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Search Results for " leg "

Targets Recommended: PPAR

19

抑制剂 & 化合物

9

天然产物

16

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T14176	Aleglitazar RO0728804,R1439	PPAR	DNA Damage/DNA Repair; Metabolism
	Aleglitazar (R1439) 是一种高效的 PPARα/γ 双重激动剂，对人 PPARα 和 PPARγ 作用的 IC50 分别为 38 nM 和 19 nM。Aleglitazar 可用于 II 型糖尿病的研究。
T39905	Legumain inhibitor 1	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Legumain inhibitor 1 是一种具有高效性和特异性的 Legumain 抑制剂，具有潜在的抗癌活性，可用于研究癌症。
T77016	Galegenimab
	Galegenimab (FHTR 2163; RG 6147; RO 7171009)，一种抗 HTRA1抗体片段。Galegenimab 可用于年龄相关性黄斑变性 (AMD) 研究。
T65134	3-Indoleglyoxylic acid	Others	Others
	3-Indoleglyoxylic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65134，CAS号为 1477-49-2。
T76235L	Peceleganan acetate
	Peceleganan (PL-5) acetate，一种人工合成的肽类似物，由天蚕素 A (1-10) 和蜂毒素 B (3-18) 杂化而成，具有 (10+16) 的结构。该化合物有效抑制伤口感染。
T33027	Lycophlegmine	Others	Others
	Lycophlegmine is a bioactive chemical.
T125013	(S)-(-)-Pulegone	Others	Others
	(S)-(-)-Pulegone 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125013。
T25311	Desmethylselegiline	Others	Others
	Desmethylselegiline is an Enzyme Inhibitor.
T32623	Legumin	Others	Others
	Legumin is a herbicide, which is a mixture of Embutone and Tropotox.
T24849	TachypleginA-2 tA 2,tA-2,tA2	Others	Others
	TachypleginA-2 is a parasite motility and invasion inhibitor.
T125548	(-)Isopulegone	Others	Others
	(-)Isopulegone 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125548。
T33026	Lycophlegmarine	Others	Others
	Lycophlegmarine is a bioactive chemical.
T76235	Peceleganan
	Peceleganan (PL-5) 是一种合成的肽类似物，由天蚕素 A (1-10) × 蜂毒素 B (3-18) 杂化而成，具有 (10+16) 的结构。该化合物具有抑制伤口感染的作用。
T24848	TachypleginA Tachyplegin A,Tachyplegin-A	Others	Others
	TachypleginA is a parasite motility and invasion inhibitor.
T19525	PPA-904	Parasite	Microbiology/Virology
	PPA-904 是一种选择性的吩噻嗪光敏剂，具有潜在的抗肿瘤活性，可用于研究糖尿病足溃疡和慢性腿部溃疡。
T19525L	PPA-904 FA PPA-904 FA（30189-85-6 Free base）	Antibiotic	Microbiology/Virology
	PPA-904 FA 是一种阳离子光敏剂，具有广谱的抗菌活性，可用于光动力研究 (PDT) 研究，可用于研究慢性腿部溃疡和糖尿病足溃疡。
T6647	Rotigotine- Neupro,N-0923,罗替戈汀,N-0437,SPM 962	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Rotigotine (N-0923) 是多巴胺受体激动剂，是5-HT1A receptor 的部分激动剂，以及α2B-肾上腺素受体的拮抗剂，用于治疗帕金森病和不宁腿综合征。
T6651L	Safinamide EMD1195686,FCE26743,FCE 26743,EMD-1195686,EMD 1195686,FCE-26743	MAO	Metabolism; Neuroscience
	Safinamide (FCE-26743) 是一种可逆选择性单胺氧化酶 B (IC50 0.098μM)抑制剂，可减少多巴胺的降解，也是一种谷氨酸释放抑制剂(IC50 8μM)。它还能抑制多巴胺的再摄取。 Safinamide 还能阻断钠和钙通道。 Safinamide 的潜在的其他用途可能是帕金森病、不宁腿综合征和癫痫。
T38984	Z-Ala-Ala-Asn-AMC Cbz-Ala-Ala-Asn-AMC,Z-Ala-Ala-Asn-AMC
	Z-Ala-Ala-Asn-AMC, also known as Cbz-Ala-Ala-Asn-AMC, serves as a substrate for legumain. The overexpression of legumain in 293 HEK-Leg cells results in efficient cleavage of Cbz-Ala-Ala-Asn-AMC.

