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Targets Recommended: Ferroptosis

27

抑制剂 & 化合物

1

天然产物

29

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T11631	iFSP1	Ferroptosis	Apoptosis
	iFSP1 是一种强效、选择性和谷胱甘肽独立的铁死亡抑制蛋白 1 (FSP1) (AIFM2) 抑制剂，具有EC50 为 103 nM。它能够使多种人类癌细胞系对铁死亡诱导剂敏感，例如 (1S,3R)-RSL3。它在过表达 FSP1 的 GPX4 敲除细胞中选择性地诱导铁死亡。
T2121	SW033291	Dehydrogenase	Metabolism
	SW033291 是有效的15-PGDH 抑制剂，与15-PGDH 亲和力高，Ki 为 0.1 nM。它增加骨髓和其他组织中前列腺素 PGE2 的水平。它还可促进组织再生。
T3722	MK-1064 Urokinase inhibitor 1,MK 1064	OX Receptor	GPCR/G Protein; Neuroscience
	MK-1064 (Urokinase inhibitor 1) 是一种选择性食欲素 2 (2-SORA)受体拮抗剂，可用于失眠患者的研究。
T10087	24-Norursodeoxycholic acid nor-UDCA	Others	Others
	24-Norursodeoxycholic acid (nor-UDCA) 是一种侧链缩短的 UDCA 的 C23 同系物，表现出有效的抗胆汁淤积，抗炎和抗纤维化活性。
T27957	LY-465608 LY 465608	Others	Others
	LY-465608, a PPAR Agonist, inhibits macrophage activation and atherosclerosis in apolipoprotein E knockout mice.
T85198	Cholesteryl Docosapentaenoate	Others	Others
	Cholesteryl docosapentaenoate, a cholesterol ester, exhibits increased levels in the liver, plasma, and skeletal muscle of acyl-CoA binding protein (ACBP) knockout mice relative to homozygous controls.
T70340	JHU-58	Others	Others
	JHU-58 is a novel dipeptide MrgC agonist. JHU-58 inhibited both mechanical and heat hypersensitivity in rats after an L5 spinal nerve ligation (SNL). JHU58 attenuated the evoked excitatory postsynaptic currents in substantia gelatinosa (SG) neurons in wild-type mice, but not in Mrg knockout mice, after peripheral nerve injury.
T37023	MB 0223	Others	Others
	Dynamin-related GTPase DRP1 partial inhibitor (IC50 = 1.2 μM). Selective for DRP1 over other dynamin-related GTPases, OPA1 and DYN1. Increases mitochondrial DNA levels in mfn1- knockout MEFs deficient in mitochondrial fusion. Mallat et al (2018) Discovery and characterization of selective small molecule inhibitors of the mammalian mitochondrial division dynamin, DRP1. Biochem.Biophys.Res.Commun. 499 556 PMID:29601815
T38172	RO 5263397 hydrochloride	Others	Others
	Potent trace amine 1 (TA1) receptor agonist (EC50 values are 0.12, 35 and 17-85 nM for mouse, rat and human receptors, respectively). Increases wakefulness and reduces REM and NREM sleep duration in wild type mice. Inhibits spontaneous locomotor activity in dopamine transport (DAT) knockout mice. Espinoza et al (2018) Biochemical and functional characterization of the trace amine-associated receptor 1 (TAAR1) agonist RO5263397. Front.Pharmacol. 9 645 PMID:29977204 \|Galley et al (2015) Discovery ...
T71845	Lockdown	Others	Others
	Lockdown is a reversible and non-competitive PPM1F inhibitor. Lockdown is selective for PPM1F, because this compound does not inhibit other protein phosphatases in vitro and does not induce additional phenotypes in PPM1F knockout cells. Lockdown acts in a dose-dependent, allosteric manner with high selectivity for PPM1F
