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Search Results for " carbonic anhydrases "

Targets Recommended: Carbonic Anhydrase

7

抑制剂 & 化合物

10

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T6781	Benzenesulfonamide Benzenesulphonamide,苯磺酰胺,Phenyl sulfonamide,Benzosulfonamide	Carbonic Anhydrase	Metabolism
	Benzenesulfonamide (Benzosulfonamide) 是碳酸酐酶的抑制剂。
T2134	Dorzolamide hydrochloride MK507 hydrochloride,L671152 hydrochloride,MK-507 (L-671152) HCl,盐酸多佐胺,Dorzolamide HCl	Carbonic Anhydrase	Metabolism
	Dorzolamide hydrochloride (MK507 hydrochloride) 是一种碳酸酐酶carbonic anhydrase II 抑制剂，能够抑制红细胞CA-II(IC50:0.18 nM) 和CA-I(IC50:600 nM) 。
T0782	Benzthiazide Aquatag,苄噻嗪,Lemazide,Dihydrex	Carbonic Anhydrase	Metabolism
	Benzthiazide (Lemazide) 是长效利尿剂及抗高血压剂。它也是碳酸酐酶 9 的抑制剂，他对 CA9，CA2 和 CA1 的 Ki 分别为 8.0，8.8 和 10 nM。它对肿瘤细胞增殖具有抑制作用。
T61829	Carbonic anhydrase inhibitor 4	Others	Others
	Carbonic anhydrase inhibitor 4 is a photoprobe that inhibits the activity of carbonic anhydrase. It specifically targets human carbonic anhydrases, including hCA I-XIV, with K i values ranging from 640-1166 nM [1].
T35713	N-desethyl Brinzolamide (oxalate)	Others	Others
	N-desethyl Brinzolamide is an active metabolite of the carbonic anhydrase (CA) inhibitor brinzolamide .1It inhibits CAII and CAIV activities (IC50s = 1.28 and 128 nM, respectively). 1.Kim, C.-Y., Whittington, D.A., Chang, J.S., et al.Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IVJ. Med. Chem.45(4)888-893(2002)
T79753	hCAIX/XII-IN-8	Carbonic Anhydrase	Metabolism
	hCAIX/XII-IN-8（compound 3g）是一种对人类（碳酸酐酶）CA IX和XII高效的抑制剂，Ki值分别为8.5和6.7 nM。该化合物对与肿瘤相关的膜结合异构体hCA IX和XII表现出显著的抑制作用，且相对于胞内异构体hCA I和II具有较高的选择性。
T79591	hCA/VEGFR-2-IN-4	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	hCA/VEGFR-2-IN-4 (化合物15b) 是一种具有癌症治疗潜力的吲哚酮基苯磺酰胺类双重抑制剂，旨在抑制与癌症相关的hCA IX/XII 和VEGFR-2。该化合物对VEGFR-2具有较强的抑制能力（IC50=0.811 μM），并对hCAs展现高亲和性，其Ki值分别为hCA XII的3.8 nM，hCA IX的6.2 nM，hCA II的19.8 nM，以及hCA I的35.5 nM。此外，hCA/VEGFR-2-IN-4 对于VEGFR-2过表达的乳腺癌细胞有抗增殖作用。

化合物

Benzenesulfonamide

Cat.No: T6781

Synonym: Benzenesulphonamide,苯磺酰胺,Phenyl sulfonamide,Benzosulfonamide

Target: Carbonic Anhydrase

Dorzolamide hydrochloride

Cat.No: T2134

Synonym: MK507 hydrochloride,L671152 hydrochloride,MK-507 (L-671152) HCl,盐酸多佐胺,Dorzolamide HCl

Target: Carbonic Anhydrase

Cat.No: T0782

Synonym: Aquatag,苄噻嗪,Lemazide,Dihydrex

Target: Carbonic Anhydrase

Carbonic anhydrase inhibitor 4

Cat.No: T61829

Target: Others

N-desethyl Brinzolamide (oxalate)

