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Search Results for " cholesterol pathway "

Targets Recommended: HMG-CoA Reductase

7

抑制剂 & 化合物

2

天然产物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T21405	Fluvastatin Canef,XU-62320,Vastin,Cranoc,Lescol	HMG-CoA Reductase	Metabolism
	Fluvastatin (XU-62320) 是一种具有高效性和竞争性的 HMG-CoA 还原酶抑制剂（IC50 ：8 nM），可通过依赖 Nrf2 通路抑制血管平滑肌细胞免受氧化应激，用于降低血浆胆固醇水平和预防心血管疾病。
T40781L1	Geranylgeranyl pyrophosphate, t-BA (1:2) Geranylgeranyl pyrophosphate tetrabutylammonium（1：2）(6699-20-3 Free base)	Others	Others
	Geranylgeranyl pyrophosphate tetrabutylammonium(1：2)是甲羟戊酸途径产生内源性胆固醇和中间体之一。Geranylgeranyl pyrophosphate tetrabutylammonium(1：2) 香叶基香叶基焦磷酸三铵是二萜类化合物的常见前体，例如紫杉醇，可用于癌症研究。
T35589	Geranyl pyrophosphate triammonium	Others	Others
	Geranyl pyrophosphate is an intermediate in the mevalonate pathway. It is formed from dimethylallyl pyrophosphate and isopentenyl pyrophosphate by geranyl pyrophosphate synthase. Geranyl pyrophosphate is used in the biosynthesis of farnesyl pyrophosphate , geranylgeranyl pyrophosphate , cholesterol, terpenes, and terpenoids.
T13483	RP 54275 2-Octadecyl-1H-indole-5-carboxylic acid	Others	Others
	RP 54275 是一种天然存在的脂肪酸衍生物，一种新的降胆固醇化合物。它可以激活过氧化物酶体增殖物激活受体γ（PPARγ）途径，该途径参与脂质代谢、炎症和细胞分化的调节。
T32825	L-Mevalonic acid (S)-Mevalonic acid	Others	Others
	L-Mevalonic acid ((S)-Mevalonic acid) 是胆固醇的远源前体，是甲羟戊酸途径的代谢产物，可用于研究自身免疫性疾病、动脉粥样硬化和阿尔茨海默病。
T62052	AMPK activator 6	Others	Others
	AMPK activator 6 (Compound GC) 可降低 HepG2 和 3T3-L1 细胞中的脂质含量并激活AMPK 通路。AMPK activator 6 对血清中甘油三酯 (TG)、总胆固醇 (TC)、低密度脂蛋白-C (LDL-C) 和其他生化指标的增加有显著的抑制作用。AMPK activator 6 在非酒精性脂肪肝（NAFLD）和代谢综合征中有研究价值。
T73755	Farnesyl pyrophosphate	Others	Others
	Farnesyl pyrophosphate (Farnesyl diphosphate) 是一种由15个碳原子组成的异戊二烯类化合物，作为甲羟戊酸 (MVA) 途径的关键代谢中间体。它充当TRPM2 (TRP Channel) 的激动剂，通过激活并打开TRPM2通道，促使离子流入细胞。此外，Farnesyl pyrophosphate 在胆固醇合成、泛醌合成、蛋白质法尼基化修饰以及香叶基-香叶基焦磷酸 (GGPP) 合成过程中扮演着至关重要的底物角色。

化合物

Cat.No: T21405

Synonym: Canef,XU-62320,Vastin,Cranoc,Lescol

Target: HMG-CoA Reductase

Geranylgeranyl pyrophosphate, t-BA (1:2)

Cat.No: T40781L1

Synonym: Geranylgeranyl pyrophosphate tetrabutylammonium（1：2）(6699-20-3 Free base)