T37112	YNT-185 dihydrochloride	Others	Others
	Potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice. Nagahara et al (2015) Design and synthesis of non-peptide, selective orexin receptor 2 agonists. J.Med.Chem. 58 7931 ...
T84539	N-Lignoceroyl Taurine	Others	Others
	N-Acyl taurines, such as N-lignoceroyl taurine, alongside various arachidonoyl amino acid conjugates like N-arachidonoyl dopamine and N-arachidonoyl-L-serine, have been identified in bovine brain and through mass spectrometry lipidomic studies in the brain and spinal cord of both wild-type and FAAH knockout mice. Notably, N-lignoceroyl taurine levels were found to be 23-26 times higher in FAAH knockout mice than in wild types, suggesting its degradation by FAAH, despite in vitro evidence showing...
T78898	Lysyl hydroxylase 2-IN-2	Monoamine Oxidase	Neuroscience
	Lysyl hydroxylase 2-IN-2（compound 13）为一高效Lysyl hydroxylase 2 (LH2)抑制剂，其IC50约为500 nM。该化合物能够抑制344SQ野生型细胞迁移，而对于LH2敲除的344SQ细胞迁移则无影响。
T36260	NR 7h	Others	Others
	Potent and selective p38α and p38β degrader (DC50 < 50 nM). Displays no significant degradation of p38γ, p38δ, JNK1/2 or ERK1/2. Inhibits phosphorylation of MK2 in UV-treated cancer cells and LPS-stimulated bone marrow-derived macrophages (BMDM). Exhibits similar effect to p38α gene knockout in BBL358 cells. Active in vivo.
T78241	Asfotase alfa ENB-0040
	Asfotase alfa (ENB-0040) 是一款针对骨骼的基因重组糖蛋白。该药物提升了Akp2−/−基因敲除小鼠的存活率、骨矿化及骨骼生长，并且缓解了脚部、胸部、下肢及颌骨矿化缺损。它主要用于对围产期、婴幼儿及青少年型低磷酸酶血症(HPP)进行研究。
T74743	M47	Others	Others
	M47 是一种小分子，可选择性地破坏隐花色素 1 (CRY1) 的稳定性并增加细胞核中 CRY1 的降解。M47 增强Ras 转化的 P53 缺陷小鼠皮肤成纤维细胞系的细胞凋亡，并延长 p53 基因敲除小鼠的寿命。M47 可用于癌症研究。
T37845	Taurocholic Acid 3-sulfate (sodium salt)	Others	Others
	Taurocholic acid 3-sulfate (TCA3S) is a metabolite of the conjugated bile acid taurocholic acid .1Plasma levels of TCA3S are elevated in wild-type andSortilin 1(Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and are further elevated inSort1knockout mice at 24 hours post-BDL.2 1.Lefebvre, P., Cariou, B., Lien, F., et al.Role of bile acids and bile acid receptors in metabolic regulationPhysiol. Rev.89(1)147-191(2009) 2.Li, J., Woolbright, B.L., Zhao, W., et al.Sortilin 1 loss-o...
T80248	PKCε (85-92)	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	PKCε(85-92) 是一种具有生物活性的肽，其作为 e-PKC 特异性激活剂，能够促进野生型细胞中的 MARCKS 磷酸化作用，对基因敲除小鼠来源的细胞中的 MARCKS 磷酸化则无影响。
T38160	STING Agonist 1a	Others	Others
	STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 μM). STING agonist 1a (12.5-100 μM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 . 1.Hou, H., Yang, R., Liu, X., et al.Discovery of triazoloquinoxaline as novel STING agonists via structure-based vir...