化合物

Cat.No: T14176

Synonym: RO0728804,R1439

Target: PPAR

Legumain inhibitor 1

Cat.No: T39905

Target: Gamma-secretase

Cat.No: T77016

3-Indoleglyoxylic acid

Cat.No: T65134

Target: Others

Peceleganan acetate

Cat.No: T76235L

Cat.No: T33027

Target: Others

(S)-(-)-Pulegone

Cat.No: T125013

Target: Others

Desmethylselegiline

Cat.No: T25311

Target: Others

Cat.No: T32623

Target: Others

Cat.No: T24849

Synonym: tA 2,tA-2,tA2

Target: Others

Cat.No: T125548

Target: Others

Lycophlegmarine

Cat.No: T33026

Target: Others

Cat.No: T76235

Cat.No: T24848

Synonym: Tachyplegin A,Tachyplegin-A

Target: Others

Cat.No: T19525

Target: Parasite

Cat.No: T19525L

Synonym: PPA-904 FA（30189-85-6 Free base）

Target: Antibiotic

Cat.No: T6647

Synonym: Neupro,N-0923,罗替戈汀,N-0437,SPM 962

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Cat.No: T6651L

Synonym: EMD1195686,FCE26743,FCE 26743,EMD-1195686,EMD 1195686,FCE-26743

Target: MAO

Z-Ala-Ala-Asn-AMC

Cat.No: T38984

Synonym: Cbz-Ala-Ala-Asn-AMC,Z-Ala-Ala-Asn-AMC

Cat. No.	Product Name	Target	Signaling Pathways
T0070	Pentoxifylline Oxpentifylline,PTX,己酮可可碱,BL-191	HIV Protease; PDE; Adenosine Receptor; Autophagy	Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Pentoxifylline (PTX) 是一种具有口服活性的磷酸二酯酶非选择性抑制剂，具有免疫调节、抗炎、抗纤溶、抗增殖和血液流变学改善作用。它可研究周围血管疾病、脑血管疾病和其他一些涉及局部微循环缺陷的疾病。
T3333	Cyclogalegenin 环黄芪醇,Cyclogalegigenin,Cyclogalagenin,Astramembrangenin,Cycloastragenol	Telomerase	DNA Damage/DNA Repair
	Cyclogalegenin (Astramembrangenin) 是一种发现于Astragalus galegiformis 中的类异戊二烯，是 Cycloastragenol 的异构体。
TCS0102	Pulegone 胡薄荷酮,(+)-Pulegone,蒲勒酮，胡薄荷酮，长叶薄荷酮	Calcium Channel; Endogenous Metabolite; TRP/TRPV Channel	Membrane transporter/Ion channel; Metabolism
	Pulegone ((+)-Pulegone) 是 Calamintha nepeta (L.) Savi 的精油的主要化学成分，也是禽类驱虫剂之一。它在禽类物种中驱避作用的分子靶点是伤害感受性 TRP 锚蛋 1。它刺激鸡感觉神经元中的 TRPM8 和 TRPA1 通道，并在高浓度下抑制前者但不抑制后者。
Fr14207	(-)-Isopulegol	Others	Others
	(-)-Isopulegol 具有抗氧化和神经活性特性。它还具有由异胡薄荷醇诱导的胃保护作用，似乎至少部分由内源性前列腺素介导，K+ATP 通道开放和与 GSH 相关的抗氧化特性增加。
T8275	(+)-Isopulegol 异苏木精,異洋薄[荷]醇	Parasite	Microbiology/Virology
	(+)-Isopulegol 是加拿大薄荷树中发现的一种萜类，是T. confusum 成虫和T. granarium 幼虫的摄食引诱剂，对S. granarius 和T. confusum 的成虫具有刺激作用。
TN4322	Isopulegol	ATPase; Potassium Channel; GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Isopulegol presents depressant- and anxiolytic-like effects, it also has anticonvulsant and bioprotective effects against PTZ-induced convulsions are possibly related to positive modulation of benzodiazepine-sensitive GABAA receptors and to antioxidant properties.Isopulegol presents significant gastroprotective effects in both ethanol- and indomethacin-induced ulcer models, which appear to be mediated, at least in part, by endogenous prostaglandins, K(ATP) channel opening, and antioxidant proper...
TN6280	Aquilegiolide
	Aquilegiolide 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6280，CAS号为 94481-79-5。
T35532	Galegine hydrochloride	Others	Others
	Galegine hydrochloride, a guanidine derivative derived from G. officinalis, plays a role in inducing weight loss in mice and has contributed to the development of biguanides, including metformin and phenformin. This compound stimulates AMPK activation in 3T3-L1 adipocytes, L6 myotubes, H4IIE rat hepatoma, and HEK293 human kidney cell lines. Additionally, galegine hydrochloride exhibits antibacterial properties, particularly demonstrating a minimum inhibitory concentration of 4 mg/L against Staph...
TN4763	Phlegmanol C	Others	Others
	Phlegmanol C 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4763，CAS号为 1260-05-5。

