首页工具

登录

搜索结果

Search Results for " chondrocytes "

Targets Recommended: TGF-beta/Smad

9

抑制剂 & 化合物

3

天然产物

19

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T1748	Kartogenin KGN	TGF-beta/Smad	Stem Cells
	Kartogenin (KGN) 是一种人间充质干细胞分化为软骨细胞的诱导剂(EC50:100 nM)。它能够结合纤维蛋白 A，破坏其与转录因子核心结合因子 β 亚基 (CBFβ) 的相互作用，并通过调节 CBFβ-RUNX1 转录程序，诱导软骨形成，可用于研究骨关节炎。
T9138	Indirubin-3′-oxime Indirubin-3'-monoxime	GSK-3; CDK; JNK	Cell Cycle/Checkpoint; MAPK; PI3K/Akt/mTOR signaling; Stem Cells
	Indirubin-3′-oxime 是一种有效的细胞周期蛋白依赖性蛋白激酶抑制剂，是 indirubin 的合成衍生物。它可通过激活软骨细胞中的 Wnt/β-catenin 信号来促进身高增长，可能在阿尔茨海默病的神经元凋亡中发挥作用。
TQ0228	Derazantinib ARQ-087	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Derazantinib (ARQ-087) 是一种有效的，ATP 竞争型的，具有口服活性的酪氨酸激酶抑制剂，能够抑制软骨细胞FGFR1 (IC50:4.5 nM)、FGFR2 (IC50:1.8 nM)、FGFR3 (IC50:4.35nM)。
T40795	BNTA	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	BNTA 是一种有效的细胞外基质 (ECM) 调节剂。在大鼠关节炎模型中，BNTA 通过诱导超氧化物歧化酶 3 (SOD3) 促进软骨细胞上软骨结构分子的合成和超氧阴离子消除调节软骨生成从而调节关节炎。
T39531	RAD16-I hydrochloride RAD16-I hydrochloride
	RAD16-I hydrochloride is a self-assembling peptide with nanofibrous morphology that provides an optimal microenvironment for the proliferation and differentiation of human mesenchymal stem cells (hMSC) into chondrocytes. This peptide, known as RAD16-I, has been extensively studied and serves as a model to assess the amyloid-like staining properties of self-assembling peptide nanofibers (SAPNFs).
T10997	Derazantinib Racemate ARQ-087 Racemate	Others	Others
	Derazantinib Racemate (ARQ-087 Racemate) 是 Derazantinib 的外消旋体。Derazantinib 是一种有效的，ATP 竞争型的，具有口服活性的酪氨酸激酶抑制剂，能够抑制软骨细胞 FGFR1 (IC50:4.5 nM)、FGFR2 (IC50:1.8 nM)、FGFR3 (IC50:4.5nM)。
T76277L	Vosoritide acetate
	Vosoritide (BMN 111) acetate，一种NPR2（利尿钠肽受体2）激动剂，作用于软骨细胞增殖与分化，促进骨骼生长。
T71525	AB05831	Others	Others
	AB05831, also known as 2-Acetamido-1,2-dideoxynojirimycin, is a highly potent and specific inhibitor of beta-hexosaminidase. N-Acetyl-3-hexosaminidase (HEX) is a member of lysosomal hydrolases, which catalyzes hydrolysis of terminal, non-reducing N-acetyl-\|3-D-glucosamine (GlcNAc) andN-acetyl-(3-D-galactosamine (GalNAc) residues in glycoproteins, gan-gliosides, and glycosaminoglycans (GAGs). HEX, released by chondrocytes into the extracellular compartment, promotes cartilage matrix degradation. ...
T83733	TIP39 (human, bovine) TFA Tuberoinfundibular Peptide of 39 Residues
	TIP39作为一种神经肽及甲状旁腺激素受体2型(PTH2R)激动剂，在表达重组人或大鼠PTH2R的COS-7细胞中诱导cAMP积累（EC50分别为0.5和0.8 nM），以及在内源性表达PTH2R的F-11细胞中（EC50 = 1.15 nM）。在CFK2大鼠软骨细胞中，TIP39 (1 nM)诱导细胞周期在G0/G1阶段停滞，并减少软骨分化的主要调控因子Sox9的表达。此外，TIP39 (100 pmol/动物)在小鼠强迫游泳测试中减少了不动时间。

