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Search Results for " cyclophilin "

Targets Recommended: Others

17

抑制剂 & 化合物

1

天然产物

17

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10919	Cyclophilin inhibitor 1	Others	Others
	Cyclophilin inhibitor 1 is an effective and orally bioavailable cyclophilin A inhibitor with a Kd of 5 nM, showing potent anti-HCV activity, and an EC50 for HCV 2a of 98 nM.
T64220	Cyclophilin inhibitor 3	Others	Others
	Cyclophilin inhibitor 3 (compound 7c) 是一种 cyclophilin A (CypA) 的有效抑制剂，表现出有效的抗 HCV 作用，其 EC50 值为 4.2 μM。
T9936	ZX-J-19J N-(2,3-Diphenyl-6-quinoxalinyl)octanamide	Others	Others
	ZX-J-19J (N-(2,3-Diphenyl-6-quinoxalinyl)octanamide) 是 Cyclophilin J 的抑制剂，对肿瘤细胞生长有显着的抑制作用，与环孢素 A 相当，但比 5-氟尿嘧啶强得多。
T13171	TMN355 2-氯-N-[(9H-芴-9-氨基)羰基]-6-氟苯甲酰胺	Others	Others
	TMN355 是一种化学亲环素 A 抑制剂，能够抑制泡沫细胞形成和细胞因子分泌，可用于动脉粥样硬化的研究。
T18928	Brilliant Black BN 亮黑1,E 151	Others; Virus Protease	Microbiology/Virology; Others
	Brilliant Black BN (E 151) 是一种偶氮染料和一种食品着色剂。它抑制 EV71 与其细胞脱壳因子亲环蛋白 A 之间的相互作用，是一种很有前途的抗 EV71 感染的抗病毒药物。
T12226	NIM811 SDZ NIM811,(Melle-4)cyclosporin	Others	Others
	NIM811 is an orally bioavailable dual inhibitor of mitochondrial permeability transition and cyclophilin.
T70811	CRV431	Others	Others
	CRV431 is a novel Pan-Cyclophilin Inhibitor, potently inhibiting all cyclophilin isoforms tested - A, B, D, and G (IC50 values ranged from 1-7 nM).
T14180	Alisporivir DEB-025,Debio-025	Others	Others
	Alisporivir (Debio-025) is a cyclophilin inhibitor molecule.It has potent anti-hepatitis C virus (HCV) activity.
T76228	ASP5286
	ASP5286 是一种新型的非免疫 cyclophilin 抑制剂，用于研究 HCV。
T71997	CypD-IN-29	Others	Others
	CypD-IN-29 is a non-peptidic inhibitor of cyclophilin D as a neuroprotective agent in Aβ-induced mitochondrial dysfunction.
TP1665	Cyclosporin D
	Cyclosporin D is a metabolite of cyclosporin A, an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells.
TP1387	Cyclosporin A-Derivative 2
	Derivative 2 is A novel Derivative of Cyclosporin A.Cyclosporin A is an immunosuppressant that binds to cyclophilin and inhibits calcineurin.
T36642	RAS/RAS-RAF-IN-1	Others	Others
	RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a KD of 5.0 μμ-15 μμ for cyclophilin A (CYPA) binding affinity. RAS/RAS-RAF-IN-1 has antitumor activity[1]. RAS/RAS-RAF-IN-1 (compound 89; for 4 hours) has an EC50 of 0.5 μμ-5.0 μμ for BRAF-GTP-KRAS-G12C disruption and has an IC50 of 1.0 μμ-10 μμ for pERK inhibition in H358 cells[1]. [1]. Meizhong Jin, et al. Compounds that participate in cooperative binding and uses thereof. WO2020132597A1.
T63090	SMCypI C31	Others	Others
	SMCypIC31 是一种非肽类 cyclophilin 抑制剂，能够有效抑制肽基-脯氨酰顺/反异构酶 (PPIase) (IC50: 0.1 μM)。SMCypI C31 可以破坏亲环蛋白 A-NS5A 相互作用。SMCypI C31 具有泛基因型抗 HCV 效果，对基因型 1a，1b，2a，3a 和 5a HCV-SGRs 和嵌合基因型 2a/4a HCV-SGRs 的 EC50 范围为 1.20-7.76 μM。
T74965	CypE-IN-1	Others	Others
	CypD-IN-1 是一种有效的亚型选择性亲环蛋白 E (CypE) 抑制剂。CypD-IN-1 具有 CypE 亲和力，IC50和 Ki 值分别为 0.013 μM 和 0.072 μM。CypD-IN-1 可用于多种疾病的研究，如氧化应激、神经退行性疾病、肝病、衰老、自噬和糖尿病。
T74963	CypD-IN-3	Others	Others
	CypD-IN-3是一种高效的CypD (亲环蛋白D) 选择性抑制剂，其对CypD的IC50值仅为0.01 μM。该化合物在氧化应激、神经退行性疾病、肝病、衰老、自噬及糖尿病等多种疾病的研究中有潜在应用。
T74964	CypD-IN-4	Others	Others
	CypD-IN-4是一种针对亲环蛋白D(CypD)的有效亚型选择性抑制剂，展现出0.057 μM的IC50，表明其对CypD具有高度亲和力。该化合物适用于氧化应激、神经退行性疾病、肝病、衰老、自噬及糖尿病等多种疾病的研究。

