neuraminidase in 1

Neuraminidase-IN-1 (Compound Y-1) 是一种神经氨酸酶抑制剂，其IC50值为 0.21 μM，具有抗H1N1流感病毒的活性。

Neuraminidase-IN-18 (compound N5) 作为一款新型多杂环神经氨酸酶 (NA) 抑制剂，在抑制H5N1型NA方面展现出显著效能。该化合物针对野生型H5N1 NA与H5N1-H274Y突变型NA的IC50值分别为0.14 μM 和0.27 μM。Neuraminidase-IN-18能够通过与NA的结合，在细胞水平上有效抑制流感病毒的复制。

Neuraminidase-IN-5 (Compound 5b) 是一种有效的 neuraminidase 抑制剂，IC50为 0.02 μM。神经氨酸酶（NA）是开发抗流感药物的有希望的靶点。Neuraminidase-IN-5 是一种二氢呋喃香豆素衍生物化合物。

Neuraminidase-IN-6 (Compound 5c) 是1,3,4-triazole-3-acetamide 的衍生物。Neuraminidase-IN-6 是神经氨酸酶的有效抑制剂，IC50值为 0.11 μM。神经氨酸酶 (NA) 是抗流感药物开发的理想靶点。

Oseltamivir acid methyl ester 是Oseltamivir acid 的前体形式，可通过羧酸酯酶1 (CES1) 转化为Oseltamivir acid。Oseltamivir acid 是神经氨酸酶抑制剂和抗病毒剂。

3,5-O-Dicaffeoylquinic acid (Isochlorogenic Acid A) 能够改善由三甲基锡诱导的学习和记忆缺陷。

The binding affinities of ganoderic acid DM andGanoderic acid ζ (ΔGbind, -16.83 and-10.99 kcal mol-1) are comparable to that of current commercial drug oseltamivir (-23.62 kcal mol-1);Ganoderic acid DM is a potential source of anti-influenza ingredient, with novel binding pattern and advantage over oseltamivir, it has steric hindrance on the 150 cavity of N1 protein, and exerts activities across the H274Y and N294S mutations, is the attractive candidates of novel neuraminidase (NA) inhibitors.Ganoderic acid zeta has cytotoxicity in vitro against Meth-A and LLC cell lines.

Neuraminidase-IN-13 (Compound 10) 为神经氨酸酶抑制剂，展现抗病毒功效及低细胞毒性。该化合物显著抑制Vero细胞中NDV感染，其作用机制为阻断病毒颗粒从受感染细胞的释放。

NDV-IN-1 是一种具有高神经氨酸酶抑制活性的抗病毒剂。 NDV-IN-1 对新城疫病毒 (NDV) 具有体外抑制活性。NDV-IN-1 通过阻止病毒颗粒从感染细胞中释放出来，显著抑制 Vero 细胞的 NDV 感染。

Influenza A virus-IN-4 (compound 23b), a derivative of Oseltamivir, is a highly effective neuraminidase inhibitor. It exerts potent inhibitory effects on influenza viruses [1].

Zanamivir-13C,15N2is intended for use as an internal standard for the quantification of zanamivir by GC- or LC-MS. Zanamivir is a sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles.1It has been shown to selectively inhibit the growth of influenza A and B viruses in plaque reduction assays with IC50values ranging from 5 to 14 nM and to directly inhibit influenza A and B virus neuraminidases with IC50values ranging from 0.6 to 7.9 nMin vitro. Intranasal zanamivir administration at 0.4 mg kg twice daily reduces mortality and viral titers in lung homogenates of mice infected with influenza. 1.Elliott, M.Zanamivir: From drug design to the clinicPhilos. Trans. R. Soc. Lond. B Biol Sci.356(1416)1885-1893(2001)

Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase. Ganglioside GM1 asialo is a glycolipid receptor for P. aeruginosa flagellin and stimulates defensive responses in host cells, including extracellular ATP release, calcium mobilization, and ERK1/2 phosphorylation when stimulated by flagellin and an anti-ganglioside GM1 asialo antibody. The percentage of ganglioside GM1 asialo-positive natural killer (NK) and CD8+ T cells in lung is increased in a mouse model of respiratory syncytial virus (RSV) infection compared with healthy animals. Depletion of ganglioside GM1 asialo-positive NK and T cells reduces IFN-γ levels in the lung, reduces weight loss, and increases lung viral load in RSV-infected mice. Ganglioside GM1 asialo mixture contains ganglioside GM1 asialo molecular species with C18:1 and C20:1 sphingoid backbones.

Neuraminidase-IN-17 (compound N10) 作为一种有效的神经氨酸酶抑制剂，其EC50为0.11 μM，体现了优异的体外抗病毒活性。

Neuraminidase-IN-16 (Compound 43b) 是一种有效的神经氨酸酶 (neuraminidase) 抑制剂，对 H5N1、H5N8、H1N1、H3N2、H5N1–H274Y 和 H1N1–H274Y 的神经氨酸酶抑制作用的 IC50分别为 0.031、0.15、0.25、0.60、0.63 和 10.08 μM。

Neuraminidase-IN-8 (Compound 6d) 是一种有效的神经氨酸酶 (neuraminidase) 抑制剂，其IC50值为 0.027 μM。Neuraminidase-IN-8 具有抗流感活性。