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Search Results for " hepcidin "

Targets Recommended: Others

14

抑制剂 & 化合物

1

天然产物

5

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T61144	Hepcidin antagonist-1	Others	Others
	Hepcidin antagonist-1 是一种铁调素拮抗剂。Hepcidin antagonist-1 可用于研究像缺铁疾病和贫血类的代谢紊乱。
T80413	Bass hepcidin
	Bass hepcidin是一种具有针对大肠埃希菌活性的抗菌肽。
T80341	Seabream hepcidin
	Seabream hepcidin是一种抗菌肽，具有针对细菌(V.anguillarum)、真菌(S.cerevisiae)以及病毒性出血性败血症病毒的活性。
T76271	Hepcidin-25 (human)
	Hepcidin-25 (human) 是调节铁代谢的化合物，具有调控铁介导的氧化损伤功能，并表现出抗炎和抗菌活性。
T80108	Hepcidin-1 (mouse)
	Hepcidin-1 (mouse) 是调控铁平衡的内源性多肽激素，通过上调TRAP、组织蛋白酶K和MMP-9的mRNA水平及增强TRAP-5b蛋白的分泌作用。此外，Hepcidin-1 (mouse) 降低FPN1蛋白水平并提升细胞内铁含量，且促进破骨细胞的分化。
T76585	Hepcidin-20 (human)
	Hepcidin-20 (human) 是一种β-折叠结构肽，含有组氨酸和丰富的半胱氨酸，具备抗真菌活性，并能抑制多糖细胞间粘附素 (PIA) 阳性及阴性菌株的生物膜形成及细菌细胞代谢[3]。
T80082	Hepcidin-25 (human) (acetate)	Endogenous Metabolite	Metabolism
	Hepcidin-25 (human) acetate 作为铁代谢调节剂，表现出抗炎和抗菌活性，其作用机制涉及调节铁介导的氧化剂损伤。
T78037	Hepcidin-1 (mouse) TFA
	Hepcidin-1 (mouse) TFA是调控铁代谢平衡的肽类激素。该化合物通过提高TRAP、组织蛋白酶K及MMP-9的mRNA水平并促进TRAP-5b蛋白的分泌，同时降低FPN1蛋白表达，导致细胞内铁含量上升。此外，Hepcidin-1 (mouse) TFA还有助于破骨细胞的分化。
T7606	Guanosine 5'-diphosphate disodium salt 5'-二磷酸鸟苷二钠,5'-GDP-Na2,鸟苷-5'-二磷酸二钠盐	Endogenous Metabolite	Metabolism
	Guanosine 5'-diphosphate disodium salt (5'-GDP-Na2) 是一种核苷二磷酸。它是一种潜在的铁动员剂，能够阻断铁调素-铁转运蛋白相互作用，也可以调节白 IL-6/stat-3 途径。
T15170	DS28120313	Others	Others
	DS28120313 is an oral inhibitor of hepcidin production (IC50: 0.093 μM).
T71861	Sulfonyl quinoxaline 1	Others	Others
	Sulfonyl quinoxaline 1 is an inhibitor of RhoG-hepcidin uptake.
T81560	Palsucibep pegol
	Palsucibep pegol为工程化人类lipocalin-2结合蛋白，与hepcidin发生结合。
T72120	Guanosine 5'-diphosphate sodium GDP sodium	Others	Others
	Guanosine 5'-diphosphate (GDP) sodium 是一种核苷二磷酸，可激活 5'-三磷酸腺苷敏感的 K+通道。Guanosine 5'-diphosphate sodium 是一种潜在的铁动员剂，可阻断铁调素-铁转运蛋白 (hepcidin-ferroportin) 相互作用并调节 IL-6/stat-3通路。Guanosine 5'-diphosphate sodium 可用于炎症研究，如炎症性贫血 (AI)。
T74840	ERRγ agonist-2	Others	Others
	ERRγagonist-2 是一种有效的选择性 ERRγ反向激动剂，Kd 值为 6.5 μM。ERRγagonist-2 抑制铁调素、纤维蛋白原和糖异生基因的表达。ERRγagonist-2 具有抗菌、抗凝血和抗糖尿病活性。

