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Search Results for " fibrils "

Targets Recommended: Microtubule Associated

30

抑制剂 & 化合物

2

天然产物

10

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T22118	NQTrp	Microtubule Associated	Cytoskeletal Signaling
	NQTrp 是芳香萘醌-色氨酸杂交分子，可以抑制 tau 蛋白的聚集，具有抗淀粉样蛋白活性。NQTrp 对六肽 (41GCWMLY46，γD-crystallin 的 N 端)和全长 γD-crystallin 的体外聚集有抑制作用。
T13048	SynuClean-D SC-D	Others	Others
	SynuClean-D (SC-D) 是一种 α-突触核蛋白聚集的抑制剂，能够破坏成熟的淀粉样蛋白原纤维，抑制原纤维繁殖，防止帕金森氏病动物模型中多巴胺能神经元的变性。
T35941	DC-Chol hydrochloride Cholesteryl 3β-N-(dimethylaminoethyl)carbamate hydrochloride,DC-Chol (hydrochloride),DC-Cholesterol hydrochloride,Cholesteryl 3β-N-(dimethylaminoethyl)carbamate	Beta Amyloid	Neuroscience
	DC-Chol hydrochloride(DC-Cholesterol hydrochloride) 在适当的实验条件下能抑制 Aβ40 纤维的形成且以剂量依赖性的方式显著抑制氧化hCT的淀粉样蛋白形成。DC-Chol hydrochloride可诱导改善和平衡的免疫力，能够促进乙型肝炎疫苗的研究。
T32609	Lawsoniaside	Others	Others
	Lawsoniaside can hinder the growth of amyloid-β42 fibrils.
T68836	ADS-J1	Others	Others
	ADS-J1 is an HIV-1 entry inhibitor that potently inhibits seminal amyloid fibrillization and block fibril-mediated enhancement of viral infection. Semen-derived amyloid fibrils, comprising SEVI (semen-derived enhancer of viral infection) fibrils and SEM1 fibrils, may remarkably enhance HIV-1 sexual transmission and are potential targets for the development of an effective microbicide.
T19837	O4 O 4,O-4	Others	Others
	O4 is a novel stabilizer of amyloid- fibrils. O4 used for accelerating the formation of end-stage mature fibrils.
T19730	12-Crown-4 12 C 4,12-Crown-4 ether,12C4,12-C-4	Others	Others
	12-Crown-4 disrupts Aβ40 fibrils. 12-Crown-4 can enter into the hydrophobic core region and form competitive, hydrophobic interactions with key hydrophobic residues.
T10530	BF 227	Others	Others
	BF 227 is a candidate for an amyloid imaging probe for PET (Ki: 4.3 nM for Aβ1-42 fibrils).
T19018	K114	Others	Others
	K114 binds tightly to amyloid fibrils (EC50: 20-30 nM). K114 is an efficient detector of semen-derived enhancer of virus infection (SEVI).
TP1645	β-Amyloid (1-9) β-Amyloid 1-9
	This is an N-terminal fragment of beta amyloid. It consists of amino acid residues 1 to 9. Truncated beta amyloid peptide (10-40) still forms amyloid fibrils and shows fibril polymorphism.
T84812	CNS-11	Others	Others
