34
2
46
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3133 |
YM-90709
YM90709,YM 90709 |
IL Receptor; Interleukin | Immunology/Inflammation |
YM-90709是新型的能够抑制IL-5与IL-5受体结合的拮抗剂, 。 | |||
T8462 |
Enoximone
依诺昔酮,烯氟酮 |
PDE | Metabolism |
Enoximone 是一种选择性的,具有口服活性的磷酸二酯酶 III 抑制剂,也是正性肌力血管舒张剂。它通过抑制 cGMP 抑制的 PDE 来诱导血管舒张并增加细胞内 cAMP 水平。它还表现出 PDE4抑制作用,对心肌 PDE4A 的 IC50为 21.1 μM。它用于充血性心力衰竭的研究,并具有支气管扩张,抗哮喘和抗炎作用。 | |||
T1083L |
Theophylline monohydrate
Quibron,茶碱一水合物 |
HDAC; PDE; Adenosine Receptor | Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience |
Theophylline monohydrate (Quibron) 似乎抑制磷酸二酯酶和前列腺素的产生,调节钙通量和细胞内钙分布,并拮抗腺苷。茶碱是黄嘌呤的天然生物碱衍生物,从植物山茶花和小粒咖啡中分离出来。在生理上,该药剂可放松支气管平滑肌,产生血管舒张(脑血管除外),刺激中枢神经系统,刺激心肌,利尿,增加胃酸分泌;它还可以抑制炎症并改善横膈膜的收缩性。 | |||
T30819 |
CGP 20376
CGP-20376,CGP20376 |
Others | Others |
CGP 20376 是一种苯并噻唑化合物,是一种驱虫剂,对嗜酸性粒细胞呼吸爆发的双重剂量依赖性调节体外作用,具有抗纤特性。 | |||
T10497 |
Benralizumab
BIW-8405,MEDI-563 |
Apoptosis; IL Receptor; Interleukin | Apoptosis; Immunology/Inflammation |
Benralizumab (MEDI-563) 是一种靶向白介素 5 受体 α (IL-5Rα) 单克隆抗体,通过增强抗体依赖性细胞介导的细胞毒性促使嗜酸性粒细胞快速进行反应。Benralizumab 可用于严重的嗜酸性哮喘,可用于预防慢性阻塞性肺病加重。 | |||
T31719 |
Etiprednol dicloacetate
BNP 166,BNP166,BNP-166 |
Others | Others |
Etiprednol dicloacetate (BNP-166) 是一种具有抗炎活性的皮质类固醇,可有效降低了脂多糖刺激淋巴细胞中的细胞因子产生,并减弱了凝集素诱导的组织培养中血液单核细胞的增殖。。Etiprednol dicloacetate 抑制嗜酸性粒细胞的积累,可用于哮喘等炎症性气管疾病的研究和治疗克罗恩病。 | |||
T22879 |
JNJ 10191584 maleate
JNJ 10191584 maleate salt,VUF6002 maleate |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
JNJ 10191584 maleate (VUF6002 maleate) 是一种具有口服活性的选择性 H4 受体拮抗剂 (Ki = 26 nM)。 JNJ 10191584 maleate 抑制嗜酸性粒细胞和肥大细胞的趋化性(IC50 = 530 nM 和 138 nM)。 | |||
T3520 |
Setipiprant
KYTH-105,塞替匹仑,ACT-129968 |
GPR; Prostaglandin Receptor | Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation |
Setipiprant (ACT-129968) 是一种口服的选择性 CRTH2 拮抗剂,IC50为6.0 nM。 | |||
TP1597L |
Secretoneurin, rat acetate
Secretoneurin, rat acetate(149146-12-3 Free base) |
Others | Others |
Secretoneurin, rat acetate 是一种 33 个氨基酸的多肽,由分泌粒蛋白 II (SgII) 的蛋白水解加工产生。它在体内和体外诱导大鼠纹状体中的多巴胺释放,它对单核细胞和嗜酸性粒细胞有很强的趋化作用,但对粒细胞没有。 | |||
T4674 |
SB297006
SB 297006 |
CCR | Immunology/Inflammation; Microbiology/Virology |
SB297006 是一种CCR3拮抗剂,IC50为39 nM。它能够显著抑制 CCL11 处理的神经祖细胞的增殖和神经球形成。 | |||
T26470 |
A1777
AA1777,AA-1777,AA 1777 |
Others | Others |
A1777, a selective 5-lipoxygenase inhibitor, reduces leukocytes proliferation without affecting the eosinophils of mast cells. | |||
T15565 |
Imetit dihydrobromide
VUF 8325 dihydrobromide,SKF 91105 dihydrobromide |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Imetit dihydrobromide is a high affinity and effective agonist of histamine H3 and H4 receptors (Ki: 0.3 and 2.7 nM). Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50: 25 nM). | |||
T17099 |
Timapiprant sodium
OC000459 sodium |
Others | Others |
Timapiprant sodium inhibits mast cell activation of Th2 lymphocytes and eosinophils. Timapiprant sodium is a potent and selective D prostanoid receptor 2 antagonist. Timapiprant sodium potently displaces [3H] PGD2 from human recombinant DP2 (Ki=13 nM), ra | |||
T68474 |
RWJ-58643 HCl
|
Others | Others |
RWJ 58643 is a reversible beta-tryptase and trypsin inhibitor. Low-dose RWJ-58643 (100 microg) and budesonide (200 microg) significantly reduced symptoms, eosinophils and levels of IL-5 following NAC. However, higher doses of RWJ-58643 (300 and 600 microg) caused a late eosinophilia and preceding increases in IL-5 compared with placebo. | |||
T37650 |
5(S),15(S)-DiHETE
|
Others | Others |
5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE. It potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB4. 5(S),15(S)-DiHETE is chemotactic for eosinophils with an ED50 value of 0.3 μM. | |||
T37303 |
5-OxoETE
5-KETE,5-OxoETE |
Others | Others |
5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils by a specific dehydrogenase.[1] It stimulates cytosolic calcium levels in neutrophils with an EC50 value of 2 nM.[2] 5-OxoETE selectively stimulates the migration and degranulation of eosinophils and activates the MAPK pathway in stimulated neutrophils via a specific G protein-coupled receptor.[3],[4],[5],[6] | |||