T82719	Cisd2 agonist 2	Others	Others
	Cisd2 agonist 2（compound 6）是Cisd2激活剂，具有191 nM的EC50值，其中Cisd2水平与NAFLD相关。在Cisd2hKO-het小鼠（杂合子肝细胞特异性Cisd2敲除）中，Cisd2 agonist 2未显示出显著的体内毒性。
T37487	1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE	Others	Others
	1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3.
T36380	GLP-1 (1-36) amide (human, rat) (trifluoroacetate salt)
	GLP-1 amide is a peptide hormone cleaved from proglucagon in the pancreas.1,2 Mice lacking the glucagon receptor (Gcgr-/-) have approximately nine-fold higher levels of total GLP-1 amide, including GLP-1 (1-36) amide and truncated GLP-1 (7-36) amide , in pancreatic tissue compared to wild-type mice.2References1. Schjoldager, B.T., Mortensen, P.E., Christiansen, J., et al. GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans...
T36461	CAY10748 CAY10748	Others	Others
	CAY10748 is an agonist of stimulator of interferon genes (STING; IC50= 0.3794 μM in a competition binding assay).1It activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 μM, respectively, in a reporter assay). It induces phosphorylation of STING at the serine in position 366, as well as phosphorylation of TBK1 and IFN regulatory factor 3 (IRF3), indicating activation of the STING-TBK1-IRF3 signaling pathway. CAY10748 increases the secretion of IFN-β an...
T37980	N-methyl Leukotriene C4 N-methyl Leukotriene C4	Others	Others
	Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl Leukot...
T83676	Tianeptine Metabolite MC5 sodium
	Tianeptine metabolite MC5是一种来自非典型抗抑郁化合物tianeptine的活性代谢物，通过β-氧化形成。此代谢物在使用表达人类μ-阿片受体（MOR）而非人类δ-阿片受体（DOR；EC50s = 0.454和 >100 µM, 分别）的HEK293T细胞进行的生物发光共振能量转移(BRET)试验中，特异性诱导G蛋白激活。在野生型小鼠上，30 mg/kg剂量的Tianeptine metabolite MC5可减少强迫游泳测试中的静止时间，但在MOR敲除小鼠中则不会，表明其具有MOR依赖的抗抑郁样活性。
T83825	Trofinetide acetate NNZ-2566
	Trofinetide是一种衍生自具有神经保护作用的三肽Gly-Pro-Glu的化合物，后者是胰岛素样生长因子-1（IGF-1）的N-端序列。在10 nM的浓度下使用时，它能减少由蛋白磷酸酶抑制剂奥卡达酸在原代大鼠胚胎纹状体神经元中引起的细胞死亡。Trofinetide在一种由穿透性弹道样脑损伤引起的大鼠神经炎症模型中减少了编码IL-1β、TNF-α、IL-6和E-selectin的mRNA的脑表达。在通过中脑动脉闭塞（MCAO）引起的大鼠脑损伤模型中，以30和60 mg/kg的剂量给药时，它减少了皮层和纹状体梗塞区域。Trofinetide（每天100 mg/kg）减少了树突棘的数量，并逆转了在fmr1-/-敲除小鼠脆性X综合征模型中的社交识别和情景恐惧条件反射的缺陷，同时也减少了睾丸重量的增加。含有Trofinetide的制剂已被用于治疗Rett综合征。
T36722	Deltorphin II (trifluoroacetate salt)	Others	Others
	Deltorphin II is a peptide agonist of δ2-opioid receptors.1,2It is selective for δ-opioid receptors over μ- and κ-opioid receptors in radioligand bindings assays (Kis = 0.0033, >1, and >1 μM, respectively) and induces [35S]GTPγS binding in mouse brain membrane preparations (EC50= 0.034 μM). Deltorphin II (0.12 mg/kg) decreases the infarction zone:risk zone ratio in a rat model of myocardial ischemia-reperfusion injury induced by coronary occlusion, an effect that can be reversed by the δ2-opioid...

