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Search Results for " nootropic "

Targets Recommended: Others

24

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7891	Ipidacrine 伊匹达克林,NIK‐247	Others	Others
	Ipidacrine (NIK‐247) 是一种具有益智作用的化合物，也是一种胆碱酯酶抑制剂，具有药物活性，可用于阿尔茨海默病的治疗。
T0322	Fipexide	Dopamine Receptor; AChR	GPCR/G Protein; Neuroscience
	Fipexide 是对氯苯乙酸衍生物，是哌嗪化学类的精神活性药物，作为促智药物，有用于老年痴呆的研究潜力。它可降低了纹状体腺苷酸环化酶的活性，通过多巴胺能神经传递对认知表现出积极的作用。
T7599	Sunifiram 桑尼菲拉姆,DM-235,桑尼非拉姆	iGluR	Membrane transporter/Ion channel; Neuroscience
	Sunifiram (DM-235) 是一种 ampakine 样促智剂。
T16783	Rolziracetam 罗拉西坦,CI-911	Others	Others
	Rolziracetam (CI-911) 是 racetam 家族的益智药物之一，能够改善老鼠和猴子的有效记忆。
T1884	CX516 Ampakine CX516,BDP 12,Ampalex,安帕来斯	GluR; iGluR	Membrane transporter/Ion channel; Neuroscience
	CX516 (Ampalex) 是AMPA 受体正向调节剂，可用于研究阿尔茨海默病，精神分裂等。
T0333	Aniracetam Ro 13-5057,阿尼西坦,茴拉西坦	Dopamine Receptor; 5-HT Receptor; GluR; AChR; iGluR	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Aniracetam (Ro 13-5057) 是一种促智和神经保护药物，可选择性地调节 AMPA 受体和 nAChR。
T8583	Tenilsetam 替尼西坦,3-(2-thienyl)- (9CI),Piperazinone	Others	Others
	Tenilsetam (Piperazinone) 是一种核酸内切酶调节剂；一种促智剂和晚期糖基化终产物 (AGE) 抑制剂，具有治疗阿尔茨海默病 (AD) 的潜力。
T1833	NSI189 NSI-189,NSI 189	Others	Others
	NSI189 (NSI-189) 是一种促智和神经源性研究化学品，源自烟酰胺和吡嗪。
T7108	Omberacetam SGS-111,Noopept,GVS-111	Others; iGluR	Membrane transporter/Ion channel; Neuroscience; Others
	Omberacetam (Noopept) 是一种可作为膳食补充剂的合成二肽，有促智和提高认知作用。
T12201	Nebracetam hydrochloride WEB 1881 FU hydrochloride	AChR	Neuroscience
	Nebracetam hydrochloride (WEB 1881 FU hydrochloride) 是促智 M1-毒蕈碱的激动剂。它诱导细胞内 Ca2+ 浓度升高， EC50 为 1.59 mM。
T0183	Pramiracetam CI-879,普拉西坦	Others	Others
	Pramiracetam (CI-879) 来源于piracetam，能改善脑外伤引起的认知障碍。它是更有效的促智药物。
T38192	Unifiram	Others	Others
	Unifiram 是一种认知增强剂。 Unifiram 诱导大鼠海马 CA1 区场兴奋性突触后电位 (fEPSP) 幅度的持久增加 (EC50= 27 nM) 并增加大鼠大脑皮层中乙酰胆碱 (ACh) 的释放。
T17308	(R)-Oxiracetam 奥拉西坦,(R)-(+)-Oxiracetam	Others	Others
	(R)-Oxiracetam is the (R)-enantiomer of the nootropic drug oxiracetam. Oxiracetam is a nootropic drug of the racetam family and stimulant.
T34197	PWZ-029 PWZ029	Others	Others
	PWZ-029 is an inverse agonist selective for α₅ GABAA receptors with nootropic effects.
T27959	LY503430 LY-503430,LY 503430	Others	Others
	LY503430 is a AMPA receptor potentiator with oral activity. LY503430 has both nootropic and neuroprotective effects, reducing brain damage caused by 6-hydroxydopamine or MPTP.
T26045	Razobazam Razobazamum	Others	Others
	Razobazam is a benzodiazepine derivative agent. It produces nootropic (improves cognitive function) effects in animal studies.
T70714	(-)-Donepezil	Others	Others
	(-)-Donepezil is an isomer of Donepezil -- a nootropic acting as an inhibitor of acetylcholinesterase.
T70697	(+)-Donepezil	Others	Others
	(+)-Donepezil is an isomer of Donepezil -- a nootropic acting as an inhibitor of acetylcholinesterase.
T33715	Nooglutil ONK-10	Others	Others
	Nooglutil is a nootropic agent being studied. In animal models, it has a variety of central nervous system effects.
T28689	SB357134 SB-357134,SB 357134	Others	Others
	SB357134 is a potent, selective and orally active antagonist of 5-HT6 receptor and shows nootropic effects in animal studies.
T28158	Neramexane Mesylate KRP209,KRP-209,KRP 209	Others	Others
	Neramexane is an NMDA antagonist with neuroprotective effects. Neramexane has antidepressant and nootropic actions. It also acts as a nicotinic acetylcholine receptor antagonist.
T75003	Antidepressant agent 4	Others	Others
	Antidepressant agent 4为一种口服活性抗抑郁剂，具备抗抑郁、抗焦虑、性能增强以及促智活性。
T75002	Antidepressant agent 3	Others	Others
	Antidepressant agent 3, 一种具有口服活性的抗抑郁剂，具备抗抑郁、抗焦虑、性能增强及促智活性。
T60463	Bifemelane	Others	Others
	Bifemelane 是一种益智化合物，通过刺激细胞内 Ca2+储存的释放产生第一个峰值，通过储存操作的 Ca2+通道的电容进入产生第二个峰值。Bifemelane 可作为星形胶质细胞基础研究的药理学工具。

