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TMPH-01915
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PREB Protein, Human, Recombinant (His & Myc)
Mammalian guanine nucleotide exchange factor mSec12...
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Human
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E. coli
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PREB Protein, Human, Recombinant (His & Myc) is expressed in E. coli. |
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TMPH-02041
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ARHGEF12 Protein, Human, Recombinant (His)
ARHGEF12,KIAA0382,Rho guanine nucleotide exchange f...
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Human
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E. coli
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ARHGEF12 Protein, Human, Recombinant (His) is expressed in E. coli. |
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TMPH-00993
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SLC4A1 Protein, Human, Recombinant (His & Myc)
Anion exchange protein 1,Band 3 anion transport pro...
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Human
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E. coli
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SLC4A1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 50.3 kDa and the accession number is P02730. |
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TMPY-02956
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Apolipoprotein L/APOL1 Protein, Human, Recombinant (His)
APOL1,apolipoprotein L1,APOL,FSGS4,APOL-I,APO-L
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Human
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Baculovirus Insect Cells
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APOL1, also known as apolipoprotein L1, is a minor apoprotein component of HDL (High-density lipoprotein) or 'good cholesterol' which is synthesized in the liver and also in many other tissues, including pancreas, kidney, and brain. APOL1 belongs to the apolipoprotein L family. It may play a role in lipid exchange and transport throughout the body. It may also participate in reverse cholesterol transport from peripheral cells to the liver. Defects in APOL1 are the cause of focal segmental glomer... |
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TMPH-01994
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GDI2 Protein, Human, Recombinant (His)
Rab GDP dissociation inhibitor beta,Guanosine diphosphate di...
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Human
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P. pastoris (Yeast)
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Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. GDI2 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 52.7 kDa and the accession number is P50395. |
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TMPH-01209
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DENND1A Protein, Human, Recombinant (His & SUMO)
KIAA1608,Connecdenn 1,DENN domain-containing protein 1A,DENN...
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Human
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E. coli
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Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes. Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P. DENND1A Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6... |
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TMPH-03750
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SLC7A11 Protein, Human, Recombinant (His)
SLC7A11,Calcium channel blocker resistance protein CCBR1,Sol...
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Human
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E. coli
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Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. |
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TMPH-00638
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RuvB Protein, E. coli, Recombinant (His & SUMO)
ruvB,Holliday junction branch migration complex subunit RuvB
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E. coli
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E. coli
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The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvB Protein, E. coli, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 53.2 kDa and the accession number is ... |
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TMPH-03259
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Carbonic Anhydrase 2 Protein, Rat, Recombinant (His)
CA-II,Carbonate dehydratase II,Carbonic anhydrase II,Cyanami...
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Rat
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E. coli
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Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. Carbonic Anhydrase 2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.7 kDa and the accession number is P27139. |
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TMPJ-01057
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PSP Protein, Human, Recombinant (His)
PSPH,L-3-Phosphoserine Phosphatase,PSPase,Phosphoserine Phos...
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Human
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E. coli
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Phosphoserine phosphatase (PSP) is an enzyme that belongs to the serB family. PSPH catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. Deficiency of this protein is thought to be linked to Williams syndrome. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial fea... |
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TMPH-01207
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DOCK8 Protein, Human, Recombinant (His)
DOCK8,Dedicator of cytokinesis protein 8
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Human
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P. pastoris (Yeast)
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Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing c... |
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TMPH-00739
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Thioredoxin-1 Protein, E. coli, Recombinant (His)
Thioredoxin 1,trxA
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E. coli
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E. coli
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Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Thioredoxin-1 Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 15.7 kDa and the accession number is P0AA25. |
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TMPJ-01274
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ERO1L Protein, Human, Recombinant (His)
ERO1-L-Alpha,ERO1-L-α,Oxidoreductin-1-L-α,Endoplasmic Oxidor...
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Human
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HEK293 Cells
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ERO1-Like Protein α (ERO1L) is an enzyme that belongs to the EROs family. ERO1L is expressed at high level in esophagus and upper digestive tract. ERO1L is an essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. ERO1L acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. It associates with ERP44, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. It... |
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TMPH-00530
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SSB Protein, Enterobacteria phage T4, Recombinant (His & Myc)
Gp32,Helix-destabilizing protein,Single-stranded DNA-binding...
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Enterobacteria phage T4
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E. coli
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Single-stranded DNA-binding protein that participates in viral DNA replication, recombination, and repair (Probable). Coats the lagging-strand ssDNA as the replication fork advances. Stimulates the activities of viral DNA polymerase and DnaB-like SF4 replicative helicase, probably via its interaction with the helicase assembly factor. Together with DnaB-like SF4 replicative helicase and the helicase assembly factor, promotes pairing of two homologous DNA molecules containing complementary single... |
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TMPH-02195
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TXNDC17 Protein, Human, Recombinant (GST)
Thioredoxin-like protein 5,Protein 42-9-9,Thioredoxin domain...
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Human
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E. coli
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Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide. |
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TMPH-01285
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EEF1D Protein, Human, Recombinant (His)
Elongation factor 1-delta,EF1D,EF-1-delta,EEF1D,Antigen NY-C...