化合物

Cat.No: T11631

Target: Ferroptosis

Cat.No: T2121

Target: Dehydrogenase

Cat.No: T3722

Synonym: Urokinase inhibitor 1,MK 1064

Target: OX Receptor

24-Norursodeoxycholic acid

Cat.No: T10087

Synonym: nor-UDCA

Target: Others

Cat.No: T27957

Synonym: LY 465608

Target: Others

Cholesteryl Docosapentaenoate

Cat.No: T85198

Target: Others

Cat.No: T70340

Target: Others

Cat.No: T37023

Target: Others

RO 5263397 hydrochloride

Cat.No: T38172

Target: Others

Cat.No: T71845

Target: Others

YNT-185 dihydrochloride

Cat.No: T37112

Target: Others

N-Lignoceroyl Taurine

Cat.No: T84539

Target: Others

Lysyl hydroxylase 2-IN-2

Cat.No: T78898

Target: Monoamine Oxidase

Cat.No: T36260

Target: Others

Cat.No: T78241

Synonym: ENB-0040

Cat.No: T74743

Target: Others

Taurocholic Acid 3-sulfate (sodium salt)

Cat.No: T37845

Target: Others

Cat.No: T80248

Target: PKC

STING Agonist 1a

Cat.No: T38160

Target: Others

Cisd2 agonist 2

Cat.No: T82719

Target: Others

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE

Cat.No: T37487

Target: Others

GLP-1 (1-36) amide (human, rat) (trifluoroacetate salt)

Cat.No: T36380

Cat.No: T36461

Synonym: CAY10748

Target: Others

N-methyl Leukotriene C4

Cat.No: T37980

Synonym: N-methyl Leukotriene C4

Target: Others

Tianeptine Metabolite MC5 sodium

Cat.No: T83676

Trofinetide acetate

Cat.No: T83825

Synonym: NNZ-2566

Deltorphin II (trifluoroacetate salt)

Cat.No: T36722

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T83913	Mitraciliatine	Others	Others
	Mitraciliatine是一种在M. speciosa（泰国称为Kratom）中发现的生物碱，是μ-阿片受体（MOR）部分激动剂和κ-阿片受体（KOR）激动剂。该化合物对MOR和KOR具有选择性，与δ-阿片受体（DOR; EC50s分别为228, 218, 和 >1,000 nM，针对小鼠受体在GTPγS结合实验中的表现）。Mitraciliatine（100 nmol/动物，脑室内注射）在小鼠的热水尾部缩回实验中延长了撤回潜伏期，这一效果可以通过敲除MOR而非KOR来逆转。与吗啡不同，Mitraciliatine不会诱发过度活动或呼吸抑制。