T84937 |
1,1'-Ethylidene-bis-(L-tryptophan)
Peak 97 Contaminant |
Others | Others |
1,1'-Ethylidene-bis-(L-tryptophan) is a potential impurity in L-tryptophan commercial products, promoting EoL-3 eosinophilic leukemia cell proliferation, enhancing eosinophil cationic protein release from human peripheral blood eosinophils, and boosting IL-5 production in human T cells. At 40 µg/kg, it triggers fascia thickening, mast cell infiltration, inflammation, and fibrosis in mouse superficial adipose and panniculus carnosus tissues, serving as an eosinophilia-myalgia syndrome research mo... | |||
T60366 |
Epinastine
|
Others | Others |
Epinastine (WAL801) 是一种抗组胺剂和肥大细胞稳定剂。Epinastine 是一种有效的,选择性的,口服活性的组胺 H1 受体 (histamine H1 receptor) 拮抗剂。Epinastine 还抑制人嗜酸性粒细胞释放 IL-8 并具有抗过敏作用。 | |||
T80882 |
Val-Gly-Ser-Glu
NSC 350591 |
||
Val-Gly-Ser-Glu (NSC 350591) 是一种ECF-A四肽。该化合物能剂量依赖性地提升人类嗜酸性粒细胞的数量,而不影响中性粒细胞的数量,并可与补体包被的绵羊红细胞(EAC3b)形成玫瑰花结。 | |||
T62604 |
Flunisolide hemihydrate
|
Others | Others |
Flunisolide hemihydrate 是一种皮质类固醇,是一种口服具有活力的糖皮质激素受体 (Glucocorticoid receptor) 激活剂,具有抗炎作用。Flunisolide hemihydrate 能够诱导嗜酸性粒细胞凋亡 (apoptosis),能够用于研究哮喘或鼻炎、炎症。 | |||
T37273 |
BLX3887
|
Others | Others |
BLX3887 is an inhibitor of 15-lipoxygenase type 1 (15-LO-1; IC50 = 32 nM in a cell-free enzyme assay).1 It is selective for 15-LO-1 over 15-LO-2, which it does not inhibit, 5-LO (IC50 = 472 nM), and 12-LO (IC50 = 3,310 nM). BLX3887 inhibits the production of 15-LO metabolites selectively in eosinophils over neutrophils when used at a concentration of 10 μM. It also inhibits endocytosis in, and the migration of, isolated human peripheral blood mononuclear cell-derived dendritic cells in vitro. |1... | |||
T84634 |
15(R)-Prostaglandin D2
15R-PGD2 |
Others | Others |
15(R)-Prostaglandin D2作为一种潜在的前列腺素DP(2)受体激动剂,展现出抗炎活性。它能促进人嗜酸性粒细胞内肌动蛋白的聚合,同时提高血小板中的cAMP水平。 | |||
T36603 |
(±)5-HEPE
|
Others | Others |
(±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological... | |||
T76869 |
Lirentelimab
|
||
Lirentelimab (AK002) 是一种人源化IgG1单克隆抗体,目标为唾液酸结合Ig样凝集素8 (SIGLEC8)。该化合物通过诱导IL-5激活的嗜酸性粒细胞细胞凋亡并抑制IL-5介导的肥大细胞激活,用于嗜酸性胃炎、十二指肠炎的研究。 | |||
T37492 |
11-trans Leukotriene C4
11-trans Leukotriene C4 |
Others | Others |
11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils, but not in human neutrophils or RBL-1 cells. It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum. In a radioligand binding assay using guinea pig ileum ... | |||
T38365 |
CAY10597
|
Others | Others |
The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD2. CAY10597, as a racemic mixture, is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 37 nM. The R enantiomer is slightly more potent exhibiting Ki values of 23 and 22 nM at the... | |||
T84623 |
15-deoxy-Δ12,14-Prostaglandin D2
15-deoxy-Δ12,14-PGD2 |
Others | Others |
15-deoxy-Δ12,14-Prostaglandin D2 (15-deoxy-Δ12,14-PGD2) is a PGD2 metabolite functioning as an agonist for the PGD2 receptor 2 (DP2), with a binding affinity (Ki) of 50 nM for the mouse DP2 receptor expressed in HEK293 cell membranes. It activates eosinophils with an EC50 of 8 nM and enhances the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ), initiating PPARγ-mediated transcription at 5 µM concentration. Furthermore, it exhibits cyt... | |||
T85266 |
3-Bromotyrosine TFA
3-bromo-Tyr |
Others | Others |
3-Bromotyrosine, a product of protein oxidation, is generated after eosinophil activation during allergic responses. It serves as a biomarker for eosinophil peroxidase-induced protein oxidation both in vitro and in vivo. Beyond its association with eosinophils, 3-bromotyrosine levels are significantly elevated in peritoneal exudate from K. pneumoniae-infected mice, indicating a fivefold increase compared to uninfected controls, which implies that neutrophils may release increased levels of oxidi... | |||
T84522 |
14,15-Leukotriene C4
Eoxin C4 |
Others | Others |
