Cyclo(L-Ala-L-Pro) and cyclo(L-Val-L-Pro) inhibit aflatoxin production of Aspergillus parasiticus and Aspergillus flavus in liquid medium at concentrations of several hundred uM without affecting fungal growth.
Cyclo (Ala-Gly) is a mangrove endophytic fungus, a metabolite of Penicillium thomi, which is cytotoxic to A549, HepG2 and HT29 cells. The IC50 value is in the range of 9.5-18.1 μM.