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Search Results for " fertility "

Targets Recommended: Estrogen/progestogen Receptor Progesterone Receptor

14

抑制剂 & 化合物

3

天然产物

15

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T6713	Ulipristal	Estrogen/progestogen Receptor; Progesterone Receptor	Endocrinology/Hormones; Others
	Ulipristal 是性孕酮受体 (progesterone receptor) 的选择性调节剂。它能够与孕激素受体结合，抑制 PR 介导的基因表达，降低生殖系统中孕激素的活性。
T2527	Ulipristal acetate Ulipristal,醋酸乌利司他,CDB-2914	Estrogen/progestogen Receptor; Progesterone Receptor; Autophagy	Autophagy; Endocrinology/Hormones; Others
	Ulipristal acetate (CDB-2914) 是一种具有抗孕酮活性的选择性孕酮受体调节剂。它可抑制子宫平滑肌瘤病的生长。它通过抑制或延迟排卵和影响子宫内膜组织，可用作紧急避孕药。
T20720	Norethisterone enanthate NSC 9564,Norethindrone enanthate,LG-202,LG202,NSC9564,LG 202,炔诺酮庚酸酯,NSC-9564	Estrogen/progestogen Receptor	Endocrinology/Hormones
	Norethisterone enanthate (NSC-9564) 是一种口服有效的长效的孕激素。
T0384	Estradiol benzoate Benzoestrofol,Benzhormovarine,苯甲酸雌二醇,Benovocylin	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	Estradiol benzoate (Benzhormovarine) 是一种类固醇性激素，是一种雌二醇的前体药物。它表现出轻微的合成代谢特性，增加血液凝固性。
T20506	Maleuric acid N-Carbamoylmaleamic acid,AI3 32778,AI3-32778,AI332778	Others	Others
	Maleuric acid (N-Carbamoylmaleamic acid) 可抗有丝分裂，可与放射自显影技术结合起来用于生物研究。Maleuric acid 可用于改善动植物的生长和繁殖力以及治疗乳清酸缺乏症。
T2408	Ostarine MK-2866,GTX-024,Enobosarm	Androgen Receptor	Endocrinology/Hormones
	Ostarine (MK-2866) 是一种具有合成代谢活性的非甾体药物。选择性雄激素受体调节剂 (SARM) GTx-024 旨在像睾酮一样发挥作用，从而促进和/或维持性欲、生育能力、前列腺生长以及肌肉生长和力量。模仿睾酮的作用，这种药物可以增加瘦体重，从而改善癌症恶病质高代谢状态下的肌肉萎缩。
T23737	Anordiol H 241,H241,AF-45,AF 45,AF45	Others	Others
	Anordiol is an antiestrogen with estrogenic activity. It also is known to inhibit fertility.
T33725	Norgestrienone Planor,A-301,A301,Ogyline,A 301	Others	Others
	Nogotrienone is an anabolic steroid with fertility and contraceptive activity that has been studied as a therapeutic agent for hereditary angioneurotic edema.
T24084	Gamendazole	Others	Others
	Gamendazole is a novel drug candidate for male contraception. It has been shown to reduce fertility in male rats without affecting testosterone levels.
T78515	Follicle-stimulating hormone	Others	Others
	卵泡刺激素(Follicle-stimulating hormone, FSH)为一种由垂体前叶分泌的异二聚体糖蛋白，其参与调控动物的生殖能力与繁殖效率。
T77769	Menotropin Human Menopausal Gonadotrophin	Others	Others
	Menotropin (Human Menopausal Gonadotropin)为治疗生育障碍的激素活性药物，源自绝经后妇女的尿液提取。
T36916	Estrone-3-Glucuronide (sodium salt hydrate)	Others	Others
	Estrone-3-Glucuronide is a metabolite of the primary premenopausal estrogen 17β-estradiol .1,2Urinary levels of estrone-3-Glucuronide peak approximately 36 hours prior to ovulation and have been used as a marker of fertility in women. 1.Blackwell, L.F., Brown, J.B., and Cooke, D.Definition of the potentially fertile period from urinary steroid excretion rates. Part II. A threshold value for pregnanediol glucuronide as a marker for the end of the potentially fertile period in the human menstrual ...
T83428	1-Myristoyl-3-chloropropanediol	Others	Others
	1-Myristoyl-3-chloropropanediol 是一种MCPD (3-一氯丙二醇) 脂肪酸酯。慢性口服该化合物可导致肾病、小管增生和腺瘤形成，在大鼠中也观察到生育能力下降，不育发生率增加，以及免疫功能受到抑制。
T83870	BHD	Others	Others
	BHD作为一种可逆的男性避孕化合物，在体内通过(100 和 500 mg/kg)剂量引发精子生成细胞凋亡和精子管异常，破坏血-睾丸屏障，降低雄性小鼠的生育指数，效果持续两至六周。

