首页工具

登录

搜索结果

Search Results for " equine "

24

抑制剂 & 化合物

3

天然产物

10

重组蛋白

3

同位素标记化合物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
TP1647	β-Endorphin, equine
	Endorphin Beta is A substance produced in the brain, especially in the pituitary gland, Endorphin Beta blocks the sensation of pain. Endorphin Beta is produced in response to pain, exercise, and other forms of stress. Endorphin Beta belongs to a group of
TP1391	β-Endorphin, equine (TFA)
	β-Endorphin, equine (TFA) is an endogenous opioid peptide, which binds at high affinity to both μ/δ opioid receptors.
T1172	Diclazuril 地克珠利,R-64433	Antibiotic; Parasite	Microbiology/Virology
	Diclazuril (R-64433) 是一种具有口服活性的抗球虫剂，是苯乙腈衍生物。它可用于某些传染病和寄生虫病的相关研究。
T21900	ML-336 (E)-2-((1,4-二甲基哌嗪-2-亚基)氨基)-5-硝基-N-苯基苯甲酰胺	Others	Others
	ML-336 是一种喹唑啉酮类的委内瑞拉马脑炎病毒 (VEEV) 抑制剂，其VEEV TC-83 CPE(IC50:32 nM)、VEEV V3526 CPE(IC50:20 nM)、VEEV 野生型 CPE (IC50:42 nM)，有效抑制 VEEV 诱导的三种病毒株 (V3526、TC-83和野生型) 细胞病变效应。
T8498	EIDD-1931 Beta-d-N4-hydroxycytidine	Virus Protease; HCV Protease; SARS-CoV; Topoisomerase	DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	EIDD-1931 (Beta-d-N4-hydroxycytidine) 是一种核苷类抗病毒试剂，可抑制丙型肝炎病毒、基孔肯亚病毒和委内瑞拉马脑炎病毒的复制活性。
T1060	Flumequine Flumigal,氟甲喹,R-802	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Flumequine (R-802) 是一种喹诺酮类抗生素，对革兰氏阳性菌和革兰氏阴性菌均有效。它是拓扑异构酶 II 抑制剂，抑制细胞分裂，IC50值为 15 μM (3.92 μg/mL)。
T19897	Anavenol 2-(2-萘氧基)乙醇,2-(naphthalen-2-yloxy)ethanol	Others	Others
	Anavenol (2-(naphthalen-2-yloxy)ethanol) 是一种马麻醉剂。
T19776	Equilenin Equilenine,E 400,NSC 9901,d-Equilenin	Others	Others
	Equilenin is an equine estrogen found in the urine of pregnant mares. It is also a naturally fluorescent steroid, has a high binding affinity for human sex steroid-binding protein (SBP).
T63218	Encephalitic alphavirus-IN-1	Others	Others
	Encephalitic alphavirus-IN-1 能够抑制委内瑞拉马脑炎病毒 (VEEV) (EC50: 0.24 μM)和东部马脑炎病毒 (EEEV) (EC50: 0.16 μM)的活性。Encephalitic alphavirus-IN-1 没有明显的细胞毒性，而且表现出较强的小鼠血浆稳定性。
T60529	AChE/BChE-IN-3	Others	Others
	AChE/BChE-IN-3 (BMC-1) 是AChE 和BChE 的双重抑制剂，对电鳗 AChE (elAChE) 的IC50值为 6.08 μM ，对马血清 BChE (eqBChE) 的IC50值为 0.383 μM。
T61399	Z164597606	Others	Others
	Z164597606 is a compound that acts as a selective inhibitor of the enzyme Butyrylcholinesterase (BChE), with IC50 values of 1.3 μM and 1.7 μM for equine BChE and human BChE, respectively. Through a π-π stacking interaction, Z164597606 specifically interacts with the amino acid Trp82 of human BChE. This compound has potential applications in Alzheimer's disease research [1] [2].
T36880	NHC-diphosphate	Others	Others
	NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a diphosphate form[1]. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV)[1]. Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC.Intracellular levels of the parental compounds and ...