化合物

Cat.No: T1748

Synonym: KGN

Target: TGF-beta/Smad

Indirubin-3′-oxime

Cat.No: T9138

Synonym: Indirubin-3'-monoxime

Target: GSK-3, CDK, JNK

Cat.No: TQ0228

Synonym: ARQ-087

Target: FGFR

Cat.No: T40795

Target: Reactive Oxygen Species

RAD16-I hydrochloride

Cat.No: T39531

Synonym: RAD16-I hydrochloride

Derazantinib Racemate

Cat.No: T10997

Synonym: ARQ-087 Racemate

Target: Others

Vosoritide acetate

Cat.No: T76277L

Cat.No: T71525

Target: Others

TIP39 (human, bovine) TFA

Cat.No: T83733

Synonym: Tuberoinfundibular Peptide of 39 Residues

Cat. No.	Product Name	Target	Signaling Pathways
T2795	Amygdalin 苦杏仁苷,Laetrile	Others	Others
	Amygdalin (Laetrile) 是一种植物葡萄糖苷，分离自蔷薇果实的果核中，如杏，桃，杏仁，樱桃和李子。
T6S1579	Monotropein 水晶兰苷,Monotropeine	Others	Others
	Monotropein (Monotropeine) 是从Morinda officinalis 中获得，能够抑制硫酸葡聚糖硫酸钠诱导的结肠炎小鼠模型中炎性因子的表达。
TN5171	Tricetin	Apoptosis; Others; Nrf2	Apoptosis; Immunology/Inflammation; Others
	Tricetin 是一种从石榴中分离出的类黄酮。Tricetin 是 Keap1-Nrf2 蛋白相互作用（PPI）的强效竞争性抑制剂，通过激活 Nrf2/HO-1 信号通路和阻止线粒体依赖性细胞凋亡通路，保护帕金森病患免受 6-OHDA 诱导的神经毒性的影响。Tricetin 通过 Akt/GSK-1β途径抑制鼻咽癌的迁移和指示性蛋白酶早老素-1（PS-1）表达。Tricetin 抑制由Egr-1介导的氧化LDL 诱导的内皮炎症，保护大鼠软骨细胞免受IL-1β诱导的炎症和细胞凋亡。

