cdk9 in 1

CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection (IC50: 39 nM for CDK9 CycT1).

CDK9 Antagonist-1 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1]. CDK9|17 μM (IC50, MCF-7 cells) [1]. Bian J , et al. Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity. Bioorg Chem. 2018 Dec;81:373-381.

CDK9/10/GSK3β-IN-1 是一种激酶抑制剂 (Flavopiridol 类似物)，能有效抑制 HsGSK3β、HsCDK9/CyclinT、HsCDK5/p25 和 HsCDK2/CyclinA，其 IC50 值分别为 59 nM、64 nM、1.093 μM 和 1.725 μM。CDK9/10/GSK3β-IN-1 表现出相当或高于 Flavopiridol 的抗癌细胞活性，在体外对多达七种癌细胞系表现出高抗增殖活性。

CDK9-Cyclin T1 PPI-IN-1 (Compound B19) 是CDK9-Cyclin T1蛋白-蛋白相互作用的选择性抑制剂。该化合物能够有效抑制TNBC MDA-MB-231细胞系的细胞增殖(IC50: 0.044 μM)，诱导细胞凋亡，同时降低CDK9的转录活性并减少RNA Pol II CTD ser2的磷酸化，有效地抑制了4T1移植瘤模型小鼠中肿瘤的生长。

PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs.

EGFR HER2 CDK9-IN-1 (Compound 4) 是一种有效的 EGFR HER2 CDK9 抑制剂，他们的 IC50 值分别为 90.17、131.39 和 67.04 nM。EGFR HER2 CDK9-IN-1 表现出明显的抗肿瘤作用。

PROTACFLT3/CDK9 degrader-1 是一种有效的FLT3和CDK9双PROTAC 降解剂。PROTACFLT3/CDK9 degrader-1 诱导细胞凋亡 (Apoptosis) 并有效降解靶蛋白FLT3和 CDK9。PROTACFLT3/CDK9 degrader-1具有研究 FLT3-ITD 突变型 AML 的潜力。

PROTAC CDK9 Degrader-1 是一种选择性 CDK9 降解剂，是由Cereblon 配体和CDK 配体相连的PROTAC。

Substance P 1-9 aceate 是九肽，可减少豚鼠回肠和膀胱对 P 物质的失活。

Angiotensin 1/2 (1-9) TFA(34273-12-6(free base)) 含有从血管紧张素 I/II 肽转化而来的氨基酸 1-9。

G280-9 acetate(156761-76-1 free base) 是一种常见的黑色素瘤 gp100 表位，受 MHC 相关 HLA-A2 限制。 G280-9 序列是独特的，因为它可以在非常低的浓度下被细胞毒性 T 淋巴细胞识别，但是它显示出低的总免疫原性，这可能是由于该肽对 HLA-A2 的亲和力相对较低。

GLP-1 receptor agonist 9 citrate 是 GLP-1 的激动剂。

PD-1 PD-L1-IN-9 是一种有效和具有口服活性的 PD-1 PD-L1 相互作用抑制剂，IC50 值为 3.8 nM。PD-1 PD-L1-IN-9 可以增强免疫细胞对肿瘤细胞的杀伤活性。PD-1 PD-L1-IN-9 在 CT26 小鼠模型中表现出显着的体内抗肿瘤活性。

CDK9 inhibitor HH1 (8019-9719) 是人类 CDK2-cyclin A2复合物的抑制剂，IC50为2 μM。

MMP-9-IN-1 是特异性的基质金属蛋白酶-9 抑制剂，选择性靶向 MMP-9 的血红素域，对其他 MMP 无影响。

GLP-1(9-36)amide 是胰高血糖素样肽-1 (7-36) amide 的主要代谢产物，对人胰腺 GLP-1受体具有拮抗作用。

TLR7 8 9-IN-1 是具有口服活性的Toll 样受体7 8 9小分子拮抗剂，IC50为43 nM。

1H-Benzimidazole-6-carboxylic acid 是GLP-1 receptor 激动剂。

CDK6 9-IN-1 (compound 66) is a potent dual inhibitor of CDK 6 and CDK 9 that can be administered orally. It exhibits inhibitory activity with IC 50 values of 40.5 nM and 39.5 nM against CDK6 and CDK9, respectively.

CDK7 9-IN-1 is a specific inhibitor of cyclin-dependent kinases 7 9 (CDK7 9). It specifically targets CDK7, while also displaying inhibitory activity against CDK9. CDK7 9-IN-1 demonstrates excellent inhibitory potency against CDK7, with IC50 values of 0.0656 μM and 0.00574 μM without pre-incubation and after 3 hours pre-incubation, respectively. Furthermore, CDK7 9-IN-1 inhibits CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation. Its application in cancer research makes it valuable for such investigations.

