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Search Results for " electrophilic "

Targets Recommended: TRP/TRPV Channel

11

抑制剂 & 化合物

4

天然产物

2

化合物库

3

重组蛋白

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Cat. No.	Product Name
L7860	Mini片段亲电杂环化合物库		369 compounds
	高溶解度共价杂环片段库中的 369 个化合物
L9411	半胱氨酸共价化合物库		70 compounds
	半胱氨酸共价库包含 70 个化合物。

化合物库

Mini片段亲电杂环化合物库

Cat.No: L7860

Compounds: 369

半胱氨酸共价化合物库

Cat.No: L9411

Compounds: 70

Cat. No.	Product Name	Target	Signaling Pathways
T4385	PF-4840154	TRP/TRPV Channel	Membrane transporter/Ion channel
	PF4840154 是有效的大鼠和人TrpA1通道选择性激动剂，EC50分别为 97 和 23 nM。PF-4840154 可以诱导 TrpA1 介导的小鼠伤害行为。
T8483	Cysteine thiol probe Methyl (4-bromobenzoyl)-L-cysteinate	Others	Others
	Cysteine thiol probe (Methyl (4-bromobenzoyl)-L-cysteinate) 是基于硫醇的探针，旨在标记亲电子的天然产物。它能够结合基于烯酮，β-内酰胺和 β-内酯的亲电子代谢物。它具有理想药效团探针的每个特征，并具有发色团。
T9432	6-Bromo-2-naphthol	Others	Others
	6-Bromo-2-naphthol 是一种亲电卡宾(carbene) 中间体。
T31413	DiaAlk	Others	Others
	DiaAlk is a clickable, electrophilic diazene probe which enables capture and site-centric proteomic analysis of oxidative post-translational modification (OxiPTM).
T73542	DB008	Others	Others
	DB008 是一种有效的选择性PARP16抑制剂，IC50值为 0.27 μM，含有丙烯酰胺亲电试剂。DB008 具有膜渗透性，可选择性标记PARP16。
T81776	MN551	Others	Others
	MN551是一种高效的半胱氨酸定位亲电共价键抑制剂，对SOCS2与其CRL5复合物的生物作用及在PROTACs诱导的目标蛋白降解过程中扮演关键角色。
T78158	MitoCur-1	Others	Others
	MitoCur-1为一种姜黄素类似物，作为线粒体抗氧化硫氧还蛋白还原酶2（TrxR2）抑制剂，展现亲电性与线粒体靶向特性。该化合物能特异性诱导活性氧（ROS）生成，表现出抗肿瘤活性。
T78949	AM841	Cannabinoid Receptor	GPCR/G Protein
	AM841是一种高亲和力的亲电子配体，能与CB1大麻素受体中第六螺旋的半胱氨酸发生共价作用并激活该受体。此外，AM841能减少Forskolin刺激下的cAMP积累，并且减缓胃肠蠕动。
TNU0658	2-bromomethyl benzothizaole	Others	Others
	2-bromomethyl benzothizaole 是苯并噻唑的衍生物。它是一种中间体和构建块亲电试剂，已被用于合成许多化合物，如2-bromo-4-methyl-1,3-benzothiazole，一种用于合成新型抗真菌剂的化合物。
T36614	DL-Sulforaphane N-acetyl-L-cysteine	Others	Others
	Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents. DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is a major ...
T37594	Pericosine A	Others	Others
	Pericosine A is a fungal metabolite that has been found inP. byssoidesand has anticancer activity.1It inhibits the growth of a variety of cancer cells, including breast, colon, lung, ovary, stomach, and prostate cell lines (GI50s = 0.05-24.55 μM) and increases survival in a P388 mouse xenograft model when administered at a dose of 25 mg/kg. Pericosine A inhibits EGFR by 40 to 70% when used at a concentration of 100 μg/ml. It also reacts with organosulfur compounds in skunk spray to form stable t...

