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Cat. No. | Product Name | ||
---|---|---|---|
L5510 | 肝脏毒性化合物库 | 1001 compounds | |
1001 个肝脏毒性化合物的特有集合,可用于高通量、高内涵筛选,是毒理学研究的良好工具; | |||
L8700 | 铁死亡化合物库 | 779 compounds | |
779 种与铁死亡通路相关的化合物,可用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37906 |
Dibenamine hydrochloride
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Dibenamine hydrochloride 是竞争性的、不可逆的肾上腺素能阻断剂,可以修饰肾上腺素的药理作用。它对小鼠体内肾上腺素的破坏率显著增加。 | |||
T36125 |
Tienilic Acid
|
P450 | Metabolism |
Tienilic Acid 是一种具有一定肝毒性的排尿酸利尿剂 | |||
T7747 |
Datelliptium chloride hydrochloride
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Datelliptium chloride hydrochloride 是一种衍生自玫瑰树碱的 DNA 嵌入剂,具有抗肿瘤活性。 | |||
T0840 |
Methimazole
Tapazole,Thiamazole,甲巯咪唑 |
Thyroid hormone receptor(THR) | Endocrinology/Hormones |
Methimazole (Thiamazole) 是抗甲状腺化合物,具有显著的肝毒性,常用于研究甲亢。 | |||
T13231L |
Trovafloxacin mesylate
|
Others; DNA/RNA Synthesis; Topoisomerase; Antibacterial | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others |
Trovafloxacin是一种广谱氟喹诺酮类抗生素,可阻断 DNA 促旋酶 (DNA gyrase) 和拓扑异构酶 IV (topoisomerase IV) 的活性,也是一种有效的特异性 pannexin 1 通道抑制剂 (PANX1, IC50 = 4 μM)。 | |||
T21439 |
Tacrine
他克林,CS 12602,Tacrinum,Tetrahydroaminocrine |
AChR | Neuroscience |
Tacrine (CS 12602) 一种间接胆碱能激动剂和中枢作用的抗胆碱酯酶。它被批准用于治疗阿尔茨海默病。 | |||
T8845 |
UTL-5g
3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-,GBL-5g |
TNF | Apoptosis |
UTL-5g (3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-) 是一种抗炎性TNF-α抑制剂,可通过抑制 TNF-α 等因子降低顺铂引起的肝毒性、肾毒性和骨髓毒性,具有化学保护和肝脏放射保护作用。 | |||
T1090 |
Perphenazine
Perphenazin,Etaperazine,Trilafon,奋乃静 |
CaMK; Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Perphenazine (Trilafon) 是吩噻嗪衍生物和多巴胺拮抗剂,具有止吐和抗精神病特性。它能够抑制5-HT2A 受体,α1A 肾上腺素能受体,多巴胺D2、D3、D2L 受体,以及组胺H1受体,对应的Ki 值分别为5.6、10、0.765、0.13、3.4 和 8 nM。 | |||
T13231 |
Trovafloxacin
|
DNA gyrase; Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Trovafloxacin 是广谱喹诺酮类抗生素,对革兰氏阳性,革兰氏阴性和厌氧菌有活性。它可阻断 DNA 促旋酶 和拓扑异构酶 IV 的活性。它也是口服活性的 Pannexin 1通道选择性抑制剂,对 PANX1内向电流的 IC50为 4 μM。 | |||
T67509 |
Cholesteryl Hemisuccinate
Cholesterol hydrogen succinate |
Apoptosis; DNA/RNA Synthesis; Topoisomerase | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) 是一种经常使用在极性溶液中具有高溶解度的胆固醇类似物 ,具有保肝、抗癌和抑制肿瘤生长的作用。Cholesteryl Hemisuccinate 抑制对乙酰氨基酚 的肝毒性,并防止 AAP 诱导的肝细胞凋亡 和坏死 。Cholesteryl Hemisuccinate 抑制 DNA 聚合酶 和 DNA 拓扑异构酶 ,从而抑制 DNA 复制和修复以及细胞分裂。 | |||
TF0106 |
Cholesteryl Hemisuccinate Tris Salt
|
Apoptosis | Apoptosis |
Cholesteryl Hemisuccinate Tris Salt 是一种具有保肝和抗癌活性的酸性胆固醇酯,是一种含有柴胡皂苷-d的二棕榈酰磷脂酰胆碱脂质体中的膜稳定剂,可增强顺铂的抗癌功效。Cholesteryl hemisuccinate 具有抗肿瘤活性,抑制肿瘤生长,抑制对乙酰氨基酚 (AAP) 的肝毒性,预防 AAP 诱导的肝细胞凋亡。Cholesteryl hemisuccinate 可保护啮齿动物免受对乙酰氨基酚、阿霉素、四氯化碳、氯仿和半乳糖胺的毒性作用。 | |||
T31043 |
CP-199330
UNII-V4WYK6T8QA,CP 199330,UNII-74573Q728X,CP-199330 sodium |
Others | Others |
CP-199330 is a cysteyl LT1 receptor antagonist with no hepatotoxicity and is equivalent to the commercially available CYSLT1 receptor antagonists Zafirlukast and Pranlukas. | |||
