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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T32558 |
Lanosteryl acetate
Lanosterol acetate |
Others | Others |
Lanosteryl acetate is a bioactive chemical. | |||
T8490 |
Butoconazole
1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole,布康唑 |
Antifungal | Microbiology/Virology |
Butoconazole (1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole) 是一种咪唑类抗真菌药物,可治疗白色念珠菌引起的阴道感染。它可通过抑制类固醇起抗菌作用。 | |||
T84285 |
MM0299
|
Others | Others |
MM0299 具有脑渗透性,具有抗胶质母细胞瘤活性,抑制羊毛甾醇合酶 (LSS),诱导原位GBM肿瘤中EPC的产生。 | |||
T3934 |
Isavuconazonium sulfate
|
Antifungal | Microbiology/Virology |
Isavuconazonium sulfate 是一种口服活性抗真菌药,是活性三唑类抗真菌药物 Isavuconazole 的前药,可用于侵袭性曲霉菌病和毛霉菌病。 | |||
T7866 |
Difenoconazole
|
Others; Antifungal | Microbiology/Virology; Others |
Difenoconazole 是一种广谱三唑类杀菌剂,通过抑制羊毛甾醇的细胞色素 P450 依赖性 14α-去甲基化来抑制麦角甾醇的生物合成,从而导致真菌细胞膜的破坏和细胞死亡。 | |||
T5966 |
Hexaconazole
己唑醇,(-)-Hexaconazol |
Reactive Oxygen Species; Antifungal | Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Hexaconazole ((-)-Hexaconazol) 是一种广谱三唑类杀菌剂,通过抑制羊毛甾醇的细胞色素 P450 依赖性 14α-去甲基化来抑制麦角甾醇的生物合成,从而导致真菌细胞膜的破坏和细胞死亡。 | |||
T1438 |
Butoconazole nitrate
RS 35887,硝酸布康唑 |
Estrogen/progestogen Receptor; Antifungal | Endocrinology/Hormones; Microbiology/Virology |
Butoconazole nitrate (RS 35887) 是一种咪唑类抗真菌药物,可治疗由白色念珠菌引起的阴道感染。它可通过抑制类固醇合成起到抗菌作用。 | |||
T1187 |
Bifonazole
联苯苄唑,Bay H-4502 |
P450; Antibiotic; Antifungal | Metabolism; Microbiology/Virology |
Bifonazole (Bay H-4502) 是咪唑类抗真菌剂。 | |||
T1290 |
Oxiconazole nitrate
硝酸奥昔康唑,Ro 13-8996 |
Others; Antibiotic; Antifection; Antifungal | Microbiology/Virology; Others |
Oxiconazole nitrate (Ro 13-8996) 是广谱抗真菌药物,抑制T. tonsurans 和T.rubrum 的生长,MIC90值分别为 0.25 和 0.5 μg/mL。 | |||
T4039 |
BIBB 515
|
Others | Others |
BIBB 515 是口服具有活力的 2,3-氧化角鲨烯环化酶选择性抑制剂,在大鼠和小鼠中的 ED50值分别为 0.2-0.5 mg/kg 和 0.36-33.3 mg/kg (1-5 小时)。它主要利用抑制低密度脂蛋白的产生,从而发挥降脂作用。 | |||
T25127 |
Azalanstat
RS-21607,RS 21607,RS21607 |
Others | Others |
Azalanstat is a lanosterol 14 alpha-demethylase inhibitor. The enzyme catalyzes the first step in the conversion of lanosterol to cholesterol in mammals. | |||
T32095 |
Holothurinogenin
Nobilisidenol A |
Others | Others |
Holothurinogenin, as a lanosterol derivative, has toxic to nerve tissue. | |||
T25625 |
Lanomycin
|
Others | Others |
Lanomycin, isolated from Pycnidiophora dispersa, inhibits lanosterol 14alpha-demethylase. | |||
T69167 |
Buthiobate
|
Others | Others |
Buthiobate is a fungicide which inhibits lanosterol 14 alpha-demethylation catalyzed by a cytochrome P-450. | |||
T71536 |
Mdl 28815
|
Others | Others |
Mdl 28815 is a potent inhibitor of 2,3-oxidosqualene cycloartenol & lanosterol cyclases. | |||
T70661 |
Azalanstat mesylate
|
Others | Others |
Azalanstat mesylate is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor. Azalanstat mesylate has been shown to inhibit cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes and hamster liver, by inhibiting the cytochrome P450 enzyme lanosterol 14 alpha-demethylase. When administered orally to hamsters fed regular chow, RS-21607 (50 mg/kg/day) lowered serum cholesterol in a dose-dependent manner (ED50 = 62 mg/kg) in a period of 1 week. It preferentially... | |||
T26191 |
SK&F 104976
SK&F104976,Skf104976,Skf 104976,SK&F-104976,Skf-104976 |
Others | Others |
SK&F 104976 is a 32-carboxylic acid derivative of lanosterol. It was found to be a potent lanosterol 14 alpha-demethylase (14 alpha DM) inhibitor. | |||
T64029 |
Antifungal agent 42
|
Others | Others |
Antifungal agent 42 是一种抗真菌剂,对生物膜形成具有抑制作用。Antifungal agent 42 能够抑制 C.alb.的 lanosterol 14α-demethylase (CYP51)。 | |||
T26424 |
A 60586
A60586,A-60586 |
Others | Others |
