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Search Results for " gingival "

Targets Recommended: Antibacterial Antifungal

7

抑制剂 & 化合物

14

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T0328	Hexetidine NSC-17764,海克替啶	Antibacterial; Antifungal	Microbiology/Virology
	Hexetidine (NSC-17764) 是一种口服活性的抗菌抗真菌试剂，可用于口腔感染的相关研究。
T68123	Oxodipine	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Oxodipine 是一种二氢吡啶型钙拮抗剂，抑制了KCl 诱导的兔主动脉收缩，降低了效力较低的大鼠心室试纸收缩的心脏力量。在大鼠培养的新生儿心室肌细胞中，Oxodipine 降低了L 型Ca 电流（I），IC 为0.24μM，对T 型Ca 电流（I）的IC 为0.41μM。Oxodipine 会使小鼠便秘和狗牙龈增生。
T67915	Succinate/succinate receptor antagonist 1	Others	Others
	Succinate/succinate receptor antagonist 1 是一种有效的琥珀酸受体拮抗剂。Succinate/succinate receptor antagonist 1 中断牙龈组织中的琥珀酸信号，抑制琥珀酸受体 1 (SucnRl Antagonist 1) 的激活，对琥珀酸受体 1的 IC50 值为 20 μΜ。Succinate/succinate receptor antagonist 1 可用于治疗牙周病。
T26838	BLXA-4 BLXA4,BLXA-4 ME,BLXA 4,BLXA-4-ME,BLXA4ME	Others	Others
	BLXA-4 is used potentially to treat gingival diseases.
T78549	Ethylene glycol dimethacrylate	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Ethylene glycol dimethacrylate 是一种具有细胞毒性和基因毒性作用的甲基丙烯酸酯单体。它可增加人牙龈成纤维细胞 (HGF) 内的活性氧 (ROS) 产生，引发 DNA 损伤和细胞凋亡 (apoptosis)，并使细胞周期在 G1/G0 期停滞。
T34811	Terrein NSC 291308,土曲霉酮,Terrain,(+)Terrein,NSC291308,NSC-291308	Others	Others
	Terrain, also known as NSC 291308, is a fungal metabolite with diverse biological activities. Terrein reduces age-related inflammation induced by oxidative stress through Nrf2/ERK1/2/HO-1 signalling in aged HDF cells. (+)-terrein suppresses interleukin-6/
T38309	LL-37 amide (trifluoroacetate salt)	Others	Others
	LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions. It inhibits growth of Gram-positive E. coli D21 and Gram-negative B. megatarium in a concentration-dependent manner and LL-37 expression is induced in A549 epithelial cells, alveolar macrophages, neutrophils, and monocyte-derived macrophages following M. tuberculosis infection. LL-37 binds sheep erythrocytes coated with S. ...

化合物

Cat.No: T0328

Synonym: NSC-17764,海克替啶

Target: Antibacterial, Antifungal

Cat.No: T68123

Target: Calcium Channel

Succinate/succinate receptor antagonist 1

Cat.No: T67915

Target: Others

Cat.No: T26838

Synonym: BLXA4,BLXA-4 ME,BLXA 4,BLXA-4-ME,BLXA4ME

Target: Others

Ethylene glycol dimethacrylate

Cat.No: T78549

Target: Reactive Oxygen Species

Cat.No: T34811

Synonym: NSC 291308,土曲霉酮,Terrain,(+)Terrein,NSC291308,NSC-291308

Target: Others

LL-37 amide (trifluoroacetate salt)