化合物

Cyclophilin inhibitor 1

Cat.No: T10919

Target: Others

Cyclophilin inhibitor 3

Cat.No: T64220

Target: Others

Cat.No: T9936

Synonym: N-(2,3-Diphenyl-6-quinoxalinyl)octanamide

Target: Others

Cat.No: T13171

Synonym: 2-氯-N-[(9H-芴-9-氨基)羰基]-6-氟苯甲酰胺

Target: Others

Brilliant Black BN

Cat.No: T18928

Synonym: 亮黑1,E 151

Target: Others, Virus Protease

Cat.No: T12226

Synonym: SDZ NIM811,(Melle-4)cyclosporin

Target: Others

Cat.No: T70811

Target: Others

Cat.No: T14180

Synonym: DEB-025,Debio-025

Target: Others

Cat.No: T76228

Cat.No: T71997

Target: Others

Cat.No: TP1665

Cyclosporin A-Derivative 2

Cat.No: TP1387

RAS/RAS-RAF-IN-1

Cat.No: T36642

Target: Others

Cat.No: T63090

Target: Others

Cat.No: T74965

Target: Others

Cat.No: T74963

Target: Others

Cat.No: T74964

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5S1133	Ganoderic acid D 灵芝酸D,灵芝酸 D	Apoptosis; Sirtuin	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Ganoderic acid D 是高度氧化的四环三萜，是灵芝的主要活性成分，可诱导 HeLa 人宫颈癌细胞凋亡。它上调 SIRT3的蛋白质表达并通过 SIRT3 诱导脱乙酰化的亲环蛋白 D 。它抑制结肠癌细胞的能量重编程，包括结肠癌细胞中的葡萄糖摄取，乳酸、丙酮酸和乙酰辅酶的产生。