Target: Others

Geranyl pyrophosphate triammonium

Cat.No: T35589

Target: Others

Cat.No: T13483

Synonym: 2-Octadecyl-1H-indole-5-carboxylic acid

Target: Others

L-Mevalonic acid

Cat.No: T32825

Synonym: (S)-Mevalonic acid

Target: Others

AMPK activator 6

Cat.No: T62052

Target: Others

Farnesyl pyrophosphate

Cat.No: T73755

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN6714	Geranylgeraniol FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,香叶基香叶醇,CJ-24095	Apoptosis	Apoptosis
	Geranylgeraniol (FT0626663) 是一种类异戊二烯，存在于水果、蔬菜和谷物中，包括大米。 Geranylgeraniol (FT0626663) 抑制生长并诱导各种肿瘤细胞的凋亡。 Geranylgeraniol (FT0626663) 保护单核细胞免受他汀类药物诱导的细胞毒性并抑制分枝杆菌的生长。
T5S0053	Coptisine 黄连碱,Coptisin	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine (Coptisin) 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。

天然产物

Geranylgeraniol

Cat.No: TN6714

Synonym: FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,香叶基香叶醇,CJ-24095

Target: Apoptosis

Cat.No: T5S0053

Synonym: 黄连碱,Coptisin

Target: Indoleamine 2,3-Dioxygenase (IDO)

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00218	DHCR7 Protein, Bovine, Recombinant (His) DHCR7,7-dehydrocholesterol reductase,Sterol Delta(7...	Bovine	E. coli
	7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. DHCR7 Protein, Bovine, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 55.8 kDa and the accession number is Q5E9J5.
TMPH-01603	Lanosterol synthase/LSS Protein, Human, Recombinant (His) Lanosterol synthase,LSS,2,3-epoxysqualene--lanosterol cyclas...	Human	E. coli
	Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.
TMPY-04767	PMVK Protein, Human, Recombinant (His) PMK,PMKA,phosphomevalonate kinase,HUMPMKI,PMKASE	Human	E. coli
	PMVK is a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of PMVK is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis.
TMPY-00055	LCAT Protein, Human, Recombinant (His) lecithin-cholesterol acyltransferase	Human	HEK293 Cells
	Lecithin: cholesterol acyltransferase (LCAT) is the sole enzyme that esterifies cholesterol in plasma, thus determining the maturation of high-density lipoproteins. Because it maintains an unesterified cholesterol gradient between peripheral cells and extracellular acceptors, for a long time, LCAT has been considered as a key enzyme in reverse cholesterol transport. Lecithin cholesterol acyltransferase (LCAT) plays a pivotal role in HDL metabolism.LCAT is intimately involved in HDL maturation an...
TMPH-01624	GBA Protein, Human, Recombinant Lysosomal glycosylceramidase,Acid beta-glucosidase,Alglucera...	Human	E. coli
	Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction tha...
TMPH-01623	GBA Protein, Human, Recombinant (His & Myc & SUMO) Lysosomal acid glucosylceramidase,GBA1,Lysosomal galactosylc...	Human	E. coli
	Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction tha...
TMPY-04476	MVK Protein, Human, Recombinant (His & GST) POROK3,LRBP,MVLK,MK,mevalonate kinase	Human	Baculovirus Insect Cells
	Mevalonate kinase belongs to the GHMP kinase family, Mevalonate kinase subfamily. It can be found in a wide variety of organisms from bacteria to mammals. Mevalonate kinase may be a regulatory site in the cholesterol biosynthetic pathway. Defects in mevalonate kinase can cause mevalonic aciduria (MEVA). It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia,...

重组蛋白

DHCR7 Protein, Bovine, Recombinant (His)

Cat.No: TMPH-00218

Species: Bovine

Expression System: E. coli

Lanosterol synthase/LSS Protein, Human, Recombinant (His)

Cat.No: TMPH-01603

Species: Human

Expression System: E. coli

PMVK Protein, Human, Recombinant (His)

Cat.No: TMPY-04767

Species: Human

Expression System: E. coli

LCAT Protein, Human, Recombinant (His)

Cat.No: TMPY-00055

Species: Human

Expression System: HEK293 Cells

GBA Protein, Human, Recombinant

Cat.No: TMPH-01624

Species: Human

Expression System: E. coli

GBA Protein, Human, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-01623

Species: Human

Expression System: E. coli

MVK Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04476

Species: Human

Expression System: Baculovirus Insect Cells

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