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Search Results for " hydratase "

Targets Recommended: Mitochondrial Metabolism

4

抑制剂 & 化合物

3

天然产物

11

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T11337	Fumarate hydratase-IN-1	Mitochondrial Metabolism	Metabolism
	Fumarate hydratase-IN-1 是一种细胞可渗透性的富马酸水合酶抑制剂,具有抗增殖活性，可用于研究细胞活性。
T11336	Fumarate hydratase-IN-2 sodium salt	Others	Others
	Fumarate hydratase-IN-2 sodium salt (compound 3) 是一种具有细胞渗透性和竞争性的富马酸水合酶(fumarate hydratase)抑制剂 (Ki=4.5 μM)，具有营养依赖性细胞毒性。
T6759	AP-III-a4 ENOblock	Glucokinase	Metabolism
	AP-III-a4 (ENOblock) 是第一个非底物类似物，可直接与烯醇酶结合，IC50=0.576 uM，可阻碍体内癌细胞转移。
T71901	MP-1	Others	Others
	MP-1 is a covalent inhibitor of fumarate hydratase (FH) that exhibits cytotoxicity dependent on FH. MP-1 engages a functional cysteine in the Zn-finger domain of the tRNA methyltransferase enzyme TRMT1.

化合物

Fumarate hydratase-IN-1

Cat.No: T11337

Target: Mitochondrial Metabolism

Fumarate hydratase-IN-2 sodium salt

Cat.No: T11336

Target: Others

Cat.No: T6759

Synonym: ENOblock

Target: Glucokinase

Cat.No: T71901

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5564	Tricarballylic acid β-Carboxyglutaric acid,1,2,3-Propanetricarboxylic acid,三碳烯丙酸,Carballylic acid,Propane-1,2,3-tricarboxylic acid,丙三酸	aconitase; Mitochondrial Metabolism	Metabolism
	Tricarballylic acid (Carballylic acid) 是三碳烯丙酸酯的共轭酸，是一种乌头酸水合酶的竞争性抑制剂，其 Ki= 0.52 mM。
T4766	3-Methylglutaric acid	Endogenous Metabolite	Metabolism
	3-Methylglutaric acid 是亮氨酸代谢物，是一种与两种亮氨酸途径 HMGCL、AUH 酶缺陷显著相关的 C6 二元羧酸有机酸。
T78467	trans-10-Heptadecenoic acid	Others	Others
	trans-10-Heptadecenoic acid 是一种能在特定酶作用下参与生物合成与代谢过程的反式脂肪酸。在 2,4-二烯酰基-CoA 还原酶与 Delta3,Delta2-烯酰基-CoA 异构酶催化下，trans-10-Heptadecenoic acid 可合成聚羟基链烷酸酯。当缺乏 2,4-二烯酰基-CoA 还原酶时，该化合物则经由多功能酶 (MFE) 中的烯酰辅酶 A 水合酶 II 进行降解。此外，trans-10-Heptadecenoic acid 能通过还原酶依赖性与直接 MFE 依赖性途径引起细胞内的碳外流。

天然产物

Tricarballylic acid

Cat.No: T5564

Synonym: β-Carboxyglutaric acid,1,2,3-Propanetricarboxylic acid,三碳烯丙酸,Carballylic acid,Propane-1,2,3-tricarboxylic acid,丙三酸