天然产物

Ganoderic acid D

Cat.No: T5S1133

Synonym: 灵芝酸D,灵芝酸 D

Target: Apoptosis, Sirtuin

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01593	Cyclophilin A Protein, Mouse, Recombinant (His) peptidylprolyl isomerase A (cyclophilin A),Cphn,CyP...	Mouse	E. coli
	Cyclophilin A Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 18.8 kDa and the accession number is P17742.
TMPY-02177	Cyclophilin A Protein, Human, Recombinant (His) CYPA,peptidylprolyl isomerase A (cyclophilin A),HEL...	Human	E. coli
	Cyclophilin A Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 19.4 kDa and the accession number is P62937.
TMPY-01380	Cyclophilin B Protein, Human, Recombinant (His) CYPB,peptidylprolyl isomerase B (cyclophilin B),HEL...	Human	HEK293 Cells
	PPIB is identified as a candidate gene for OI-IX. Osteogenesis imperfecta (OI) is an inherited disorder of connective tissue typically caused by defects in either COL1A1 or COL1A2. A number of other genes causative of this disorder have been found, including PPIB, which forms one subunit of the prolyl 3-hydroxylase enzyme complex. Patients with OI caused by PPIB mutation should have appropriate early and regular management of their hearing.
TMPJ-01389	PPIE Protein, Human, Recombinant (His) Rotamase E,PPIE,Cyclophilin E,PPIase E,CYP33,Cy...	Human	E. coli
	Peptidyl-prolyl cis-trans isomerase E, also known as Cyclophilin E, Cyclophilin-33, Rotamase E, CYP33, PPIE, is an enzyme which belongs to the cyclophilin-type PPIase family of PPIase E subfamily. PPIE found in all the examined tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. PPIE contains one PPIase cyclophilin-type domain and one RRM (RNA recognition motif) domain. PPIE accelerates the folding of proteins. It catalyzes the cis-trans isomerization of ...
TMPY-00156	Cyclophilin F Protein, Human, Recombinant (His) peptidylprolyl isomerase F,CYP3,Cyp-D,CyP-M,CypD	Human	HEK293 Cells
	Cyclophilin F Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.3 kDa and the accession number is A0A024QZS4.
TMPJ-01090	PPID Protein, Human, Recombinant (His) Cyclophilin-40,CYPD,Peptidyl-Prolyl Cis-Trans Isome...	Human	E. coli
	Peptidyl-Prolyl Cis-Trans Isomerase D (PPID) belongs to the cyclophilin-type PPIase family and PPIase D subfamily. PPID is widely expressed and it contains one PPIase cyclophilin-type domain and three TPR repeats. PPID catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerates the folding of proteins. PPID can bind to the immunosuppressant cyclosporine A and is known that its overexpression suppresses the apoptosis in cancer cells.
TMPH-00705	PPIase A Protein, E. coli, Recombinant (His & SUMO) Rotamase A,Cyclophilin A,ppiA,Peptidyl-prolyl cis-t...	E. coli	E. coli
	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
TMPY-03285	PPIL1 Protein, Human, Recombinant (His) CGI-124,PPIase,CYPL1,hCyPX,peptidylprolyl isomerase (cyc...	Human	E. coli
	PPIL1 is a member of the cyclophilin family. Cyclophilins are well conserved and ubiquitous. Members of cyclophilin family take a significant part in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. PPIL1 is a peptidylprolyl isomerase(PPIase). It increases the folding of proteins and catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIL1 is involved in proliferation of cancer cells through modulation of phosphorylation of...
TMPH-00687	PPIase A Protein, E. coli O6:H1, Recombinant (His & Myc & SUMO) ppiA,Cyclophilin A,Peptidyl-prolyl cis-trans isomer...	E. coli	E. coli
	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIase A Protein, E. coli O6:H1, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 38.1 kDa and the accession number is P0AFL4.
TMPY-03413	PPIL2 Protein, Human, Recombinant (aa 280-457, His) UBOX7,Cyp-60,CYP60,CYC4,peptidylprolyl isomerase (cyclop...	Human	E. coli
	PPIL2, is an enzyme that belongs to the cyclophilin family. The cyclophilins are peptidylprolyl isomerases and are highly conserved ubiquitous. They play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. PPIL2 interacts with the proteinase inhibitor eglin c and is localized in the nucleus. It contains 1 PPIL2 cyclophilin-type domain and 1 U-box domain. PPIL2 accelerate the folding of proteins. It catalyzes the cis-trans isomerization of pro...
TMPJ-00676	PPIH Protein, Human, Recombinant (His) Peptidyl-Prolyl Cis-Trans Isomerase H,Rotamase H,PPIase H,Sm...	Human	E. coli
	Peptidyl-Prolyl Cis-Trans Isomerase H (PPIH) belongs to the Cyclophilin-type PPIase family that accelerate the folding of proteins. PPIases can catalyze the cis-trans isomerization of Proline Imidic peptide bonds in oligopeptides. PPIH participates in pre-mRNA splicing. It is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. In addition, PPIH has PPIase activity and may play a role as a chaperone mediating the i...
TMPJ-00971	PPIC Protein, Human, Recombinant (Trx & His) PPIase C,Peptidyl-Prolyl Cis-Trans Isomerase C,PPIC,Cycl...	Human	E. coli
	Cyclophilin C is an enzyme (EC 5.2.1.8) found in both prokaryotes and eukaryotes that interconverts the cis and trans isomers of peptide bonds with the amino acid proline. Proline has an unusually conformationally restrained peptide bond due to its cyclic structure with its side chain bonded to its secondary amine nitrogen. Most amino acids have a strong energetic preference for the trans peptide bond conformation due to steric hindrance, but prolines unusual structure stabilizes the cis form so...
TMPJ-00048	CYPA Protein, Mouse, Recombinant SP18,PPIA,PPIase A,Peptidyl-prolyl cis-trans isomerase A,CYP...	Mouse	E. coli
	Peptidyl-prolyl cis-trans isomerase A is a cytoplasm protein which belongs to the cyclophilin-type PPIase family and PPIase A subfamily. Cyclophilins(CyPs) are a family of proteins found in organisms ranging from prokaryotes to humans. These molecules exhibit peptidyl-prolyl isomerase activity, suggesting that they influence the conformation of proteins in cells. Cyclophilin A accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopep...
TMPJ-01049	CYPA Protein, Human, Recombinant Rotamase A,Peptidyl-prolyl cis-trans isomerase A,PPIase A,PP...	Human	E. coli
	Peptidyl-prolyl cis-trans isomerase A is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, which catalyzes the cis-trans isomerization of proline imidic peptide bonds. Cyclophilin A regulate many biological processes, including intracellular signaling, transcription, inflammation, and apoptosis. Cyclophilin is also incorporated into many viruses, including HIV1, where it has been speculated to be involved in functions such as viral assembly and infectivity. The immunosuppressi...
TMPK-01254	BAFFR/TNFRSF13C Protein, Cynomolgus, Recombinant (His) CVID4,prolixin,TNFRSF13C,CD268,BROMIX,BAFFR,BR3	Cynomolgus	HEK293 Cells
	BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA / TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL (a proliferation-inducing ligand), BAFF R selectively binds BAFF.
TMPK-00070	BAFFR/TNFRSF13C Protein, Human, Recombinant (His & Avi), Biotinylated CD268,TNFRSF13C,BAFFR,BR3,BROMIX,prolixin,CVID4	Human	HEK293 Cells
	BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL (a proliferation-inducing ligand), BAFF R selectively binds BAFF.
TMPJ-00067	BAFFR/TNFRSF13C Protein, Human, Recombinant (His) BR3,BAFFR,CD268,TNFRSF13C,BAFF R	Human	HEK293 Cells
	Tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. BAFF promotes the survival of B cells and is essential for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF...

