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Search Results for " creatinine "

Targets Recommended: Others

18

抑制剂 & 化合物

7

天然产物

4

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T40631	4-Hydroxytryptamine creatinine sulfate	Others	Others
	4-Hydroxytryptamine creatinine sulfate, a derivative of tryptamine, acts as an agonist for neurotransmitters.
T29899	alpha-MSCS alpha-Methylserotonin creatinine sulfate,alpha Methylserotonin creatinine sulfate,alphaMSCS	Others	Others
	α-MSCs (α-methylserotonin creatinine sulfate) are neurotransmitters.
T76125	Creatininase CAH,Creatinine amidohydrolase	Endogenous Metabolite	Metabolism
	Creatininase (CAH) 是一种从 Pseudomonas putida 中发现的同六聚体酶，可用于研究肌酐检测的生物传感器和慢性肾功能衰竭。
T125448	Creatinine Phosphate Disodium Salt	Others	Others
	Creatinine Phosphate Disodium Salt 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125448。
T10353	APX-115 free base Ewha-18278 free base	NADPH-oxidase; NADPH	Immunology/Inflammation; Metabolism
	APX-115 free base (Ewha-18278 free base) 是口服具有活性的、非选择性的 Nox 抑制剂，对 Nox1，Nox2和 Nox4的 Ki 分别为 1.08 μM，0.57 μM 和 0.63 μM。它能够有效预防糖尿病小鼠的肾损伤。
T19356	HTBA	Others	Others
	HTBA 是一种用于测定尿肌酐的低成本酶促纸基分析试剂 (enz-PAD)。
T8845	UTL-5g 3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-,GBL-5g	TNF	Apoptosis
	UTL-5g (3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-) 是一种抗炎性TNF-α抑制剂，可通过抑制 TNF-α 等因子降低顺铂引起的肝毒性、肾毒性和骨髓毒性，具有化学保护和肝脏放射保护作用。
T10492	BD-AcAc 2 Ketone Ester	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	BD-AcAc 2 (Ketone Ester) 是一种酮单酯，是口服营养酮的来源。小鼠口服 BD-AcAc 2 后可提高血浆乙酰乙酸和β-羟基丁酸水平、血液钠离子、血糖水平和血肌酐水平。BD-AcAc 2 可以一定程度预防脓毒症小鼠的肌无力。BD-AcAc 2 显示出提高动物机体耐力和运动能力的潜力。BD-AcAc 2 还可用于研究糖尿病或帕金森病。
T28222	5-Hydroxy-1-methylhydantoin HD-003,HD003,5-羟基-1-甲基咪唑啉-2,4-二酮,NZ419,NZ-419,HD 003,NZ 419	Bradykinin Receptor	GPCR/G Protein
	5-Hydroxy-1-methylhydantoin (HD-003) 是一种可能用于治疗肾衰竭的抗氧化剂。它是肌酐代谢物，是一种羟基自由基清除剂，此前已显示通过抑制大鼠慢性肾病的进展来提供肾脏保护。它是一种新型抗氧化药物，可完全抑制 B2-激肽受体(B2KR) 对 VSMC 中高葡萄糖 (25 mM) 刺激的反应，并且还显示可减弱 BK 对 VSMC 重塑的影响。它抑制 BK 诱导的 MAPK 磷酸化增加并减弱 VSMC 中结缔组织生长因子 (CTGF) 蛋白水平的增加。这些研究结果表明，它可能通过其抗氧化特性赋予血管保护免受高葡萄糖浓度和 BK 刺激以改善血管损伤和重塑。
T38062	N-acetyl Leukotriene E4 N-acetyl Leukotriene E4	Others	Others
	N-acetyl LTE4 is the major inactive metabolite of LTE4 found in bile. This route of metabolism is prominent in the rat, but of minor importance in humans. N-acetyl LTE4 is 100 times less potent than LTC4 as a vasoconstricting agent. In healthy human subjects urinary excretion of N-acetyl LTE4 is about 1.5 nmol/mol creatinine, which is considerably less than that of LTE4 (12 nmol/mol creatinine).
T76144	Creatinase	Others	Others
	Creatinase(Creatine amidohydrolase) 是一种水解酶，可以催化肌酸水解为肌氨酸和尿素，在酶促测定肌酸酐浓度中发挥重要作用。
T38306	tetranor-PGDM	Others	Others
	Prostaglandin D2 is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. PGD2 is also produced in the brain by lipocalin-PGD-synthase also known as β-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. tetranor-PGDM is a major metabolite of PG...
T61983	Trichlormethiazide sodium	Others	Others
	Trichlormethiazide sodium 是口服有效的噻嗪类利尿剂，显示降压活性。在急性肾功能衰竭大鼠中，Trichlormethiazide sodium 可增加尿量、Na 和 K 排泄，并有改善肌酐清除率 (CCRE)。
T78445	Bromocresol green
	Bromocresol green是一种pH敏感的三苯甲烷染料，专用于测定蛋白质及血清中的白蛋白浓度。此生物碱性染料在pH值3.0至7.5的范围内颜色从黄绿到蓝绿变化。在酸性条件下（例如pH=4.15），Bromocresol green显黄色（λmax=435 nm，质子化形式），而在碱性环境下则转为蓝色（λmax=615 nm，去质子化形式）。因此，它被广泛用作pH指示剂，在生化分析中有着重要应用。Bromocresol green还用于测定肌酐等分子浓度及评估细胞存活率。
T84626	2,3-dinor Thromboxane B2 2,3-dinor TXB2	Others	Others
	Thromboxane B2 (TXB2) is a compound significantly released from aggregating platelets and undergoes metabolic transformation during circulation into 11-dehydro TXB2 and 2,3-dinor TXB2. The latter, 2,3-dinor TXB2, serves as a prevalent urinary metabolite of TXB2 and acts as an indicator for in vivo TXA2 synthesis. Studies have shown that in healthy male volunteers, the median excretion rate of 2,3-dinor TXB2 is measured at 10.3 ng/hour, equivalent to 138 pg/mg of creatinine.
T63248	NTU281	Others	Others
	NTU281 是转谷氨酰胺酶-2 (transglutaminase-2) 的有效抑制剂，能够减少糖尿病大鼠血清肌酐和蛋白尿的升高，并降低肾小球 I 型胶原积累、Hic-5 和α-SMA 表达，以及减少细胞凋亡 (apoptosis)，能够用于糖尿病引起的肾小球硬化的研究。
T65387	Paromomycin, sulfate (1:1)	Others	Others
	Paromomycin (Sulfate Salt) is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin in combination with sodium stibogluconate has proven to be effective in African and Indian VL (visceral leishmaniasis) and improves survival in African VL[3]. PS (Paromomycin Sulfate) is effective for elimination of B. coli without hematological side effects[4]. The activity of phosphoglucose isomerase was slightly inhibited by 10...
T83770	Klotho-derived Peptide 1 (56-87) (human) TFA KP1 (56-87)
	Klotho衍生肽1（KP1）(56-87)是从人类Klotho蛋白质中衍生的肽，具有扰乱TGF-β信号传导的作用。它与TGF-β受体类型1（TGFBR2）和TGF-β受体类型2（TGFBR2；Kds分别为1.41和14.6µM）结合。KP1（10 µg/ml）的预孵育抑制TGF-β在NRK-49F大鼠成纤维细胞中诱导的纤维连接蛋白和α-平滑肌肌动蛋白（α-SMA）水平的增加。在体内，KP1（每天1 mg/kg）选择性地定位于受损的肾脏，并减少血清肌酐和血尿素氮水平，这些是肾功能的标志物，同时也减少了小鼠单侧输尿管阻塞（UUO）和单侧缺血-再灌注损伤诱导的肾脏纤维化模型中的肾纤维化。