Leukotriene C4 (14,15-LTC4) is an inflammatory mediator synthesized from arachidonic acid through the actions of 15- and 12-lipoxygenases (LOs), involving intermediates such as 15-HpETE and 14,15-LTA4. Unlike the majority of leukotrienes formed via the 5-LO pathway, 14,15-LTC4 is an eoxin predominantly produced by eosinophils, although mast cells and nasal polyps can also synthesize it. While its physiological roles are not well understood, 14,15-LTC4 exhibits limited contractile activity on gui... | |||
T35955 |
PAR2 (1-6) amide (human) (trifluoroacetate salt)
PAR2 (1-6) amide (human) (trifluoroacetate salt) |
||
PAR2 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR2 and residues 37-42 of the full-length sequence.1It binds to NCTC 2544 cells expressing human PAR2 (Ki= 9.64 μM in a radioligand binding assay) and induces calcium mobilization in the same cells (EC50= 0.075 μM).2PAR2 (1-6) amide (100 μM) reduces colony formation of A549 lung cancer cells.1It induces superoxide prod... | |||
T37261 |
14,15-Leukotriene D4
14,15-Leukotriene D4 |
Others | Others |
14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTD4 is classified as an eoxin (EXD4), because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTD4 as well. Little is known about the physiological actions of 14,15-LTD4. It has weak contractile activity on both ... | |||
T37262 |
14,15-Leukotriene E4
14,15-Leukotriene E4 |
Others | Others |
Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. These metabolites are classified as eoxins because they are formed mostly by eosinophils... | |||
T35453 |
β-Defensin-4 (human) (trifluoroacetate salt)
|
||
β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It induces migration of monocytes in vitro when used at a concentration of 10 nM but does not affect migration of neutrophils and eosinophils. β-Defensin-4 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes. It also stimulates calcium mobilization, migration, and pro... | |||
T83906 |
Tirzepatide sodium
LY3298176 |
||
Tirzepatide 是一种glucagon-like peptide 1 receptor (GLP-1R) 和 G protein-coupled receptor 119 (GPR119)的激动剂。它在表达人类GLP-1R或GPR119的HEK293细胞中诱导cAMP的产生(EC50s分别为6.54和1.01 nM)。Tirzepatide(100 nM)在表达人类GLP-1R或GPR119的HEK293细胞中诱导受体内化。在体内,Tirzepatide(每天10 nmol/kg)降低高脂饮食诱导的肥胖小鼠模型的体重、食物摄入量、血浆leptin、三酸甘油酯和free fatty acids (FFAs)水平、肝脏三酸甘油酯和血糖水平。它通过每三天给药50 nmol/kg的剂量,阻止A. alternata诱导的A. alternata挑战小鼠的支气管肺泡灌洗液(BALF)中嗜酸性粒细胞和淋巴细胞数量的增加。Tirzepatide(每三天50 nmol/kg)抑制由毒蕈碱受体激动剂methacholine (acetyl-β-methylcholine)导致的在糖尿病诱导的哮喘... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1083 |
Theophylline
Theo-24,1,3-Dimethylxanthine,茶碱 |
Endogenous Metabolite; HDAC; PDE; Adenosine Receptor; Autophagy | Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience |
Theophylline (1,3-Dimethylxanthine) 是茶中的甲基黄嘌呤衍生物,具有利尿、平滑肌松弛、支气管扩张、心脏和中枢神经系统兴奋作用。 | |||
T37272 |
9(S),12(S),13(S)-TriHOME
|
Others | Others |
9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01465 |
GM-CSF/CSF2 Protein, Human, Recombinant (E. coli)
Colony-Stimulating Factor,CSF2,CSF,Sargramostim,集落刺激因子,Molgr... |
Human | E. coli |
Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryo... | |||
TMPJ-00051 |
IL-3 Protein, Mouse, Recombinant (His)
Mast cell growth factor,Il3,Multipotential colony-stimulatin... |
Mouse | HEK293 Cells |
Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. In addition, IL-3 also affects the functional activity of mature mast cells, basophils, eosinophils and macrophages.Because of its multiple functions and targets, it was originally studied under different names, including mast cell growth factor P-cell stimulating factor, bu... | |||
TMPY-02550 |
Eotaxin/CCL11 Protein, Human, Recombinant (His)
SCYA11,chemokine (C-C motif) ligand 11 |
Human | E. coli |
CCL11 or chemokine (C-C motif) ligand 11 is a member of the chemokine (C-C motif) ligand family. Chemokin (C-C motif) ligand 11 is a member of the chemokine family. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. Chemokines are a family of small ... | |||
TMPH-02578 |
CHI3L4 Protein, Mouse, Recombinant (His)
Chil4,Secreted protein Ym2,Ym2,Chitinase-3-like protein 4,Ch... |
Mouse | P. pastoris (Yeast) |
Has low chemotactic activity for eosinophils. May play a role in inflammation and allergy. Has no chitinase activity. | |||
TMPJ-00020 |