重组蛋白

Cyclophilin A Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01593

Species: Mouse

Expression System: E. coli

Cyclophilin A Protein, Human, Recombinant (His)

Cat.No: TMPY-02177

Species: Human

Expression System: E. coli

Cyclophilin B Protein, Human, Recombinant (His)

Cat.No: TMPY-01380

Species: Human

Expression System: HEK293 Cells

PPIE Protein, Human, Recombinant (His)

Cat.No: TMPJ-01389

Species: Human

Expression System: E. coli

Cyclophilin F Protein, Human, Recombinant (His)

Cat.No: TMPY-00156

Species: Human

Expression System: HEK293 Cells

PPID Protein, Human, Recombinant (His)

Cat.No: TMPJ-01090

Species: Human

Expression System: E. coli

PPIase A Protein, E. coli, Recombinant (His & SUMO)

Cat.No: TMPH-00705

Species: E. coli

Expression System: E. coli

PPIL1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03285

Species: Human

Expression System: E. coli

PPIase A Protein, E. coli O6:H1, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00687

Species: E. coli

Expression System: E. coli

PPIL2 Protein, Human, Recombinant (aa 280-457, His)

Cat.No: TMPY-03413

Species: Human

Expression System: E. coli

PPIH Protein, Human, Recombinant (His)

Cat.No: TMPJ-00676

Species: Human

Expression System: E. coli

PPIC Protein, Human, Recombinant (Trx & His)

Cat.No: TMPJ-00971

Species: Human

Expression System: E. coli

CYPA Protein, Mouse, Recombinant

Cat.No: TMPJ-00048

Species: Mouse

Expression System: E. coli

CYPA Protein, Human, Recombinant

Cat.No: TMPJ-01049

Species: Human

Expression System: E. coli

BAFFR/TNFRSF13C Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01254

Species: Cynomolgus

Expression System: HEK293 Cells

BAFFR/TNFRSF13C Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00070

Species: Human

Expression System: HEK293 Cells

BAFFR/TNFRSF13C Protein, Human, Recombinant (His)

Cat.No: TMPJ-00067

Species: Human

Expression System: HEK293 Cells

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