T60831	AChE/BChE-IN-3 hydrochloride	Others	Others
	AChE/BChE-IN-3 (BMC-1) hydrochloride 是 AChE 和 BChE 的双重抑制剂。AChE/BChE-IN-3 对马血清 BChE (eqBChE) 和电鳗 AChE (elAChE) 的 IC50值分别为 0.383 μM 和 6.08 μM。
T79502	PD24	Others	Others
	PD24是AChE和BuChE的抑制剂，表现出一定的抑制效力（hAChE IC50: 1.72 μM；eeAChE IC50: 1.76 μM；eqBuChE IC50: 2.64 μM）。该化合物还具备抗氧化性能，能有效抑制DPPH自由基（IC50: 28.72 μM）。因此，PD24适用于阿尔茨海默病相关的研究。
T79423	BuChE-IN-9	Others	Others
	BuChE-IN-9 (compound 22a) 作为eqBuChE的抑制剂，表现出相当的效力，具有173 nM的IC50值。除此之外，BuChE-IN-9对人BACE1、Aβ聚集及小鼠mGAT1和mGAT4也具有抑制作用，并且显示出显著的抗遗忘特性。
T39678	Multitarget AD inhibitor-1	Others	Others
	Multitarget AD inhibitor-1 is a reversible and selective inhibitor of butyrylcholinesterase (BuChE) with IC50 values of 7.22 μM and 1.55 μM for human BuChE (hBuChE) and equine serum BuChE (eqBuChE), respectively. Additionally, it exhibits inhibitory activity towards β-secretase (IC50 value of 41.60 μM), amyloid β aggregation (IC50 value of 3.09 μM), and tau aggregation. As a diphenylpropylamine derivative, Multitarget AD inhibitor-1 holds promise for research pertaining to the multifunctional, d...
T79501	PD10	Others	Others
	PD10为同时针对AChE与BuChE的抑制剂，在人脑AChE (hAChE IC50: 0.56 μM)、电鳗AChE (eeAChE IC50: 0.59 μM)、马血清BuChE (eqBuChE IC50: 1.06 μM) 均有显著抑制效果，适用于阿尔茨海默病相关研究。
T61994	AChE/BChE-IN-8	Others	Others
	AChE/BChE-IN-8 (Compound 5a) 是非竞争性AChE 抑制剂和混合型BChE 抑制剂。AChE/BChE-IN-8抑制电鳗 AChE (EeAChE) 和马 BChE (eqBChE) 的Ki 值分别为 0.788 μM 和 2.364 μM。AChE/BChE-IN-8 具有血脑屏障通透性和低细胞毒性。
T73187	BuChE-IN-7	Others	Others
	BuChE-IN-7 是一种 hBuChe 和 eqBuChE 的高选择性抑制剂，IC50分别为 40 nM、80 nM。BuChE-IN-7 能透过血脑屏障促进认知，改善了情境性与恐惧性记忆，表现出对新事物的偏好。
T78905	AChE-IN-29	Others	Others
	AChE-IN-29，是一款3-OH 吡咯烷衍生的胆碱酯酶 (ChE) 抑制剂。针对hAChE、eeAChE及eqBChE的抑制活性表现出的IC50值分别为0.25 μM、0.23 μM和0.72 μM，可作为阿尔茨海默病研究中的实验化合物。
T79342	BChE-IN-17	Others	Others
	BChE-IN-17（compound 6n）是一种高效的BChE选择性抑制剂，对eqBChE和hBChE的IC50值为10.5 nM和32.5 nM。与AChE相比，其对BChE的选择性提高了1000倍，且表现出较低的神经毒性和中等程度的神经保护效果。
T37492	11-trans Leukotriene C4 11-trans Leukotriene C4	Others	Others
	11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils, but not in human neutrophils or RBL-1 cells. It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum. In a radioligand binding assay using guinea pig ileum ...
T62441	AChE-IN-14	Others	Others
	AChE-IN-14 是一种有效的胆碱酯酶抑制剂，能够作用于电鳗乙酰胆碱酯酶 (eeAChE) (IC50: 0.46 μM)、人重组乙酰胆碱酯酶 (hAChE) (IC50: 0.48 μM) 和马血清丁酰胆碱酯酶 (eqBuChE) (IC50: 0.44 μM)。AChE-IN-14 对人 H3 受体 (H3R) 的亲和力高 (Ki: 159.8 nM)。AChE-IN-14 能够用于研究阿尔茨海默病。
T38161	STING Agonist C11 STING Agonist C11	Others	Others
	STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses gro...

