类似物，可作为一种选择性强的 ATP 敏感型 K+ 通道开放剂。

NS 11021 (NS11021) 是特异性 Ca2+激活的大电导 K+(KCa1.1)通道激活剂。当浓度高于0.3 μM 时，它通过平行移动通道激活曲线产生更多负电位，以浓度依赖的方式激活 KCa1.1。

ICA 110381 是一种KCNQ2/Q3钾通道开放剂，有潜力用于癫痫的研究。ICA 110381 是KCNQ2/Q3激动剂 (EC50=0.38 μM) 以及KCNQ1拮抗剂 (IC50=15 μM)。

ZM 226600是一种 ATP 敏感的钾通道开启剂 ，EC50值是500 nM。ZM226600 对膀胱自发活动有抑制作用。

Foslevcromakalim (QLS-101 ) 是一种ATP 敏感的钾通道开启剂。Foslevcromakalim 是用于降眼压作用的前体。

ICA-105665 (PF-04895162) 是一种有效的口服活性的神经元 Kv7.2 7.3和 Kv7.3 7.5钾通道激动剂。ICA-105665 在人肝细胞中具有低细胞毒性潜力，但抑制肝线粒体功能和胆盐输出蛋白 (BSEP) 转运 (IC50为 311 μM)。ICA-105665 可穿透中枢神经系统 (CNS)并具有抗癫痫作用。

Flupirtine HCl is the salt form of Flupirtine, also known as W-2964, an aminopyridine that functions as a centrally acting non-opioid analgesic. It first became available in Europe in 1984, and is sold mainly under the names Katadolon, Trancolong, Awegal, Efiret, Trancopal Dolo, and Metanor. Like nefopam, it is unique among analgesics in that it is a non-opioid, non-NSAID, non-steroidal centrally acting analgesic. Flupirtine is a selective neuronal potassium channel opener that also has NMDA receptor antagonist and GABAA receptor modulatory properties.

PF05020182 is novel potent and selective Kv7.2 4 potassium channel opener. PF-05020182 (2) significantly inhibits convulsions in the MES assay at doses tested, consistent with in vitro activity measure. The physiochemical properties, in vitro and in vivo activities of PF-05020182 support further development as an adjunctive treatment of refractory epilepsy. Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in controlling spontaneous electrical activity during epileptic seizures.

Cromakalim (BRL 34915) 是一种 ATP 依赖性 K（+） 通道开启剂，是一种平滑肌松弛剂。Cromakalim 具有抗癫痫和抗惊厥活性，可用于研究哮喘和与血管扩张相关的疾病。

Flupirtine-d4 (D 9998-d4) hydrochloride，Flupirtine (D 9998) hydrochloride的氘代物，为神经元钾通道开放剂，具有拮抗NMDA受体的作用。

Y-26763 is a K+ channel opener and active metabolite of Y-27152. This is an ATP-sensitive K+ (KATP) channel activator.

QO-58 is a Kv7 channel opener with EC50 values of 7.0, 1.0, 5.2, 0.6 μM for Kv7.1, Kv7.2, Kv7.3 7.5, Kv7.4 respectively. QO-58 increases the pain threshold of neuropathic pain in a sciatic nerve CCI in vivo.

Y-27152 is a prodrug of the KATP (Kir6) channel opener Y-26763 and is a long-acting K+ channel opener.

Flupirtine(D 9998)是神经元钾通道的选择性开放剂，并且具有NMDA 受体拮抗剂的特性。

NC00075159 is an opener of human KCNQ4 (Kv7.4) potassium channel.

KCO-912 is a potent and selective opener of ATP-dependent potassium (K ATP) channels. KCO-912 suppresses airways hyperreactivity at doses devoid of cardiovascular effects.

Naminidil is an opener of cyanoguanidine KATP.

Iptakalim hydrochloride 是一种亲脂性的对氨基化合物，是 ATP 敏感的钾通道的开放剂，也是含α4β2的烟碱乙酰胆碱受体拮抗剂。它也是一种 K(ir) 6.1/SUR2B 激活剂，可通过保护内皮功能减轻大鼠缺氧引起的肺动脉高压。

Ro 31-7837 is an opener of potassium channel.

ZM 260384 is a potassium channel opener.

BMS 180448 is a prototype mitochondrial ATP-sensitive K+ (Mitok (ATP)) channel opener with cardioprotective and vasodilating properties.

NS004 is a large-conductance K+ channel opener, it inhibits mitochondrial function in glioma cells.

U-89232 is an opener of the cardioselective KATP channel.

KRN 4884 is an opener of the K+ channel. KRN 4884 (0.1-3 μM) activates KATP channels in a concentration-dependent manner (EC50=0.55 μM), in the presence of intracellular ATP (1 mM).

ICA-27243 是选择性的，口服有效的 KCNQ2/Q3钾通道开放剂，EC50为 0.38 μM。对 KCNQ4 和 KCNQ3/Q5 的激活效果较差。它具有抗惊厥和抗癫痫作用。

TREK1 and TREK2 channel activator (EC50 = 0.76 μM in Rb efflux assay in TREK1-expressing CHO cells). Exhibits selectivity for TREK1/2 over TRAAK, TASK3 and a range of other potassium channels. Hyperpolarizes membrane potential of dorsal root ganglion neurons and depresses neuronal activity in vitro. Loucif et al (2018) GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P) channel opener, reduces rat dorsal root ganglion neuron excitability. Br.J.Pharmacol. 175 2272 PMID:29150838

Tifenazoxide is an effective and SUR1/Kir6.2 selective KATP channels opener. Tifenazoxide has an anti-diabetic effect, can inhibit glucose-stimulated insulin release in vitro and in vivo.