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Search Results for " heart tissue "

Targets Recommended: Others

10

抑制剂 & 化合物

2

天然产物

2

化合物库

19

重组蛋白

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Cat. No.	Product Name
L1120	AMPK靶向分子库		80 compounds
	80 个靶向AMPK 的分子集合，可用于高通量和高内涵筛选；
L8500	HIF-1化合物库		1336 compounds
	1336 个HIF-1相关小分子的独特集合，可用于缺血性疾病、癌症等相关领域的药物开发和药理研究；

化合物库

AMPK靶向分子库

Cat.No: L1120

Compounds: 80

HIF-1化合物库

Cat.No: L8500

Compounds: 1336

Cat. No.	Product Name	Target	Signaling Pathways
T22341	GSK-114	Others	Others
	GSK 114 是口服有活性的、高选择性的TNNI3K 抑制剂 (IC50= 25 nM)。其中TNNI3K (又称 CARK) 是酪氨酸样激酶家族的成员，选择性在心脏组织中表达。它对 TNNI3K 的选择性是 B-Raf 激酶的 40 倍 (IC50= 1 µM)。
T71421	Bemoradan	Others	Others
	Bemoradan is an inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue
T33006	LY-104119 LY 104119,LY104119	Others	Others
	LY-104119 is a thermogenic weight loss compound that rapidly reduces noradrenaline concentrations in brown adipose tissue between the scapulas, the heart, and the liver.
T71927	Adenosine-5'-diphosphate disodium salt	Others	Others
	Adenosine 5'-diphosphate disodium salt has been shown to inhibit the binding of serotonin (5-hydroxytryptamine) to 5-HT2 receptors, which are present in heart tissue.
T78377	CTP
	CTP为一种具心脏靶向性的肽。它在体外能够转导心肌细胞，并能有效特异性地转导小鼠心脏组织。CTP可专门用于将治疗性肽、蛋白质及核酸传递至心脏。
T73610	Lipoprotein lipase	Others	Others
	Lipoprotein lipase 是来自于脂肪组织、心肌和骨骼肌、胰岛和巨噬细胞的多功能酶。Lipoprotein lipase 促进正常脂蛋白代谢、组织特异性底物的输送和利用。Lipoprotein lipase 催化脂质在血液循环的限速步骤。
TP2221	ANP (1-11), rat	Others	Others
	Atrial Natriuretic Peptide (ANP) has the sequence of H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-OH, is a 28 amino acid peptide. ANP is a powerful vasodilator, and a protein (polypeptide) hormone secreted by heart muscle cells. It is involved in the hom
T36454	1-Stearoyl-rac-glycerol Glyceryl monostearate,Monostearin
	1-Stearoyl-rac-glycerol 是一种在 sn-1 位含有硬脂酸的单酰甘油。在偶氮甲烷诱发的小鼠结肠直肠癌模型中，肿瘤组织中的 1-Stearoyl-rac-glycerol水平降低。1-Stearoyl-rac-glycerol 已被用于大鼠透皮递送阿霉素的传递体的组成，导致阿霉素在淋巴结、脾脏和心脏中积聚。
T35772	Emestrin	Others	Others
	Emestrin is a mycotoxin originally isolated from E. striata that has antimicrobial, immunomodulatory, and cytotoxic activities.1,2,3,4,5 It is active against the fungi C. albicans and C. neoformans, as well as the bacteria E. coli, S. aureus, and methicillin-resistant S. aureus (MRSA; IC50s = 3.94, 0.6, 2.21, 4.55, and 2.21 μg/ml, respectively).2 Emestrin is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50 = 5.4 μM in a radioligand binding assay using isolated human monocytes).3 Emestr...
T35604	Osteocalcin (1-49) (human) (trifluoroacetate salt)
	Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone. Secretion of osteocalcin (1-49) is stimulated by 1,25-dihydroxy vitamin D and plasma levels increase in diseases that induce dysregulated bone turnover such as osteoporosis, Paget's disease, and primary hyperparathyroidism. Osteocalcin (1-49) is positively correlated with insulin sensitivity and negatively correlated with high blood glucose levels in w...

