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Search Results for " inward current "

Targets Recommended: Others

12

抑制剂 & 化合物

2

天然产物

1

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T23101	o-3M3FBS	Others	Others
	o-3M3FBS 是 m-3M3FBS 的阴性对照。它以独立于 PLC 的机制及拮抗方式抑制内向和外向电流。它以与 m-3M3FBS 竞争的方式增加 [Ca2+]i 增加。
T27205	DPI 201-106 DPI-201-106	Sodium Channel	Membrane transporter/Ion channel
	DPI 201-106对电压门控钠通道的有心脏选择性调节活性，从而产生正性肌力作用。DPI 201-106 具有协同肌膜和细胞内作用机制。
T0207	Ranolazine dihydrochloride 盐酸雷诺嗪,雷诺嗪二盐酸盐,RS 43285,Ranolazine 2HCl	Calcium Channel; Sodium Channel; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism
	Ranolazine dihydrochloride (Ranolazine 2HCl) 是一种抗心绞痛和抗缺血剂，可通过抑制内向钠电流的后期作用来发挥功效，而不会影响心率或血压。它对 INa 和 IKr 的 IC50值分别为 6 μM 和 12 μM。它还是脂肪酸氧化的部分抑制剂。
T0866	Propafenone Rythmol,普罗帕酮,Propafenonum	Potassium Channel; MRP; Sodium Channel	Immunology/Inflammation; Membrane transporter/Ion channel
	Propafenone (Propafenonum) 是钠通道阻滞剂，它对 β 受体具有高亲和力 (IC50=32 nM)。它能够阻断瞬时外向钾电流 (Ito) (IC50: 4.9 nM) 和持续延迟整流器K+电流 (Isus) (IC50: 8.6 nM) ，具有抗心律失常的作用。它能够诱导线粒体功能障碍及诱导细胞凋亡，从而抑制食管癌增殖。
T6541	Ibutilide Fumarate Corvert Fumarate,U70226E,富马酸伊布利特	Calcium Channel; Sodium Channel	Membrane transporter/Ion channel; Metabolism
	Ibutilide Fumarate (U70226E) 是一种 III 类抗心律失常药物，可作用于急性心梗阻塞。
T15555	IK1 inhibitor PA-6	Potassium Channel	Membrane transporter/Ion channel
	IK1 inhibitor PA-6 是一种喷他脒类似物，是选择性的 IK1(KIR2.x 离子通道携带向内整流电流) 抑制剂，对人和老鼠中 KIR2.x 电流的 IC50值为 12-15 nM。它可上调 KIR2.1 的蛋白表达，诱导细胞内 KIR2.1 的蛋白的积累。它在房颤和心律失常的研究中具有潜力。
T2535	Ivabradine hydrochloride 盐酸伊伐布雷定,S 16257-2,Ivabradine HCl	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Ivabradine hydrochloride (S 16257-2) 是一种可口服的，超极化激活的环核苷酸门控离子通道通道阻滞剂。
T5336L	Zacopride Racemic zacopride	Others	Others
	Zacopride is a selective agonist of inward rectifier potassium current (I K1) channel, inhibiting ventricular arrhythmias without affecting atrial arrhythmias.
T68361	Asocainol hydrochloride	Others	Others
	Asocainol hydrochloride ia an antiarrhythmic drug which inhibits slow Ca2+ influx. This is accompanied by alterations in normal Na+-carried action potentials. Therefore, Asocainol not only inhibits Ca2+ inflow but also interferes with the fast inward Na+ current.
T37093	4,9-Anhydrotetrodotoxin 4,9-Anhydrotetrodotoxin,4,9-anhydro-TTX	Others	Others
	4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes). [1][2][3] It demonstrates IC50 values of 1.3, 0.34, 0.99, 78.5, 1.3, and >30 &#181M for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively.[1]
T75855	Phrixotoxin 3 TFA
	Phrixotoxin 3 TFA 是一种高效的电压门控钠通道阻滞剂，对NaV1.2、NaV1.3、NaV1.4、NaV1.1及NaV1.5的IC50值分别为0.6、42、72、288和610 nM。该化合物通过改变门控动力学的去极化并阻断钠电流的内向流，调控电压门控钠通道，表现出类似典型门控修饰毒素的作用机制。
TP1513	Egg Laying Hormone, aplysia
	Egg-laying hormone (ELH) is a neuropeptide synthesized by the bag cell neurons, Egg-laying hormone (ELH) induces egg laying and its correlated behavior in Aplysia californica. Egg-laying hormone (ELH) has been purified to homogeneity and Egg-laying hormon

化合物

Cat.No: T23101

Target: Others

Cat.No: T27205

Synonym: DPI-201-106

Target: Sodium Channel

Ranolazine dihydrochloride

Cat.No: T0207

Synonym: 盐酸雷诺嗪,雷诺嗪二盐酸盐,RS 43285,Ranolazine 2HCl

Target: Calcium Channel, Sodium Channel, Autophagy

Cat.No: T0866

Synonym: Rythmol,普罗帕酮,Propafenonum

Target: Potassium Channel, MRP, Sodium Channel

Ibutilide Fumarate

Cat.No: T6541

Synonym: Corvert Fumarate,U70226E,富马酸伊布利特

Target: Calcium Channel, Sodium Channel

IK1 inhibitor PA-6

Cat.No: T15555

Target: Potassium Channel

Ivabradine hydrochloride

Cat.No: T2535

Synonym: 盐酸伊伐布雷定,S 16257-2,Ivabradine HCl

Target: Adrenergic Receptor

Cat.No: T5336L

Synonym: Racemic zacopride

Target: Others

Asocainol hydrochloride

Cat.No: T68361

Target: Others

4,9-Anhydrotetrodotoxin

Cat.No: T37093

Synonym: 4,9-Anhydrotetrodotoxin,4,9-anhydro-TTX

Target: Others

Phrixotoxin 3 TFA

Cat.No: T75855

Egg Laying Hormone, aplysia

Cat.No: TP1513

Cat. No.	Product Name	Target	Signaling Pathways
T8195	Lotusine	Others	Others
	Lotusine 是一种提取自Nelumbo nucifera Gaertn 的绿色种胚中的纯生物碱。它能够作用于心肌中动作电位及心脏浦肯野纤维缓慢内向电流。
T78489	Lotusine hydroxide	Others	Others
	Lotusine (hydroxide)为纯生物碱，源自Nelumbo nucifera Gaertn绿色种胚提取。该化合物能够影响心肌动作电位和心脏浦肯野纤维的缓慢内向电流。

天然产物

Cat.No: T8195

Target: Others

Lotusine hydroxide

Cat.No: T78489

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01889	KCNK3 Protein, Human, Recombinant (His & Myc) Potassium channel subfamily K member 3,TWIK-related acid-sen...	Human	E. coli
	pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. KCNK3 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 50.5 kDa and the accession number is O...

重组蛋白

KCNK3 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01889

Species: Human

Expression System: E. coli

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