Cat.No: T38309

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03156	Lys-gingipain Protein, Porphyromonas gingivalis, Recombinant (His & SUMO) Lysine-specific cysteine proteinase Kgp,Lys-gingipain,kgp	Porphyromonas gingivalis	E. coli
	Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria. Lys-gingipain Protein, Porphyromonas gingivalis, Recombinant (His & SUMO) is expressed in E. col...
TMPH-03157	Fimbrillin Protein, Porphyromonas gingivalis, Recombinant (His & Myc) fimA,Major fimbrial subunit protein type I,Major fimbrium su...	Porphyromonas gingivalis	E. coli
	Fimbrillin Protein, Porphyromonas gingivalis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 43.9 kDa and the accession number is B2RH54.
TMPH-03151	Gingipain R1 Protein, Porphyromonas gingivalis, Recombinant (His) Gingipain 1,Gingipain R1,RGP-1,Arg-gingipain,rgpA	Porphyromonas gingivalis	P. pastoris (Yeast)
	Thiol protease. Acts synergistically with RgpB to catalyze the maturation of fimbrial subunits, such as FimA. Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defense mechanisms (Probable). Gingipain R1 Protein, Porphyromonas gingivalis, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 56.0 kDa and the accession number is P28784.
TMPH-03158	PAD Protein, Porphyromonas gingivalis, Recombinant (His) Peptidylarginine deiminase	Porphyromonas gingivalis	E. coli
	Deiminates the guanidino group of C-terminal arginine residues on a variety of peptides, including the vasoregulatory peptide-hormone bradykinin, to yield ammonia and a citrulline residue. May promote the growth of the pathogen in the periodontal pocket by producing ammonia, ammonia having a protective effect during acidic cleaning cycles in the mouth. PAD Protein, Porphyromonas gingivalis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weig...
TMPH-03152	Gingipain R1 Protein, Porphyromonas gingivalis, Recombinant (B2M & His) RGP-1,Arg-gingipain,Gingipain R1,Gingipain 1,rgpA	Porphyromonas gingivalis	E. coli
	Thiol protease. Acts synergistically with RgpB to catalyze the maturation of fimbrial subunits, such as FimA. Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defense mechanisms (Probable). Gingipain R1 Protein, Porphyromonas gingivalis, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 68.0 kDa and the accession number is P28784.
TMPH-03153	Gingipain R2 Protein, Porphyromonas gingivalis, Recombinant (His) rgpB,Gingipain 2,RGP-2,Arg-gingipain,Gingipain R2	Porphyromonas gingivalis	E. coli
	Thiol protease. Acts synergistically with RgpA to catalyze the maturation of fimbrial subunits, such as FimA. Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defense mechanisms. Gingipain R2 Protein, Porphyromonas gingivalis, Recombinant (His) is expressed in E. coli expression system with C-10xHis tag. The predicted molecular weight is 57.1 kDa and the accession number is P95493.
TMPH-03155	Lys-gingipain HG66 Protein, Porphyromonas gingivalis, Recombinant (His & Myc) Lys-gingipain HG66,kgp	Porphyromonas gingivalis	E. coli
	Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria. Lys-gingipain HG66 Protein, Porphyromonas gingivalis, Recombinant (His & Myc) is expressed in E....
TMPH-03154	Lys-gingipain 381 Protein, Porphyromonas gingivalis, Recombinant (His) kgp,Lys-gingipain 381	Porphyromonas gingivalis	E. coli
	Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria. Lys-gingipain 381 Protein, Porphyromonas gingivalis, Recombinant (His) is expressed in E. coli e...
TMPH-02414	Lys-gingipain W83 Protein, Porphyromonas gingivalis, Recombinant (His) Lys-gingipain W83,Lysine-specific cysteine proteinase,PrtK48...	Porphyromonas gingivalis	E. coli
	Lys-gingipain W83 Protein, Porphyromonas gingivalis, Recombinant (His) is expressed in E. coli expression system with C-10xHis tag. The predicted molecular weight is 51.6 kDa and the accession number is Q51817.
TMPH-03150	FtsZ Protein, Porphyromonas gingivalis, Recombinant (His) Cell division protein FtsZ,ftsZ	Porphyromonas gingivalis	E. coli
	FtsZ Protein, Porphyromonas gingivalis, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 56.3 kDa and the accession number is B2RIF5.
TMPU-00002	SOS1-Cat Protein, Human, Recombinant (His) SOS-1,Son of sevenless homolog 1	Human	E. coli
	Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1) [MIM:135300]; also known as GINGF1. Gingival fibromatosis is a rare overgrowth condition. Defects in SOS1 are the cause of Noonan syndrome type 4 (NS4) [MIM:610733]. NS4 is an autosomal dominant disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incid...
TMPJ-00003	DEFB1 Protein, Human, Recombinant Beta-Defensin 1,BD-1,HBD1,Defensin β1,BD1,Defensin Beta 1,β-...	Human	E. coli
	β-Defensin 1 (DEFB1) is a member of the β-defensin family, which is highly expressed by epithelial cells. β-defensins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal peptide. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-defensin 1 is an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. Defects in β-Defensin-1 contribute to asthma diagnosis,...
TMPY-04303	FAM20C Protein, Human, Recombinant (His) GEF-CK,DMP4,RNS,DMP-4,family with sequence similarity 20, me...	Human	Baculovirus Insect Cells
	The Family with sequence similarity 20 member C (FAM20C) catalyzes the phosphorylation of secreted proteins, and participates in a variety of biological processes, including cell proliferation, migration, mineralization, and phosphate homeostasis. FAM20C is an evolutionarily reserved molecule highly expressed in mineralized tissues. Mutations in the Family with sequence similarity (FAM) 20 gene family are associated with mineralized tissue phenotypes in humans. Among these genes, FAM20A mutation...
TMPY-03861	Amelotin Protein, Human, Recombinant (mFc) amelotin,UNQ689	Human	HEK293 Cells
	Amelotin (AMTN) is a tooth enamel protein which is expressed in maturation-stage ameloblasts and also in the internal basal lamina of junctional epithelium, a unique epithelial structure attached to the tooth surface which protects against the constant microbiological challenge to the periodontium. TNF-α stimulates AMTN gene transcription in human gingival epithelial cells via C/EBP1, C/EBP2, and YY1 elements in the human AMTN gene promoter.AMTN mRNA levels increased at 6 h and reached maximum a...