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Human
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E. coli
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EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). |
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TMPH-01320
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CAPZA2 Protein, Human, Recombinant (His & SUMO)
CAPZA2,CapZ alpha-2,F-actin-capping protein subunit alpha-2
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Human
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E. coli
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F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. CAPZA2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 48.8 kDa and the accession number is P47755. |
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TMPH-01379
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GSN Protein, Human, Recombinant (His)
GSN,Actin-depolymerizing factor,Brevin,AGEL,Gelsolin
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Human
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E. coli
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Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. GSN Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 33.5 kDa and the accession number is P06396. |
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TMPJ-00826
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TXN Protein, Human, Recombinant (His)
ADF,TXN,TRX1,Thioredoxin,TRX,ATL-Derived Factor,TRDX,Surface...
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Human
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E. coli
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Thioredoxin (TXN) is a member of the Thioredoxin family. Thioredoxin exists as a disulfide-linked homodimer and contains one Thioredoxin domain. Thioredoxin is up-regulated by ionizing radiation. Thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Thioredoxin also plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contri... |
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TMPY-03788
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ATP1B1 Protein, Human, Recombinant (His)
ATPase, Na+/K+ transporting, β 1 polypeptide,ATPase, Na+/K+ ...
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Human
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HEK293 Cells
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ATP1B1 belongs to the family of Na+/K+and H+/K+-ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. ATP1B1 is a subunit of Na+/K+-ATPase. Na+/K+-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. Na+/K+-ATPase is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). ATP1B1 regulates, through assembly of alpha/beta heterodim... |
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TMPH-02623
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DOCK8 Protein, Mouse, Recombinant (His)
Dedicator of cytokinesis protein 8,DOCK8
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Mouse
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P. pastoris (Yeast)
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Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing cent... |
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TMPH-02622
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DOCK8 Protein, Mouse, Recombinant (E. coli, His)
DOCK8,Dedicator of cytokinesis protein 8
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Mouse
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E. coli
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Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing cent... |
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TMPH-00531
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SSB Protein, Enterobacteria phage T7, Recombinant (His & SUMO)
Single-stranded DNA-binding protein,Gene product 2.5,2.5 pro...
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Enterobacteria phage T7
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E. coli
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Single-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks. Coats the lagging-strand ssDNA as the replication fork advances and stimulates the activities of viral DNA polymerase and primase/helicase. Coordinates simultaneous synthesis of leading- and lagging-strands. Together with DNA primase/helicase, promotes pairing of two homologous DNA molecules containing complementary single-stranded regions ... |
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TMPH-00532
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SSB Protein, Enterobacteria phage T7, Recombinant
Gene product 2.5,Single-stranded DNA-binding protein,2.5 pro...
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Enterobacteria phage T7
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P. pastoris (Yeast)
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Single-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks. Coats the lagging-strand ssDNA as the replication fork advances and stimulates the activities of viral DNA polymerase and primase/helicase. Coordinates simultaneous synthesis of leading- and lagging-strands. Together with DNA primase/helicase, promotes pairing of two homologous DNA molecules containing complementary single-stranded regions ... |
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TMPY-04443
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NEK3 Protein, Mouse, Recombinant (His & GST)
NIMA-related kinase 3
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Mouse
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Baculovirus Insect Cells
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NEK3 (NIMA (never in mitosis gene a)-related expressed kinase 3), contains 1 protein kinase domain and is a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. Members of the NEK family of protein kinases share high amino acid homology with NIMA (never in mitosis gene a). NEK3 differs from other NimA family members in that it is not the cell cycle-regulated and is found primarily in the cytoplasm. It is activated by prolactin stimulation, leading to phosphorylatio... |
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TMPY-01958
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RhoA Protein, Human, Recombinant (His)
ras homolog family member A,ARHA,RHO12,RHOH12,ARH12
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Human
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Baculovirus Insect Cells
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Transforming protein RhoA, also known as Rho cDNA clone 12, Ras homolog gene family member A, RHOA and ARH12, is a cell membrane and cytoplasm protein that belongs to the small GTPase superfamily and Rho family. The Rho family of small GTPases plays a key role in the dynamic regulation of the actin cytoskeleton that underlies various important cellular functions such as shape changes, migration, and polarity. RHOA / ARH12 is part of a larger family of related proteins known as the Ras superfamil... |
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TMPY-02220
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HRAS Protein, Human, Recombinant (His)
HAMSV,Harvey rat sarcoma viral oncogene homolog,C-H-RAS,C-HA...
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Human
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Baculovirus Insect Cells
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HRas, also known as HRAS, belongs to the small GTPase superfamily, Ras family, and is widely expressed. It functions in signal transduction pathways. HRas can bind GTP and GDP, and they have intrinsic GTPase activity. It undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Defects in HRAS are the cause of faciocutaneoskeletal syndrome (FCSS). FCSS is a rare condition characterized by prenatally increase... |
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TMPH-03753
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MYLK Protein, Human, Recombinant (His)
MYLK,Myosin light chain kinase, smooth muscle,Telokin,Kinase...
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Human
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E. coli
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Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscl... |
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TMPY-01187
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Rac1 Protein, Human, Recombinant (GST)
Rac-1,p21-Rac1,MIG5,ras-related C3 botulinum toxin substrate...
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Human
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Baculovirus Insect Cells
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RAC1 is a GTPase that belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for RAC1 gene. RAC1 is a plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, bind... |
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TMPH-02521
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PYCARD Protein, Mouse, Recombinant (His & Myc)
Pycard,PYD and CARD domain-containing protein,Apoptosis-asso...
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Mouse
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E. coli
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Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved ... |
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