天然产物

Cat.No: T0070

Synonym: Oxpentifylline,PTX,己酮可可碱,BL-191

Target: HIV Protease, PDE, Adenosine Receptor, Autophagy

Cat.No: T3333

Synonym: 环黄芪醇,Cyclogalegigenin,Cyclogalagenin,Astramembrangenin,Cycloastragenol

Target: Telomerase

Cat.No: TCS0102

Synonym: 胡薄荷酮,(+)-Pulegone,蒲勒酮，胡薄荷酮，长叶薄荷酮

Target: Calcium Channel, Endogenous Metabolite, TRP/TRPV Channel

Cat.No: Fr14207

Target: Others

Cat.No: T8275

Synonym: 异苏木精,異洋薄[荷]醇

Target: Parasite

Cat.No: TN4322

Target: ATPase, Potassium Channel, GABA Receptor

Cat.No: TN6280

Galegine hydrochloride

Cat.No: T35532

Target: Others

Cat.No: TN4763

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00876	Legumain Protein, Mouse, Recombinant (His) AI746452,AEP,AU022324,Prsc1,legumain	Mouse	HEK293 Cells
	Legumain Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.8 kDa and the accession number is A2RTI3.
TMPY-02873	Legumain Protein, Sus scrofa (Pig), Recombinant (His) legumain	Sus scrofa (Pig)	HEK293 Cells
	Legumain Protein, Sus scrofa (Pig), Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.7 kDa and the accession number is A0A287AW67.
TMPH-03134	Leghemoglobin Lb120-8 Protein, Pisum sativum, Recombinant (His) Leghemoglobin Lb120-8	Pisum sativum	E. coli
	Provides oxygen to the bacteroids. This role is essential for symbiotic nitrogen fixation. Leghemoglobin Lb120-8 Protein, Pisum sativum, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 19.9 kDa and the accession number is Q9SAZ1.
TMPH-02432	Legumain Protein, Cynomolgus, Recombinant (E. coli, His & Myc) Legumain,Protease, cysteine 1,LGMN,Asparaginyl endo...	Cynomolgus	E. coli
	Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Legumain Protein, Cynomolg...
TMPH-02398	ASA dehydrogenase Protein, Legionella pneumophila, Recombinant (His) Aspartate-beta-semialdehyde dehydrogenase,asd,Aspartate-semi...	Legionella pneumophila	E. coli
	Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
TMPH-02402	Zinc metalloproteinase Protein, Legionella pneumophila, Recombinant (His) Zinc metalloproteinase,PEP1,PRO A	Legionella pneumophila	E. coli
	Cleaves collagen, gelatin, casein, alpha-1-antitrypsin, and bovine insulin. May play a role in the pathogenesis of legionnaires disease.
TMPH-03092	Leghemoglobin A Protein, Phaseolus vulgaris, Recombinant (His & Myc) Leghemoglobin A	Phaseolus vulgaris	E. coli
	Provides oxygen to the bacteroids. This role is essential for symbiotic nitrogen fixation. Leghemoglobin A Protein, Phaseolus vulgaris, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 22.9 kDa and the accession number is P02234.
TMPH-02397	MIP Protein, Legionella longbeachae, Recombinant (His & Myc) Macrophage infectivity potentiator,Peptidyl-prolyl cis-trans...	Legionella longbeachae	E. coli
	Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.
TMPH-03407	NIFH Protein, Rhizobium leguminosarum, Recombinant (GST & His & Myc) Nitrogenase iron protein,Nitrogenase reductase,Nitrogenase c...	Rhizobium leguminosarum	E. coli
	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein. NIFH Protein, Rhizobium leguminosarum, Recombinant (GST & His & Myc) is expressed in E. coli expression system with N-10xHis-GST and C-Myc tag. The predicted molecular weight is 35.0 kDa and the accession number is P20623.
TMPY-06640	Legumain Protein, Human, Recombinant (His) PRSC1,AEP,legumain,LGMN1	Human	HEK293 Cells
	Legumain Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.12 kDa and the accession number is Q99538.
TMPH-02400	Pal Protein, Legionella pneumophila, Recombinant (His) 19 kDa surface antigen,Peptidoglycan-associated lipoprotein,...	Legionella pneumophila	P. pastoris (Yeast)
	Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Very strongly associated with the peptidoglycan.
TMPH-00772	Leghemoglobin C2 Protein, Glycine max, Recombinant (His) Leghemoglobin C2	Glycine max	E. coli
	Provides oxygen to the bacteroids. This role is essential for symbiotic nitrogen fixation.
TMPH-00434	Ovomucoid Protein, Coturnix delegorguei, Recombinant (His & Myc & SUMO) Ovomucoid	Coturnix delegorguei	E. coli
	Ovomucoid Protein, Coturnix delegorguei, Recombinant (His & Myc & SUMO) is expressed in E. coli.
TMPH-02431	Legumain Protein, Cynomolgus, Recombinant (His & Myc) Legumain,Protease, cysteine 1,Asparaginyl endopepti...	Cynomolgus	Baculovirus Insect Cells
	Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Legumain Protein, Cynomolg...
TMPH-02401	rplL Protein, Legionella pneumophila, Recombinant (His & Myc) Large ribosomal subunit protein bL12,50S ribosomal protein L...	Legionella pneumophila	E. coli
	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation. rplL Protein, Legionella pneumophila, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 20.4 kDa and the accession number is Q5ZYQ1.
TMPH-02399	Pal Protein, Legionella pneumophila, Recombinant (E. coli, His) pal,19 kDa surface antigen,Peptidoglycan-associated lipoprot...	Legionella pneumophila	E. coli
	Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Very strongly associated with the peptidoglycan.