天然产物

Cat.No: T2795

Synonym: 苦杏仁苷,Laetrile

Target: Others

Cat.No: T6S1579

Synonym: 水晶兰苷,Monotropeine

Target: Others

Cat.No: TN5171

Target: Apoptosis, Others, Nrf2

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00249	TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated TGF-Beta-1,TGFB1,Transforming Growth Factor β-1,Latency-Asso...	Human	HEK293 Cells
	Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family...
TMPY-00203	LOXL2 Protein, Mouse, Recombinant (His) 1110004B06Rik,4930526G11Rik,9430067E15Rik,lysyl oxidase-like...	Mouse	HEK293 Cells
	Lysyl oxidase homolog 2, also known as Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14 and LOXL2, is a secreted protein that belongs to the lysyl oxidase family. LOXL2 contains four SRCR domains. The lysyl oxidase family is made up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 ( LOXL1, LOXL2, LOXL3, LOXL4 ). All members share conserved C-terminal catalytic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme act...
TMPJ-01245	UCMA Protein, Human, Recombinant UCMA,Unique cartilage matrix-associated protein,Gla-rich pro...	Human	E. coli
	C10orf49 is a secreted protein which encoded by the UCMA gene. It is a member of the UCMA family. C10orf49 is predominantly expressed in resting chondrocytes. It may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
TMPK-00685	CYTL1 Protein, Mouse, Recombinant (hFc) CYTL1,C4orf4,Protein C17	Mouse	HEK293 Cells
	Cytokine-like protein 1 (Cytl1), also named Protein C17 or C4orf4 is located on human chromosome 4p15-p16 and encodes a polypeptide of 126 amino acid residues that displays characteristics of a secretory protein. Cytl1 is expressed by a sub-population of CD34 human mononuclear cells from bone marrow and cord blood, and by chondrocytes (cartilage-forming cells).
TMPY-01933	CHI3L2 Protein, Human, Recombinant (His) YKL-39,CHIL2,chitinase 3 like 2,YKL39	Human	HEK293 Cells
	Chondrocyte protein 39 (YKL-39), also known as Chitinase 3-like 2 (CHI3L2), is a secretory protein of articular chondrocytes belonging to the glycosyl hydrolase 18 family. Its highest expression is in chondrocytes, followed by synoviocytes, lung and heart. YKL-39/CHI3L2 is not detected in spleen, pancreas, and liver. YKL-39/CHI3L2 may also be expressed in developing brain and placenta. YKL-39/CHI3L2, a cartilage-related protein, is found to induce arthritis accompanied by pathologic changes in b...
TMPH-01069	CTGF/CCN2 Protein, Human, Recombinant (His) Hypertrophic chondrocyte-specific protein 24,CCN family memb...	Human	E. coli
	Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. CTGF/CCN2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 15.1 kDa and...
TMPY-01860	Collagen II/COL2A1 Protein, Human, Recombinant (aa 1242-1487, His) SEDC,collagen, type II, alpha 1,COL11A3,AOM,STL1,collagen, t...	Human	HEK293 Cells
	COL2A1 is the alpha-1 chain of type II collagen which is a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this protein are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of th...
TMPH-02568	CTGF/CCN2 Protein, Mouse, Recombinant (GST) betaIG-M2,Connective tissue growth factor,Protein FISP-12,Fi...	Mouse	E. coli
	Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
TMPY-00044	CYTL1 Protein, Human, Recombinant (mFc) C4orf4,C17,cytokine-like 1	Human	HEK293 Cells
	Cytokine-like protein 1 (CYTL1) is a small widely expressed secreted protein lacking significant primary sequence homology to any other known protein. Cytokine-like 1 (CYTL1) is a novel potential cytokine that was first identified in CD34(+) cells derived from bone marrow and cord blood, and it was also found using our immunogenomics strategy. CYTL1 expression appears to be highest in the hematopoietic system and in chondrocytes; however, maintenance of cartilage in mouse models of arthritis is ...
TMPK-00019	B2M/beta 2-Microglobulin Protein, Human, Recombinant (hFc) Beta-2-microglobulin,B2M/β 2-Microglobulin,β-2-microglobulin...	Human	HEK293 Cells
	To assess whether beta-2 microglobulin (B2M) has effects on articular chondrocytes that would implicate B2M involvement in osteoarthritis (OA) pathogenesis.The average B2M level in OA synovial fluid is significantly higher than that found in normal synovial fluid. B2M is highly expressed in OA cartilage and synovial fluid compared to normal, and suggest that B2M may have effects on chondrocyte function that could contribute to OA pathogenesis.
TMPJ-01200	IMPA3 Protein, Mouse, Recombinant (His) Inositol monophosphatase 3,Impad1	Mouse	HEK293 Cells
	IMPAD1 protein (IMPA3, gPAPP or IMPase 3) belongs to the inositol monophosphatase family. It is found in Purkinje cells, brain stem, lung and chondrocytes. Mouse IMPAD1 gene encodes a type II transmembrane Golgi-embedded glycoprotein with 356 amino acid residues which generates a 306 amino acid residues mature protein after processing. It is expressed in embryo, and in theory may catalyze myo-inositol monophosphate to myo-inositol. Free myo-inositol is used to generate inositol phospholipid, an ...
TMPY-03384	CALM2 Protein, Human, Recombinant (His) caM,calmodulin 2 (phosphorylase kinase, delta),PHKD,calmodul...	Human	E. coli
	Calmodulin 2, also known as CALM2, is a calmodulin. Calmodulin 2 mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). It is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Calmodulin 2 gene may be a genetic determinant of hip osteoarthritis (OA). OA is a degenerative disease characterized by gradual loss of articular cartilage and is a leading cause of disability in elderly populations. CALM2 was most...
TMPJ-01119	Osteoactivin/GPNMB Protein, Human, Recombinant (aa 22-486, His) Transmembrane Glycoprotein NMB,HGFIN,NMB,GPNMB,Transmembrane...	Human	HEK293 Cells
	Osteoactivin is an intracellular glycoprotein belongs to the NMB/pMEL-17 family, which is asscociated with cell endosomal/lysomal compartments. Human Osteoactivin is a 560 amino acid type I transmembrane protein, and one alternate splice form shows a 12 amino acid insert between amino acid 339-340. An additional 206 amino acid isoform shows a mutation at position 181 that results in a 26 amino acid substitution for the C-terminal 380 amino acids. Cells knowns to express Osteoactivin include fibr...
TMPY-00564	MCP-4 Protein, Human, Recombinant (His) MCP-4,CCL13,SCYL1,NCC-1,MCP4,NCC1,CKb10,SCYA13,chemokine (C-...	Human	P. pastoris (Yeast)
	Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. CCL13/MCP-4, is a CC family chemokine that is chemoattractant for eosinophils, basophils, monocytes, macrophages, immature dendritic cells, and T cells, and its capable of inducing crucial immuno-modulatory responses through its effects on epithelial, muscular and endothelial cells. Similar to other CC chem...
TMPY-02387	NF-kB p65 Protein, Human, Recombinant (aa 1-306, GST) NFKB3,p65,v-rel avian reticuloendotheliosis viral oncogene h...	Human	E. coli
	RELA (v-rel reticuloendotheliosis viral oncogene homolog A), also known as Nuclear factor NF-kappa-B p65 subunit, or Transcription factor p65, is a transcription factor expressed in growth plate chondrocytes where it facilitates chondrogenesis. The v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) gene encodes the major component of the NF-?B complex. NF-kappaB is a generic name for an evolutionarily conserved transcription-factor system that contributes to the mounting of an eff...
TMPJ-01137	MIA Protein, Human, Recombinant (His) MIA,Melanoma Inhibitory Activity Protein,Melanoma-Derived Gr...	Human	E. coli
	Melanoma Inhibitory Activity Protein (MIA) is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells, which was the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family: MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA acts as a potent tumor cell growth inhibitor for malignant melanoma cells and some other neuroectodermal tumors, including gliomas, in an au...
TMPY-01879	S100A14 Protein, Human, Recombinant (His) S100 calcium binding protein A14,BCMP84,S100A15	Human	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from theneural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of in...
TMPY-01466	S100A12 Protein, Human, Recombinant MRP6,MRP-6,S100A12,S100 calcium binding protein A12,CAGC,p6,...	Human	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of i...
TMPY-01926	S100A10 Protein, Human, Recombinant (His) ANX2L,S100 calcium binding protein A10,p10,CLP11,MGC111133,G...	Human	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S1 proteins have been implicated in a variety of int...

