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Search Results for " connexin "

14

抑制剂 & 化合物

1

天然产物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T82683	Connexin mimetic peptide 40GAP27
	Connexin mimetic peptide 40GAP27 是一种生物活性肽，对应于主要的血管连接蛋白Cx40第二个细胞外环的GAP27结构域（40Gap27）。该化合物在研究氧化应激所致的损伤以及间隙连接通讯机制中有应用。40Gap27能够在给药后减少内皮依赖性的内膜下平滑肌的超极化现象。
T82684	Connexin mimetic peptide 40,37GAP26
	Connexin mimetic peptide 40,37GAP26是一种生物活性肽，对应Cx37和Cx40主要血管连接蛋白的胞外环GAP26结构域，命名基于Cx同源性为37,40Gap26。本化合物主要用于研究间隙连接对环吡嗪酸(CPA)通过啮齿动物髂动脉壁导致的内皮超极化扩散的影响。Cx37和Cx40形成的间隙连接斑块在内皮细胞中高度丰富，而Connexin mimetic peptide 40,37GAP26能抑制内膜下超极化。
TP1563	Gap19	Gap Junction Protein	Cytoskeletal Signaling
	Gap19 是一种衍生自 Cx43 细胞质环九个氨基酸的肽，是选择性连接蛋白 43 半通道阻滞剂。它可以防止 C 末端与 CL 的分子内相互作用，具有保护心肌作用。
T5192	Gap 26	Gap Junction Protein	Cytoskeletal Signaling
	Gap 26 是模拟肽，对应于连接蛋白 43 的残基 63-75，是间隙连接阻断剂。
TP1333	Gap 27	Gap Junction Protein	Cytoskeletal Signaling
	Gap 27是一种合成的 connexin43 模拟肽，是一种间隙连接抑制剂。它与通往第二跨膜连接蛋白区段的第二细胞外环的一部分具有保守的序列同源性。
T75795	Gap 26 TFA
	Gap 26 TFA 是一种连接蛋白 (connexin) 模拟肽，由连接蛋白 connexin 43 (gap junction 阻滞剂)一个胞外环的第 63-75 残基组成，包含SHVR 氨基酸基序。
T34120L	PQ1 Succinate PQ 1 Succinate,PQ-1 Succinate	Others	Others
	PQ1 Succinate, a gap junction enhancer, acts by restoring GJIC and increasing connexin expression in breast cancer cell lines while not affecting normal mammary cells.
TP1511	Gap19 TFA (1507930-57-5 free base) Gap19 TFA
	Gap19 TFA is a peptide derived from nine amino acids of Cx43 cytoplasmic ring (CL), an effective, selective connexin 43 (Cx43) half-channel blocker.
T34120	PQ1 PQ-1,PQ 1	Others	Others
	PQ1, as an enhancer of gap junction in SW480 human colorectal cancer cells can act by restoring GJIC and increasing connexin expression in breast cancer cell lines while not affecting normal mammary cells.
T78061	Peptide5 TFA	Gap Junction Protein	Cytoskeletal Signaling
	Peptide5 TFA，一种connexin 43模拟肽，能够降低动物脊髓损伤后的肿胀、抑制星形胶质细胞增生和神经元死亡。该化合物还可抑制NLRP3炎症小体，具有抗炎作用。
T80852	VRT-534	Others	Others
	VRT-534 针对连接蛋白 26 (Cx26)。在与重组WT Cx26及其突变体Cx26 K188N的结合中，VRT-534 显示出剂量依赖性，其EC50值分别为19 μM与5 μM。该化合物可应用于听力障碍的相关研究。
T61941	BMT-090605 hydrochloride	Others	Others
	BMT-090605 hydrochloride 是有效的，选择性的连接蛋白-2 相关激酶 1(AAK1)抑制剂，（IC50=0.6 nM）。BMT-090605 hydrochloride 抑制 BMP-2 诱导蛋白激酶 (BIKE) （IC50=45 nM）和细胞周期蛋白 G 相关激酶 GAK（IC50=60 nM）。BMT-090605 hydrochloride 显示抗伤害活性。BMT-090605 hydrochloride 在神经性疼痛中具有研究价值。
T75820	Gap19 TFA
	Gap19 TFA，源自Cx43胞浆环(CL)的九个氨基酸肽，是高效且选择性的连接蛋白43 (Cx43) 半通道阻滞剂。该肽阻止C末端（CT）与CL之间的分子内相互作用，但不影响GJ通道或Cx40/pannexin-1半通道。此外，Gap19 TFA对心肌有保护作用。
T36851	Peptide5
	Connexin43 mimetic peptide. Reduces swelling, astrogliosis, neuroinflammation and neuronal cell death following spinal cord injury ex vivo and in vivo. Exhibits analgesic effects in models of neuropathic pain. O'Carroll et al (2008) Connexin 43 mimetic peptides reduce swelling, astrogliosis and neuronal cell death after spinal cord injury. Cell.Commun.Adhes. 15 27 PMID:18649176 \|Mao et al (2017) Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats....