化合物

Cat.No: T7891

Synonym: 伊匹达克林,NIK‐247

Target: Others

Cat.No: T0322

Target: Dopamine Receptor, AChR

Cat.No: T7599

Synonym: 桑尼菲拉姆,DM-235,桑尼非拉姆

Target: iGluR

Cat.No: T16783

Synonym: 罗拉西坦,CI-911

Target: Others

Cat.No: T1884

Synonym: Ampakine CX516,BDP 12,Ampalex,安帕来斯

Target: GluR, iGluR

Cat.No: T0333

Synonym: Ro 13-5057,阿尼西坦,茴拉西坦

Target: Dopamine Receptor, 5-HT Receptor, GluR, AChR, iGluR

Cat.No: T8583

Synonym: 替尼西坦,3-(2-thienyl)- (9CI),Piperazinone

Target: Others

Cat.No: T1833

Synonym: NSI-189,NSI 189

Target: Others

Cat.No: T7108

Synonym: SGS-111,Noopept,GVS-111

Target: Others, iGluR

Nebracetam hydrochloride

Cat.No: T12201

Synonym: WEB 1881 FU hydrochloride

Target: AChR

Cat.No: T0183

Synonym: CI-879,普拉西坦

Target: Others

Cat.No: T38192

Target: Others

Cat.No: T17308

Synonym: 奥拉西坦,(R)-(+)-Oxiracetam

Target: Others

Cat.No: T34197

Synonym: PWZ029

Target: Others

Cat.No: T27959

Synonym: LY-503430,LY 503430

Target: Others

Cat.No: T26045

Synonym: Razobazamum

Target: Others

Cat.No: T70714

Target: Others

Cat.No: T70697

Target: Others

Cat.No: T33715

Synonym: ONK-10

Target: Others

Cat.No: T28689

Synonym: SB-357134,SB 357134

Target: Others

Neramexane Mesylate

Cat.No: T28158

Synonym: KRP209,KRP-209,KRP 209

Target: Others

Antidepressant agent 4

Cat.No: T75003

Target: Others

Antidepressant agent 3

Cat.No: T75002

Target: Others

Cat.No: T60463

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1286	Vincamine Angiopac,Oxybral,Devincan,Novicet,Equipur,长春胺,Perval	GPR; Others	Endocrinology/Hormones; GPCR/G Protein; Others
	Vincamine (Perval) 是从长春花中提取的单萜类吲哚生物碱，可作为外周血管扩张剂，对脑微血管循环有选择性的血管调节作用。它可改善体内葡萄糖稳态，对 2 型糖尿病具有研究潜力。它是GPR40激动剂，通过改善 β 细胞功能障碍和促进葡萄糖刺激型胰岛素分泌发挥 β 细胞保护作用。
T12536	Pregnenolone monosulfate 3β-Hydroxy-5-pregnen-20-one monosulfate	NMDAR	Neuroscience
	Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) 是一种强效神经类固醇，可正向调节 NMDA 记录,可用于研究神经分裂和抑郁症。
T5273	2-Hydroxy-3-methylbutanoic acid 2-Hydroxy-3-methylbutyric acid,2-Hydroxyisovaleric Acid,2-羟基-3-甲基丁酸,(±)-2-Hydroxyisopentanoic Acid	Others; Endogenous Metabolite	Metabolism; Others
	2-Hydroxy-3-methylbutyric acid 是一种 GHB 的结构类似物，其中GHB 是一种中枢神经系统中发现的天然物质，也是一种神经药物。
TN1017	Physion 8-O-β-D-glucoside 大黄素甲醚-8-o-β-D-葡萄糖苷,Physcion 1-O-beta-D-glucoside	Others	Others
	Physcion 1-O-beta-D-glucoside 是一种 Fallopia multiflora 的活性成分，可用于头晕的研究。
T0905	Pyrithioxin 吡硫醇,Pyridoxine disulfide,Encefabol,Vitamin B6 disulfide,Pyritinol,Bonifen,吡硫醇(维生素B6衍生品)	Others; Endogenous Metabolite	Metabolism; Others
	Pyrithioxin (Encefabol) 是神经动力化合物，能够促进脑内葡萄糖及氨基酸的代谢，改善全身同化作用，增加颈动脉血流量，改善脑血流。

天然产物

Cat.No: T1286

Synonym: Angiopac,Oxybral,Devincan,Novicet,Equipur,长春胺,Perval

Target: GPR, Others

Pregnenolone monosulfate

Cat.No: T12536

Synonym: 3β-Hydroxy-5-pregnen-20-one monosulfate

Target: NMDAR

2-Hydroxy-3-methylbutanoic acid

Cat.No: T5273

Synonym: 2-Hydroxy-3-methylbutyric acid,2-Hydroxyisovaleric Acid,2-羟基-3-甲基丁酸,(±)-2-Hydroxyisopentanoic Acid

Target: Others, Endogenous Metabolite

Physion 8-O-β-D-glucoside

Cat.No: TN1017

Synonym: 大黄素甲醚-8-o-β-D-葡萄糖苷,Physcion 1-O-beta-D-glucoside

Target: Others

Cat.No: T0905

Synonym: 吡硫醇,Pyridoxine disulfide,Encefabol,Vitamin B6 disulfide,Pyritinol,Bonifen,吡硫醇(维生素B6衍生品)

Target: Others, Endogenous Metabolite

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