天然产物

Cat.No: T83913

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03425	Tau Protein, Human, Recombinant (His) PPND,FTDP-17,MTBT1,DDPAC,MAPTL,MTBT2,microtubule-associated ...	Human	E. coli
	MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP...
TMPK-00585	FOLR4/Juno Protein, Human, Recombinant (His) Folate receptor 4,FR-δ,Folbp3,FR-delta,Izumo1r,Juno,FR δ,FOL...	Human	HEK293 Cells
	Izumo1 is the only essential sperm-egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for Izumo1 and female knockout mice for Juno are both healthy but sterile. Here, both sperm-egg binding proteins are shown to be evolving under positive selection. Juno's presence in mammals alone, suggesting a recent mammalian-specific duplication and neofunctionalization of the ancestral folate receptor. FOLR4/Juno Pro...
TMPK-01171	FOLR4/Juno Protein, Mouse, Recombinant (His) Juno,FOLR4, LOC390243,Folate receptor 4,FR δ,FR-delta,Folbp3...	Mouse	HEK293 Cells
	Izumo1 is the only essential sperm-egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for Izumo1 and female knockout mice for Juno are both healthy but sterile. Here, both sperm-egg binding proteins are shown to be evolving under positive selection. Juno's presence in mammals alone, suggesting a recent mammalian-specific duplication and neofunctionalization of the ancestral folate receptor. FOLR4/Juno Pro...
TMPK-01065	SEZ6 Protein, Mouse, Recombinant (His) BSRP-C,SEZ-6,BSRPC,SEZ6	Mouse	HEK293 Cells
	Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is...
TMPK-00541	SEZ6 Protein, Cynomolgus, Recombinant (His) SEZ-6,BSRPC,BSRP-C,SEZ6	Cynomolgus	HEK293 Cells
	Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weig...
TMPK-00997	SEZ6 Protein, Human, Recombinant (hFc) SEZ-6,BSRP-C,SEZ6,BSRPC	Human	HEK293 Cells
	Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is...
TMPK-00972	PK-1/PROK1 Protein, Mouse, Recombinant (hFc) PROK1,Mambakine,Prokineticin-1,EG-VEGF	Mouse	HEK293 Cells
	PK-1 (Ac10) is a baculovirus-encoded serine/threonine kinase,a pk-1 knockout AcMNPV failed to produce infectious progeny, while the pk-1 repair virus could rescue this defect.the kinase activity of PK-1 is essential in regulating viral propagation. Electron microscopy revealed that pk-1 deletion affected the formation of normal nucleocapsids.PK-1 appears to phosphorylate some viral or cellular proteins that are essential for DNA packaging to regulate nucleocapsid assembly.
TMPK-00998	SEZ6 Protein, Human, Recombinant (His) BSRPC,BSRP-C,SEZ-6,SEZ6	Human	HEK293 Cells
	Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is...
TMPK-00555	CDH17 Protein, Cynomolgus, Recombinant (His) Cdh17,HPT-1,FLJ26931,LI-cadherin,BILL-cadherin,P130,Cadherin...	Cynomolgus	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Protein, Cynomolgus, Recombinant (His) is expressed i...
TMPK-00948	CDH17 Protein, Human, Recombinant (hFc) Cdh17,cadherin-16,FLJ26931,Cadherin-17,HPT-1,P130,CDH16,LI-c...	Human	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Protein, Human, Recombinant (hFc) is expressed in HEK...
TMPK-00953	CDH17 Domain 6-7 Protein, Human, Recombinant (mFc) Cdh17,CDH16,MGC138218,BILL-cadherin,HPT-1,cadherin-16,MGC142...	Human	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Domain 6-7 Protein, Human, Recombinant (mFc) is expre...
TMPK-01224	CDH17 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated P130,BILL-cadherin,LI-cadherin,MGC138218,FLJ26931,CDH16,Cadh...	Mouse	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Protein (Primary Amine Labeling), Mouse, Recombinant ...
TMPK-00949	CDH17 Domain 7 Protein, Human, Recombinant (hFc) CDH16,P130,MGC142024,Cdh17,FLJ26931,Cadherin-17,MGC138218,ca...	Human	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Domain 7 Protein, Human, Recombinant (hFc) is express...
TMPK-00951	CDH17 Domain 5-7 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated FLJ26931,CDH16,LI-cadherin,MGC138218,cadherin-16,Cadherin-17...	Human	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Domain 5-7 Protein (Primary Amine Labeling), Human, R...
TMPJ-01401	NTNG1 Protein, Human, Recombinant (hFc) NTNG1,LMNT1,Netrin-G1,Laminet-1	Human	HEK293 Cells
	Netrin-G1, known as NTNG-1, and is a member of the UNC-6/Netrin family of proteins. The NTNG1 gene is located on chromosome 1p13.3 and encodes a glycosylphosphatidylinositol protein anchored to the presynaptic membrane. Netrin G1 molecule has been described to be involved in axonal guidance/maintenance and axonal growth cone by specifically interacting with its receptor the Netrin G1 ligand (NGL-1), which is located at the postsynaptic compartment. Netrin Gs knockout mice have disturbed subdendr...
TMPK-00996	SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated BSRPC,BSRP-C,SEZ6,SEZ-6	Human	HEK293 Cells
	Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predi...
TMPK-00952	CDH17 Domain 3 & 4 Protein, Human, Recombinant (mFc) BILL-cadherin,Cadherin-17,LI-cadherin,CDH16,cadherin-16,Cdh1...	Human	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Domain 3 & 4 Protein, Human, Recombinant (mFc) is exp...
TMPK-00947	CDH17 Protein, Human, Recombinant (His & Avi), Biotinylated CDH16,Cdh17,P130,cadherin-16,HPT-1,LI-cadherin,Cadherin-17,B...	Human	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Protein, Human, Recombinant (His & Avi), Biotinylated...