化合物

β-Endorphin, equine

Cat.No: TP1647

β-Endorphin, equine (TFA)

Cat.No: TP1391

Cat.No: T1172

Synonym: 地克珠利,R-64433

Target: Antibiotic, Parasite

Cat.No: T21900

Synonym: (E)-2-((1,4-二甲基哌嗪-2-亚基)氨基)-5-硝基-N-苯基苯甲酰胺

Target: Others

Cat.No: T8498

Synonym: Beta-d-N4-hydroxycytidine

Target: Virus Protease, HCV Protease, SARS-CoV, Topoisomerase

Cat.No: T1060

Synonym: Flumigal,氟甲喹,R-802

Target: Topoisomerase, Antibacterial, Antibiotic

Cat.No: T19897

Synonym: 2-(2-萘氧基)乙醇,2-(naphthalen-2-yloxy)ethanol

Target: Others

Cat.No: T19776

Synonym: Equilenine,E 400,NSC 9901,d-Equilenin

Target: Others

Encephalitic alphavirus-IN-1

Cat.No: T63218

Target: Others

Cat.No: T60529

Target: Others

Cat.No: T61399

Target: Others

NHC-diphosphate

Cat.No: T36880

Target: Others

AChE/BChE-IN-3 hydrochloride

Cat.No: T60831

Target: Others

Cat.No: T79502

Target: Others

Cat.No: T79423

Target: Others

Multitarget AD inhibitor-1

Cat.No: T39678

Target: Others

Cat.No: T79501

Target: Others

Cat.No: T61994

Target: Others

Cat.No: T73187

Target: Others

Cat.No: T78905

Target: Others

Cat.No: T79342

Target: Others

11-trans Leukotriene C4

Cat.No: T37492

Synonym: 11-trans Leukotriene C4

Target: Others

Cat.No: T62441

Target: Others

STING Agonist C11

Cat.No: T38161

Synonym: STING Agonist C11

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T76027	β-Endorphin, equine TFA	Others	Others
	β-Endorphin, equine TFA，是具备强效亲和力于μ和δ阿片受体(μ/δ opioid receptors)的内源性阿片类多肽，主要功能包括止痛。
TN7524	Bassianin	Others	Others
	Bassianin, a fungal metabolite identified in Beauveria, demonstrates inhibition of Mg2+-, Ca2+-, and Na+/K+-ATPase activities in equine erythrocyte ghosts, with inhibition rates of 81%, 58%, and 23%, respectively, at a concentration of 200 µg/ml. Additionally, bassianin exhibits cytotoxic properties against Sf9 and Sf21 insect cells, with 50% cytotoxic concentration (CC50) values of 4.91 µM and 12.12 µM, respectively.
T35779	Oosporein	Others	Others
	Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ...