重组蛋白

Lys-gingipain Protein, Porphyromonas gingivalis, Recombinant (His & SUMO)

Cat.No: TMPH-03156

Species: Porphyromonas gingivalis

Expression System: E. coli

Fimbrillin Protein, Porphyromonas gingivalis, Recombinant (His & Myc)

Cat.No: TMPH-03157

Species: Porphyromonas gingivalis

Expression System: E. coli

Gingipain R1 Protein, Porphyromonas gingivalis, Recombinant (His)

Cat.No: TMPH-03151

Species: Porphyromonas gingivalis

Expression System: P. pastoris (Yeast)

PAD Protein, Porphyromonas gingivalis, Recombinant (His)

Cat.No: TMPH-03158

Species: Porphyromonas gingivalis

Expression System: E. coli

Gingipain R1 Protein, Porphyromonas gingivalis, Recombinant (B2M & His)

Cat.No: TMPH-03152

Species: Porphyromonas gingivalis

Expression System: E. coli

Gingipain R2 Protein, Porphyromonas gingivalis, Recombinant (His)

Cat.No: TMPH-03153

Species: Porphyromonas gingivalis

Expression System: E. coli

Lys-gingipain HG66 Protein, Porphyromonas gingivalis, Recombinant (His & Myc)

Cat.No: TMPH-03155

Species: Porphyromonas gingivalis

Expression System: E. coli

Lys-gingipain 381 Protein, Porphyromonas gingivalis, Recombinant (His)

Cat.No: TMPH-03154

Species: Porphyromonas gingivalis

Expression System: E. coli

Lys-gingipain W83 Protein, Porphyromonas gingivalis, Recombinant (His)

Cat.No: TMPH-02414

Species: Porphyromonas gingivalis

Expression System: E. coli

FtsZ Protein, Porphyromonas gingivalis, Recombinant (His)

Cat.No: TMPH-03150

Species: Porphyromonas gingivalis

Expression System: E. coli

SOS1-Cat Protein, Human, Recombinant (His)

Cat.No: TMPU-00002

Species: Human

Expression System: E. coli

DEFB1 Protein, Human, Recombinant

Cat.No: TMPJ-00003

Species: Human

Expression System: E. coli

FAM20C Protein, Human, Recombinant (His)

Cat.No: TMPY-04303

Species: Human

Expression System: Baculovirus Insect Cells

Amelotin Protein, Human, Recombinant (mFc)

Cat.No: TMPY-03861

Species: Human

Expression System: HEK293 Cells

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