TMPK-01069	TMEM106B Protein, Mouse, Recombinant (hFc) Transmembrane protein 106B,Tmem106b	Mouse	HEK293 Cells
	TMEM106B is a well-recognised risk factor for FTD caused by GRN mutation. Elegant experiments have suggested that increased risk for FTD is due to elevated levels of TMEM106B (Nicholson et al, 2013; Gallagher et al, 2017). Therefore, recent work has explored the therapeutic potential of reducing TMEM106B levels, with initial results looking encouraging, as crossing a Grn-deficient mouse to a Tmem106b knockout showed a rescue in FTD-related behavioural defects and specific aspects of lysosome dys...
TMPK-00950	CDH17 Domain 6-7 Protein, Human, Recombinant (hFc) HPT-1,P130,MGC138218,LI-cadherin,FLJ26931,cadherin-16,Cdh17,...	Human	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Domain 6-7 Protein, Human, Recombinant (hFc) is expre...
TMPK-01223	CDH17 Protein, Mouse, Recombinant (His) CDH16,LI-cadherin,Cdh17,MGC138218,HPT-1,MGC142024,FLJ26931,B...	Mouse	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Protein, Mouse, Recombinant (His) is expressed in HEK...
TMPK-00473	CDH17 Protein, Rhesus macaque, Recombinant (His) CDH16,Cdh17,MGC142024,Cadherin-17,cadherin-16,P130,MGC138218...	Rhesus	HEK293 Cells
	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. CDH17 Protein, Rhesus macaque, Recombinant (His) is express...
TMPJ-01083	Serpin E2 Protein, Mouse, Recombinant (His) Pi7,Protease nexin I,Spi4,Pn1,Serine protease-inhibitor 4,PI...	Mouse	HEK293 Cells
	Serpin E2 is a member of the Serpin superfamily. It is differentially expressed during neuronal differentiation and is able to transform human embryonic kidney cells into neuronlike cells. Its over-expression in mice leads to progressive neuronal and motor dysfunction in these animals. It is also over-expressed in the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples whereas it is weakly expressed in all normal pancreas and chronic pancreatitis tissue samples. Ser...
TMPY-05014	INSL6 Protein, Human, Recombinant (His) RIF1,insulin-like 6	Human	HEK293 Cells
	INSL6 (Insulin-Like 6) is a Protein Coding gene. An important paralog of this gene is RLN1. The protein encoded by this gene contains a classical signature of the insulin superfamily and is significantly similar to relaxin and relaxin-like factor. INSL6 is a newly identified insulin/relaxin family peptide hormone that is predominantly expressed by the male germ cells in testes. It may have a role in sperm development and fertilization. A recent murine study demonstrated that INSL6-knockout resul...
TMPY-04373	CAMKII alpha/CAMK2A Protein, Human, Recombinant (GST) calcium/calmodulin-dependent protein kinase II alpha,calcium...	Human	Baculovirus Insect Cells
	Ca2+/calmodulin-dependent protein kinase2A (CAMK2A) belongs to the serine/threonine protein kinase family and, together with other 28 different isoforms, belongs to the Ca2+/ calmodulin-dependent protein kinase subfamily. CaM kinase Ⅱ is thought to be an important mediator of learning and memory and is also necessary for Ca2+homeostasis and reuptake in cardiomyocytes chloride transport in epithelia, positive T-cell selection, and CD8 T-cell activation. CAMKIIA is one of the major forms of CAMKII...
TMPJ-00796	Serpin E2 Protein, Human, Recombinant (His) PN-1,PI-7,Protease nexin 1,PI7,GDN,Peptidase inhibitor 7,Ser...	Human	HEK293 Cells
	Serpin E2 is a secreted protein that belongs to the serpin family. Serpin E2 is a serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Serpin E2 expression is weak or absent in all normal pancreas and chronic pancreatitis tissue. In contrast, it was strongly over-expressed in the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples. Serpin E2 promotes neurite extension by inhibiting thrombin. It also can bind heparin. It has been shown tha...
TMPJ-01154	SLAMF3 Protein, Mouse, Recombinant (His) SLAM family member 3,T-lymphocyte surface antigen Ly-9,Ly-9,...	Mouse	HEK293 Cells
	CD229(SLAMF3) is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family. Mature mouse CD229 consists of a 406 aa extracellular domain (ECD) with two Ig-like V-set and two Ig-like truncated C2-set domains, a 21 aa transmembrane segment, and a 180 aa cytoplasmic domain with two immunoreceptor tyrosinebased switch motifs ITSMs. Within the first two Ig-like domains that are common to all SLAM proteins, mouse CD229 shares 22%-36% aa sequence identity with mouse 2B4, BLAME, CD2F10,...
TMPJ-00067	BAFFR/TNFRSF13C Protein, Human, Recombinant (His) BR3,BAFFR,CD268,TNFRSF13C,BAFF R	Human	HEK293 Cells
	Tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. BAFF promotes the survival of B cells and is essential for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF...
TMPY-04813	ACAT2 Protein, Rat, Recombinant (His) acetyl-CoA acetyltransferase 2	Rat	E. coli
	Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and ACAT2) have been identified. Together, these two enzymes are involved in storing cholesteryl esters as lipid droplets, in macrophage foam-cell formation, in absorbing dietary cholesterol, and in supplying cholesteryl esters as part of the core lipid for lipoprotein synthesis and assembly. The key difference in tissue distributio...