	CNS-11为一种能够分解tau原纤维的化学化合物，适用于阿尔茨海默病(AD)的研究。
T37370	Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)
	Amyloid-β (25-35) (Aβ (25-35)) is an 11-residue fragment of the Aβ protein that retains the physical and biological characteristics of the full length peptide. It forms fibrils that react to thioflavin T and Congo red and are organized in a cross-β arrangement of β-strands similar to Aβ (1-40) and Aβ (1-42) fibrils. Aggregated Aβ (25-35) decreases the viability of rat adrenal PC12 cells. It also decreases the viability of primary rat cortical neurons at concentrations ranging from 1 nM to 30 μM....
T83106	Anselamimab
	Anselamimab (CAEL-101) 为一种靶向血清淀粉样蛋白 A1 (SAA1) 的人源 IgG1-κ 抗淀粉样蛋白原纤维抗体。
T74158	Aβ Fibrillization modulator 1	Others	Others
	Aβ Fibrillization Modulator 1 能够稳定Aβ单体，这有助于防止其聚集形成纤维状结构。
T39638	Eprodisate	Others	Others
	Eprodisate is a novel compound specifically developed to disrupt the interactions between amyloidogenic proteins and glycosaminoglycans, effectively impeding the polymerization of amyloid fibrils and their deposition in tissues. This compound shows potential for delaying the advancement of AA amyloidosis-related renal disease and could apply to various forms of amyloidosis.
T73495	q-FTAA	Others	Others
	q-FTAA 与 Aβ1-42 原纤维结合，对 Aβ1-42 原纤维和阿尔茨海默病 PIB 结合复合物 (ADPBC) 的 EC50值分别为 330-630，300-500 nM。q-FTAA 具有研究阿尔茨海默病 (AD) 的潜力。
T37472	TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt)	Others	Others
	TAMRA-Amyloid-β (1-42) peptide is a fluorescently labeled peptide. Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-residue protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease. Aggregation of Aβ42 results in the formation of neurotoxic fibrils or globular oligomers. TAMRA-Amyloid-β (1-42) peptide is a labeled form of Aβ42 containing carboxytetramethyl rhodamine (TAMRA), which displays excitation/emission maxima of 543/572 nm, respectively.
T60335	BTA-1	Others	Others
	BTA-1 是一种不带电的硫代黄素-T 衍生物。BTA-1 对 Aβ 原纤维具有高亲和力，并具有良好的脑进入和清除能力。
T31828	AZD4694 Flutafuranol,AZD 4694,NAV-4694,AZD-4694,NAV 4694,NAV4694	Others	Others
	Flutafuranol, also known as AZD 4694 and NAV4694, is a bio-active chemical. AZD4694 shows high affinity for beta-amyloid fibrils in vitro (K(d) = 2.3 +/- 0.3 nM). The fluorine-18 labeled AZD4694 may have potential for PET-visualization of cerebral beta-am