天然产物

β-Endorphin, equine TFA

Cat.No: T76027

Target: Others

Cat.No: TN7524

Target: Others

Cat.No: T35779

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00512	Influenza A H7N7 (A/equine/Kentucky/1a/1975) Hemagglutinin/HA Protein (His) Harvey rat sarcoma viral oncogene homolog	H7N7	Baculovirus Insect Cells
	Influenza A H7N7 (A/equine/Kentucky/1a/1975) Hemagglutinin/HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 61.6 kDa and the accession number is B8K0J1.
TMPY-00200	Influenza A H3N8 (A/equine/Gansu/7/2008) Hemagglutinin/HA1 Protein (His) Harvey rat sarcoma viral oncogene homolog	H3N8	Baculovirus Insect Cells
	Influenza A H3N8 (A/equine/Gansu/7/2008) Hemagglutinin/HA1 Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 37.9 kDa and the accession number is C6ZEJ7.
TMPJ-00038	IL-7 Protein, Mouse, Recombinant (His) interleukin-7,白介素,IL-7,IL-7 interleukin-7,PBGF,Lymphopoietin...	Mouse	HEK293 Cells
	Mouse interleukin-7(IL-7) is the member of hemopoietin family which is important to the differentiation, proliferation, and survival of lymphocyte. Mouse IL-7 shares approximately 88% aa sequence identity with rat IL-7 and 58-60% with human, equine, bovine, ovine, porcine, feline and canine IL-7. It is widely expressed in primary and secondary lymphoid tissues cell and stromal epithelial cells of the thymus, bone marrow, and intestines. IL-7 activation of IL-7 R alpha is critical for both T cell...
TMPJ-01011	FGF-9 Protein, Mouse, Recombinant (His) heparin-binding growth factor-9,GAF,HBGF-9,Glia-activating f...	Mouse	E. coli
	Fibroblast growth factor-9 (FGF-9) is an approximately 26 kDa secreted glycoprotein of the FGF family. Secreted mouse FGF-9 lacks the N-terminal 1-3 aa and shares >98% sequence identity with rat, human, equine, porcine and bovine FGF-9. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In the mouse embryo the location and timing of FGF-9 expression affects development of the skeleton, cerebellum, lungs, heart, v...
TMPK-00954	Hyaluronidase 2/HYAL2 Protein, Human, Recombinant (His) LuCa-2,Hyaluronidase 2,LUCA2,HYAL2,Hyal-2,Hyaluronidase-2	Human	HEK293 Cells
	Hyaluronidases, a family of enzymes that are able to degrade hyaluronic acid (HA), are employed in medicine to increase drug diffusion and reverse the effects of HA filler injections. Hyaluronidases are able to dissolve subcutaneous nodules or to correct excessive quantities of injected filler. Upregulation of hyaluronidase 2 (HYAL2), one of somatic hyaluronidase (HAase), was demonstrated in granulation tissue during the healing of equine superficial digital flexor tendon injuries. Hyaluronidase...
TMPK-00725	Hyaluronidase 2/HYAL2 Protein, Mouse, Recombinant (His) Hyaluronidase-2,Hyal-2,Hyaluronidase 2,HYAL2	Mouse	HEK293 Cells
	Hyaluronidases, a family of enzymes that are able to degrade hyaluronic acid (HA), are employed in medicine to increase drug diffusion and reverse the effects of HA filler injections. Hyaluronidases are able to dissolve subcutaneous nodules or to correct excessive quantities of injected filler. Upregulation of hyaluronidase 2 (HYAL2), one of somatic hyaluronidase (HAase), was demonstrated in granulation tissue during the healing of equine superficial digital flexor tendon injuries. Hyaluronidase...
TMPJ-01051	Pleiotrophin/PTN Protein, Mouse, Recombinant (His) HBGF-8,OSF-1,PTN,HBBM,Pleiotrophin,Heparin-binding brain mit...	Mouse	HEK293 Cells
	Pleiotrophin (PTN) is a secreted, strongly heparinbinding, developmentally regulated cytokine. PTN is a highly conserved protein，Human, mouse, rat, canine, porcine, equine and bovine PTN share 98% aa sequence identity or greater. PTN and midkine share 50% amino acid (aa) sequence identity, share some functions, and constitute a family. During development, PTN is involved in development of brain, bone, and organs undergoing branching morphogenesis. PTN causes PTPRB dimerization and inactivates it...
TMPJ-00028	CCL2 Protein, Mouse, Recombinant Ccl2,Je,Mcp1,C-C motif chemokine 2,Platelet-derived growth f...	Mouse	E. coli
	C-C motif chemokine 2 (CCL2) is a member of the C-C or β chemokine family. Mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence, and 58%, 56%, 55%, 53% and 53% aa identity with human, equine, porcine, bovine and canine CCL2, respectively. Fibroblasts, glioma cells, smooth muscle cells, endothelial cells, lymphocytes and mononuclear phagocytes can produce CCL2 either constitutively or upon mitogenic stimulation, but monocytes and macrophages appear to be the major...
TMPJ-01182	SIRP alpha Protein, Mouse, Recombinant (MIgG2a) SIRP,CD172 Antigen-Like Family Member A,SIRPA,MFR,Signal-Reg...	Mouse	HEK293 Cells
	SIRPα is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain. Mouse SIRP alpha ECD shares 61%, 75%, 62%, 61%, and 59% aa sequence identity with human, rat, equine, bovine, and porcine SIRP alpha, respectively.SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-l...
TMPJ-00948	Endostatin Protein, Mouse, Recombinant (His) antiangiogenic agent,type XVIII,collagen α-1(XVIII)chain,col...	Mouse	HEK293 Cells
	Endostatin, an endogenous non‑glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMP‑2 and MMP‑9, and cathepsins S, B and L. The N‑terminal ~27 aa of Endostatin appear to contain the majority of its activity. This region contains zinc binding sites that are thought to be critical for its anti‑endothelial and anti‑tumor effects, as well as multiple cleavage sites that, when used, can modify its activity. Mouse End...

