guanylin

Guanylin (mouse, rat) 是一种由15个氨基酸组成的多肽，并作为肠道鸟苷酸环化酶的激活剂。它可用于腹泻研究。

Guanylin (human) TFA is a 15-amino acid peptide that serves as an endogenous activator of intestinal guanylate cyclase. This compound is primarily located in the gastrointestinal tract, where it regulates electrolyte and water transport in the intestinal and renal epithelia through a mechanism dependent on cyclic GMP. [1][2]

Endogenous peptide activator of intestinal guanylyl cyclase; secreted mainly by the gastrointestinal mucosa. Regulates water and electrolyte transport in intestinal and renal epithelia.

Uroguanylin-15 (Rat) 是一种具备调节肾脏钠排泄功能的生物活性肽，尤其在摄入过量氯化钠时发挥作用。它与尿鸟苷蛋白及鸟苷蛋白相关，这两种肽能够激活肠道及肾脏中的鸟苷酸环化酶信号传导分子。尽管从尿液和十二指肠可分离出尿鸟苷素，大鼠结肠的提取物中却未观察到其存在。

Uroguanylin (human) 作为一种在转移性结直肠癌肿瘤中表达的观音酰环化酶(GCC)受体的天然配体，Guanylyl Cyclase 在人类结肠癌动物模型中展现出抗肿瘤活性。