T61087	THK-5105	Others	Others
	THK-5105为芳基喹啉衍生物，具备与tau原纤维高度结合的亲和力。它对tau蛋白聚集体及含tau的阿尔茨海默病(AD)脑匀浆显示出显著的结合能力。18F-THK-5105展现出作为tau成像PET探针的潜能。
T80374	HBA(111–142)	HSV	Microbiology/Virology
	HBA(111-142) 是一种源于 α-血红蛋白 C 端的32-聚体抗菌肽片段，对 ESKAPE 病原体展示出了抗菌效果。它能形成淀粉样原纤维结构，并表现出针对多种病毒，包括麻疹病毒和疱疹病毒（HSV-1、HSV-2、HCMV）的抗病毒活性。
T75958	β-Amyloid (22-35) (TFA)
	β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA是β-淀粉样蛋白22-35残基段，具细胞毒性，能影响无血清培养大鼠海马神经元。在中性缓冲液中，此化合物能形成聚集体与典型淀粉样纤维，模拟β-淀粉样蛋白行为。
T37367	Amyloid-β (1-42) Peptide (trifluoroacetate salt)	Others	Others
	Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-amino acid protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease.1,2,3Aggregation of Aβ42 results in the formation of neurotoxic fibrils or globular oligomers.1Aβ42 accumulates in the brain of many transgenic mouse models of Alzheimer's disease and, in many models, the onset of amyloid deposition positively correlates with deficits in spatial learning and memory.4 1.Wolfe, M.S.Therapeutic strategi...
T73912	Maysin	Others	Others
	Maysin 是一种具有神经保护作用的 C-糖基黄酮，可以从玉米须中分离得到。Maysin 对 Syn 淀粉样蛋白聚集体-低聚物和原纤维引起的损伤具有保护作用。Maysin 可防止氧化应激和细胞内钙稳态失衡，激活自噬降解过程。Maysin 可用于帕金森病(PD) 的研究。
T60907	THK-5117	Others	Others
	THK-5117 是一种芳基喹啉衍生物，具有作为 tau 成像 PET 探针的潜力。THK-5117 对 tau 原纤维表现出高结合亲和力，Ki 值为 10.5 nM。THK-5117 还显示出对 tau 蛋白聚集体和富含 tau 的阿尔茨海默病 (AD) 脑匀浆的高结合亲和力。
T80362	Human α-Defensin 6
	Human α-Defensin 6，含32个半胱氨酸残基的抗菌肽，能够阻止细菌入侵，促进粘膜免疫。该肽通过自组装形成有序的原纤维和纳米网，能随机结合细菌表面蛋白，进而围绕并缠绕细菌。此外，Human α-Defensin 6抑制C. albicans生物膜的形成。
T78842	α-Synuclein inhibitor 9	Others	Others
	α-Synuclein inhibitor9 (Compound 20C) 是一种针对 α-Synuclein 的抑制剂，通过与成熟 α-Synuclein 原纤维内的空腔结合，减少了 β-折叠构型，并有效阻止 A53T α-Syn 的聚集。由于其神经保护性质，该化合物能够改善大脑功能性连接并缓解运动障碍，适用于帕金森病 (PD) 的相关研究。
T74645	Eplontersen	Others	Others
	Eplontersen 是一种三触角的、N-乙酰半乳糖胺 (GalNAc3)-缀合的反义寡核苷酸，能够靶向甲状腺素运载蛋白 TTR 的 mRNA，抑制变体和野生型 TTR 产生。错误折叠的 TTR 诱导心脏和周围神经的淀粉样原纤维形成，并介导淀粉样 TTR (ATTR) 蛋白变性疾病。
T82379	FN-A208 fusion peptide
	FN-A208 是源自鼠层粘连蛋白 a1 的 A208 与纤连蛋白 (GRGDS) 活性位点和甘氨酸间隔区融合形成的生物活性肽。该肽能形成淀粉样原纤维，并有助于促进肌动蛋白应力纤维的形成，进而介导成纤维细胞附着，显示出其在组织再生和工程生物粘合剂方面的应用潜力。FN-A208 与 IKVAV 受体和整合素发生相互作用，而在 EDTA 存在下，其活性则会被破坏。
T83507	[Asn23] β-Amyloid (1-40), Iowa mutation
	[Asn23] β-Amyloid (1-40), Iowa mutation 是一种与重度大脑淀粉样蛋白血管病 (CAA) 相关的生物活性肽。该突变涉及 APP 694 位点的错义突变，Asp 23 位置的天冬酰胺被天冬酰氨酸取代。这种变异的 β-Amyloid 肽倾向于更快聚集，并形成有害的原纤维。