重组蛋白

Influenza A H7N7 (A/equine/Kentucky/1a/1975) Hemagglutinin/HA Protein (His)

Cat.No: TMPY-00512

Species: H7N7

Expression System: Baculovirus Insect Cells

Influenza A H3N8 (A/equine/Gansu/7/2008) Hemagglutinin/HA1 Protein (His)

Cat.No: TMPY-00200

Species: H3N8

Expression System: Baculovirus Insect Cells

IL-7 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00038

Species: Mouse

Expression System: HEK293 Cells

FGF-9 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01011

Species: Mouse

Expression System: E. coli

Hyaluronidase 2/HYAL2 Protein, Human, Recombinant (His)

Cat.No: TMPK-00954

Species: Human

Expression System: HEK293 Cells

Hyaluronidase 2/HYAL2 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00725

Species: Mouse

Expression System: HEK293 Cells

Pleiotrophin/PTN Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01051

Species: Mouse

Expression System: HEK293 Cells

CCL2 Protein, Mouse, Recombinant

Cat.No: TMPJ-00028

Species: Mouse

Expression System: E. coli

SIRP alpha Protein, Mouse, Recombinant (MIgG2a)

Cat.No: TMPJ-01182

Species: Mouse

Expression System: HEK293 Cells

Endostatin Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00948

Species: Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T36021	Flumequine-13C3 Flumequine-13C3
	Flumequine-13C3is intended for use as an internal standard for the quantification of flumequine by GC- or LC-MS. Flumequine is a fluoroquinolone antibiotic.1It is active againstS. aureus, S. pyogenes, B. subtilis, E. coli, P. aeruginosa, S. faecalis, andK. pneumoniae(MICs = 1-100 μg/ml). Flumequine is also active against field isolates of B. hyodysenteriae (MICs = 6.25-200 μg/ml).2It inhibits DNA gyrase, disrupting supercoiling of bacterial DNA to block transcription and replication.3In vivo, fl...
T71288	Phenylbutazone-d9
	Phenylbutazone-d9 is intended for use as an internal standard for the quantification of phenylbutazone by GC- or LC-MS. Phenylbutazone is a non-steroidal anti-inflammatory drug and an inhibitor of the peroxidase activity of COX (IC50 = ~100 µM in the presence of hydrogen peroxide). It also inhibits prostaglandin I synthase (IC50 = ~25 µM in the presence of hydrogen peroxide). Phenylbutazone (2 mg/kg) reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-in...
T71984	Enrofloxacin-d5
	Enrofloxacin-d5 is intended for use as an internal standard for the quantification of enrofloxacin by GC- or LC-MS. Enrofloxacin is a fluoroquinolone antibiotic. It is active against panels of Campylobacter, E. coli, and Salmonella isolates (mean MIC50s = 0.06, 0.5, and 0.03 µg/ml, respectively). It is also active against equine isolates of L. intracellularis (MICs = 0.125-0.5 µg/ml). Enrofloxacin inhibits bacterial DNA gyrase. In vivo, enrofloxacin (10 mg/kg) increases survival in a mouse model...

同位素标记化合物

Flumequine-13C3

Cat.No: T36021

Synonym: Flumequine-13C3

Phenylbutazone-d9

Cat.No: T71288

Enrofloxacin-d5

Cat.No: T71984

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