化合物

4-Hydroxytryptamine creatinine sulfate

Cat.No: T40631

Target: Others

Cat.No: T29899

Synonym: alpha-Methylserotonin creatinine sulfate,alpha Methylserotonin creatinine sulfate,alphaMSCS

Target: Others

Cat.No: T76125

Synonym: CAH,Creatinine amidohydrolase

Target: Endogenous Metabolite

Creatinine Phosphate Disodium Salt

Cat.No: T125448

Target: Others

APX-115 free base

Cat.No: T10353

Synonym: Ewha-18278 free base

Target: NADPH-oxidase, NADPH

Cat.No: T19356

Target: Others

Cat.No: T8845

Synonym: 3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-,GBL-5g

Target: TNF

Cat.No: T10492

Synonym: Ketone Ester

Target: Reactive Oxygen Species

5-Hydroxy-1-methylhydantoin

Cat.No: T28222

Synonym: HD-003,HD003,5-羟基-1-甲基咪唑啉-2,4-二酮,NZ419,NZ-419,HD 003,NZ 419

Target: Bradykinin Receptor

N-acetyl Leukotriene E4

Cat.No: T38062

Synonym: N-acetyl Leukotriene E4

Target: Others

Cat.No: T76144

Target: Others

Cat.No: T38306

Target: Others

Trichlormethiazide sodium

Cat.No: T61983

Target: Others

Bromocresol green

Cat.No: T78445

2,3-dinor Thromboxane B2

Cat.No: T84626

Synonym: 2,3-dinor TXB2

Target: Others

Cat.No: T63248

Target: Others

Paromomycin, sulfate (1:1)

Cat.No: T65387

Target: Others

Klotho-derived Peptide 1 (56-87) (human) TFA

Cat.No: T83770

Synonym: KP1 (56-87)