化合物

Cat.No: T22341

Target: Others

Cat.No: T71421

Target: Others

Cat.No: T33006

Synonym: LY 104119,LY104119

Target: Others

Adenosine-5'-diphosphate disodium salt

Cat.No: T71927

Target: Others

Cat.No: T78377

Lipoprotein lipase

Cat.No: T73610

Target: Others

ANP (1-11), rat

Cat.No: TP2221

Target: Others

1-Stearoyl-rac-glycerol

Cat.No: T36454

Synonym: Glyceryl monostearate,Monostearin

Cat.No: T35772

Target: Others

Osteocalcin (1-49) (human) (trifluoroacetate salt)

Cat.No: T35604

Cat. No.	Product Name	Target	Signaling Pathways
T4883	Creatine Methylguanidoacetic acid,肌酸	Endogenous Metabolite	Metabolism
	Creatine (Methylguanidoacetic acid) 是一种内源性氨基酸代谢物，在细胞能量中发挥重要作用，尤其是在肌肉和大脑中。
T20123	L-Carnitine hydrochloride L-Carnitine chloride,LC 80,Levocarnitine chloride,(R)-Carnitine hydrochloride,LC-80,LC80	Others	Others
	Carnitine is a quaternary amine that occurs naturally in most mammalian tissue. Carnitine is present in relatively high concentrations in skeletal muscle and heart where it is involved in regulating energy metabolism. It has also been used to allow the en

天然产物

Cat.No: T4883

Synonym: Methylguanidoacetic acid,肌酸

Target: Endogenous Metabolite

L-Carnitine hydrochloride

Cat.No: T20123

Synonym: L-Carnitine chloride,LC 80,Levocarnitine chloride,(R)-Carnitine hydrochloride,LC-80,LC80