T33707 |
N-Nitrosofenfluramine, (S)-
J1.936.463A |
Others | Others |
N-Nitrosofenfluramine is a compound that is thought to cause hepatotoxicity in subjects. | |||
T69613 |
Ar-H047108 free base
|
Others | Others |
Ar-H047108 free base is an imidazopyridine potassium competitive acid blocker (P-CAB). This drug may be used to treat early stellate cell activation and veno-occlusive-disease (VOD)-like hepatotoxicity. | |||
T71358 |
Nialamide monohydrochloride
|
Others | Others |
Nialamide monohydrochloride is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was used as an antidepressant. It was withdrawn by Pfizer several decades ago due to the risk of hepatotoxicity. | |||
T36837 |
(E,Z)-2-propyl-2-Pentenoic Acid
|
Others | Others |
(E,Z)-2-propyl-2-Pentenoic acid is a bioactive metabolite of valproic acid that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity and hepatotoxicity. | |||
T62057 |
Anticancer agent 12
|
Others | Others |
Anticancer agent 12 具有恶性细胞的细胞毒性,且没有肝毒性。 | |||
T83050 |
Anti-inflammatory agent 62
|
Others | Others |
Anti-inflammatory agent 62 减轻乙酰氨基酚诱导的HepG2肝毒性,其机制是通过调节炎症和氧化应激途径。 | |||
T60771 |
Metamizol
|
Others | Others |
Metamizol (Methamizole) 阻止甲状腺产生甲状腺激素,是一种抗甲状腺药物。然而,Metamizol 具有肝毒性的副作用。 | |||
T38312 |
L-Cysteine-glutathione disulfide
|
Others | Others |
L-Cysteine-glutathione disulfide, a glutathione derivative endogenous to mammalian cells, is comprised of the oxidized form of free glutathione tripeptide linked via a disulfide bond to L-cysteine. It has been shown to protect mice against acetaminophen-induced hepatotoxicity. | |||
T37463 |
CAY10704
|
Others | Others |
CAY10704 is a potent inhibitor of hepatitis C virus (HCV) infection (EC50 = 17 nM) that displays low cytotoxicity of virally-infected human hepatoma Huh7.5.1 cells (CC50 = 21.3 μM). It displays good pharmacokinetics in mice when delivered intraperitoneally, with preferential liver distribution without significant hepatotoxicity. CAY10704 is selective for HCV over dengue virus (EC50 = 4.62 μM). | |||
T38206 |
3-Cysteinylacetaminophen (trifluoroacetate salt)
APAP-Cys,3-(cysteine-S-yl)acetaminophen,3-Cysteinylacetaminophen (trifluoroacetate salt) |
Others | Others |
3-Cysteinylacetaminophen is an acetaminophen-protein adduct formed during the metabolism of acetaminophen.[1],[2] 3-Cysteinylacetaminophen has been found in isolated human serum following therapeutic and supratherapeutic doses of acetaminophen and in the presence and absence of hepatotoxicity.[3],[4] In mice, 3-cysteinylacetaminophen decreases renal glutathione (GSH) levels, an effect that can be blocked by the γ-glutamyl inhibitor acivicin. | |||
T73245 |
AChE-IN-9
|
Others | Others |
AChE-IN-9 是一种Tacrine 连接乙酰化 β-葡萄糖的糖缀合物。AChE-IN-9 也是一种AChE 抑制剂,IC50为 0.4 μM,对健康细胞的肝毒性低。Tacrine 可用于阿兹海默症的研究。 | |||
T73255 |
Akt1-IN-1
|
Others | Others |
Akt1-IN-1 是一种有效的 Akt1抑制剂,对 MIA Paca-2 细胞的 IC50为 18.79 nM。Akt1-IN-1 不具有明显的致畸性、肝毒性和心脏毒性 (有害作用剂量大于 100 µM)。Akt1-IN-1 可用于抗癌研究。 | |||