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65266，CAS号为 86069-86-5。

(2S,4R)-1-((9H-Fluoren-9-yl)methyl) 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66076，CAS号为 122350-59-8。

Cecropin A (1-7)-Melittin A (2-9) 为一种具抗菌效能的肽，对广谱革兰氏阳性及革兰氏阴性需氧菌显示出显著的抗菌活性，同时展现出抗疟能力，而无蜂毒肽所致的不良溶血现象。

HIV-1protease-IN-9 (compound 5b)为HIV-1蛋白酶抑制剂，具有0.028 nM的Ki值和66.8 nM的IC50，表现出显著的抗病毒活性。

Nucleoside Derivatives - Xylo-nucleosides; 8-Modified purine nucleosides; Amino nucleosides; N-Methylated alkylated nucleosides

1-Amino-8-benzyloxy-9-(b-D-xylofuranosyl)guanine is a Nucleoside Derivative - Xylo-nucleoside; 8-Modified purine nucleoside; Amino nucleoside.

Phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67229，CAS号为 379270-35-6。

Substance P (1-9) is a nonapeptide that reduces the inactivation of substance P in the guinea-pig ileum and urinary bladder, and is responsible for various excitatory effects on central and peripheral neurons.

(2S,4R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66981，CAS号为 176486-63-8。

GLP-1(9-36)amide TFA, 作为胰高血糖素样肽-1 (7-36)amide的主要代谢产物，是人胰腺GLP-1受体的拮抗剂。

9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-(naphthalen-1-yl)purine is a Nucleoside Derivative - Fluoro-modified nucleoside, 6-Modified purine nucleoside, 3'-Modified nucleoside.

9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-[5-(propyn-1-yl)pyridin-3-yl]purine is a Nucleoside Derivative - Fluoro-modified nucleoside, 6-Modified purine nucleoside, 3'-Modified nucleoside.

This is an N-terminal fragment of beta amyloid. It consists of amino acid residues 1 to 9. Truncated beta amyloid peptide (10-40) still forms amyloid fibrils and shows fibril polymorphism.

ACTH (1-17) TFA is a corticotrophin analogue and an effective human melanocortin 1 (MC1) receptor agonist with Ki value of 0.21 nM.

cis-9-Hexadecen-1-yl formate是信息素类似物，可从夜蛾科(鳞翅目)物种中分离。

1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28,31,34,37-dodecaoxa-4-azatetracontan-40-oic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64564。

Enpp-1-IN-9, a powerful inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (ENPP1), exhibits wide substrate specificity, capable of cleaving various bonds such as phosphodiester bonds of nucleotides and nucleotide sugars, as well as pyrophosphate bonds of nucleotides and nucleotide sugars. Its potential application lies in the fields of cancer and infectious disease research[1].

N-(1-((6aR,8R,9aR)-9-Cyano-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T67388。

Mcl-1 inhibitor9 (example 2) 是一种 myeloid cell leukemia 1(Mcl-1) 抑制剂，IC50值为 0.21889 nM，其具有抗肿瘤活性。

1-Amino-7,8-dihydro-8-oxo-9-(b-D-xylofuranosyl) guanine is a Nucleoside Derivative - Xylo-nucleoside; 8-Modified purine nucleoside; Amino nucleoside.

(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl (Z)-octadec-9-en-1-yl carbonate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65075，CAS号为 17110-51-9。

Nucleoside Derivatives - Tricyclic nucleosides; Xylo-nucleosides

CDK-IN-9 (compound 24) 是一种 CDK 的有效抑制剂。CDK-IN-9 也是一种能够诱导 CDK12 和 DDB1 相互作用的分子胶， 能够作用于 CDK2 E (IC50: 4 nM) 。CDK-IN-9 能够导致细胞周期蛋白 K (cyclin K) 的多泛素化及其随后的降解。CDK-IN-9 可以利用去磷酸化视网膜母细胞瘤蛋白和RNA 聚合酶 II，进而诱导细胞凋亡 (apoptosis)。

CDK9/CycT1-IN-93 is a highly specific, ATP-competitive inhibitor of CDK9/CycT1 with antiviral activity.

1-Hydroxy-9-medroxycanthin-6-one 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2537，CAS号为 622408-85-9。

Angiotensin 1 2 (1-9) 含有从血管紧张素 I II 肽转化而来的氨基酸 1-9。

Aristolan-1(10)-en-9-ol，一种倍半萜，可从Laurencia similis中提取。