Cat. No.	Product Name	Target	Signaling Pathways
T0496	Creatinine 肌酸酐,NSC13123	Endogenous Metabolite	Metabolism
	Creatinine (NSC-13123) 由肌肉中磷酸肌酸分解产生。
T4860	5-Hydroxytryptamine creatinine sulfate monohydrate Serotonin creatinine sulfate monohydrate,5-Hydroxytryptamine creatinine sulfate complex,5-五羟色胺肌酸酐	Others; Endogenous Metabolite	Metabolism; Others
	5-Hydroxytryptamine creatinine sulfate monohydrate (Serotonin creatinine sulfate monohydrate) 是内源性代谢产物的一种。
T5236	N-Methylhydantoin 甲酰乙内脲,Dioxy-creatinine,1-Methyl-hydantoin	Others; Endogenous Metabolite	Metabolism; Others
	N-Methylhydantoin (1-Methyl-hydantoin) 是一种小分子量极性物质，是细菌降解肌酐的产物。在哺乳动物中，N-Methylhydantoin 的代谢是通过 5-hydroxy-1-methylhydantoin 进行的。在一个报告的人类病例中，N-Methylhydantoin 被发现是影响智力的物质dupracetam的代谢物。
T5269	N-Acetylornithine Acetyl-ornithine,N-Acetyl-L-ornithine,N-乙酰鸟氨酸	Others; Endogenous Metabolite	Metabolism; Others
	N-Acetylornithine (N-Acetyl-L-ornithine) 是一种人内源性代谢物，是 L-谷氨酸到 L-精氨酸的酶促合成中的中间体。
T5250	Levoglucosan 1,6-anhydro-b-D-Glucose,1,6-脱水-β-D-葡萄糖	Others; Endogenous Metabolite	Metabolism; Others
	Levoglucosan (1,6-anhydro-b-D-Glucose) 是一种无水己糖，是 β -D-葡萄糖的 1,6-无水衍生物。它是由碳水化合物，如淀粉和纤维素的热解形成的。左旋葡聚糖还可用于手性聚合物如不可水解葡萄糖聚合物的合成。左旋葡聚糖也可以通过糖的焦糖化产生。食用焦糖或含焦糖的甜食可导致尿中左旋葡聚糖水平短期增加5倍(从20 μm /mM肌酐增加到100 μm /mM肌酐)。
T4904	1-Methylguanidine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	1-Methylguanidine hydrochloride 是内源性代谢产物的一种。
T4883	Creatine Methylguanidoacetic acid,肌酸	Endogenous Metabolite	Metabolism
	Creatine (Methylguanidoacetic acid) 是一种内源性氨基酸代谢物，在细胞能量中发挥重要作用，尤其是在肌肉和大脑中。

天然产物

Cat.No: T0496

Synonym: 肌酸酐,NSC13123

Target: Endogenous Metabolite

5-Hydroxytryptamine creatinine sulfate monohydrate

Cat.No: T4860

Synonym: Serotonin creatinine sulfate monohydrate,5-Hydroxytryptamine creatinine sulfate complex,5-五羟色胺肌酸酐

Target: Others, Endogenous Metabolite

N-Methylhydantoin

Cat.No: T5236

Synonym: 甲酰乙内脲,Dioxy-creatinine,1-Methyl-hydantoin

Target: Others, Endogenous Metabolite

N-Acetylornithine

Cat.No: T5269

Synonym: Acetyl-ornithine,N-Acetyl-L-ornithine,N-乙酰鸟氨酸

Target: Others, Endogenous Metabolite

Cat.No: T5250

Synonym: 1,6-anhydro-b-D-Glucose,1,6-脱水-β-D-葡萄糖

Target: Others, Endogenous Metabolite

1-Methylguanidine hydrochloride

Cat.No: T4904

Target: Others, Endogenous Metabolite

Cat.No: T4883

Synonym: Methylguanidoacetic acid,肌酸

Target: Endogenous Metabolite

Cat. No.	Product Name	Target	Signaling Pathways
T19249	Creatinine-D3 NSC13123-D3,氘代肌酸酐	Others	Others
	Creatinine-D3 is a deuterium-labeled Creatinine which is a break-down product of creatine phosphate in muscle.
TMID-0162	Creatinine-d5
	Creatinine-d5 是 Creatinine 的氘代化合物。Creatinine 的 CAS 号为 60-27-5。Creatinine 由肌肉中磷酸肌酸分解产生。
TMID-0231	α,α,β,β-d4-Serotonin-Creatinine Sulfate Complex H2O
	α,α,β,β-d4-Serotonin-Creatinine Sulfate Complex H2O 是 α,α,β,β-Serotonin-Creatinine Sulfate Complex H2O 的氘代化合物。
T70313	Indoxyl Sulfate-d5 potassium salt
	Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). ...

同位素标记化合物

Creatinine-D3

Cat.No: T19249

Synonym: NSC13123-D3,氘代肌酸酐

Target: Others

Creatinine-d5

Cat.No: TMID-0162

α,α,β,β-d4-Serotonin-Creatinine Sulfate Complex H2O

Cat.No: TMID-0231

Indoxyl Sulfate-d5 potassium salt

Cat.No: T70313

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