重组蛋白

Tau Protein, Human, Recombinant (His)

Cat.No: TMPY-03425

Species: Human

Expression System: E. coli

FOLR4/Juno Protein, Human, Recombinant (His)

Cat.No: TMPK-00585

Species: Human

Expression System: HEK293 Cells

FOLR4/Juno Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01171

Species: Mouse

Expression System: HEK293 Cells

SEZ6 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01065

Species: Mouse

Expression System: HEK293 Cells

SEZ6 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00541

Species: Cynomolgus

Expression System: HEK293 Cells

SEZ6 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00997

Species: Human

Expression System: HEK293 Cells

PK-1/PROK1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00972

Species: Mouse

Expression System: HEK293 Cells

SEZ6 Protein, Human, Recombinant (His)

Cat.No: TMPK-00998

Species: Human

Expression System: HEK293 Cells

CDH17 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00555

Species: Cynomolgus

Expression System: HEK293 Cells

CDH17 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00948

Species: Human

Expression System: HEK293 Cells

CDH17 Domain 6-7 Protein, Human, Recombinant (mFc)

Cat.No: TMPK-00953

Species: Human

Expression System: HEK293 Cells

CDH17 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated

Cat.No: TMPK-01224

Species: Mouse

Expression System: HEK293 Cells

CDH17 Domain 7 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00949

Species: Human

Expression System: HEK293 Cells

CDH17 Domain 5-7 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated

Cat.No: TMPK-00951

Species: Human

Expression System: HEK293 Cells

NTNG1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-01401

Species: Human

Expression System: HEK293 Cells

SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00996

Species: Human

Expression System: HEK293 Cells

CDH17 Domain 3 & 4 Protein, Human, Recombinant (mFc)

Cat.No: TMPK-00952

Species: Human

Expression System: HEK293 Cells

CDH17 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00947

Species: Human

Expression System: HEK293 Cells

TMEM106B Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01069

Species: Mouse

Expression System: HEK293 Cells

CDH17 Domain 6-7 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00950

Species: Human

Expression System: HEK293 Cells

CDH17 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01223

Species: Mouse

Expression System: HEK293 Cells

CDH17 Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPK-00473

Species: Rhesus

Expression System: HEK293 Cells

Serpin E2 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01083

Species: Mouse

Expression System: HEK293 Cells

INSL6 Protein, Human, Recombinant (His)

Cat.No: TMPY-05014

Species: Human

Expression System: HEK293 Cells

CAMKII alpha/CAMK2A Protein, Human, Recombinant (GST)

Cat.No: TMPY-04373

Species: Human

Expression System: Baculovirus Insect Cells

Serpin E2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00796

Species: Human

Expression System: HEK293 Cells

SLAMF3 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01154

Species: Mouse

Expression System: HEK293 Cells

BAFFR/TNFRSF13C Protein, Human, Recombinant (His)

Cat.No: TMPJ-00067

Species: Human

Expression System: HEK293 Cells

ACAT2 Protein, Rat, Recombinant (His)

Cat.No: TMPY-04813

Species: Rat

Expression System: E. coli

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