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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8528 |
AC1903
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
AC1903是一种选择性的TRPC5抑制剂,具有足细胞保护特性,对 TRPC4 或 TRPC6没有影响,并且在激酶谱分析中没有显示出脱靶效应。在局灶节段性肾小球硬化大鼠模型中,AC1903抑制严重蛋白尿,并且防止足细胞丢失。 | |||
T16708 |
R-268712
|
ALK; TGF-beta/Smad | Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors |
R-268712 是选择性的 ALK5 抑制剂(IC50:2.5 nM)。 | |||
T30087 |
Antroquinonol
|
Reactive Oxygen Species; Nrf2 | Immunology/Inflammation; Metabolism; NF-κB |
Antroquinonol 是一种来源于 Antrodia camphorata 的泛醌衍生物,具有抗炎和抗癌活性。Antroquinonol 通过增强 Nrf2 信号通路降低氧化应激,抑制局灶节段性肾小球硬化小鼠的炎症和硬化。Antroquinonol 具有治疗非小细胞肺癌的潜力,可用于结肠癌的研究。 | |||
T40109 |
APOL1-IN-1
APOL1-IN-1 |
Others | Others |
APOL1-IN-1是一种有效的载脂蛋白 L1(APOL1) 的抑制剂,可用于研究局灶节段性肾小球硬化 (FSGS) 和非糖尿病肾病 (NDKD) 的发病原理,促进对此类疾病的研究。 | |||
T76681 |
Fresolimumab
GC1008 |
TGF-beta/Smad | Stem Cells |
Fresolimumab (GC1008) 是一种具有特异性的人抗转化生长因子 β单克隆抗体,可与人 TGFβ1、TGFβ2 和 TGFβ3 的活性形式结合,可用于研究成人局灶节段性肾小球硬化和癌症。 | |||
T13604 |
CDDO-dhTFEA
|
Others; NF-κB; Nrf2 | Immunology/Inflammation; NF-κB; Others |
CDDO-dhTFEA 是合成的齐墩果烷三萜化合物,可有效激活Nrf2并抑制促炎转录因子NF-κB。 它可以恢复高血压 (MAP),提高 Nrf2 及其靶基因的表达,抑制 NF-κB 的活化和转化生长因子-β 途径,并减少慢性肾病 (CKD) 大鼠的肾小球硬化,间质纤维化和炎症。 | |||
T71450 |
Ilacirnon sodium
|
Others | Others |
Ilacirnon sodium is a potent CCR2 antagonist that may be useful in the treatment of renal diseases including Focal Segmental Glomerulosclerosis and Diabetic Nephropathy. | |||
T63248 |
NTU281
|
Others | Others |
NTU281 是转谷氨酰胺酶-2 (transglutaminase-2) 的有效抑制剂,能够减少糖尿病大鼠血清肌酐和蛋白尿的升高,并降低肾小球 I 型胶原积累、Hic-5 和α-SMA 表达,以及减少细胞凋亡 (apoptosis),能够用于糖尿病引起的肾小球硬化的研究。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02956 |
Apolipoprotein L/APOL1 Protein, Human, Recombinant (His)
APOL1,apolipoprotein L1,APOL,FSGS4,APOL-I,APO-L |
Human | Baculovirus Insect Cells |
APOL1, also known as apolipoprotein L1, is a minor apoprotein component of HDL (High-density lipoprotein) or 'good cholesterol' which is synthesized in the liver and also in many other tissues, including pancreas, kidney, and brain. APOL1 belongs to the apolipoprotein L family. It may play a role in lipid exchange and transport throughout the body. It may also participate in reverse cholesterol transport from peripheral cells to the liver. Defects in APOL1 are the cause of focal segmental glomer... |