A 60586, a non-azole inhibitor of ergosterol biosynthesis, inhibits lanosterol 14alpha-demethylase and displays in-vitro antifungal activity. | |||
T70660 |
Azalanstat HCl
|
Others | Others |
Azalanstat HCl is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor. Azalanstat HCl has been shown to inhibit cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes and hamster liver, by inhibiting the cytochrome P450 enzyme lanosterol 14 alpha-demethylase. When administered orally to hamsters fed regular chow, RS-21607 (50 mg/kg/day) lowered serum cholesterol in a dose-dependent manner (ED50 = 62 mg/kg) in a period of 1 week. It preferentially lowered l... | |||
T70158 |
Quilseconazole besylate
|
Others | Others |
Quilseconazole besylate, also known as VT-1129 besylate, is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor. | |||
T63285 |
Antifungal agent 40
|
Others | Others |
Antifungal agent 40 是抗真菌剂,能够延伸到 C.alb.CYP51 的狭窄疏水口袋 II 中,可抑制 lanosterol 14α-demethylase (CYP51) 的活性,对生物膜的形成具有抑制作用。 | |||
T68998 |
Parconazole Free Base
|
Others | Others |
Parconazole Free Base is used in veterinary as an oral fungicide with a broad-spectrum activity against dermatophytes, yeasts, and others fungi. This compound does not have any antibacterial effect. The mechanism of action involves inhibition of the fungal cytochrome P450 dependent 14alpha-dimethylation of lanosterol to ergosterol. | |||
T64105 |
Voriconazole camphorsulfonate
|
Others | Others |
Voriconazole (UK-109496) camphorsulfonate 是一种二代广谱的三唑类抗真菌 (antifungal) 化合物,对真菌麦角甾醇的生物合成表现出抑制作用。Voriconazole camphorsulfonate 能够抑制由真菌细胞色素 P450 酶介导的 14-α-羊毛甾醇去甲基化作用,表现出抗真菌效果。 | |||
T79550 |
Antifungal agent 68
|
Others | Others |
Antifungalagent 68(compound 10)是抗真菌剂,针对念珠菌和格特隐球菌。它通过抑制麦角甾醇的生物合成发挥作用,靶向羊毛甾醇 14α-去甲基酶(CYP51)。Antifungalagent 68的咪唑环能与CYP51的血红素基团发生相互作用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4970 |
LANOSTEROL
羊毛甾醇,3β-Hydroxy-8,24-lanostadiene,8,24-Lanostadien-3β-ol |
Endogenous Metabolite | Metabolism |
Lanosterol (3β-Hydroxy-8,24-lanostadiene) 是胆固醇合成的中间产物,能够诱导胆固醇合成的速率控制酶 HMG-CoA 还原酶的泛素化和降解。Lanosterol 可以抑制神经退行性疾病相关错误折叠蛋白的聚集和细胞毒性。 | |||
T1011 |
Itraconazole
伊曲康唑,R51211 |
P450; Hedgehog/Smoothened; Antibiotic; Autophagy; Antifungal | Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Stem Cells |
Itraconazole (R51211) 属于三唑类天然产物,是一种抗真菌剂,具有口服活性。Itraconazole 是一种 Hedgehog 信号通路拮抗剂,一种 oxysterol-binding protein (OSBP) 抑制剂,也是一种细胞色素 P-450 依赖性酶的抑制剂。 | |||
TN6736 |
Dihydrolanosterol
24,25-Dihydrolanosterol,Lanostenol,二氢羊毛甾醇 |
Others | Others |
Dihydrolanosterol 是一种 CYP51 的底物,能够阻碍胆固醇的合成。 | |||
T41052 |
24,25-Dihydrolanosterol
Lanostenol,二氢羊毛甾醇 |
Others | Others |
24,25-Dihydrolanosterol (Lanostenol) is a chemical compound found in the seeds of the red pepper (Capsicum annuum). |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01603 |
Lanosterol synthase/LSS Protein, Human, Recombinant (His)
Lanosterol synthase,LSS,2,3-epoxysqualene--lano... |
Human | E. coli |
Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency. | |||
TMPH-03447 |
ERG11 Protein, S. cerevisiae, Recombinant (GST)
Ergosterol biosynthetic protein 11,Cytochrome P450 51,ERG11,... |
Saccharomyces cerevisiae | E. coli |
Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. ERG11 Protein, S. cerevisiae, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 29.1 kDa and the accession number is P10614. | |||
TMPH-03017 |
CYP51 Protein, Mycobacterium tuberculosis, Recombinant (His & Myc)
Cytochrome P450-14DM,Sterol 14alpha-demethylase,Sterol 14-al... |
Mycobacterium tuberculosis | Baculovirus Insect Cells |
Its precise biological substrate is not known. Catalyzes C14-demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. |