化合物

Cat.No: T6713

Target: Estrogen/progestogen Receptor, Progesterone Receptor

Ulipristal acetate

Cat.No: T2527

Synonym: Ulipristal,醋酸乌利司他,CDB-2914

Target: Estrogen/progestogen Receptor, Progesterone Receptor, Autophagy

Norethisterone enanthate

Cat.No: T20720

Synonym: NSC 9564,Norethindrone enanthate,LG-202,LG202,NSC9564,LG 202,炔诺酮庚酸酯,NSC-9564

Target: Estrogen/progestogen Receptor

Estradiol benzoate

Cat.No: T0384

Synonym: Benzoestrofol,Benzhormovarine,苯甲酸雌二醇,Benovocylin

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Cat.No: T20506

Synonym: N-Carbamoylmaleamic acid,AI3 32778,AI3-32778,AI332778

Target: Others

Cat.No: T2408

Synonym: MK-2866,GTX-024,Enobosarm

Target: Androgen Receptor

Cat.No: T23737

Synonym: H 241,H241,AF-45,AF 45,AF45

Target: Others

Cat.No: T33725

Synonym: Planor,A-301,A301,Ogyline,A 301

Target: Others

Cat.No: T24084

Target: Others

Follicle-stimulating hormone

Cat.No: T78515

Target: Others

Cat.No: T77769

Synonym: Human Menopausal Gonadotrophin

Target: Others

Estrone-3-Glucuronide (sodium salt hydrate)

Cat.No: T36916

Target: Others

1-Myristoyl-3-chloropropanediol

Cat.No: T83428

Target: Others

Cat.No: T83870

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1048	Estradiol 雌二醇,E2,17β-Estradiol,17β-Oestradiol,β-Estradiol	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Estradiol (E2) 是一种天然的类固醇性激素，对于女性生育能力和第二性征的维持至关重要。Estradiol 通过雌激素受体 β (ERβ) 上调 IL-6 表达。
T78474	6PPD-Q 6PPD-Quinone	Endogenous Metabolite	Metabolism
	6PPD-Q (6PPD-Quinone) 是一种存在于环境和土壤中的污染物，是轮胎抗氧剂N-（1,3-二甲基丁基）-N'-苯基对苯二胺（6PPD）的衍生物，会损害小鼠精子质量并诱发雄性生殖能力的受损。
TN2120	Quassin	Others; Antifection	Microbiology/Virology; Others
	Quassin has female anti-fertility properties, possibly acting via inhibition of estrogen secretion.