IL-5 Protein, Human, Recombinant (His & Avi), Biotinylated
白介素,Eosinophil differentiation factor,B-cell differentiation... |
Human | HEK293 Cells |
IL-5 is expressed in eosinophils, NK cells, TC2 CD8+ T cells, mast cells, CD45+ CD4+ T cells, gamma delta T cells and IL-1 beta activated endothelial cells. IL-5 acts as a growth and differentiation factor for both B cells and eosinophils. Relative to B cells, IL-5 appears to induce the differentiation of activated conventional B-2 cells into Ig-secreting cells. In addition, it induces the growth of B-1 progenitors as well as IgM production by B-1 cells.IL-5 appears to perform a number of functi... | |||
TMPK-00772 |
IL-5 Protein, Mouse, Recombinant (His & Avi), Biotinylated
白细胞介素,T-cell replacing factor,IL-5,Interleukin-5,EDF,TRF,白介素 |
Mouse | HEK293 Cells |
IL-5 is an important cytokine for priming and survival of mature eosinophils and for proliferation and maturation of their progenitors. IL-5(Rα) targeting will be increasingly used in diseases where eosinophils are the key immune effector cells such as eosinophilic asthma (EA), hypereosinophilic syndrome (HES), eosinophilic esophagitis (EE), and eosinophilic granulomatosis with polyangiitis (EGPA). IL-5 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells ... | |||
TMPJ-00525 |
LGALS14 Protein, Human, Recombinant (His)
Galectin-14,PPL13,Placental Protein 13-Like,LGALS14,Gal-14,C... |
Human | HEK293 Cells |
Galectin-14 is a member of the Galectin family of carbohydrate binding proteins. The members of Galectin family contain one or two carbohydrate recognition domains, which can bind β-Galactoside. LGALS14 is expressed intracellularly in placenta and eosinophils, and is released by eosinophils following allergen stimulation. LGALS14 may be involved in the development of allergic inflammation. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. | |||
TMPK-00021 |
IL-5 Protein, Human, Recombinant (His & Avi)
Interleukin-5,TRF,IL-5,T-cell replacing factor,白细胞介素,EDF,白介素 |
Human | HEK293 Cells |
IL-5 is an important cytokine for priming and survival of mature eosinophils and for proliferation and maturation of their progenitors. IL-5(Rα) targeting will be increasingly used in diseases where eosinophils are the key immune effector cells such as eosinophilic asthma (EA), hypereosinophilic syndrome (HES), eosinophilic esophagitis (EE), and eosinophilic granulomatosis with polyangiitis (EGPA). IL-5 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with N-His-Avi... | |||
TMPK-00771 |
IL-5 Protein, Mouse, Recombinant (His & Avi)
白介素,Interleukin-5,EDF,TRF,IL-5,白细胞介素,T-cell replacing factor |
Mouse | HEK293 Cells |
IL-5 is an important cytokine for priming and survival of mature eosinophils and for proliferation and maturation of their progenitors. IL-5(Rα) targeting will be increasingly used in diseases where eosinophils are the key immune effector cells such as eosinophilic asthma (EA), hypereosinophilic syndrome (HES), eosinophilic esophagitis (EE), and eosinophilic granulomatosis with polyangiitis (EGPA). IL-5 Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with N-His-Avi... | |||
TMPK-01316 |
CCR8 Protein, Cynomolgus, Recombinant (mFc)
GPR-CY6,CY6,CKRL1,CDw198,CMKBR8,ChemR1,CKR-L1,CD198,CCR-8,TE... |
Cynomolgus | HEK293 Cells |
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis and is alternative coreceptor with CD4 for HIV-1 infection. CCR8 Protein, Cynomolgus, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 29.73 kDa and the accession number is A0A8J8XUI3. | |||
TMPK-00897 |
CCR8 Protein, Human, Recombinant (mFc)
GPR-CY6,CY6,CKRL1,CMKBRL2,TER-1,CDw198,CCR-8,CCR8,CKR-L1,CD1... |
Human | HEK293 Cells |
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis and is alternative coreceptor with CD4 for HIV-1 infection. CCR8 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 30.25 kDa and the accession number is P51685-1. | |||
TMPK-00049 |
IL-3 Protein, Mouse, Recombinant (hFc)
IL3,MULTI-CSF,MCGF,白细胞介素,IL-3MGC79398,IL-3,白介素,interleukin-3 |
Mouse | HEK293 Cells |
Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. IL-3 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 42.2 kDa and the accession num... | |||
TMPK-00896 |
CCR8 Protein, Human, Recombinant (hFc)
GPR-CY6,CKR-L1,CMKBRL2,ChemR1,CDw198,CCR-8,CY6,TER-1,CCR8,CM... |
Human | HEK293 Cells |
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis and is alternative coreceptor with CD4 for HIV-1 infection. CCR8 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 30.62 kDa and the accession number is P51685-1. | |||
TMPK-00590 |
IL-3 Protein, Human, Recombinant (E. coli)
interleukin-3,IL-3,MULTI-CSF,MCGF,IL-3MGC79398,IL3 |
Human | E. coli |
Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. IL-3 Protein, Human, Recombinant(E. coli) is expressed in E. coli expression system. The predicted molecular weight is 15.09 kDa and the accession number is A... | |||
TMPK-00236 |
CEACAM8 Protein, Human, Recombinant (His & Avi), Biotinylated
NCA-95,CD67,CGM6,CD66b,CEACAM8 |
Human | HEK293 Cells |
Eosinophils and their products are likely important in the pathophysiology of allergic diseases, such as bronchial asthma, and in host immunity to parasitic organisms. CD66b (CEACAM8, CGM6, NCA-95) is a single chain, GPI-anchored, highly glycosylated protein belonging to the carcinoembryonic Ag supergene family. CD66b is an activation marker for human granulocytes. | |||
TMPY-02795 |
Eotaxin-2 Protein, Human, Recombinant (His)
MPIF-2,chemokine (C-C motif) ligand 24,SCYA24,MPIF2,Ckb-6 |
Human | Baculovirus Insect Cells |
CCL24, also known as Eotaxin-2 and MPIF-2, belongs to the intercrine beta (chemokine CC) family. CCL24 gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. CCL24 displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. CCL24 is als... | |||
TMPK-00033 |
IL-3 Protein, Human, Recombinant (hFc)
IL3,interleukin-3,IL-3,MULTI-CSF,白介素,白细胞介素,IL-3MGC79398,MCGF |
Human | HEK293 Cells |
Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. IL-3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 41.6 kDa and the accession num... | |||
TMPK-00031 |
IL-3 Protein, Human, Recombinant (His & Avi)
IL-3,IL3,IL-3MGC79398,白介素,interleukin-3,MULTI-CSF,白细胞介素,MCGF |
Human | E. coli |
Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. IL-3 Protein, Human, Recombinant (His & Avi) is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 16.9 kDa and the ... | |||
TMPJ-00532 |
PADI4 Protein, Human, Recombinant (E. coli, His)
PDI5,PADI4,Protein-arginine Deiminase type IV,HL-60 PAD,PADI... |
Human | E. coli |
Protein-Arginine Deiminase Type-4 (PADI4) belongs to the Protein Arginine Deiminase family. PADI4 is expressed in eosinophils and neutrophils, but it is not expressed in peripheral monocytes or lymphocytes. PADI4 catalyzes the citrullination/deimination of arginine residues of proteins. In addition, PADI4 may play an important role in tumourigenesis. Genetic variations in PADI4 are a cause of susceptibility to rheumatoid arthritis (RA), which is a systemic inflammatory disease with autoimmune fe... | |||
TMPK-00655 |
IL-3 Protein, Cynomolgus, Recombinant (His)
MCGF,IL3,MULTI-CSF,IL-3MGC79398,interleukin-3,IL-3 |
Cynomolgus | E. coli |
Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. IL-3 Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 15.13 kDa and the acce... | |||
TMPK-00032 |
IL-3 Protein, Human, Recombinant (His & Avi), Biotinylated
白细胞介素,白介素,interleukin-3,MULTI-CSF,IL-3,IL3,IL-3MGC79398,MCGF |
Human | E. coli |
Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. IL-3 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 16.... | |||
TMPK-00212 |
CD300A Protein, Mouse, Recombinant (His)
MAIR-I,IGSF12,IRp60,Mcipr1,CLM8,NKRL,IRC1,CD300a,Pigr4,CLM-8... |
Mouse | HEK293 Cells |
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.CD300a expression on peritoneal cells is regulated from inflammation to resolution. CD300a activation on mouse bone marrow-derived mast cells regulated ALX/FPR2 expression levels following IgE-mediated activation. CD300A Protein, Mouse, Recombinant (His) is expressed in HEK293 mam... | |||
TMPK-00617 |
IL-13 Protein, Human, Recombinant (His & Avi)
