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Search Results for " encephalopathy "

Targets Recommended: Antibacterial Antibiotic

6

抑制剂 & 化合物

4

天然产物

7

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T2096	Framycetin sulfate Neomycin Sulphate B,硫酸新霉素B,Framycetin sulphate	Antibacterial; Antibiotic	Microbiology/Virology
	Framycetin sulfate (Neomycin Sulphate B) 是一种氨基糖苷类抗生素，是 RNase P 裂解活性抑制剂，Ki 为 35 μM。它抑制锤头状核酶，Ki 值为 13.5 μM，可用于肝性脑病和肠致病性大肠杆菌感染的研究。
T25384	Erbulozole R-55104,R55104,R 55104	Microtubule Associated	Cytoskeletal Signaling
	Erbulozole (R 55104) 是一种有效的合成微管抑制剂，具有抗侵袭、抗肿瘤和放射增敏活性，可诱发 Wernicke 脑病样神经毒性。
T19399	L-Ornithine L-aspartate Ornithine Aspartate,L-鸟氨酸 L-天冬氨酸	Others	Others
	L-Ornithine L-aspartate (Ornithine Aspartate) 由鸟氨酸和天冬氨酸组成。它能够减少血氨浓度，并消除与肝硬化相关的肝性脑病的症状。
T25458	Golexanolone Golexanolonum,Golexanolona,GR-3027	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Golexanolone (Golexanolona) 是一种新的 GABA-A 受体调节类固醇拮抗剂，可减少外周炎症和神经炎症，并改善慢性高氨血症大鼠的认知和运动功能，可用于研究肝性脑病。
T16844	Sarmazenil R-154513,Ro 15-3505	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Sarmazenil (Ro 15-3505) 是苯二氮卓受体部分反向激动剂，具有促惊厥作用，可用于研究慢性肝性脑病（HE）。
T0299	Lactitol monohydrate D-Lactitol monohydrate,单水合乳糖醇	Others	Others
	Lactitol monohydrate (D-Lactitol monohydrate) 是一种乳果糖的糖类似物，是一种糖醇，用作替代甜味剂。有用于便秘和肝性脑病的研究潜力。。

化合物

Framycetin sulfate

Cat.No: T2096

Synonym: Neomycin Sulphate B,硫酸新霉素B,Framycetin sulphate

Target: Antibacterial, Antibiotic

Cat.No: T25384

Synonym: R-55104,R55104,R 55104

Target: Microtubule Associated

L-Ornithine L-aspartate

Cat.No: T19399

Synonym: Ornithine Aspartate,L-鸟氨酸 L-天冬氨酸

Target: Others

Cat.No: T25458

Synonym: Golexanolonum,Golexanolona,GR-3027

Target: GABA Receptor

Cat.No: T16844

Synonym: R-154513,Ro 15-3505

Target: GABA Receptor

Lactitol monohydrate

Cat.No: T0299

Synonym: D-Lactitol monohydrate,单水合乳糖醇

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T0799	Lactulose Duphalac,4-O-β-D-Galactopyranosyl-D-fructose,D-Lactulose,Lactulosum,乳果糖	Others	Others
	Lactulose (Lactulosum) 是一种不易吸收的糖，一般给药 8 到 12 小时后开始发挥药效，但可能需要两天时间改善便秘。它可用于便秘和肝性脑病的研究。
T5231	2-Methylsuccinic acid Pyrotartaric Acid,Methylbutanedioic acid,甲基丁二酸	Others; Endogenous Metabolite	Metabolism; Others
	2-Methylsuccinic acid (Pyrotartaric Acid) 是乙基丙二酸脑病的主要生化指标，是人体液中的正常代谢物。
TN1911	Marein 马里苷,马里甙	transporter; Akt; HDAC; AMPK	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling
	Marein 能通过CaMKK/AMPK/GLUT1促进葡萄糖摄取，IRS/Akt/GSK-3β增加糖原合成，并通过Akt/FoxO1减少糖异生，从而改善 HepG2 细胞中高葡萄糖诱导的胰岛素抵抗。它对甲基乙二醛诱导的 PC12 细胞损伤具有神经保护作用，还有抗氧化、降压、降血脂和抗糖尿病作用。
T4880	L-Dihydroorotic acid	Others; Endogenous Metabolite	Metabolism; Others
	L-Dihydroorotic acid 是一种能够通过二氢乳清酶，能够逆水解产生的无环 L-脲基琥珀酸。