Target: aconitase, Mitochondrial Metabolism

3-Methylglutaric acid

Cat.No: T4766

Target: Endogenous Metabolite

trans-10-Heptadecenoic acid

Cat.No: T78467

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02003	FH/Fumarate Hydratase Protein, Human, Recombinant (His) fumarate hydratase,MCL,LRCC,MCUL1,FMRD,HLRCC	Human	E. coli
	Fumarate Hydratase (FH) is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. Fumarate Hydratase is similar to some thermostable class II fumarases and func...
TMPJ-00313	Fumarase Protein, Human, Recombinant FH,Fumarase,Fumarate Hydratase Mitochondrial	Human	E. coli
	Fumarase is an enzyme that catalyze the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid or Krebs cycle. Fumarase exists in both form, cytosolic formand N-terminal extend mitochondrial form. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension is the same form as in the cytoplasm. Fumarase is thought to act as a tumor suppressor, which deficiency can lead to progressive encephalopathy, cerebral atrophy...
TMPY-03464	ECH1 Protein, Human, Recombinant (His) enoyl CoA hydratase 1, peroxisomal,HPXEL	Human	E. coli
	ECH1 is a member of the hydratase/isomerase superfamily. ECH1 shows high sequence similarity to enoyl-CoA hydratases of several species, particularly within a conserved domain characteristic of these proteins. ECH1 contains a C-terminal peroxisomal targeting sequence and localizes to peroxisomes. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans, 5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-de...
TMPH-02642	ECHS1 Protein, Mouse, Recombinant (C225S, HA & His) mECH,Enoyl-CoA hydratase, mitochondrial,SCEH,mECH1,...	Mouse	Baculovirus Insect Cells
	Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate. ECHS1 Protein, Mouse, Recombinant (C225S, HA & His) is expressed in Baculovirus insect cells with N-10xHis, C-HA tag. The predicted molecular weight is 32.0...
TMPH-03759	ECHS1 Protein, Mouse, Recombinant (HA & His) Enoyl-CoA hydratase, mitochondrial,ECHS1,mECH,mECH1...	Mouse	E. coli
	Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate. ECHS1 Protein, Mouse, Recombinant (HA & His) is expressed in E. coli expression system with N-10xHis, C-HA tag. The predicted molecular weight is 35.6 kDa a...
TMPH-01298	EPHX1 Protein, Human, Recombinant (His) EPHX1,Microsomal epoxide hydrolase,Epoxide hydratase	Human	E. coli
	Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol.
TMPH-03259	Carbonic Anhydrase 2 Protein, Rat, Recombinant (His) CA-II,Carbonate dehydratase II,Carbonic anhydrase I...	Rat	E. coli
	Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. Carbonic Anhydrase 2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.7 kDa and the accession number is P27139.
TMPH-03258	Carbonic Anhydrase 1 Protein, Rat, Recombinant (His & SUMO) Cyanamide hydratase CA1,CA-I,Carbonate dehydrat...	Rat	E. coli
	Reversible hydration of carbon dioxide. Carbonic Anhydrase 1 Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 44.2 kDa and the accession number is B0BNN3.
TMPH-03468	D-serine dehydratase Protein, Salmonella heidelberg, Recombinant (His & SUMO) D-serine deaminase,dsdA,DSD,D-serine dehydratase	Salmonella heidelberg	E. coli
	D-serine dehydratase Protein, Salmonella heidelberg, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 63.3 kDa and the accession number is B4TA53.
TMPH-02245	HADHB Protein, Human, Recombinant (GST) HADHB,TP-beta,Trifunctional enzyme subunit beta, mitochondri...	Human	E. coli
	Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex compo...
TMPY-02375	acnB Protein, E. coli, Recombinant yacI,yacJ	E. coli	E. coli
	Escherichia coli contains two major aconitases (Acns), AcnA and AcnB. They are distantly related monomeric Fe-S proteins that contain different arrangements of four structural domains. acnA is specifically subject to SoxRS-mediated activation, whereas acnB encodes the major aconitase that is synthesized earlier in the growth cycle than AcnA. It is concluded that AcnB is the major citric acid cycle enzyme. Aconitate hydratase 2 (acnB) catalyzes the isomerization of citrate to isocitrate via cis-a...

重组蛋白

FH/Fumarate Hydratase Protein, Human, Recombinant (His)

Cat.No: TMPY-02003

Species: Human

Expression System: E. coli

Fumarase Protein, Human, Recombinant

Cat.No: TMPJ-00313

Species: Human

Expression System: E. coli

ECH1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03464

Species: Human

Expression System: E. coli

ECHS1 Protein, Mouse, Recombinant (C225S, HA & His)

Cat.No: TMPH-02642

Species: Mouse

Expression System: Baculovirus Insect Cells

ECHS1 Protein, Mouse, Recombinant (HA & His)

Cat.No: TMPH-03759

Species: Mouse

Expression System: E. coli

EPHX1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01298

Species: Human

Expression System: E. coli

Carbonic Anhydrase 2 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03259

Species: Rat

Expression System: E. coli

Carbonic Anhydrase 1 Protein, Rat, Recombinant (His & SUMO)

Cat.No: TMPH-03258

Species: Rat

Expression System: E. coli

D-serine dehydratase Protein, Salmonella heidelberg, Recombinant (His & SUMO)

Cat.No: TMPH-03468

Species: Salmonella heidelberg

Expression System: E. coli

HADHB Protein, Human, Recombinant (GST)

Cat.No: TMPH-02245

Species: Human

Expression System: E. coli

acnB Protein, E. coli, Recombinant

Cat.No: TMPY-02375

Species: E. coli

Expression System: E. coli

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