化合物

Cat.No: T22118

Target: Microtubule Associated

Cat.No: T13048

Synonym: SC-D

Target: Others

DC-Chol hydrochloride

Cat.No: T35941

Synonym: Cholesteryl 3β-N-(dimethylaminoethyl)carbamate hydrochloride,DC-Chol (hydrochloride),DC-Cholesterol hydrochloride,Cholesteryl 3β-N-(dimethylaminoethyl)carbamate

Target: Beta Amyloid

Cat.No: T32609

Target: Others

Cat.No: T68836

Target: Others

Cat.No: T19837

Synonym: O 4,O-4

Target: Others

Cat.No: T19730

Synonym: 12 C 4,12-Crown-4 ether,12C4,12-C-4

Target: Others

Cat.No: T10530

Target: Others

Cat.No: T19018

Target: Others

β-Amyloid (1-9)

Cat.No: TP1645

Synonym: β-Amyloid 1-9

Cat.No: T84812

Target: Others

Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)

Cat.No: T37370

Cat.No: T83106

Aβ Fibrillization modulator 1

Cat.No: T74158

Target: Others

Cat.No: T39638

Target: Others

Cat.No: T73495

Target: Others

TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt)

Cat.No: T37472

Target: Others

Cat.No: T60335

Target: Others

Cat.No: T31828

Synonym: Flutafuranol,AZD 4694,NAV-4694,AZD-4694,NAV 4694,NAV4694

Target: Others

Cat.No: T61087

Target: Others

Cat.No: T80374

Target: HSV

β-Amyloid (22-35) (TFA)

Cat.No: T75958

Amyloid-β (1-42) Peptide (trifluoroacetate salt)

Cat.No: T37367

Target: Others

Cat.No: T73912

Target: Others

Cat.No: T60907

Target: Others

Human α-Defensin 6

Cat.No: T80362

α-Synuclein inhibitor 9

Cat.No: T78842

Target: Others

Cat.No: T74645

Target: Others

FN-A208 fusion peptide

Cat.No: T82379

[Asn23] β-Amyloid (1-40), Iowa mutation

Cat.No: T83507

Cat. No.	Product Name	Target	Signaling Pathways
T2987	(-)-Epigallocatechin 表没食子儿茶素,(-)-表没食子儿茶素,l-Epigallocatechin,Epigallocatechin,EGC	MMP; Autophagy	Autophagy; Proteases/Proteasome
	(-)-Epigallocatechin (Epigallocatechin) 是绿茶中含量最丰富的黄酮类天然产物，可与未折叠的天然多肽结合，阻止转化为淀粉样蛋白原纤维。
T40641	Crocin-4	Others	Others
	Crocin-4, a carotenoid compound found in saffron, possesses potent antioxidant properties and can penetrate the brain. It effectively inhibits the aggregation and deposition of Aβ fibrils, making it useful for Alzheimer's Disease research. Additionally, Crocin-4 demonstrates antitumor and anti-inflammatory activities.