NC30,ALRH,IL13,MGC116786,MGC116789,P600,MGC116788,BHR1,IL-13... |
Human | HEK293 Cells |
Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macro... | |||
TMPK-00561 |
CD300A Protein, Cynomolgus, Recombinant (His)
Mcipr1,IGSF12,IRp60,LMIR1,CD300a,MAIR-I,Pigr4,CLM-8,IRC1,NKR... |
Cynomolgus | HEK293 Cells |
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.CD300a expression on peritoneal cells is regulated from inflammation to resolution. CD300a activation on mouse bone marrow-derived mast cells regulated ALX/FPR2 expression levels following IgE-mediated activation. CD300A Protein, Cynomolgus, Recombinant (His) is expressed in HEK29... | |||
TMPK-00560 |
CD300A Protein, Cynomolgus, Recombinant (Avi), Biotinylated
IGSF12,Mcipr1,NKRL,IRp60,LMIR1,Pigr4,MAIR-I,CLM-8,CD300a,CLM... |
Cynomolgus | HEK293 Cells |
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.CD300a expression on peritoneal cells is regulated from inflammation to resolution. CD300a activation on mouse bone marrow-derived mast cells regulated ALX/FPR2 expression levels following IgE-mediated activation. CD300A Protein, Cynomolgus, Recombinant (Avi), Biotinylated is expr... | |||
TMPK-00186 |
CD300A Protein, Human, Recombinant (Avi)
Mcipr1,CLM-8,MAIR-I,IGSF12,NKRL,LMIR1,CLM8,IRC1,IRp60,CD300a... |
Human | HEK293 Cells |
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.CD300a expression on peritoneal cells is regulated from inflammation to resolution. CD300a activation on mouse bone marrow-derived mast cells regulated ALX/FPR2 expression levels following IgE-mediated activation. CD300A Protein, Human, Recombinant (Avi) is expressed in HEK293 mam... | |||
TMPK-00559 |
CD300A Protein, Cynomolgus, Recombinant (Avi)
LMIR1,NKRL,CLM8,Mcipr1,Pigr4,IGSF12,MAIR-I,IRp60,IRC1,CLM-8,... |
Cynomolgus | HEK293 Cells |
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.CD300a expression on peritoneal cells is regulated from inflammation to resolution. CD300a activation on mouse bone marrow-derived mast cells regulated ALX/FPR2 expression levels following IgE-mediated activation. CD300A Protein, Cynomolgus, Recombinant (Avi) is expressed in HEK29... | |||
TMPK-00187 |
CD300A Protein, Human, Recombinant (Avi), Biotinylated
Pigr4,LMIR1,IGSF12,CLM-8,CD300a,CLM8,IRC1,MAIR-I,Mcipr1,IRp6... |
Human | HEK293 Cells |
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.CD300a expression on peritoneal cells is regulated from inflammation to resolution. CD300a activation on mouse bone marrow-derived mast cells regulated ALX/FPR2 expression levels following IgE-mediated activation. CD300A Protein, Human, Recombinant (Avi), Biotinylated is expressed... | |||
TMPJ-01341 |
CCL24 Protein, Mouse, Recombinant
Scya24,Eosinophil chemotactic protein 2,Small-inducible cyto... |
Mouse | E. coli |
Mouse CCL24 is a secreted protein, which is a member of the CC chemokine subfamily. Mouse Ccl24 cDNA encodes a 119 amino acid residue precursor protein, shares approximately 58% amino acid sequence identity with human Ccl24. It is predominantly expressed in the jejunum and spleen and also be induced in the lung by allergen challengeand IL4. Mouse ccl24 has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Ccl24 is chemotactic for resting T-lymphocytes, ... | |||
TMPJ-00451 |
IL-16 Protein, Human, Recombinant
Interleukin-16,IL16,Lymphocyte Chemoattractant Factor,IL-16,... |
Human | E. coli |
Interleukin-16 (IL-16) is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-... | |||
TMPJ-00574 |
RNASE3 Protein, Human, Recombinant (His)
RNase 3,RNS3,ECP,Eosinophil Cationic Protein,RNASE3,Ribonucl... |
Human | HEK293 Cells |
Ribonuclease 3 (RNASE3) is a basic protein that is localized to the eosinophil primary matrix and belongs to the pancreatic ribonuclease family. RNASE3 is released during degranulation of eosinophils. RNASE3 possesses a wide variety of biological activities. RNASE3 interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). RNASE3 exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. It p... | |||
TMPJ-00019 |
CCL28 Protein, Human, Recombinant
Small-Inducible Cytokine A28,Protein CCK1,CCL28,SCYA28,C-C M... |