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00117	FGF-16 Protein, Human, Cynomolgus, Recombinant fibroblast growth factor 16	Human,Cynomolgus	Baculovirus Insect Cells
	Fibroblast growth factor 16 (FGF16) is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the MEF2 site resulted in a blunting of FGF16 promoter activity in transfected neonatal rat cardiac myocytes, that chromatin remodeling and MEF2 binding in the FGF16 promoter contribute to expression in the postnatal heart. FGF16 involvement in the fine tuning of the human skeleton of ...
TMPJ-01011	FGF-9 Protein, Mouse, Recombinant (His) heparin-binding growth factor-9,GAF,HBGF-9,Glia-activating f...	Mouse	E. coli
	Fibroblast growth factor-9 (FGF-9) is an approximately 26 kDa secreted glycoprotein of the FGF family. Secreted mouse FGF-9 lacks the N-terminal 1-3 aa and shares >98% sequence identity with rat, human, equine, porcine and bovine FGF-9. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In the mouse embryo the location and timing of FGF-9 expression affects development of the skeleton, cerebellum, lungs, heart, v...
TMPK-01090	Transthyretin/Prealbumin Protein, Cynomolgus, Recombinant (His) Prealbumin,TBPA,CTS,HEL111,Transthyretin,TTR,ATTR,CTS1,HsT26...	Cynomolgus	HEK293 Cells
	Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other functions have emerged, namely in the nervous system. TTR aggregates are responsible for many amyloidosis such as familial amyloidotic polyneuropathy and cardiomyopathy. Normal TTR can also aggregate and deposit in the heart of old people and in preeclampsia placental tissue.
TMPJ-01163	CTGF/CCN2 Protein, Human, Recombinant (HEK293, His) CTGF,Connective tissue growth factor	Human	HEK293 Cells
	Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CYR61/CTGF/NOV) family of secreted matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF has various biological functions, including cell adhesion, migration, proliferation, differentiation, and ECM production, and participates in the development of many organs under normal physio...
TMPY-02965	MMP-19 Protein, Human, Recombinant MMP18,matrix metallopeptidase 19,RASI-1	Human	E. coli
	MMP19, also known as RASI-1, is a member of the peptidase M1A family. It contains 4 hemopexin-like domains and is expressed in the mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart, and blood vessel walls. It is a matrix metalloproteinase (MMP). Proteins of the MMP family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well a...
TMPJ-00650	FIBP Protein, Human, Recombinant FIBP,aFGF Intracellular-Binding Protein,FGF-1 Intracellular-...	Human	E. coli
	Acidic Fibroblast Growth Factor Intracellular-Binding Protein (FIBP) is highly expressed in the heart, skeletal muscle, and pancreas. Acidic Fibroblast Growth Factor is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FIBP is an intracellular protein that binds ...
TMPK-00693	HSP27/HSPB1 Protein, Human, Recombinant (His) Hsp27,SRP27,HMN2B,HSP 27,HSPB1,CMT2F,HSP28	Human	E. coli
	Heat shock protein beta-1 (HSPB1, also known as HSP27) is a small heat shock protein involved in many cellular processes and reportedly protects cells against oxidative stress. This protein is expressed only in insulin-dependent tissues (heart, skeletal muscle, and fat tissue), and expression of HspB7 is regulated by many different factors. HspB7 has an unusual N-terminal sequence, a conservative α-crystallin domain, and very short C-terminal domain lacking conservative IPV tripeptide involved i...
TMPY-01771	Latexin Protein, Mouse, Recombinant (His) latexin	Mouse	E. coli
	Latexin, also known as endogenous carboxypeptidase inhibitor, tissue carboxypeptidase inhibitor, TCI, ECI, and LXN, is a cytoplasm protein that belongs to the protease inhibitor I47 (latexin) family. It is highly expressed in the heart, prostate, ovary, kidney, pancreas, and colon. Latexin / LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional spe...
TMPY-01099	GPT Protein, Rat, Recombinant (His) Gpt1,ALAT,glutamic-pyruvate transaminase (alanine aminotrans...	Rat	Baculovirus Insect Cells
	Alanine aminotransferase (ALT), also known as glutamate pyruvate transaminase (GPT), is a pyridoxal enzyme that belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family, Alanine aminotransferase subfamily. Gpt / Gpt1 / ALT catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate and plays a key role in the intermediary metabolism of glucose and amino acids. Gpt / Gpt1 / ALT is expressed in the liver, kidney, heart, and skeletal musc...
TMPJ-00014	Resistin Protein, Human, Recombinant (His) Resistin,C/EBP-epsilon-regulated myeloid-specific secreted c...	Human	E. coli
	Resistin known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. The length of the resistin pre-peptide in human is 108 amino acid residues and in the mouse and rat it is 114 aa; the molecular weight is ~12.5 kDa. Resistin is a cytokine whose physiologic role has been the subject of much controversy regarding its involvement wit...
TMPY-02133	Carbonic Anhydrase VB Protein, Human, Recombinant (His) carbonic anhydrase VB, mitochondrial,CA-VB,MGC39962	Human	E. coli
	Carbonic anhydrase 5B, also known as carbonate dehydratase VB, carbonic anhydrase VB, CA-VB and CA5B, is amember of the alpha-carbonic anhydrase family. The strongest expression of CA5B / CA-VB is in heart, pancreas, kidney, placenta, lung, and skeletal muscle. It is not expressed in liver. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological process...
TMPJ-01237	IL-17D Protein, Human, Recombinant IL17D,Interleukin-17D,IL-17D	Human	E. coli
	The Interleukin-17 family proteins, comprising six members (IL-17, IL-17B through IL-17F),are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. IL-17 family proteins are proinflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Among IL-17 family members, IL-17D is most closely related to IL-17B, sharing 27% aa sequence ho...
TMPY-02977	PDE1C Protein, Human, Recombinant (His & GST) hCam-3,phosphodiesterase 1C, calmodulin-dependent 70kDa,cam-...	Human	Baculovirus Insect Cells
	PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDEs are expressed ubiquitously, with each subtype having a s...
TMPY-01100	GPT2 Protein, Rat, Recombinant (His) glutamic pyruvate transaminase (alanine aminotransferase) 2	Rat	Baculovirus Insect Cells
	Alanine aminotransferase (ALT), also known as glutamate pyruvate transaminase (Gpt), is a pyridoxal enzyme that catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate and plays a key role in the intermediary metabolism of glucose and amino acids. As a key enzyme for gluconeogenesis, Gpt is a widely-used serum marker for liver injury. Two ALT isoenzymes have been identified, ALT1 and ALT2 (GPT1 and GPT2), which are encoded by separate genes and share ...
TMPY-01204	SMYD2 Protein, Human, Recombinant (His) ZMYND14,SET and MYND domain containing 2,HSKM-B,KMT3C	Human	Baculovirus Insect Cells
	SET and MYND domain-containing protein 2, also known as HSKM-B, SMYD2, and KMT3C, is a member of the SMYD protein family. It contains one MYND-type zinc finger and one SET domain. Not much is known about SMYD2. However, the interest in better understanding the roles of SMYD2 has grown because of reports indicating that SMYD2 methylates p53 and histone H3. In Xenopus, SMYD1 and SMYD2 were expressed in various muscle tissues and related to muscle cell differentiation. SMYD2 mRNA is most highly exp...
TMPY-04380	DYRK3 Protein, Human, Recombinant (His & GST) REDK,RED,DYRK5,dual-specificity tyrosine-(Y)-phosphorylation...	Human	Baculovirus Insect Cells
	Dual specificity tyrosine-phosphorylation-regulated kinase 3, also known as Regulatory erythroid kinase, REDK and DYRK3, is a nucleus protein which belongs to theprotein kinase superfamily, CMGC Ser/Thr protein kinase family and MNB/DYRK subfamily. DYRKs are an emerging family of dual-specificity kinases that play key roles in cell proliferation, survival, and development. DYRK3 contains oneprotein kinase domain. Isoform 1 and isoform 2 of DYRK3 are highly expressed in testis and in hemat...
TMPY-01933	CHI3L2 Protein, Human, Recombinant (His) YKL-39,CHIL2,chitinase 3 like 2,YKL39	Human	HEK293 Cells
	Chondrocyte protein 39 (YKL-39), also known as Chitinase 3-like 2 (CHI3L2), is a secretory protein of articular chondrocytes belonging to the glycosyl hydrolase 18 family. Its highest expression is in chondrocytes, followed by synoviocytes, lung and heart. YKL-39/CHI3L2 is not detected in spleen, pancreas, and liver. YKL-39/CHI3L2 may also be expressed in developing brain and placenta. YKL-39/CHI3L2, a cartilage-related protein, is found to induce arthritis accompanied by pathologic changes in b...
TMPY-04813	ACAT2 Protein, Rat, Recombinant (His) acetyl-CoA acetyltransferase 2	Rat	E. coli
	Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and ACAT2) have been identified. Together, these two enzymes are involved in storing cholesteryl esters as lipid droplets, in macrophage foam-cell formation, in absorbing dietary cholesterol, and in supplying cholesteryl esters as part of the core lipid for lipoprotein synthesis and assembly. The key difference in tissue distributio...
TMPH-03741	BoNT/F Protein, Clostridium botulinum, Recombinant (His) Bontoxilysin-F,BoNT/F,botF,Botulinum neurotoxin type F	Clostridium botulinum	E. coli
	Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Precursor of botulinum neurotoxin F which may have 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins found in synaptic vesicles. Receptor proteins are exposed on host presynaptic cell ...