化合物

Cat.No: T4385

Target: TRP/TRPV Channel

Cysteine thiol probe

Cat.No: T8483

Synonym: Methyl (4-bromobenzoyl)-L-cysteinate

Target: Others

6-Bromo-2-naphthol

Cat.No: T9432

Target: Others

Cat.No: T31413

Target: Others

Cat.No: T73542

Target: Others

Cat.No: T81776

Target: Others

Cat.No: T78158

Target: Others

Cat.No: T78949

Target: Cannabinoid Receptor

2-bromomethyl benzothizaole

Cat.No: TNU0658

Target: Others

DL-Sulforaphane N-acetyl-L-cysteine

Cat.No: T36614

Target: Others

Cat.No: T37594

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T7995	α-Angelica lactone α-当归内酯,当归内酯,Alpha-Angelica Lactone	Others; GST	Others; oxidation-reduction
	α-Angelica lactone 是一种乙烯基亲核试剂，也是一种天然存在的抗癌剂。它可以得到手性的 δ-氨基 γ，γ-二取代丁烯醇内酯羰基衍生物，并在 γ-碳上表现出亲电子俘获。它通过选择性增强谷胱甘肽-S-硫转移酶 (GST) 和 UDP-葡糖苷转移酶 (UGT) 解毒酶发挥强大的化学保护作用。
PDK0015	4-Hydroxycoumarin	Endogenous Metabolite; Antibacterial; AChR	Metabolism; Microbiology/Virology; Neuroscience
	4-Hydroxycoumarin 是香豆素衍生物，也是通用的杂环支架之一，具有亲电和亲核性质。
TN6750	2-tert-Butyl-1,4-benzoquinone	Nrf2	Immunology/Inflammation
	2-tert-Butyl-1,4-benzoquinone 是丁基化羟基茴香醚 (BHA) 的亲电子代谢物，它在 RAW264.7 细胞中引起 Nrf2 的活化及其负调节剂 Keap1 的 S-芳基化。
T37452	Stephacidin B	Others	Others
	Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively).1It induces apoptosis in HepG2 and Huh7 hepatoc...

天然产物

α-Angelica lactone

Cat.No: T7995

Synonym: α-当归内酯,当归内酯,Alpha-Angelica Lactone

Target: Others, GST

4-Hydroxycoumarin

Cat.No: PDK0015

Target: Endogenous Metabolite, Antibacterial, AChR

2-tert-Butyl-1,4-benzoquinone

Cat.No: TN6750

Target: Nrf2

Cat.No: T37452

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00539	GSTA1 Protein, Human, Recombinant (His) glutathione S-transferase alpha 1,GTH1,GST2,glutathione S-tr...	Human	HEK293 Cells
	GSTA1 (Glutathione S-Transferase Alpha 1) is a Protein Coding gene. This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds. Glutathione S-transferases (GSTs) are involved in the detoxification of carcinogens and may be linked to carcinogenesis. As a vital component of GSTs, GSTA1 plays an important role in carcinogenesis. GSTA1 expression may be a target molecule in the early diagnosis and treatment of lung cancer. Human colonic adeno...
TMPJ-00499	GSTP1 Protein, Human, Recombinant GSTP1,GST3,GST class-pi,Glutathione S-transferase P,FAEES3,G...	Human	E. coli
	Glutathione S-transferase P (GSTP1) is an enzyme that contains 1 GST C-terminal domain, 1 GST N-terminal domain. GSTP1 belongs to the GST superfamily, the GSTs are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione ...
TMPY-03338	GSTZ1 Protein, Human, Recombinant (His) MAI,GSTZ1-1,glutathione S-transferase ζ 1,MAAI,GSTZ1,glutath...	Human	E. coli
	GSTZ1 (Glutathione S-Transferase Zeta 1) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. GSTZ1 gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. GSTZ1 is a bifunctional protein that has minimal glutathione-conjugating activity with ethacrynic acid ...

重组蛋白

GSTA1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00539

Species: Human

Expression System: HEK293 Cells

GSTP1 Protein, Human, Recombinant

Cat.No: TMPJ-00499

Species: Human

Expression System: E. coli

GSTZ1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03338

Species: Human

Expression System: E. coli

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