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Search Results for " dry eye disease "

Targets Recommended: Integrin

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T3977	Lifitegrast SHP-606,SAR 1118,立他司特,利非司特	Integrin	Cytoskeletal Signaling
	Lifitegrast (SAR 1118) 是一种整合素淋巴细胞功能相关抗原 1 拮抗剂，抑制 Jurkat T 细胞附着于ICAM-1的IC50为 2.98 nM。
T7423	Diquafosol tetrasodium 地夸磷索四钠,INS365	P2Y Receptor	GPCR/G Protein; Neuroscience
	Diquafosol tetrasodium (INS365) 是一种 P2Y2 受体激动剂，可刺激眼组织粘蛋白的分泌。它可改善泪膜稳定性和视觉功能，作为干眼症的局部治疗。
T28496	R-932348 choline R-932348,R 348,R 932348,R932348,R-348,R348	Others	Others
	R-932348 choline, a dual JAK/SYK inhibitor, is used potentially for treatment of dry eye disease.
T39293	Tivanisiran SYL1001,Tivanisiran	Others	Others
	Tivanisiran (SYL1001) is a siRNA developed specifically to inhibit the expression of transient receptor potential vanilloid 1 (TRPV1) to explore its implications in dry eye disease research.
T70346	TOP1362	Others	Others
	TOP1362 is a Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders. TOP1362 strongly inhibited the kinase targets p38α, Syk, Src, and Lck, blocked the rise in p38α expression in hyperosmolar Chang cells, and potently reduced inflammatory cytokine release in cellular models of innate and adaptive immunities. In the EIU model, TOP1362 dose-dependently attenuated the LPS-induced rise in inflammatory cell infiltration and o...
T79235	JAK-IN-30	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK-IN-30（化合物31）是一种具有水溶性的JAK抑制剂，对JAK2、JAK1、JAK3及TYK2的IC50值分别为2、15、18及2 nM。该化合物作为研究干眼症（DED）的潜在药物而备受关注。

化合物

Lifitegrast

Cat.No: T3977

Synonym: SHP-606,SAR 1118,立他司特,利非司特

Target: Integrin

Diquafosol tetrasodium

Cat.No: T7423

Synonym: 地夸磷索四钠,INS365

Target: P2Y Receptor

R-932348 choline

Cat.No: T28496

Synonym: R-932348,R 348,R 932348,R932348,R-348,R348

Target: Others

Tivanisiran

Cat.No: T39293

Synonym: SYL1001,Tivanisiran

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04550	JNK2 Protein, Human, Recombinant (His) JNK2α,SAPK1a,PRKM9,JNK2β,JNK2,SAPK,JNK2BETA,mitogen-activate...	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase 9 (MAPK9), also well known as c-Jun N-terminal kinase (JNK2), is a member of the MAP kinase subfamily belonging to the protein kinase superfamily. MAPK9 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating some transcription factors, such as c-Jun and ATF2. The crystal structure of human JNK2 complexed with an indazole inhibitor by applying a high-throughput protein engineering and surface-site mutagenesis approach. A n...