重组蛋白

TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated

Cat.No: TMPJ-00249

Species: Human

Expression System: HEK293 Cells

LOXL2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00203

Species: Mouse

Expression System: HEK293 Cells

UCMA Protein, Human, Recombinant

Cat.No: TMPJ-01245

Species: Human

Expression System: E. coli

CYTL1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00685

Species: Mouse

Expression System: HEK293 Cells

CHI3L2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01933

Species: Human

Expression System: HEK293 Cells

CTGF/CCN2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01069

Species: Human

Expression System: E. coli

Collagen II/COL2A1 Protein, Human, Recombinant (aa 1242-1487, His)

Cat.No: TMPY-01860

Species: Human

Expression System: HEK293 Cells

CTGF/CCN2 Protein, Mouse, Recombinant (GST)

Cat.No: TMPH-02568

Species: Mouse

Expression System: E. coli

CYTL1 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-00044

Species: Human

Expression System: HEK293 Cells

B2M/beta 2-Microglobulin Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00019

Species: Human

Expression System: HEK293 Cells

IMPA3 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01200

Species: Mouse

Expression System: HEK293 Cells

CALM2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03384

Species: Human

Expression System: E. coli

Osteoactivin/GPNMB Protein, Human, Recombinant (aa 22-486, His)

Cat.No: TMPJ-01119

Species: Human

Expression System: HEK293 Cells

MCP-4 Protein, Human, Recombinant (His)

Cat.No: TMPY-00564

Species: Human

Expression System: P. pastoris (Yeast)

NF-kB p65 Protein, Human, Recombinant (aa 1-306, GST)

Cat.No: TMPY-02387

Species: Human

Expression System: E. coli

MIA Protein, Human, Recombinant (His)

Cat.No: TMPJ-01137

Species: Human

Expression System: E. coli

S100A14 Protein, Human, Recombinant (His)

Cat.No: TMPY-01879

Species: Human

Expression System: E. coli

S100A12 Protein, Human, Recombinant

Cat.No: TMPY-01466

Species: Human

Expression System: E. coli

S100A10 Protein, Human, Recombinant (His)

Cat.No: TMPY-01926

Species: Human

Expression System: E. coli

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