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Search Results for " melanocytes "

Targets Recommended: Others

11

抑制剂 & 化合物

6

天然产物

15

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T7769	Nonapeptide-1 Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-,九胜肽-1,Melanostatine™ 5	Others	Others
	Nonapeptide-1 (Melanostatine™ 5) 可以抑制黑色素的合成，这使得它对治疗某些皮肤病很感兴趣。
T34321	Rhododendrol, (+/-)- AI3-31843	Others	Others
	Rhododendrol, (+/-)-, is an aromatic compound that may be useful in the treatment of hepatic diseases. However, this product is a known pro-oxidant which can be toxic to melanocytes.
T39569	Gp100 (25-33), mouse Mgp100 (25-33),Gp100 (25-33), mouse
	Gp100 (25-33) corresponds to residues 25 to 33 of the mouse self/tumor antigen glycoprotein (mgp100), which is an enzyme responsible for pigment synthesis. This epitope fragment is found in both normal melanocytes and melanoma cells.
T81563	Palmitoyl tetrapeptide-20 PTP20
	Palmitoyl tetrapeptide-20(PTP20)为具保护作用的生物活性肽，旨在维护滤泡黑素细胞，常用作化妆品配料。
T73598	Tyrosinase	Others	Others
	Tyrosinase(Polyphenol oxidase) 是控制黑色素产生的限速酶，由 TYR 基因编码。Tyrosinase 主要存在于皮肤黑素细胞合成的黑素体中。
T60821	ACA-28	Others	Others
	ACA-28 (compound 2a) 是ERK MAPK 信号的有效调节剂，可通过过度激活 ERK 诱导细胞凋亡，从而选择性抑制癌细胞生长。ACA-28 对黑色素瘤细胞 (SK-MEL-28) 和正常黑色素细胞 (NHEM) 细胞生长的IC50值分别为 5.3 和 10.1 μM。
T79378	IIIM-8	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	IIIM-8作为一种黑色素生成抑制剂，在体外和体内均表现出显著地抑制色素生成的功效，同时对成人表皮黑色素细胞（HAEM）不表现出细胞毒性。IIIM-8适用于色素沉着症研究。
T75714	Decapeptide-12
	Decapeptide-12，一个小型寡肽，作为tyrosinase的抑制剂，通过与tyrosinase的C末端残基相互作用(Kd: 61.1 μM)发挥作用。作为mushroom tyrosinase的竞争性抑制剂(IC50: 40 µM)，Decapeptide-12有效上调SIRT的转录水平，并能减少黑色素细胞中的黑色素含量，适用于黑色素生成、衰老和炎症的研究。
TP1727	Gp100 (25-33), human
	Gp100 (25-33), human is the amino acids 25-33 fragment of the human melanoma antigen. It is a 9-amino acid (AA) epitope restricted by H-2Db and recognized by the T cells.This is amino acids 25 to 33 fragment of human melanoma antigen gp100. This H-2Db res
T75715	Nonapeptide-1 acetate salt
	Nonapeptide-1 (Melanostatine-5) acetate salt，一种多肽类激素，是 MC1R 选择性拮抗剂 (Ki: 40 nM)。 Nonapeptide-1 acetate salt 是一种竞争性的α-MSH 拮抗剂，可有效抑制黑素细胞中 α-MSH 诱导的细胞内 cAMP 和黑素体扩散 (IC50分别为 2.5 nM 和 11 nM)。 Nonapeptide-1 acetate salt 抑制黑色素合成，可用于研究皮肤色素沉着和肾上腺类固醇生成的调节、皮肤癌。
T83765	Dendrogenin A DDA	Others	Others
	Dendrogenin A (DDA) 作为一种选择性肝X受体(LXR)调节剂(SLiM)、胆固醇环氧水解酶(ChEH; Ki = 120 nM)的抑制剂及胆固醇的活性代谢产物，通过DDA合成酶将5,6α-环氧胆固醇与组胺结合形成。DDA在非癌性人乳腺上皮细胞和上皮黑色素细胞中存在，但在多种乳腺癌细胞或黑色素瘤细胞中未发现，且在分离的人乳腺肿瘤组织中仅以低水平存在。它抑制22(R)-羟基胆固醇诱导的LXRβ和LXRα激活(分别以IC50 = 76和362 nM)，但也是LXR的部分激动剂，在B16/F10小鼠黑色素瘤细胞中增加Nur77、NOR-1、LC3-I和LC3-II的蛋白水平。DDA选择性调节LXRα和LXRβ，而非孕烯X受体(PXR)、芳香烃受体(AhR)、维生素D受体(VDR)、维甲酸X受体γ(RXRγ)、维甲酸受体α(RARα)、过氧化物酶体增殖物激活受体α(PPARα)、PPARγ、糖皮质激素受体、雄激素受体、雌激素受体α(ERα)及ERβ在2.5 µM下。此外，DDA在2.5和5 µM的浓度下增加B16/F10和SK-MEL-28癌细胞中LC3-II的蛋白水平，并在2...