重组蛋白

Legumain Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00876

Species: Mouse

Expression System: HEK293 Cells

Legumain Protein, Sus scrofa (Pig), Recombinant (His)

Cat.No: TMPY-02873

Species: Sus scrofa (Pig)

Expression System: HEK293 Cells

Leghemoglobin Lb120-8 Protein, Pisum sativum, Recombinant (His)

Cat.No: TMPH-03134

Species: Pisum sativum

Expression System: E. coli

Legumain Protein, Cynomolgus, Recombinant (E. coli, His & Myc)

Cat.No: TMPH-02432

Species: Cynomolgus

Expression System: E. coli

ASA dehydrogenase Protein, Legionella pneumophila, Recombinant (His)

Cat.No: TMPH-02398

Species: Legionella pneumophila

Expression System: E. coli

Zinc metalloproteinase Protein, Legionella pneumophila, Recombinant (His)

Cat.No: TMPH-02402

Species: Legionella pneumophila

Expression System: E. coli

Leghemoglobin A Protein, Phaseolus vulgaris, Recombinant (His & Myc)

Cat.No: TMPH-03092

Species: Phaseolus vulgaris

Expression System: E. coli

MIP Protein, Legionella longbeachae, Recombinant (His & Myc)

Cat.No: TMPH-02397

Species: Legionella longbeachae

Expression System: E. coli

NIFH Protein, Rhizobium leguminosarum, Recombinant (GST & His & Myc)

Cat.No: TMPH-03407

Species: Rhizobium leguminosarum

Expression System: E. coli

Legumain Protein, Human, Recombinant (His)

Cat.No: TMPY-06640

Species: Human

Expression System: HEK293 Cells

Pal Protein, Legionella pneumophila, Recombinant (His)

Cat.No: TMPH-02400

Species: Legionella pneumophila

Expression System: P. pastoris (Yeast)

Leghemoglobin C2 Protein, Glycine max, Recombinant (His)

Cat.No: TMPH-00772

Species: Glycine max

Expression System: E. coli

Ovomucoid Protein, Coturnix delegorguei, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00434

Species: Coturnix delegorguei

Expression System: E. coli

Legumain Protein, Cynomolgus, Recombinant (His & Myc)

Cat.No: TMPH-02431

Species: Cynomolgus

Expression System: Baculovirus Insect Cells

rplL Protein, Legionella pneumophila, Recombinant (His & Myc)

Cat.No: TMPH-02401

Species: Legionella pneumophila

Expression System: E. coli

Pal Protein, Legionella pneumophila, Recombinant (E. coli, His)

Cat.No: TMPH-02399

Species: Legionella pneumophila

Expression System: E. coli

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