天然产物

Cat.No: T1048

Synonym: 雌二醇,E2,17β-Estradiol,17β-Oestradiol,β-Estradiol

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite

Cat.No: T78474

Synonym: 6PPD-Quinone

Target: Endogenous Metabolite

Cat.No: TN2120

Target: Others, Antifection

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01218	M-CSF/CSF1 Protein, Rat, Recombinant CSF1,集落刺激因子,CSF-1,Macrophage colony-stimulating factor 1,M-C...	Rat	HEK293 Cells
	Rat Macrophage colony-stimulating factor 1(MCSF,CSF1) is a single-pass type I membrane cytokine. It is a hematopoietic growth factor that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. MCSF promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It is involved in the regu...
TMPJ-00327	M-CSF/CSF1 Protein, Human, Recombinant (His) Lanimostim,M-CSF,CSF-1,MCSF,CSF1,集落刺激因子,Macrophage Colony-St...	Human	HEK293 Cells
	Macrophage Colony-Stimulating Factors (m-csf) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and themonocytes-macrophages. CSF-1 promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It also plays an important role in the regulation of osteoclast proliferation and differentiation, the regulatio...
TMPJ-00796	Serpin E2 Protein, Human, Recombinant (His) PN-1,PI-7,Protease nexin 1,PI7,GDN,Peptidase inhibitor 7,Ser...	Human	HEK293 Cells
	Serpin E2 is a secreted protein that belongs to the serpin family. Serpin E2 is a serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Serpin E2 expression is weak or absent in all normal pancreas and chronic pancreatitis tissue. In contrast, it was strongly over-expressed in the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples. Serpin E2 promotes neurite extension by inhibiting thrombin. It also can bind heparin. It has been shown tha...
TMPJ-01083	Serpin E2 Protein, Mouse, Recombinant (His) Pi7,Protease nexin I,Spi4,Pn1,Serine protease-inhibitor 4,PI...	Mouse	HEK293 Cells
	Serpin E2 is a member of the Serpin superfamily. It is differentially expressed during neuronal differentiation and is able to transform human embryonic kidney cells into neuronlike cells. Its over-expression in mice leads to progressive neuronal and motor dysfunction in these animals. It is also over-expressed in the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples whereas it is weakly expressed in all normal pancreas and chronic pancreatitis tissue samples. Ser...
TMPK-01020	FSHB Protein, Mouse, Recombinant (hFc) FSH-beta,FSH-B,FSHB,FSH-β,Follitropin	Mouse	HEK293 Cells
	Fertility is dependent on follicle-stimulating hormone (FSH), a product of gonadotrope cells of the anterior pituitary gland. Hypothalamic gonadotropin-releasing hormone (GnRH) and intra-pituitary activins are regarded as the primary drivers of FSH synthesis and secretion. Both stimulate expression of the FSH beta subunit gene (Fshb), although the underlying mechanisms of GnRH action are poorly described relative to those of the activins. FSHB Protein, Mouse, Recombinant (hFc) is expressed in HE...
TMPJ-00664	Calmegin Protein, Human, Recombinant (His) Calmegin,CLGN	Human	HEK293 Cells
	Calmegin (CLGN) is a member of the calreticulin family. Calmegin is a testis-specific endoplasmic reticulum chaperone protein. The functions during spermatogenesis as a chaperone for a range of client proteins that is important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. It is required for normal male fertility, normal sperm migration from the uterus into the oviduct. Calmegin binds calcium ions and interacts with PDILT. Calmegin may play ...
TMPK-01285	FSHB Protein, Cynomolgus, Recombinant (His) Follitropin,FSH-B,FSH-beta,FSH-β,FSHB	Cynomolgus	HEK293 Cells
	Fertility is dependent on follicle-stimulating hormone (FSH), a product of gonadotrope cells of the anterior pituitary gland. Hypothalamic gonadotropin-releasing hormone (GnRH) and intra-pituitary activins are regarded as the primary drivers of FSH synthesis and secretion. Both stimulate expression of the FSH beta subunit gene (Fshb), although the underlying mechanisms of GnRH action are poorly described relative to those of the activins. FSHB Protein, Cynomolgus, Recombinant (His) is expressed ...
TMPJ-00981	PTX3 Protein, Mouse, Recombinant (His) alpha-induced protein 5,pentraxin 3, long,pentaxin-related g...	Mouse	HEK293 Cells
	Pentraxin-related protein PTX3, also known as Tumor necrosis factor-inducible gene 14 protein (TSG-14), belongs to the pentraxin family. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. It’s subunit is a disulfide-linked homooctamer that binds to C1q. PTX3 concentration is elevated in the joint fluid of patients with rheumatoid arthritis (RA), indicating that PTX3 may be a potential mediator...
TMPJ-01419	CSF1R Protein, Cynomolgus, Recombinant (His) CSF-1-R,CSF-1 receptor,Proto-oncogene c-Fms,M-CSF-R,Macropha...	Cynomolgus	HEK293 Cells
	Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region. CSF1R is expressed primarily on cells of the monocyte/macrophage lineage, dendritic cells, stem cells and in the developing placenta. CSF1 and its receptor (CSF1R, product of ...
TMPY-01816	Pentraxin 3 Protein, Human, Recombinant (His) TNFAIP5,pentraxin 3,PTX3,TSG-14	Human	HEK293 Cells
	Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cycl...
TMPY-00163	SPINK2 Protein, Human, Recombinant (hFc) serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin in...	Human	HEK293 Cells
	Human serine proteinase inhibitor Kazal-type 2 (SPINK2) functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged in fertility. The SPINK2 protein contains a typical Kazal domain composed by six cysteine residues forming three disulfide bridges. The expression of SPINK2 is closely related to cancer such as lymphomas, in that a high transcript level of SPINK2 in patients with primary cutaneous follicle center cell lymphomas ...
TMPY-02957	DYDC2 Protein, Human, Recombinant (GST) DPY30 domain containing 2	Human	E. coli
	DPY30 domain containing 2 belongs to the dpy-30 family. Dumpy-30 family members act as determinants of male fertility and interaction partners of metal-responsive transcription factor 1 (MTF-1) in Drosophila. MTF-1 plays a key role in transition metal detoxification and homeostasis. It binds to metal response elements (MREs). Two candidate dMTF-1 interactors are related to the small regulatory protein Dumpy-30 (Dpy-30) of the worm C. elegans. Dpy-30 is the founding member of a protein family inv...
TMPJ-01418	CSF1R Protein, Cynomolgus, Recombinant (hFc) M-CSF-R,CSF1R,CSF-1-R,CSF-1 receptor,CSF-1R,Macrophage colon...	Cynomolgus	HEK293 Cells
	Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region. CSF1R is expressed primarily on cells of the monocyte/macrophage lineage, dendritic cells, stem cells and in the developing placenta. CSF1 and its receptor (CSF1R, product of ...
TMPH-02690	PLA2G10 Protein, Mouse, Recombinant (His & Myc) Pla2g10,Group X secretory phospholipase A2,Phosphatidylcholi...	Mouse	E. coli
	Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls. Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density li...
TMPH-01689	PLD6 Protein, Human, Recombinant (His) Mitochondrial phospholipase,Choline phosphatase 6,Protein zu...	Human	E. coli
	Presents phospholipase and nuclease activities, depending on the different physiological conditions. Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the nuclease activity. Plays a key role in mitochondrial fusion and fission via its phospholipase activity. In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger sig...