Cat.No: T35713

Target: Others

Cat.No: T79753

Target: Carbonic Anhydrase

hCA/VEGFR-2-IN-4

Cat.No: T79591

Target: VEGFR

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00478	Carbonic Anhydrase 12 Protein, Cynomolgus, Recombinant (His) CA12,CAXII,Carbonic anhydrase,CA-XII,Tumor antigen ...	Cynomolgus	HEK293 Cells
	Carbonic anhydrases (CAs) are a family of enzymes involved in the pH regulation of metabolically active cells/tissues. Carbonic anhydrase XII (CA XII) is a key mediator of several signaling pathways that are involved in cancer development.
TMPY-02277	Carbonic Anhydrase 7 Protein, Human, Recombinant (His) CAVII,carbonic anhydrase VII	Human	E. coli
	Carbonic anhydrase 7, also known as carbonate dehydratase VII, carbonic anhydrase VII, CA-VII and CA7, is a cytoplasm protein which belongs to thealpha-carbonic anhydrase family. Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, ...
TMPY-01761	Carbonic Anhydrase 3 Protein, Human, Recombinant (His) carbonic anhydrase III,CAIII,Car3	Human	E. coli
	Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. Carbonic anhydrases (CAs) form a family of enzymes that catalyze the rapid conversion of carbon dioxide and water to bicarbonate an...
TMPK-00524	CA9/Carbonic Anhydrase IX Protein, Cynomolgus, Recombinant (His) CAIX,CA9,P54/58N,RCC,G250,EC 4.2.1.1,PMW1,CA-IX,MN	Cynomolgus	HEK293 Cells
	CA9 is a member of the carbonic anhydrases' family, that is often expressed in cancer cells under hypoxic condition. CA9 expression potentially contributes to the regulation of cancer cell differentiation and mediates tumour-associated genes and signalling pathways, including apoptosis, hypoxia, G2M checkpoint, PI3K/AKR/mTOR signalling and TGF-beta signalling pathways. CA9/Carbonic Anhydrase IX Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The pred...
TMPJ-00283	Carbonic Anhydrase 9 Protein, Human, Recombinant (Avi & His), Biotinylated G250,P54/58N,Carbonic Anhydrase IX,CA9,Carbonate de...	Human	HEK293 Cells
	Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide (H2O + CO2 = H+ + HCO3–) and thus participate in a variety of biological and physical processes. CA9 is a transmembrane enzyme expressed primarily in carcinoma cells. It is one of the best markers for hypoxia and for RCC...
TMPK-00283	CA9/Carbonic Anhydrase IX Protein, Human, Recombinant (His & Avi) RCC,EC 4.2.1.1,CA9,P54/58N,MN,CA-IX,CAIX,G250,PMW1	Human	HEK293 Cells
	CA9 is a member of the carbonic anhydrases' family, that is often expressed in cancer cells under hypoxic condition. CA9 expression potentially contributes to the regulation of cancer cell differentiation and mediates tumour-associated genes and signalling pathways, including apoptosis, hypoxia, G2M checkpoint, PI3K/AKR/mTOR signalling and TGF-beta signalling pathways. CA9/Carbonic Anhydrase IX Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The...
TMPJ-00701	Carbonic Anhydrase 11 Protein, Human, Recombinant (His) Carbonic Anhydrase-Related Protein 2,CARP XI,CA11,C...	Human	HEK293 Cells
	Carbonic Anhydrase-Related Protein 11 (CA11) is a secreted protein member of the α-carbonic anhydrase family. Carbonic Anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CA11 is expressed abundantly in the brain with moder...
TMPY-02133	Carbonic Anhydrase VB Protein, Human, Recombinant (His) carbonic anhydrase VB, mitochondrial,CA-VB,MGC39962	Human	E. coli
	Carbonic anhydrase 5B, also known as carbonate dehydratase VB, carbonic anhydrase VB, CA-VB and CA5B, is amember of the alpha-carbonic anhydrase family. The strongest expression of CA5B / CA-VB is in heart, pancreas, kidney, placenta, lung, and skeletal muscle. It is not expressed in liver. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological process...
TMPY-01877	CA5A Protein, Human, Recombinant (His) CA5,GS1-21A4.1,CA5AD,carbonic anhydrase VA, mitocho...	Human	E. coli
	Carbonic anhydrase 5A, mitochondrial, also known as Carbonate dehydratase VA, Carbonic anhydrase VA, CA-VA and CA5A, is a member of thealpha-carbonic anhydrase family. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospi...
TMPY-01734	CA13 Protein, Human, Recombinant (His) carbonic anhydrase XIII,FLJ37995,CAXIII,MGC59868	Human	E. coli
	The carbonic anhydrases (or carbonate dehydratases) are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons, a reversible reaction that takes part in maintaining acid-base balance in blood and other tissues. The carbonic anhydrasekl (CA) family consists of at least 11 enzymatically active members and a few inactive homologous proteins. The CAXIII is a member of th...

重组蛋白

Carbonic Anhydrase 12 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00478

Species: Cynomolgus

Expression System: HEK293 Cells

Carbonic Anhydrase 7 Protein, Human, Recombinant (His)

Cat.No: TMPY-02277

Species: Human

Expression System: E. coli

Carbonic Anhydrase 3 Protein, Human, Recombinant (His)

Cat.No: TMPY-01761

Species: Human

Expression System: E. coli

CA9/Carbonic Anhydrase IX Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00524

Species: Cynomolgus

Expression System: HEK293 Cells

Carbonic Anhydrase 9 Protein, Human, Recombinant (Avi & His), Biotinylated

Cat.No: TMPJ-00283

Species: Human

Expression System: HEK293 Cells

CA9/Carbonic Anhydrase IX Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00283

Species: Human

Expression System: HEK293 Cells

Carbonic Anhydrase 11 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00701

Species: Human

Expression System: HEK293 Cells

Carbonic Anhydrase VB Protein, Human, Recombinant (His)

Cat.No: TMPY-02133

Species: Human

Expression System: E. coli

CA5A Protein, Human, Recombinant (His)

Cat.No: TMPY-01877

Species: Human

Expression System: E. coli

CA13 Protein, Human, Recombinant (His)

Cat.No: TMPY-01734

Species: Human

Expression System: E. coli

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