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Search Results for " cachexia "

Targets Recommended: RAAS Autophagy

13

抑制剂 & 化合物

2

天然产物

3

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T1520	Aliskiren hemifumarate 阿利克仑半富马酸盐,CGP 60536,SPP 100,CGP60536B	RAAS; Autophagy	Autophagy; Endocrinology/Hormones
	Aliskiren hemifumarate (CGP60536B) 一种可口服非肽肾素抑制剂，IC50为1.5 nM，具有抗高血压活性。
T69526	PF-07258669	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	PF-07258669 是一种选择性黑皮质素 4 受体 (MC4) 拮抗剂，可用于研究恶病质和食欲衰退。
T76774	Ponsegromab PF 06946860	TGF-beta/Smad	Stem Cells
	Ponsegromab (PF 06946860) 是一种具有选择性和有效性的人源化抗 GDF15 抗体抑制剂。 Ponsegromab 具有抗恶病质活性，通过与 GDF15 结合来阻止其与 GFRAL 结合，从而中断 GDF15/GFRAL 介导的信号传导。 Ponsegromab 具有潜在的抗癌活性，可用于治疗患有癌症厌食-恶病质综合征的癌症患者。
T2408	Ostarine MK-2866,GTX-024,Enobosarm	Androgen Receptor	Endocrinology/Hormones
	Ostarine (MK-2866) 是一种具有合成代谢活性的非甾体药物。选择性雄激素受体调节剂 (SARM) GTx-024 旨在像睾酮一样发挥作用，从而促进和/或维持性欲、生育能力、前列腺生长以及肌肉生长和力量。模仿睾酮的作用，这种药物可以增加瘦体重，从而改善癌症恶病质高代谢状态下的肌肉萎缩。
T27986	MCL0129 MCL-0129,MCL 0129	Others	Others
	MCL0129, a selective and non-peptidergic melanocortin 4 (MC4) receptor antagonist, is a potential treatment for cachexia.
T72526	Aliskiren fumarate CGP 60536 fumarate,SPP 100 fumarate,CGP 60536 fumarate ; CGP60536B fumarate ; SPP 100 fumarate,CGP60536B fumarate	Others	Others
	Aliskiren fumarate是一种口服有效、选择性的肾素(renin)抑制剂，IC50值为1.5 nM。适用于高血压、心血管疾病和癌症恶病质的研究。
T64163	Aliskiren hydrochloride	Others	Others
	Aliskiren (CGP 60536; CGP60536B; SPP 100) hydrochloride 是一种选择性的、口服具有活力的、肾素 (renin) 抑制剂 (IC50: 1.5 nM)。Aliskiren hydrochloride 能够用于研究高血压、心血管疾病和癌症恶病质。
T80540	TCMCB07	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	TCMCB07为环状九肽，是具有口服活性及脑渗透性的黑皮质素受体4 (MC4R) 拮抗剂，在恶病质中具有关键作用。
T80541	TCMCB07 TFA	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	TCMCB07 TFA为一环状九肽，属口服活性及脑渗透性黑皮质素受体4 (MC4R) 拮抗剂，于恶病质中扮演关键角色。
T82263	GPR61 Inverse agonist 1	Others	Others
	GPR61 Inverse agonist 1 (Compound 1) 作为一种GPR61反向激动剂，显示出11 nM的IC50值。该化合物主要用于代谢和体重疾病的研究，包含肥胖和恶病质。
T39236	Relamorelin acetate Relamorelin acetate,RM-131 acetate,BIM-28131acetate
	Relamorelin (RM-131) acetate is a pentapeptide ghrelin analog that acts as a selective agonist for the ghrelin/growth hormone secretagogue receptor (GHSR). It exhibits a high affinity for the GHS-1a receptor, with a Ki value of 0.42 nM. Notably, Relamorelin acetate can cross the blood-brain barrier and target the central nervous system. This compound effectively increases growth hormone levels and promotes faster gastric emptying. Due to these properties, Relamorelin acetate holds promise for it...
T68276	Macimorelin acetate EP-1572 acetate ; AEZS-130 acetate,AEZS-130 acetate,EP-1572 acetate	Others	Others
	Macimorelin (EP-1572) acetate，一种 GH 促分泌素，是一种具有口服活性的GHSR 激动剂。Macimorelin acetate 可刺激 GH 的释放。Macimorelin acetate 可用于成人生长激素缺乏症 (AGHD) 和癌症厌食-恶病质综合征 (CACS) 的研究。
T75262	Relamorelin TFA
	Relamorelin (RM-131) TFA，一种生长素类似物，是一种选择性的生长素释放肽/生长激素促分泌素受体 (GHSR) 激动剂，对GHS-1a 受体的Ki 值为 0.42 nM。Relamorelin TFA 是一种五肽，具有中枢渗透性。Relamorelin TFA 增加生长激素水平，加速胃排空，具有用于恶病质、胃轻瘫和胃/肠运动障碍研究的潜力。

