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Search Results for " encephalitis "

Targets Recommended: Nucleoside Antimetabolite/Analog Influenza Virus DNA/RNA Synthesis

11

抑制剂 & 化合物

1

天然产物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T8354	Triazavirin	Nucleoside Antimetabolite/Analog; Influenza Virus; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Triazavirin 是一种核酸的核苷类似物和抗病毒剂，通过抑制病毒 RNA 和 DNA 的合成以及基因组片段的复制而起作用。在流感传播阶段，它可作为保护剂。
T4031	S1p receptor agonist 1 S1p-receptor-agonist-1	S1P Receptor; LPL Receptor	GPCR/G Protein
	S1p receptor agonist 1 (S1p-receptor-agonist-1) 是有口服活性的S1P 受体激动剂，具有诱导 S1P1 内化的活性，EC50为9.83 nM。它有潜力用于关节炎和实验性自身免疫性脑炎)的相关研究。
T21900	ML-336 (E)-2-((1,4-二甲基哌嗪-2-亚基)氨基)-5-硝基-N-苯基苯甲酰胺	Others	Others
	ML-336 是一种喹唑啉酮类的委内瑞拉马脑炎病毒 (VEEV) 抑制剂，其VEEV TC-83 CPE(IC50:32 nM)、VEEV V3526 CPE(IC50:20 nM)、VEEV 野生型 CPE (IC50:42 nM)，有效抑制 VEEV 诱导的三种病毒株 (V3526、TC-83和野生型) 细胞病变效应。
T8498	EIDD-1931 Beta-d-N4-hydroxycytidine	Virus Protease; HCV Protease; SARS-CoV; Topoisomerase	DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	EIDD-1931 (Beta-d-N4-hydroxycytidine) 是一种核苷类抗病毒试剂，可抑制丙型肝炎病毒、基孔肯亚病毒和委内瑞拉马脑炎病毒的复制活性。
TNU0007	3'-Deoxy-3'-fluoroadenosine	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	3'-Deoxy-3'-fluoroadenosine 是一种嘌呤核苷类似物，具有广泛的抗肿瘤活性和抗病毒活性，对蜱传脑炎病毒（TBEV），寨卡病毒和西尼罗河病毒（WNV）具有抑制作用，EC50分别为1.1μM、 0.1 μM和4.7 1.5 μM。3'-Deoxy-3'-fluoroadenosine可用于研究肿瘤疾病。
T82297	GluN1(356-385)
	GluN1 (356-385) 是抗NMDAR脑炎抗原肽，能够降低海马神经元表面NMDAR簇密度。该肽段用于探讨抗NMDAR脑炎病理机制。
T63218	Encephalitic alphavirus-IN-1	Others	Others
	Encephalitic alphavirus-IN-1 能够抑制委内瑞拉马脑炎病毒 (VEEV) (EC50: 0.24 μM)和东部马脑炎病毒 (EEEV) (EC50: 0.16 μM)的活性。Encephalitic alphavirus-IN-1 没有明显的细胞毒性，而且表现出较强的小鼠血浆稳定性。
T36880	NHC-diphosphate	Others	Others
	NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a diphosphate form[1]. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV)[1]. Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC.Intracellular levels of the parental compounds and ...
T82296	GluN1(359-378)
	GluN1(359-378)为抗N-甲基-D-天冬氨酸受体(NMDAR)抗体，具有穿透血脑屏障的能力。该化合物主要应用于抗NMDAR脑炎治疗的免疫系统研究。
T82592	DEC-RVRK-CMK Decanoyl-Arg-Val-Arg-Lys-chloromethylketone
	DEC-RVRK-CMK为一种小型合成抗病毒化合物，具不可逆性及细胞渗透性，作为竞争性弗林蛋白酶抑制剂，该化合物对寨卡病毒(ZIKV)和日本脑炎病毒(JEV)显示出显著的抗病毒活性。
T38161	STING Agonist C11 STING Agonist C11	Others	Others
	STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses gro...

化合物

Cat.No: T8354

Target: Nucleoside Antimetabolite/Analog, Influenza Virus, DNA/RNA Synthesis

S1p receptor agonist 1

Cat.No: T4031

Synonym: S1p-receptor-agonist-1

Target: S1P Receptor, LPL Receptor

Cat.No: T21900

Synonym: (E)-2-((1,4-二甲基哌嗪-2-亚基)氨基)-5-硝基-N-苯基苯甲酰胺

Target: Others

Cat.No: T8498

Synonym: Beta-d-N4-hydroxycytidine

Target: Virus Protease, HCV Protease, SARS-CoV, Topoisomerase

3'-Deoxy-3'-fluoroadenosine

Cat.No: TNU0007

Target: Nucleoside Antimetabolite/Analog

Cat.No: T82297

Encephalitic alphavirus-IN-1

Cat.No: T63218

Target: Others

NHC-diphosphate

Cat.No: T36880

Target: Others

Cat.No: T82296

Cat.No: T82592

Synonym: Decanoyl-Arg-Val-Arg-Lys-chloromethylketone

STING Agonist C11

Cat.No: T38161

Synonym: STING Agonist C11

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3795	Corilagin	Apoptosis; TLR; Reverse Transcriptase; Antibacterial; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology
	Corilagin 是一种鞣酸，有抑制 RNA 肿瘤病毒逆转录酶的活性。它抑制金黄色葡萄球菌的生长，MIC 为 25 μg/mL。它有抗肿瘤活性，可用于肝癌和卵巢癌。

天然产物

Cat.No: T3795

Target: Apoptosis, TLR, Reverse Transcriptase, Antibacterial, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02364	Japanese encephalitis virus Genome polyprotein (His & SUMO) Genome polyprotein	JEV	E. coli
	Japanese encephalitis virus Genome polyprotein (His & SUMO) is expressed in E. coli.
TMPY-06802	HSV 2 (strain 333) Glycoprotein D/gD Protein (His)	HSV2	HEK293 Cells
	Herpes simplex viruses (human herpesviruses types 1 and 2) commonly cause recurrent infection affecting the skin, mouth, lips, eyes, and genitals. Herpes simplex virus type 2 (HSV-2) infection is responsible for significant neurological morbidity, perhaps more than any other virus. Herpes simplex virus type 2–associated neurological disease may result from primary infection or reactivation of latent HSV-2. Common severe infections include encephalitis, meningitis, neonatal herpes, and, in immun...
TMPY-00261	Meprin beta Protein, Human, Recombinant (His) meprin A, β,Meprin β,meprin A, beta	Human	HEK293 Cells
	MEP1B (Meprin A Subunit Beta) is a Protein Coding gene. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in the kidney and intestine. Meprins are cell membrane, oligomeric metalloendopeptidases composed of two distinct but evolutionarily related subunits, alpha, and beta. MEP1A is mapped to the short arm of chromosome 6 by the use of radiation and som...

重组蛋白

Japanese encephalitis virus Genome polyprotein (His & SUMO)

Cat.No: TMPH-02364

Species: JEV

Expression System: E. coli

HSV 2 (strain 333) Glycoprotein D/gD Protein (His)

Cat.No: TMPY-06802

Species: HSV2

Expression System: HEK293 Cells

Meprin beta Protein, Human, Recombinant (His)

Cat.No: TMPY-00261

Species: Human

Expression System: HEK293 Cells

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