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Search Results for " endoribonuclease "

Targets Recommended: IRE1

6

抑制剂 & 化合物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9564	IRE1α kinase-IN-1	IRE1	Cell Cycle/Checkpoint
	IRE1α kinase-IN-1 是IRE1α 的选择性抑制剂(IC50为 77 nM)，对 IRE1α 的选择性高于 IRE1β 亚型 100 倍。它抑制内质网诱导的 IRE1α 寡聚和自磷酸化，并抑制 IRE1α RNase 活性 (IC50=80 nM)。
T11669	IR415	HBV	Microbiology/Virology
	IR415 选择性地与 HBx 相互作用 (Kd=2 nM) 并阻断 HBV 介导的 RNAi 抑制，逆转 HBx 蛋白对 Dicer 核糖核酸内切酶活性的抑制作用。IR415 具有抗 HBV 的活性。
T63951	ZINC000104379474	Others	Others
	ZINC000104379474 是靶向 SARS-CoV-2 内切核糖核酸酶的化合物。
T24098	GP17 GP-17,GP 17	Others	Others
	GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.
T24099	GP29 GP-29,GP 29	Others	Others
	GP29 is a Type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.
T38234	HCoV-229E-IN-1	Others	Others
	HCoV-229E-IN-1 is a potent inhibitor of HCoV-229E replication, with an EC50 of 0.65 μM and 0.6 μM in MTS and CPE cells, respectively[1]. HCoV-229E-IN-1 (compound 5h) (0.01-100 μM) fully suppresses the capacity of HCoV-229E replication in a dose-dependent manner[1].HCoV-229E-IN-1 (12 μM) fully prevented the formation of dsRNA intermediates of CoV RNA synthesis[1]. [1]. Stevaert A, et, al. Betulonic Acid Derivatives Interfering with Human Coronavirus 229E Replication via the nsp15 Endoribonuclease...

化合物

IRE1α kinase-IN-1

Cat.No: T9564

Target: IRE1

Cat.No: T11669

Target: HBV

ZINC000104379474

Cat.No: T63951

Target: Others

Cat.No: T24098

Synonym: GP-17,GP 17

Target: Others

Cat.No: T24099

Synonym: GP-29,GP 29

Target: Others

Cat.No: T38234

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00617	MazF Protein, E. coli, Recombinant (His) mRNA interferase MazF,Toxin MazF,mazF,Endoribonuclease	E. coli	P. pastoris (Yeast)
	MazF Protein, E. coli, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 13.6 kDa and the accession number is P0AE70.
TMPH-03582	MazF Protein, S. epidermidis, Recombinant (His) Endoribonuclease MazF,mRNA interferase MazF,mazF,To...	Staphylococcus epidermidis	E. coli
	Toxic component of a type II toxin-antitoxin (TA) system. Ribosome-independent, sequence-specific endoribonuclease that cleaves mRNA, thus inhibiting protein synthesis and inducing bacterial stasis. It cuts between the first and nucleotides of 5'-UACAU-3' in single-stranded RNA. Neutralized by coexpression with cognate antitoxin MazE. MazF Protein, S. epidermidis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 19.0 kDa and the acce...
TMPH-03565	MazF Protein, S. aureus, Recombinant (His) Toxin MazF,mRNA interferase MazF,mazF,Endoribonuclease	Staphylococcus aureus	E. coli
	Toxic component of a type II toxin-antitoxin (TA) system. Ribosome-independent, sequence-specific endoribonuclease that cleaves mRNA, thus inhibiting protein synthesis and inducing bacterial stasis. It cuts between the first and nucleotides of 5'-UACAU-3' in single-stranded RNA. Neutralized by coexpression with cognate antitoxin MazE. MazF Protein, S. aureus, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 17.4 kDa and the accession...
TMPH-02049	ZC3H12A Protein, Human, Recombinant (His) Regnase-1,ZC3H12A,Zinc finger CCCH domain-containing protein...	Human	E. coli
	ZC3H12A Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-02640	ZC3H12A Protein, Mouse, Recombinant (His & Myc) Zinc finger CCCH domain-containing protein 12A,Zc3h12a,Monoc...	Mouse	E. coli
	ZC3H12A Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 73.0 kDa and the accession number is Q5D1E7.
TMPH-00574	Adenylate cyclase Protein, E. coli, Recombinant (His) cyaA,EC:4.6.1.1,Adenylyl cyclase,ATP pyrophosphate-lyase	E. coli	E. coli
	Catalyzes the formation of the second messenger cAMP from ATP. Its transcript is probably degraded by endoribonuclease LS (rnlA), decreasing cAMP levels and the negative regulator Crp-cAMP, which then induces its own transcription again.
TMPH-00731	RpoS Protein, E. coli, Recombinant RNA polymerase sigma factor RpoS,rpoS,Sigma S,Sigma-38	E. coli	E. coli
	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. Controls, positively or negatively, the expression of several hundred genes, which are mainly involved in metabolism, transport, regulation and stress management.; Protects stationary phase cells from killing induced by endoribonuclease MazF.
TMPH-00730	RpoS Protein, E. coli, Recombinant (His) Sigma S,rpoS,RNA polymerase sigma factor RpoS,Sigma-38	E. coli	E. coli
	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. Controls, positively or negatively, the expression of several hundred genes, which are mainly involved in metabolism, transport, regulation and stress management.; Protects stationary phase cells from killing induced by endoribonuclease MazF.
TMPJ-01007	HRSP12 Protein, Human, Recombinant (His) p14.5,UK114 Antigen Homolog,Heat-Responsive Protein 12,Ribon...	Human	E. coli
	Heat-Responsive Protein 12 (HRSP12) is an endoribonuclease that belongs to the Rut family. HRSP12 is found mainly in the human adult kidney and liver and is responsible for inhibiting protein translation by cleaving mRNA. HRSP12 only cleaves phosphodiester bonds in single-stranded RNA and inhibits cell-free protein synthesis. The levels of both mRNA and protein are markedly reduced in heptatocellular tumors and in human hepatoma cell lines compared with normal liver tissues. Moreover the levels ...

重组蛋白

MazF Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00617

Species: E. coli

Expression System: P. pastoris (Yeast)

MazF Protein, S. epidermidis, Recombinant (His)

Cat.No: TMPH-03582

Species: Staphylococcus epidermidis

Expression System: E. coli

MazF Protein, S. aureus, Recombinant (His)

Cat.No: TMPH-03565

Species: Staphylococcus aureus

Expression System: E. coli

ZC3H12A Protein, Human, Recombinant (His)

Cat.No: TMPH-02049

Species: Human

Expression System: E. coli

ZC3H12A Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02640

Species: Mouse

Expression System: E. coli

Adenylate cyclase Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00574

Species: E. coli

Expression System: E. coli

RpoS Protein, E. coli, Recombinant

Cat.No: TMPH-00731

Species: E. coli

Expression System: E. coli

RpoS Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00730

Species: E. coli

Expression System: E. coli

HRSP12 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01007

Species: Human

Expression System: E. coli

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