Human | E. coli |
Chemokine (C-C Motif) Ligand 28 (CCL28) is a novel chemokine that shares the most homology with CCL27/CTACK. CCL28 shows chemotactic activity for resting CD4, CD8 T-cells and eosinophils. It Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner. CCR10 (GPR2 orphan receptor) is also the receptor for CCL27/CTACK. CCL28 is preferentially expressed by epithelial cells of diverse tissues, with highest expression level in normal and pathological colon. It is also expresse... | |||
TMPJ-00419 |
CD16b Protein, Human, Recombinant (hFc & His)
Fc-γ RIII-beta,FCG3,FcR-10,Fc-gamma RIII-β,FCGR3,FCGR3B,Low ... |
Human | HEK293 Cells |
Low affinity immunoglobulin gamma Fc region receptor III-B, also known as Fc-gamma RIII-beta, FcR-10, IgG Fc receptor III-1, FCG3, FCGR3, CD16b and FCGR3B. FCGR3B is a GPI-anchor membrane protein and contains two Ig-like C2 type domains. FCGR3B can be expressed in orphonuclear leukocytes and stimulated eosinophils. FCGR3B can interact with INPP5D/SHIP1. FCGR3B localizes in the FCGR gene cluster is a CN polymorphic gene involved in the recruitment of polymorphonuclear neutrophils to sites of infl... | |||
TMPJ-01001 |
CCL11 Protein, Human, Recombinant
SCYA11,C-C Motif Chemokine 11,Eosinophil Chemotactic Protein... |
Human | E. coli |
C-C Motif Chemokine 11 (CCL11) is a secreted protein that belongs to the intercrine beta (chemokine CC) family. In response to the presence of allergens, CCL11 selectively recruits eosinophils, a prominent feature of allergic inflammatory reactions. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for CCL11 include CCR2, CCR3 and CCR5. However, it has been found that CCL11 has high degree selectivity for its recept... | |||
TMPJ-00852 |
CCL2 Protein, Rat, Recombinant (His)
C-C motif chemokine 2,Small-inducible cytokine A2,Monocyte c... |
Rat | HEK293 Cells |
Monocyte chemoattractant protein 1 (MCP-1), also called CCL2, is a member of the beta (C-C) subfamily of chemokines that is a chemoattractant for monocytes and basophils but not eosinophils or neutrophils. CCL2 binds the cognate receptor CCR2, and together this signaling pair has been shown to have multiple pro-tumorigenic roles, from mediating tumor growth and angiogenesis to recruiting and usurping host stromal cells to support tumor progression. CCL2 is found in the circulation, where it has ... | |||
TMPJ-00877 |
IL-2 Protein, Rat, Recombinant (His)
白介素,白细胞介素,IL2,Interleukin-2,TCGF,IL-2,T-cell growth factor,A... |
Rat | HEK293 Cells |
Interleukin-2(IL-2)is a O-glycosylated four α-helix bundle cytokine that has potent stimulatory activity for antigenactivated T cells. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. Mature rat IL-2 shares 66% and 73% amino acid sequence identity with human and mouse IL-2,respectively. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is a powerful immunoregulatory lymphokine... | |||
TMPJ-01361 |
Siglec-8 Protein, Human, Recombinant (mFc)
CD329 antigen,Siglec-8,SAF2SAF-2,CDw329,Siglec8,SAF-2,SAF2 |
Human | HEK293 Cells |
Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8, is an approximately 75 kDa transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Siglec-8 is expressed on eosinophils, basophils, and mast cells, and it shows a binding preference for the carbohydrate 6-O sulfated sLex. At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Mature human Siglec-8 c... | |||
TMPJ-00831 |
CCL3 Protein, Mouse, Recombinant (His)
LD78 α,MIP-1 α,MIP1-a,MIP-1 alpha,LD78 alpha,chemokine (C-C ... |
Mouse | E. coli |
C-C Motif Chemokine 3 (MIP-1 alpha,CCL3 ) is a member of the beta or CC subfamily of chemokines and is closely related to CCL4/MIP-1 beta. CCL3 expression can be induced in a variety of hematopoietic cells, fibroblasts, smooth muscle cells, and epithelial cells. Mature mouse CCL3 shares 73%, 91%, and 82% amino acid sequence identity with human, rat, and cotton rat CCL3, respectively. CCL3 exerts its biological functions through interactions with CCR1, CCR3, and CCR5. It is cleared from the extra... | |||
TMPY-01480 |
LTC4S Protein, Human, Recombinant (His)