化合物

Cat.No: T7769

Synonym: Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-,九胜肽-1,Melanostatine™ 5

Target: Others

Rhododendrol, (+/-)-

Cat.No: T34321

Synonym: AI3-31843

Target: Others

Gp100 (25-33), mouse

Cat.No: T39569

Synonym: Mgp100 (25-33),Gp100 (25-33), mouse

Palmitoyl tetrapeptide-20

Cat.No: T81563

Synonym: PTP20

Cat.No: T73598

Target: Others

Cat.No: T60821

Target: Others

Cat.No: T79378

Target: Melanocortin Receptor

Cat.No: T75714

Gp100 (25-33), human

Cat.No: TP1727

Nonapeptide-1 acetate salt

Cat.No: T75715

Cat.No: T83765

Synonym: DDA

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T6S0923	Hypericin Hypericine,金丝桃素,Cyclosan	Apoptosis; Antiviral; Influenza Virus; Tyrosine Kinases; Antibacterial; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Hypericin (Cyclosan) 是贯叶连翘的提取物，有抗菌、抗病毒、抗肿瘤和抗抑郁作用。
T0501	Mequinol 4-Hydroxyanisole,Leucobasal,对苯二酚单甲醚,4-Methoxyphenol	Others	Others
	Mequinol (Leucobasal) 是一种Mercurialis spp 的生物活性成分，常用于皮肤褪色。
T2S0633	Raspberry ketone Oxyphenalon,Rasketone,Aloenin,4-(4-Hydroxyphenyl)-2-butanone,p-Hydroxybenzyl acetone,Frambinone,覆盆子酮	PPAR	DNA Damage/DNA Repair; Metabolism
	Raspberry ketone (p-Hydroxybenzyl acetone) 是覆盆子中主要的芳香族天然产物，主要用作化妆品的香料和食品增味剂，也可作 PPAR-α激动剂。
T30048	Anemonin (6CI) Pulsatilla camphor,Anemonin,Anemone camphor	Others	Others
	Anemonin is a furanone dimer found in the Buttercup (Ranunculaceae) family. Anemonin has been shown to regulate tyrosinase-related proteins and mRNA in human melanocytes and may be useful in attenuting osteoarthritis progression.
TN1583	Dihydromorin	TRP/TRPV Channel	Membrane transporter/Ion channel
	trans-Dihydromorin is an effective hypopigmenting agent in normal skin cells, hypopigmenting agents effective in melanoma system may not be effective on normal melanocytes, indicating that a non-tumor melanocyte system is more suitable for the screening o
TN4489	Manassantin A	ERK; cAMP; TNF; NF-κB; MAPK; COX; HIF; Prostaglandin Receptor; JNK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells
	Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-ÎºB act

天然产物

Cat.No: T6S0923

Synonym: Hypericine,金丝桃素,Cyclosan

Target: Apoptosis, Antiviral, Influenza Virus, Tyrosine Kinases, Antibacterial, PKC

Cat.No: T0501

Synonym: 4-Hydroxyanisole,Leucobasal,对苯二酚单甲醚,4-Methoxyphenol

Target: Others

Raspberry ketone

Cat.No: T2S0633

Synonym: Oxyphenalon,Rasketone,Aloenin,4-(4-Hydroxyphenyl)-2-butanone,p-Hydroxybenzyl acetone,Frambinone,覆盆子酮

