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Search Results for " glomerulonephritis "

Targets Recommended: ALK TGF-beta/Smad

6

抑制剂 & 化合物

3

天然产物

5

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T16708	R-268712	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	R-268712 是选择性的 ALK5 抑制剂(IC50:2.5 nM)。
T60226	CT52923	PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	CT52923 is a selective, orally active antagonist of platelet-derived growth factor receptor (PDGFR), functioning as an ATP-competitive inhibitor. It has versatile applications for researching an array of pathological diseases such as atherosclerosis, glomerulonephritis, liver cirrhosis, pulmonary fibrosis, and cancer.
T73375	CK2-IN-4	Casein Kinase	Metabolism; Stem Cells
	CK2-IN-4 是一种蛋白激酶 (CK2) 抑制剂，IC50 值为 8.6 µM。 CK2-IN-4 具有潜在的抗癌啊和抗炎活性，可用于研究病毒感染和肾小球肾炎的疾病。
T63272	Edralbrutinib TG-1701	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Edralbrutinib (TG-1701) 是有效的BTK抑制剂，具有抗癌活性，可用于治疗肿瘤、免疫系统疾病、血液及淋巴系统疾病。Edralbrutinib可用于研究膜性肾小球肾炎和视神经脊髓炎。
T68182	3-Hydroxykynurenamine	Others	Others
	3-Hydroxykynurenamine, also known as 3-Hydroxy-L-kynurenamine or 3-HKA, is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the IFN-γ mediated STAT1/NF-κΒ pathway in both mouse and human dendritic cells (DCs) with a consequent decrease in the release of pro-inflammatory chemokines and cytokines, most notably TNF, IL-6, and IL12p70. 3-HKA has protective effects in an experimental mouse model of psoriasis ...
T36673	CC 401 dihydrochloride	Others	Others
	High affinity JNK inhibitor (Ki values are 25-50 nM). Inhibits JNK via competitive binding of the ATP-binding site of active, phosphorylated JNK. Exhibits > 40-fold selectivity for JNK over p38, ERK, IKK2, protein kinase C, Lck and ZAP70. Hepatoprotective. Also inhibits HCMV replication. Uehara et al (2004) c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Transplantation. 78 324 PMID:15316358 \|Uehara et al (2005) JNK mediates hepatic ischemia reperfusion injury. J...

化合物

Cat.No: T16708

Target: ALK, TGF-beta/Smad

Cat.No: T60226

Target: PDGFR

Cat.No: T73375

Target: Casein Kinase

Cat.No: T63272

Synonym: TG-1701

Target: BTK

3-Hydroxykynurenamine

Cat.No: T68182

Target: Others

CC 401 dihydrochloride

Cat.No: T36673

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3869	Skimmin 茵芋苷,Skimmine	Others	Others
	Skimmin (Skimmine) 是一种香豆素类物质。存在于圆锥绣球中，能够抑制免疫复合物的沉积，具有抗炎作用。
T3775	Armepavine 亚美罂粟碱,R-Armepavine,(-)-Armepavine	IκB/IKK; NF-κB	NF-κB
	Armepavine (R-Armepavine) 是来自Nelumbo nucifera 的活性化合物，能够抑制 TNF-α 诱导的MAPK 和NF-κB 信号级联反应。它不仅对人外周血单核细胞具有抗炎作用，且对 T 淋巴细胞和狼疮肾炎小鼠也具有免疫抑制作用。
T78492	D-Mannuronic acid sodium	Others	Others
	D-Mannuronic acid sodium，一种可从Macrocystis pyrifera中分离得到的化合物，显示出在自身免疫性脑脊髓炎(EAE)、佐剂性关节炎(AIA)、肾病综合征以及急性肾小球肾炎的研究中具有潜在应用价值。

天然产物

Cat.No: T3869

Synonym: 茵芋苷,Skimmine

Target: Others

Cat.No: T3775

Synonym: 亚美罂粟碱,R-Armepavine,(-)-Armepavine

Target: IκB/IKK, NF-κB

D-Mannuronic acid sodium

Cat.No: T78492

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02835	PDGFD Protein, Mouse, Recombinant (His & SUMO) Platelet-derived growth factor D,Pdgfd,Spinal cord-derived g...	Mouse	E. coli
	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including inf...
TMPJ-00011	CXCL2 Protein, Mouse, Recombinant Gro-beta,GRO β,GROB,melanoma growth stimulatory activity bet...	Mouse	E. coli
	C-X-C motif chemokine 2 (CXCL2,MIP-2) belongs to the intercrine alpha (chemokine CxC) family. It was originally identified as a heparin-binding protein secreted from a murine macrophage cell line in response to endotoxin stimulation. The expression of mouse MIP-2 is stimulated by endotoxin. The mouse MIP-2 shares approximately 63% aa sequence identity with murine KC, another mouse alpha chemokine, which is induced by PDGF. It has been suggested that mouse KC and MIP-2 are the homologs of the hum...
TMPY-01712	C1QB Protein, Human, Recombinant (His) complement component 1, q subcomponent, B chain,C1QB	Human	Baculovirus Insect Cells
	Complement Component 1, q subcomponent (C1q) associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Southern blot analysis of chromosomal DNA from vertebrate species demonstrated highest similarity between the C1qB genes, followed by C1qC and finally C1qA. Sequence comparison of C1...
TMPY-05252	Myeloperoxidase/MPO Protein, Human, Recombinant (His) myeloperoxidase	Human	HEK293 Cells
	MPO (myeloperoxidase) is a peroxidase enzyme secreted by activated leukocytes that plays a pathogenic role in cardiovascular disease, mainly by initiating endothelial dysfunction. Myeloperoxidase (MPO) is an important enzyme, which is one of the components of the antibacterial system in neutrophils and monocytes. MPO participates in the inflammatory response in multiple locations in the body, including the mammary glands. Myeloperoxidase (MPO), a specific polymorphonuclear leukocyte enzyme, has ...
TMPJ-01419	CSF1R Protein, Cynomolgus, Recombinant (His) CSF-1-R,CSF-1 receptor,Proto-oncogene c-Fms,M-CSF-R,Macropha...	Cynomolgus	HEK293 Cells
	Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region. CSF1R is expressed primarily on cells of the monocyte/macrophage lineage, dendritic cells, stem cells and in the developing placenta. CSF1 and its receptor (CSF1R, product of ...

重组蛋白

PDGFD Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02835

Species: Mouse

Expression System: E. coli

CXCL2 Protein, Mouse, Recombinant

Cat.No: TMPJ-00011

Species: Mouse

Expression System: E. coli

C1QB Protein, Human, Recombinant (His)

Cat.No: TMPY-01712

Species: Human

Expression System: Baculovirus Insect Cells

Myeloperoxidase/MPO Protein, Human, Recombinant (His)

Cat.No: TMPY-05252

Species: Human

Expression System: HEK293 Cells

CSF1R Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-01419

Species: Cynomolgus

Expression System: HEK293 Cells

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