重组蛋白

M-CSF/CSF1 Protein, Rat, Recombinant

Cat.No: TMPJ-01218

Species: Rat

Expression System: HEK293 Cells

M-CSF/CSF1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00327

Species: Human

Expression System: HEK293 Cells

Serpin E2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00796

Species: Human

Expression System: HEK293 Cells

Serpin E2 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01083

Species: Mouse

Expression System: HEK293 Cells

FSHB Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01020

Species: Mouse

Expression System: HEK293 Cells

Calmegin Protein, Human, Recombinant (His)

Cat.No: TMPJ-00664

Species: Human

Expression System: HEK293 Cells

FSHB Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01285

Species: Cynomolgus

Expression System: HEK293 Cells

PTX3 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00981

Species: Mouse

Expression System: HEK293 Cells

CSF1R Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-01419

Species: Cynomolgus

Expression System: HEK293 Cells

Pentraxin 3 Protein, Human, Recombinant (His)

Cat.No: TMPY-01816

Species: Human

Expression System: HEK293 Cells

SPINK2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00163

Species: Human

Expression System: HEK293 Cells

DYDC2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02957

Species: Human

Expression System: E. coli

CSF1R Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPJ-01418

Species: Cynomolgus

Expression System: HEK293 Cells

PLA2G10 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02690

Species: Mouse

Expression System: E. coli

PLD6 Protein, Human, Recombinant (His)

Cat.No: TMPH-01689

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T35783	Zearalenone-13C18 Zearalenone-13C18
	Zearalenone-13C18is intended for use as an internal standard for the quantification of zearalenone by GC- or LC-MS. Zearalenone is a mycotoxin that has been found inFusariumand has estrogenic activities.1It binds to human estrogen receptor α (ERα) and ERβ (IC50s = 9 and 5.8 nM, respectively).2Zearalenone induces precocious development of mammary tissues in young female pigs and prepucial enlargement in young male pigs.3Zearalenone (1.5-5 mg/kg of diet) induces hyperestrogenism in pigs. It also i...

同位素标记化合物

Zearalenone-13C18

Cat.No: T35783

Synonym: Zearalenone-13C18

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