T79454 |
Anti-NASH agent 1
|
PPAR | DNA Damage/DNA Repair; Metabolism |
Anti-NASH agent 1 (compound 3d),Elafibranor衍生物,高效PPAR-α/δ激动剂,针对非酒精性脂肪性肝炎(NASH)。以3-10 mg/kg剂量,连续4周处理,能显著改善蛋氨酸胆碱缺乏(MCD)诱导的NASH小鼠高脂血症、肝脏脂肪变性及炎症状况,展现出低肝毒性和良好肝脏保护效能。 | |||
T74717 |
12-Hydroxynevirapine
|
Others | Others |
12-Hydroxyvirapine (12-hydroxy-NVP; 12-OH-NVP) 是奈韦拉平 的主要氧化代谢产物。奈韦拉平是一种非核苷类逆转录酶抑制剂,适用于 HIV-1感染,会引起特异性肝毒性和轻度至重度皮疹。12-Hydroxynevirapine 是一种非反应性代谢物,可被肝脏和皮肤中的磺基转移酶 (SULT) 生物激活,产生活性物质 12-Sulphoxy-nevirapine。 | |||
T62822 |
CT1-3
|
Others | Others |
CT1-3 是一种有效的抗癌剂。CT1-3 能够调控 JNK/Bcl-2/Bax/XIAP 通路,进而诱导线粒体介导的细胞凋亡 (apoptosis)。CT1-3 可以调控 E-cadherin/Snail 轴抑制人癌细胞 (HCCs) 的上皮间充质转化 (EMT) 电位,并抑制肿瘤发生。CT1-3 在小鼠模型中具有抗肿瘤作用,且没有表现出明显的肝、肾毒性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3913 |
Saikosaponin D
|
Estrogen Receptor/ERR; NF-κB; Antibacterial; STAT | Endocrinology/Hormones; JAK/STAT signaling; Microbiology/Virology; NF-κB; Stem Cells |
Saikosaponin D 是一种从柴胡中分离到的三萜皂苷类天然产物,具有抗炎,抗菌,抗肿瘤,抗过敏作用。它抑制 selectin,STAT3和 NF-kB 的活性,活化estrogen receptor-β。 | |||
T4S0790 |
Diosbulbin B
山药 |
Others | Others |
Diosbulbin B 是一种二萜内酯,从D. bulbifera L.中分离得到,具有抗肿瘤活性,但可引起肝损伤 。 | |||
T6S0234 |
Toosendanin
|
Others | Others |
Toosendanin 是一种从杜鹃花果实皮中提取的三萜,具有杀虫和抗炎活性,可用于研究缓解疼痛。 | |||
T7036 |
2,4'-Dihydroxybenzophenone
|
Antioxidant | oxidation-reduction |
2,4'-Dihydroxybenzophenone 可有效保护 C57BL/6J 小鼠免受 APAP 诱导的肝毒性。它对可卡因诱导的小鼠急性肝毒性和神经毒性具有保护作用。其机制可能与其抗氧化活性有关。 | |||
T5S0285 |
Cistanoside A
肉苁蓉苷 A,肉苁蓉苷A |
Others | Others |
Cistanoside A 是一种肉苁蓉中的苯丙素类化合物,能够抑制 NO 的聚集,但不影响诱导型一氧化氮合酶 iNOS 的 mRNA 和蛋白水平及其活性。它具有抗炎作用。 | |||
T3999 |
D(+)-Galactosamine hydrochloride
D-半乳糖胺盐酸盐,D-氨基半乳糖盐酸盐,D-Galactosamine HCl |
Others | Others |
D(+)-Galactosamine hydrochloride (D-Galactosamine HCl) 是一种被证实的实验毒素,它能够产生自由基及UTP 核苷酸的消耗导致肝损伤,中毒剂量会造成肾功能不全,而肾功能衰竭通常和终末期肝损伤有关。脂多糖/D-Galactosamine 诱导的急性肝损伤是一种已知的暴发性肝衰竭动物模型。 | |||
T6S2246 |
Alisol B 23-acetate
Alisol B Acetate,Alisol B monoacetate,23-O-Acetylalisol B,23-Acetylalismol B,泽泻醇B乙酸酯 |
Others | Others |
Alisol B 23-acetate (Alisol B Acetate) 是三萜类化合物,能够激活法尼醇受体,诱导受损的肝脏再生。 | |||
TWS1977 |
Kamebakaurin
尾叶香茶菜丙素,Kamebakaurine |
NF-κB | NF-κB |
Kamebakaurin (Kamebakaurine) 是一种提取自Isodon japonicus 中的天然产物,是一种NF-κB 的抑制剂,能够抑制 p50 的 DNA 结合活性。 | |||
T4S2326 |
Cornuside
7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside |
ERK; p38 MAPK; NF-κB; JNK | MAPK; NF-κB |
Cornuside (Comuside) 是从山茱萸的果实中分离出的环烯醚萜苷,可用于炎症疾病的研究和促进血液循环。 它通过下调 MAPK 和 NF-κB 信号通路抑制肥大细胞介导的过敏反应,用于炎性过敏性疾病中的潜能。 | |||
TN3871 |
Diosbulbin C
山药 |
Others | Others |
Diosbulbin C has hepatotoxicity. | |||
T20635 |
Senkirkin
Renardin |
||
Senkirkin is a pyrrolizidine alkaloid with hepatotoxicity. | |||
TN1670 |
Ganodermanondiol
灵芝酮二醇 |
HIV Protease; Nrf2; AMPK | Chromatin/Epigenetic; Immunology/Inflammation; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK. | |||
TN4513 |
Meliasenin B
|
Others | Others |