Target: PPAR

Cat.No: T30048

Synonym: Pulsatilla camphor,Anemonin,Anemone camphor

Target: Others

Cat.No: TN1583

Target: TRP/TRPV Channel

Cat.No: TN4489

Target: ERK, cAMP, TNF, NF-κB, MAPK, COX, HIF, Prostaglandin Receptor, JNK, STAT

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01649	PMEL Protein, Human, Recombinant (His & SUMO) P1,Silver locus protein homolog,Melanocytes lineage...	Human	E. coli
	Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity. PMEL Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted...
TMPK-00453	HER3/ERBB3 Protein, Human, Recombinant (His & Avi) p45-sErbB3,MDA-BF-1,ErbB-3,HER3c-erbB-3,ErbB3,MGC88033,LCCS2...	Human	HEK293 Cells
	Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG). HER3/ERBB3 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 71.6 kDa and the accession number is P21860-1.
TMPK-00452	HER3/ERBB3 Protein, Human, Recombinant (His & Avi), FITC-Labeled LCCS2,HER3c-erbB-3,p180-ErbB3,MGC88033,ErbB3,p85-sErbB3,p45-...	Human	HEK293 Cells
	Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG). HER3/ERBB3 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 71.6 kDa and the accession numbe...
TMPK-01476	HLA-A24:02&B2M&GP100 Intron 4 (VYFFLPDHL) Monomer Protein, Human, MHC (His & Avi) HLA-A24:02,P100,Glycoprotein 100,GP100 Intron 4,HLA-A2402,M...	Human	HEK293 Cells
	Glycoprotein 100, gp100 or Melanocyte protein PMEL is 661 amino acids long and is a type I transmembrane glycoprotein enriched in melanosomes, which are the melanin-producing organelles in melanocytes. This protein is involved in melanosome maturation. The Human HLA-A0201 gp100 (YLEPGPVTA) complex Protein is a complex of HLA-A0201 of the MHC Class I, B2M and YLEPGPVTA peptide of the gp100.
TMPK-01475	HLA-A24:02&B2M&GP100 Intron 4 (VYFFLPDHL) Monomer Protein, Human, MHC (His & Avi), Biotinylated HLA-A24:02,Intron 4,gp100,GP100 Intron 4,Glycoprotein 100,M...	Human	HEK293 Cells
	Glycoprotein 100, gp100 or Melanocyte protein PMEL is 661 amino acids long and is a type I transmembrane glycoprotein enriched in melanosomes, which are the melanin-producing organelles in melanocytes. This protein is involved in melanosome maturation. The Human HLA-A0201 gp100 (YLEPGPVTA) complex Protein is a complex of HLA-A0201 of the MHC Class I, B2M and YLEPGPVTA peptide of the gp100.
TMPK-01553	HLA-A*02:01&B2M&GP100 (YLEPGPVTA) Monomer Protein, Human, MHC (His & Avi), Biotinylated HLA0201,ME20-M,gp100,MHC I,Glycoprotein 100,P100	Human	HEK293 Cells
	Glycoprotein 100, gp100 or Melanocyte protein PMEL is 661 amino acids long and is a type I transmembrane glycoprotein enriched in melanosomes, which are the melanin-producing organelles in melanocytes. This protein is involved in melanosome maturation. The Human HLA-A0201 gp100 (YLEPGPVTA) complex Protein is a complex of HLA-A0201 of the MHC Class I and YLEPGPVTA peptide of the gp100.
TMPK-01540	HLA-A*02:01&B2M&GP100 (YLEPGPVTA) Tetramer Protein, Human, MHC (His & Avi) HLA0201,P100,MHC I,gp100,Glycoprotein 100,ME20-M	Human	HEK293 Cells
	Glycoprotein 100, gp100 or Melanocyte protein PMEL is 661 amino acids long and is a type I transmembrane glycoprotein enriched in melanosomes, which are the melanin-producing organelles in melanocytes. This protein is involved in melanosome maturation. The Human HLA-A0201 gp100 (YLEPGPVTA) complex Protein is a complex of HLA-A0201 of the MHC Class I, B2M and YLEPGPVTA peptide of the gp100.
TMPK-01551	HLA-A*02:01&B2M&GP100 (YLEPGPVTA) Monomer Protein, Human, MHC (His & Avi) MHC I,ME20-M,Glycoprotein 100,gp100,P100,HLA0201	Human	HEK293 Cells
	Glycoprotein 100, gp100 or Melanocyte protein PMEL is 661 amino acids long and is a type I transmembrane glycoprotein enriched in melanosomes, which are the melanin-producing organelles in melanocytes. This protein is involved in melanosome maturation. The Human HLA-A0201 gp100 (YLEPGPVTA) complex Protein is a complex of HLA-A0201 of the MHC Class I, B2M and YLEPGPVTA peptide of the gp100.
TMPK-01280	HER3/ERBB3 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) p85-sErbB3,HER3,LCCS2,p180-ErbB3,HER3c-erbB-3,ErbB-3,ERBB3,M...	Cynomolgus,Rhesus	HEK293 Cells
	Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG). HER3/ERBB3 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 69.54 kDa and the accession number i...
TMPH-02162	Synaptotagmin-1 Protein, Human, Recombinant (His) SYT1,Synaptotagmin-1,p65,Synaptotagmin I	Human	E. coli
	Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at leas...
TMPJ-01119	Osteoactivin/GPNMB Protein, Human, Recombinant (aa 22-486, His) Transmembrane Glycoprotein NMB,HGFIN,NMB,GPNMB,Transmembrane...	Human	HEK293 Cells
	Osteoactivin is an intracellular glycoprotein belongs to the NMB/pMEL-17 family, which is asscociated with cell endosomal/lysomal compartments. Human Osteoactivin is a 560 amino acid type I transmembrane protein, and one alternate splice form shows a 12 amino acid insert between amino acid 339-340. An additional 206 amino acid isoform shows a mutation at position 181 that results in a 26 amino acid substitution for the C-terminal 380 amino acids. Cells knowns to express Osteoactivin include fibr...
TMPY-03968	Secretogranin II Protein, Human, Recombinant (His) EM66,SgII,SN,CHGC,secretogranin II	Human	HEK293 Cells
	Kit ligand, also known as Hematopoietic growth factor KL, Mast cell growth factor, Steel factor, Stem cell factor, c-Kit ligand, Kitlg and KITL, is a single-pass type I membrane protein that belongs to the SCF family. KITL / kit ligand also belongs to the family of dimeric transmembrane growth factors. The soluble form of KIT ligand is a secreted protein. Mast cells are thought to participate in a variety of immune responses, such as parasite resistance and the allergic reaction. Mast cell devel...
TMPY-03117	Zinc Alpha 2 Glycoprotein/AZGP1 Protein, Human, Recombinant (His) ZAG,α-2-glycoprotein 1, zinc-binding,Zinc α 2,ZA2G,alpha-2-g...	Human	HEK293 Cells
	Alpha-2-glycoprotein, also known as AZGP1, belongs to the MHC class I family. It can be detected in body fluids such as serum, sweat, and seminal and breast cyst fluids. It has been shown that alpha-2-glycoprotein can stimulate lipolysis by adipocytes in vivo and in vitro. Thus it is believed that alpha-2-glycoprotein plays an important role in the regulation of body weight, and age-dependent changes in genetically influenced obesity, and it also regulates melanin production by normal and malign...
TMPY-03987	T Plastin/PLS3 Protein, Human, Recombinant (His) BMND18,T-plastin,plastin 3	Human	E. coli
	PLS3, also known as plastin 3, belongs to the plastin family. Members of this family are actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. There are two ubiquitous plastin isoforms in humans: L and T. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, m...
TMPJ-00990	S100B Protein, Mouse, Recombinant (His) S-100 protein subunit beta,S-100 protein beta chain,S100b,S1...	Mouse	E. coli
	S100-B, is an acidic protein with a molecular weight of 21 kDa belonging to the S100 family. S100-B contains two EF-hand-type calcium-binding motifs separated by a hinge region with a hydrophobic cleft. S100-B plays an important role in neurodevelopment, differentiation, and brain construction. S100-B has neuroprotective effects, but at high concentrations S100-B is neurotoxic. Extracellular concentration of S100-B increases following brain damage, which easily penetrates into cerebrospinal flui...

