hsv-2

HSV 2 (strain 333) Glycoprotein C gC Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.69 kDa and the accession number is P06475.

Herpes simplex viruses (human herpesviruses types 1 and 2) commonly cause recurrent infection affecting the skin, mouth, lips, eyes, and genitals. Herpes simplex virus type 2 (HSV-2) infection is responsible for significant neurological morbidity, perhaps more than any other virus. Herpes simplex virus type 2–associated neurological disease may result from primary infection or reactivation of latent HSV-2. Common severe infections include encephalitis, meningitis, neonatal herpes, and, in immunocompromised patients, disseminated infection.

Herpes simplex virus type 2 (HSV-2) is the predominant cause of genital ulcer disease in human. Glycoprotein E (gE) and glycoprotein I (gI) are expressed as a heterodimer on the surface of Herpes simplex virus (HSV). Glycoprotein E binds Fc domain of immunoglobulin G (IgG) and inhibits activities mediated by the IgG Fc domain, contributing to immune evasion by HSV.

HSV 2 (strain 333) Glycoprotein B gB Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 73.88 kDa and the accession number is P06763.