重组蛋白

FGF-16 Protein, Human, Cynomolgus, Recombinant

Cat.No: TMPY-00117

Species: Human,Cynomolgus

Expression System: Baculovirus Insect Cells

FGF-9 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01011

Species: Mouse

Expression System: E. coli

Transthyretin/Prealbumin Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01090

Species: Cynomolgus

Expression System: HEK293 Cells

CTGF/CCN2 Protein, Human, Recombinant (HEK293, His)

Cat.No: TMPJ-01163

Species: Human

Expression System: HEK293 Cells

MMP-19 Protein, Human, Recombinant

Cat.No: TMPY-02965

Species: Human

Expression System: E. coli

FIBP Protein, Human, Recombinant

Cat.No: TMPJ-00650

Species: Human

Expression System: E. coli

HSP27/HSPB1 Protein, Human, Recombinant (His)

Cat.No: TMPK-00693

Species: Human

Expression System: E. coli

Latexin Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01771

Species: Mouse

Expression System: E. coli

GPT Protein, Rat, Recombinant (His)

Cat.No: TMPY-01099

Species: Rat

Expression System: Baculovirus Insect Cells

Resistin Protein, Human, Recombinant (His)

Cat.No: TMPJ-00014

Species: Human

Expression System: E. coli

Carbonic Anhydrase VB Protein, Human, Recombinant (His)

Cat.No: TMPY-02133

Species: Human

Expression System: E. coli

IL-17D Protein, Human, Recombinant

Cat.No: TMPJ-01237

Species: Human

Expression System: E. coli

PDE1C Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02977

Species: Human

Expression System: Baculovirus Insect Cells

GPT2 Protein, Rat, Recombinant (His)

Cat.No: TMPY-01100

Species: Rat

Expression System: Baculovirus Insect Cells

SMYD2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01204

Species: Human

Expression System: Baculovirus Insect Cells

DYRK3 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04380

Species: Human

Expression System: Baculovirus Insect Cells

CHI3L2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01933

Species: Human

Expression System: HEK293 Cells

ACAT2 Protein, Rat, Recombinant (His)

Cat.No: TMPY-04813

Species: Rat

Expression System: E. coli

BoNT/F Protein, Clostridium botulinum, Recombinant (His)

Cat.No: TMPH-03741

Species: Clostridium botulinum

Expression System: E. coli

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