LTC4S,MGC33147,leukotriene C4 synthase |
Human | Baculovirus Insect Cells |
Leukotriene C4 synthase, also known as LTC4 synthase, Leukotriene-C(4) synthase, and LTC4S, is a multi-pass membrane protein that belongs to the MAPEG family. LTC4S is detected in the lung, platelets, and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells, and platelets. LTC4S is essential for the production of cysteinyl leukotrienes (Cys... | |||
TMPJ-00920 |
CD40 Ligand Protein, Mouse, Recombinant (aa 112-260, His)
TNFSF5,Tumor necrosis factor ligand superfamily member 5,CD4... |
Mouse | HEK293 Cells |
CD40 Ligand, also known as TNFSF5, CD154, is a type II transmembrane glycoprotein member of the TNF superfamily. Mature mouse CD40 Ligand consists of a 22 amino acid (aa) cytoplasmic domain, a transmembrane segment, and a 214 aa extracellular region. CD40 Ligand is expressed as a homotrimer on platelets and activated T cells and B cells. It is upregulated following stimulation of basophils, eosinophils, fibroblasts, mast cells, monocytes, natural killer cells, vascular endothelial cells, and sm... | |||
TMPY-05353 |
CCL26 Protein, Human, Recombinant
MIP-4alpha,SCYA26,MIP-4a,chemokine (C-C motif) ligand 26,IMA... |
Human | Baculovirus Insect Cells |
The eotaxin subfamily of CC chemokines consists of eotaxin-1/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26. All eotaxins induce the trafficking of eosinophils to the sites of inflammation via CC chemokine receptor 3 (CCR3), which is also expressed by several different cell types, including basophils, dendritic cells, smooth muscle cells, epithelial cells and fibroblasts. The sequence similarity between the three eotaxins is limited (<4%), but their functional properties are very similar. Eotaxin-1 ... | |||
TMPY-03728 |
CCL28 Protein, Human, Recombinant (His)
MEC,SCYA28,chemokine (C-C motif) ligand 28,CCK1 |
Human | E. coli |
CCL28 chemokine is expressed by epithelial cells of various mucosal tissues. This chemokine binds to CCR3 and CCR10 receptors and plays an essential role in the IgA antibody secreting cells (IgA-ASC) homing to mucosal surfaces and lactating mammary gland as well. Besides, CCL28 has been shown to exert a potent antimicrobial activity against both Gram-negative and Gram-positive bacteria and fungi. The potent antimicrobial function of CCL28 combined with its wide distribution in mucosal tissues an... | |||
TMPY-00564 |
MCP-4 Protein, Human, Recombinant (His)
MCP-4,CCL13,SCYL1,NCC-1,MCP4,NCC1,CKb10,SCYA13,chemokine (C-... |
Human | P. pastoris (Yeast) |
Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. CCL13/MCP-4, is a CC family chemokine that is chemoattractant for eosinophils, basophils, monocytes, macrophages, immature dendritic cells, and T cells, and its capable of inducing crucial immuno-modulatory responses through its effects on epithelial, muscular and endothelial cells. Similar to other CC chem... | |||
TMPJ-00060 |
IL-25/IL17E Protein, Human, Recombinant (His)
白细胞介素,IL17E,白介素,IL-17E,IL-25,IL25,Interleukin-25,Interleukin... |
Human | HEK293 Cells |
Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins, which is comprised of six members (IL-17, IL-17B through IL-17F). These proteins are secreted and are structurally related by sharing a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 family proteins are pro-inflammator... | |||
TMPY-04391 |
Lyn Protein, Human, Recombinant (GST)
JTK8,LYN proto-oncogene, Src family tyrosine kinase,p56Lyn,p... |
Human | Baculovirus Insect Cells |
Tyrosine-protein kinase Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. Tyrosine-protein kinase Lyn has many functions. Lyn kinase may downregulate the expression of stem cell growth factor receptor (KIT). Lyn kinase Acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between prolif... | |||
TMPH-02690 |
PLA2G10 Protein, Mouse, Recombinant (His & Myc)
Pla2g10,Group X secretory phospholipase A2,Phosphatidylcholi... |
Mouse | E. coli |
Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls. Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density li... |