Meliasenin B may cause hepatotoxicity, it displays dose-dependent toxicity on HepG2 cells. | |||
TN1588 |
Dihydroisotanshinone I
二氢异丹参酮I,二氢丹参酮 |
ATPase; Potassium Channel; Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Dihydroisotanshinone I has protective action against menadione-induced hepatotoxicity, attributed to its antioxidant properties including the free radical scavenging activity and inhibition of lipid peroxidation. | |||
T81795 |
Microcystin-WR
|
||
Microcystin-WR为蓝藻代谢产物中的一种微囊藻毒素,对小鼠表现出肝脏毒性。 | |||
TN5336 |
9-Oxo-10,11-dehydroageraphorone
4,7(11)-Cadinadiene-3,8-dione,DTD,7,11-Dehydro-8-oxoageraphorone,泽兰二酮 |
||
9-Oxo-10,11-dehydroageraphorone has acaricidal activity. It induces hepatotoxicity and cholestasis in rats. 9-Oxo-10,11-dehydroageraphorone also effectively inhibits the proliferation of HeLa cells by arresting the cell cycle transition from S to G2/M pha | |||
TN5278 |
Zederone
|
NADPH-oxidase; P450; TNF; Nrf2; Antifection | Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology |
Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads to the formation of biological reactive metabolites and that cause the oxidative stress and liver cell injuries. | |||
TN1478 |
Celosin I
|
Others | Others |
Celosin H, celosin I, and celosin J could be used as chemical markers for the quality control of C. argentea seeds. Celosin I exhibited significant hepatoprotective effect on carbon tetrachloride-induced and N,N-dimethylformamide-induced hepatotoxicity in | |||
TN3412 |
Andrographiside
|
Others | Others |
Andrographiside shows protective effects on hepatotoxicity induced in mice by carbon tetrachloride or tert-butylhydroperoxide (tBHP) intoxication, the effects could be due to its glucoside groups which may act as strong antioxidants. | |||
T82748 |
Celosin L
|
||
Celosin L,一种三萜皂苷,具备保肝活性。该化合物能够保护HepG2 细胞免受 APAP 诱导的肝毒性伤害。 | |||
T82310 |
Glomeratide A
|
||
Glomeratide A为C-葡萄糖苷类二苯甲酮,显示出对肝脏的保护效果。研究表明,该化合物能够抵御d-半乳糖胺在大鼠肝上皮干细胞样细胞引起的肝毒性。 | |||
T82219 |
Heilaohuguosu F
|
||
Heilaohuguosu F (compound 6)为一类四氢呋喃木脂素,表现出轻度肝脏保护效果。该化合物对于APAP诱导的HepG2细胞所呈现的肝毒性具有微弱的防护作用。 | |||
TN4223 |
Homopterocarpin
|
Antifection | Microbiology/Virology |
Homopterocarpin and Pterocarpus extract offer gastroprotection against indomethacin- induced ulcer by antioxidative mechanism and the modulation of gastric homeostasis, homopterocarpin may be responsible for, or contribute to the antiulcerogenic property | |||
T37770 |
Taurohyodeoxycholic acid
|
Others | Others |
Taurohyodeoxycholic acid (THDCA) is a taurine-conjugated form of the secondary bile acid hyodeoxycholic acid .1THDCA decreases the size and weight of human gallstonesin vitro. It increases bile flow, biliary cholesterol secretion, and biliary lipid secretion in rats.2Co-administration of THDCA with taurochenodeoxycholic acid prevents TCDCA-induced hepatotoxicity, increasing bile flow as well as biliary acid and phospholipid secretion in rats.3THDCA also reduces myeloperoxidase activity, expressi... |