天然产物

Cat.No: T0799

Synonym: Duphalac,4-O-β-D-Galactopyranosyl-D-fructose,D-Lactulose,Lactulosum,乳果糖

Target: Others

2-Methylsuccinic acid

Cat.No: T5231

Synonym: Pyrotartaric Acid,Methylbutanedioic acid,甲基丁二酸

Target: Others, Endogenous Metabolite

Cat.No: TN1911

Synonym: 马里苷,马里甙

Target: transporter, Akt, HDAC, AMPK

L-Dihydroorotic acid

Cat.No: T4880

Target: Others, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03658	ETHE1 Protein, Human, Recombinant (His) YF13H12,HSCO,ethylmalonic encephalopathy 1	Human	E. coli
	ETHE1, also known as HSCO, is a sulfur dioxygenase that localizes within the mitochondrial matrix. ETHE1 probably plays an important role in metabolic homeostasis in mitochondria. It may also function as a nuclear-cytoplasmic shuttling protein that binds transcription factor RELA/NFKB3 in the nucleus and exports it to the cytoplasm. ETHE1 can suppresses p53-induced apoptosis by preventing nuclear localization of RELA. Mutations in ETHE1 gene result in ethylmalonic encephalopathy. Ethylmalonic en...
TMPY-04773	TPK1 Protein, Human, Recombinant (His) THMD5,PP20,HTPK1,thiamin pyrophosphokinase 1	Human	E. coli
	Thiamine pyrophosphokinase (TPK) produces thiamine pyrophosphate, a cofactor for a number of enzymes, including pyruvate dehydrogenase and 2-ketoglutarate dehydrogenase. Episodic encephalopathy type thiamine metabolism dysfunction (OMIM 614458) due to TPK1 mutations is a recently described rare disorder. The genomic variations in the fetal and maternal TPK1 gene could contribute to the variability of birth weight in normal humans.
TMPK-00775	PRNP/Prion Protein, Mouse, Recombinant (hFc) Major prion protein,PrP,ALTPRP,PRIP,PRNP	Mouse	HEK293 Cells
	Prion protein gene (PRNP) variants determine the susceptibility of humans, sheep and mice to prion diseases, whereas polymorphisms in the open reading frame (ORF) of bovine PRNP seem to be unrelated to the incidence of bovine spongiform encephalopathy (BSE). According to the latest reports, the genetic susceptibility of cattle to BSE is associated with polymorphisms ofthe regulatory region of the PRNP gene and the level ofits expression.
TMPJ-00313	Fumarase Protein, Human, Recombinant FH,Fumarase,Fumarate Hydratase Mitochondrial	Human	E. coli
	Fumarase is an enzyme that catalyze the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid or Krebs cycle. Fumarase exists in both form, cytosolic formand N-terminal extend mitochondrial form. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension is the same form as in the cytoplasm. Fumarase is thought to act as a tumor suppressor, which deficiency can lead to progressive encephalopathy, cerebral atrophy...
TMPY-02003	FH/Fumarate Hydratase Protein, Human, Recombinant (His) fumarate hydratase,MCL,LRCC,MCUL1,FMRD,HLRCC	Human	E. coli
	Fumarate Hydratase (FH) is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. Fumarate Hydratase is similar to some thermostable class II fumarases and func...
TMPJ-00834	ACADM Protein, Human, Recombinant (His) ACADM,Medium-Chain Specific Acyl-CoA Dehydrogenase Mitochond...	Human	E. coli
	Medium-Chain Specific Acyl-CoA Dehydrogenase (ACADM) is a mitochondrial fatty acid beta-oxidation that belongs to the acyl-CoA dehydrogenase family. ACADM is a homotetramer enzyme that catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. ACADM is specific for acyl chain lengths of 4 to 16. It is essential for converting these particular fatty acids to energy, especially during fasting periods. Defects in ACADM cause medium-chain acyl-CoA dehydrogenase deficiency, a ...
TMPY-01820	Munc18-1/STXBP1 Protein, Human, Recombinant (His & GST) MUNC18-1,RBSEC1,P67,syntaxin binding protein 1,UNC18,NSEC1	Human	Baculovirus Insect Cells
	Syntaxin-binding protein 1, also known as N-Sec1, Protein unc-18 homolog 1, MUNC18-1 and STXBP1, is a peripheral membrane protein that belongs to the STXBP / unc-18 / SEC1 family. STXBP1 is an evolutionally conserved neuronal Sec1/Munc-18 (SM) protein that is essential in synaptic vesicle release in several species. It may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. STXBP1 is essential for neurotransmission and bin...

重组蛋白

ETHE1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03658

Species: Human

Expression System: E. coli

TPK1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04773

Species: Human

Expression System: E. coli

PRNP/Prion Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00775

Species: Mouse

Expression System: HEK293 Cells

Fumarase Protein, Human, Recombinant

Cat.No: TMPJ-00313

Species: Human

Expression System: E. coli

FH/Fumarate Hydratase Protein, Human, Recombinant (His)

Cat.No: TMPY-02003

Species: Human

Expression System: E. coli

ACADM Protein, Human, Recombinant (His)

Cat.No: TMPJ-00834

Species: Human

Expression System: E. coli

Munc18-1/STXBP1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-01820

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMID-0097	Ethyl-d5-malonic Acid
	Ethyl-d5-malonic Acid 是 Ethyl-malonic Acid 的氘代化合物。Ethyl-malonic Acid 的 CAS 号为 601-75-2。Ethylmalonic acid 是潜在有毒物质，非致癌性，与神经性厌食和甲氧基脱羧酶缺乏症有关。

同位素标记化合物

Ethyl-d5-malonic Acid

Cat.No: TMID-0097

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