重组蛋白

PMEL Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01649

Species: Human

Expression System: E. coli

HER3/ERBB3 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00453

Species: Human

Expression System: HEK293 Cells

HER3/ERBB3 Protein, Human, Recombinant (His & Avi), FITC-Labeled

Cat.No: TMPK-00452

Species: Human

Expression System: HEK293 Cells

HLA-A*24:02&B2M&GP100 Intron 4 (VYFFLPDHL) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01476

Species: Human

Expression System: HEK293 Cells

HLA-A*24:02&B2M&GP100 Intron 4 (VYFFLPDHL) Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01475

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&GP100 (YLEPGPVTA) Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01553

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&GP100 (YLEPGPVTA) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01540

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&GP100 (YLEPGPVTA) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01551

Species: Human

Expression System: HEK293 Cells

HER3/ERBB3 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)

Cat.No: TMPK-01280

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

Synaptotagmin-1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02162

Species: Human

Expression System: E. coli

Osteoactivin/GPNMB Protein, Human, Recombinant (aa 22-486, His)

Cat.No: TMPJ-01119

Species: Human

Expression System: HEK293 Cells

Secretogranin II Protein, Human, Recombinant (His)

Cat.No: TMPY-03968

Species: Human

Expression System: HEK293 Cells

Zinc Alpha 2 Glycoprotein/AZGP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03117

Species: Human

Expression System: HEK293 Cells

T Plastin/PLS3 Protein, Human, Recombinant (His)

Cat.No: TMPY-03987

Species: Human

Expression System: E. coli

S100B Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00990

Species: Mouse

Expression System: E. coli

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