化合物

Hepcidin antagonist-1

Cat.No: T61144

Target: Others

Bass hepcidin

Cat.No: T80413

Seabream hepcidin

Cat.No: T80341

Hepcidin-25 (human)

Cat.No: T76271

Hepcidin-1 (mouse)

Cat.No: T80108

Hepcidin-20 (human)

Cat.No: T76585

Hepcidin-25 (human) (acetate)

Cat.No: T80082

Target: Endogenous Metabolite

Hepcidin-1 (mouse) TFA

Cat.No: T78037

Guanosine 5'-diphosphate disodium salt

Cat.No: T7606

Synonym: 5'-二磷酸鸟苷二钠,5'-GDP-Na2,鸟苷-5'-二磷酸二钠盐

Target: Endogenous Metabolite

Cat.No: T15170

Target: Others

Sulfonyl quinoxaline 1

Cat.No: T71861

Target: Others

Palsucibep pegol

Cat.No: T81560

Guanosine 5'-diphosphate sodium

Cat.No: T72120

Synonym: GDP sodium

Target: Others

ERRγ agonist-2

Cat.No: T74840

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T7210	Guanosine 5'-diphosphate GDP,鸟苷-5ˊ-二磷酸	Endogenous Metabolite	Metabolism
	Guanosine 5'-diphosphate (GDP) 是核苷二磷酸，是潜在的铁动员剂，能够阻断铁调素-铁转运蛋白相互作用并调节白细胞介素-6 (IL-6)/stat-3 途径。

天然产物

Guanosine 5'-diphosphate

Cat.No: T7210

Synonym: GDP,鸟苷-5ˊ-二磷酸

Target: Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02389	Hepcidin Protein, Larimichthys crocea, Recombinant hamp,Hepcidin	Larimichthys crocea	E. coli
	Hepcidin Protein, Larimichthys crocea, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 2.5 kDa and the accession number is A1Z0M0.
TMPK-01170	Hepcidin/HAMP Protein, Mouse, Recombinant (GST) Hamp1,LEAP-1,PLTR,HFE2B,LEAP1,Hepc1,Hepc	Mouse	E. coli
	Hepcidin, the main regulator of iron metabolism, is synthesized and released by hepatocytes in response to increased body iron concentration and inflammation. Deregulation of hepcidin expression is a common feature of genetic and acquired iron disorders: in Hereditary Hemochromatosis (HH) and iron-loading anemias low hepcidin causes iron overload, while in Iron Refractory Iron Deficiency Anemia (IRIDA) and anemia of inflammation (AI), high hepcidin levels induce iron-restricted erythropoiesis.
TMPH-02646	Erythroferrone Protein, Mouse, Recombinant (His) Erythroferrone,Myonectin,Erfe,Complement C1q tumor necrosis ...	Mouse	P. pastoris (Yeast)
	Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake. Erythroferrone Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted m...
TMPJ-01062	HAMP Protein, Human, Recombinant (GST) Liver-expressed antimicrobial peptide 1,HEPC,LEAP1,Putative ...	Human	E. coli
	Hepcidin（HAMP）is a secreted protein that belongs to the hepcidin family.It is expressed in liver, heart and brain. It is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta sheet structure...
TMPH-01301	Erythroferrone Protein, Human, Recombinant (His & SUMO) Myonectin,Erythroferrone,ERFE,Complement C1q tumor necrosis ...	Human	E. coli
	Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake.

重组蛋白

Hepcidin Protein, Larimichthys crocea, Recombinant

Cat.No: TMPH-02389

Species: Larimichthys crocea

Expression System: E. coli

Hepcidin/HAMP Protein, Mouse, Recombinant (GST)

Cat.No: TMPK-01170

Species: Mouse

Expression System: E. coli

Erythroferrone Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02646

Species: Mouse

Expression System: P. pastoris (Yeast)

HAMP Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01062

Species: Human

Expression System: E. coli

Erythroferrone Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01301

Species: Human

Expression System: E. coli

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