天然产物

(-)-Epigallocatechin

Cat.No: T2987

Synonym: 表没食子儿茶素,(-)-表没食子儿茶素,l-Epigallocatechin,Epigallocatechin,EGC

Target: MMP, Autophagy

Cat.No: T40641

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01101	Coagulation factor X/F10 Protein, Human, Recombinant (His) FXA,FX,coagulation factor X,coagulation factor 10	Human	Baculovirus Insect Cells
	Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the coagulation cascade and blood clotting, as the first enzyme in the common pathway of thrombus formation. Factor X deficiency is one of the rarest of the inherited coagulation disorders. FX deficiency among the most severe of the rare coagulation defects, typically including hema...
TMPH-00264	Decorin Protein, Bovine, Recombinant (His) Decorin,Bone proteoglycan II,DCN,PG-S2	Bovine	E. coli
	May affect the rate of fibrils formation. Decorin Protein, Bovine, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 40.5 kDa and the accession number is P21793.
TMPH-02588	COL12A1 Protein, Mouse, Recombinant (His) Collagen alpha-1(XII) chain,COL12A1L,COL12A1	Mouse	E. coli
	Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.
TMPJ-00804	COL3A1 Protein, Mouse, Recombinant (His) Col3a1,Collagen alpha-1(III) chain,Collagen α-1(III) chain	Mouse	HEK293 Cells
	Collagen alpha-1(III) chain（Col3a1） is a secreted protein and belongs to the fibrillar collagen family.It contains 1 fibrillar collagen NC1 domain and 1 VWFC domain. Collagen alpha-1(III) chain is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with type I collagen. The COL3A1 gene produces the components of type III collagen, called pro-alpha1(III) chains. Three copies of this chain combine to make a mole...
TMPY-01680	Lumican Protein, Human, Recombinant (His) lumican,LDC,SLRR2D	Human	HEK293 Cells
	Lumican, a prototypic leucine-rich proteoglycan with keratan sulfate side chains, is a major component of the cornea, dermal, and muscle connective tissues. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican regulates collagenous matr...
TMPJ-01085	DPT Protein, Human, Recombinant (hFc & His) TRAMP and DPT,Tyrosine-rich acidic matrix protein,Dermatopon...	Human	HEK293 Cells
	Dermatopontin, also known as Tyrosine-rich acidic matrix protein, TRAMP and DPT, is a secreted protein which belongs to the dermatopontin family. DPT is expressed in various tissues, such as fibroblasts, heart, skeletal muscle, brain and pancreas. It seems to mediate adhesion by cell surface integrin binding. DPT may serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. DPT can enhance TGFB1 activity through interaction with decorin. ...
TMPY-03809	COL5A2 Protein, Human, Recombinant (mFc) collagen, type V, α2,collagen, type V, alpha 2	Human	HEK293 Cells
	COL5A2 is a component of type V collagen. It is known as the pro-alpha2(V) chain. COL5A2, together with two pro-alpha1(V) chains can form type V procollagen. These triple-stranded, rope-like procollagen molecules arrange themselves into long, thin fibrils that cross-link to one another in the spaces around cells. The cross-links result in the formation of very strong, mature type V collagen fibers. Type V collagen can be detected in tissues containing type I collagen and appears to regulate the ...
TMPJ-01369	DPT Protein, Mouse, Recombinant (hFc) EQ-1,Early quiescence protein 1,TRAMP,Tyrosine-rich acidic m...	Mouse	HEK293 Cells
	Dermatopontin is a widely expressed noncollagenous protein component of the extracellular matrix. It is a 22 kDa molecule that is tyrosine sulfated but not glycosylated. Dermatopontin is down regulated in fibrotic growths such as leiomyoma and scar tissue, inhibits cell proliferation, accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation, Dermatopontin deficient mice exhibit altered collagen matrix deposition and organization. Dermatopontin s...
TMPJ-00292	CD36 Protein, Human, Recombinant (hFc) FATCHDS7,Glycoprotein IIIb,SCARB3,CD36,Fatty acid translocas...	Human	HEK293 Cells
	Platelet Glycoprotein 4 (CD36) is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types including microvascular endothelium, adipocytes, skeletal muscle, epithelial cells of the retina, breast, and intestine, smooth muscle cells, erythroid precursors, platelets, megakaryocytes, dendritic cells, monocytes/macrophages, and microglia. As a member of the scavenger receptor family, CD36 is a multiligand pattern recognition rece...
TMPJ-00684	SNCA Protein, Mouse, Recombinant (His) Snca,Non-A β component of AD amyloid,Non-A4 component of amy...	Mouse	E. coli
	Alpha-synuclein (Snca) belongs to a family of proteins including a-, b-, and g-synucleins. Alpha-synuclein has been found to be implicated in the pathophysiology of many neurodegenerative diseases, including Parkinson's disease (PD) and Alzheimer's disease. Manyneurodegenerative diseases has shown that alpha-synuclein accumulates in dystrophic neurites and in Lewy bodies. The function of alpha-synuclein is closely correlated with its three-dimensional structure, especially for proteins important...

重组蛋白

Coagulation factor X/F10 Protein, Human, Recombinant (His)

Cat.No: TMPY-01101

Species: Human

Expression System: Baculovirus Insect Cells

Decorin Protein, Bovine, Recombinant (His)

Cat.No: TMPH-00264

Species: Bovine

Expression System: E. coli

COL12A1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02588

Species: Mouse

Expression System: E. coli

COL3A1 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00804

Species: Mouse

Expression System: HEK293 Cells

Lumican Protein, Human, Recombinant (His)

Cat.No: TMPY-01680

Species: Human

Expression System: HEK293 Cells

DPT Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-01085

Species: Human

Expression System: HEK293 Cells

COL5A2 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-03809

Species: Human

Expression System: HEK293 Cells

DPT Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-01369

Species: Mouse

Expression System: HEK293 Cells

CD36 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00292

Species: Human

Expression System: HEK293 Cells

SNCA Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00684

Species: Mouse

Expression System: E. coli

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