化合物

Connexin mimetic peptide 40GAP27

Cat.No: T82683

Connexin mimetic peptide 40,37GAP26

Cat.No: T82684

Cat.No: TP1563

Target: Gap Junction Protein

Cat.No: T5192

Target: Gap Junction Protein

Cat.No: TP1333

Target: Gap Junction Protein

Cat.No: T75795

Cat.No: T34120L

Synonym: PQ 1 Succinate,PQ-1 Succinate

Target: Others

Gap19 TFA (1507930-57-5 free base)

Cat.No: TP1511

Synonym: Gap19 TFA

Cat.No: T34120

Synonym: PQ-1,PQ 1

Target: Others

Cat.No: T78061

Target: Gap Junction Protein

Cat.No: T80852

Target: Others

BMT-090605 hydrochloride

Cat.No: T61941

Target: Others

Cat.No: T75820

Cat.No: T36851

Cat. No.	Product Name	Target	Signaling Pathways
T7732	Carbenoxolone Biogastrone,甘珀酸,Carbenoxolona,Carbenoxolone,Bioral	Dehydrogenase; Gap Junction Protein	Cytoskeletal Signaling; Metabolism
	Carbenoxolone (Carbenoxolona) 是 11β-HSD 和 gap junction connexin 通道的抑制剂。 Carbenoxolone 抑制巨噬细胞迁移到心房并防止脂肪肝的发展。

天然产物

Cat.No: T7732

Synonym: Biogastrone,甘珀酸,Carbenoxolona,Carbenoxolone,Bioral

Target: Dehydrogenase, Gap Junction Protein

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01373	GJA5 Protein, Human, Recombinant (His) Gap junction alpha-5 protein,GJA5,Connexin-40	Human	E. coli
	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. GJA5 Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 21.6 kDa and the accession number is P36382.
TMPH-00267	GJD2 Protein, Bovine, Recombinant (His & SUMO) Gap junction alpha-9 protein,Gap junction delta-2 protein,	Bovine	E. coli
	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. GJD2 Protein, Bovine, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 49.1 kDa and the accession number is Q866T7.
TMPH-02669	GJA1 Protein, Mouse, Recombinant (His & Myc) Gap junction 43 kDa heart protein,Gja1,Gap junction alpha-1 ...	Mouse	Baculovirus Insect Cells
	Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibi...
TMPH-01372	GJA1 Protein, Human, Recombinant (His) Gap junction 43 kDa heart protein,GJA1,Connexin-43,...	Human	E. coli
	GJA1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.3 kDa and the accession number is P17302.

重组蛋白

GJA5 Protein, Human, Recombinant (His)

Cat.No: TMPH-01373

Species: Human

Expression System: E. coli

GJD2 Protein, Bovine, Recombinant (His & SUMO)

Cat.No: TMPH-00267

Species: Bovine

Expression System: E. coli

GJA1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02669

Species: Mouse

Expression System: Baculovirus Insect Cells

GJA1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01372

Species: Human

Expression System: E. coli

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