化合物

Aliskiren hemifumarate

Cat.No: T1520

Synonym: 阿利克仑半富马酸盐,CGP 60536,SPP 100,CGP60536B

Target: RAAS, Autophagy

Cat.No: T69526

Target: Melanocortin Receptor

Cat.No: T76774

Synonym: PF 06946860

Target: TGF-beta/Smad

Cat.No: T2408

Synonym: MK-2866,GTX-024,Enobosarm

Target: Androgen Receptor

Cat.No: T27986

Synonym: MCL-0129,MCL 0129

Target: Others

Aliskiren fumarate

Cat.No: T72526

Synonym: CGP 60536 fumarate,SPP 100 fumarate,CGP 60536 fumarate ; CGP60536B fumarate ; SPP 100 fumarate,CGP60536B fumarate

Target: Others

Aliskiren hydrochloride

Cat.No: T64163

Target: Others

Cat.No: T80540

Target: Melanocortin Receptor

Cat.No: T80541

Target: Melanocortin Receptor

GPR61 Inverse agonist 1

Cat.No: T82263

Target: Others

Relamorelin acetate

Cat.No: T39236

Synonym: Relamorelin acetate,RM-131 acetate,BIM-28131acetate

Macimorelin acetate

Cat.No: T68276

Synonym: EP-1572 acetate ; AEZS-130 acetate,AEZS-130 acetate,EP-1572 acetate

Target: Others

Relamorelin TFA

Cat.No: T75262

Cat. No.	Product Name	Target	Signaling Pathways
T1284	Megestrol acetate SC10363,醋酸甲地孕酮,BDH1298	Glucocorticoid Receptor; Estrogen/progestogen Receptor; Progesterone Receptor; HIV Protease; Autophagy	Autophagy; Endocrinology/Hormones; Microbiology/Virology; Others; Proteases/Proteasome
	Megestrol acetate (BDH1298) 是具有口服活性的合成孕激素。它还具有抗雄激素特性，可用于治疗厌食症和恶病质。
TN5538	6-Methoxykaempferol	Others	Others
	6-Methoxykaempferol 是一种存在于 brazilian propolis 中的黄酮。6-Methoxykaempferol 对癌细胞具有抗增殖活性，对离体大鼠脑突触体的神经保护作用，可降低的谷胱甘肽水平。6-Methoxykaempferol 表现出一定的脂肪酶活性，可用于恶病质的治疗。

天然产物

Megestrol acetate

Cat.No: T1284

Synonym: SC10363,醋酸甲地孕酮,BDH1298

Target: Glucocorticoid Receptor, Estrogen/progestogen Receptor, Progesterone Receptor, HIV Protease, Autophagy

6-Methoxykaempferol

Cat.No: TN5538

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00033	UBE2B Protein, Human, Recombinant (His) Ubiquitin-Conjugating Enzyme E2 B,hHR6B,Ubiquitin-Conjugatin...	Human	HEK293 Cells
	Ubiquitin-Conjugating Enzyme E2 B (UBE2B) is a member of the ubiquitin-conjugating enzyme family. UBE2B accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It is shown that UBE2B interacts with RAD18, UBR2, and WAC. UBE2B is required for post-replicative DNA damage repair. Additional, UBE2B plays a role in sepsis-induced muscle protein proteolysis and cancer-induced cachexia.
TMPJ-01047	UBE2H Protein, Human, Recombinant (GST) UBE2H,UbcH2,Ubiquitin-Conjugating Enzyme E2 H,Ubiquitin-Prot...	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 H (UBE2H) belongs to the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. It has been shown to conjugate ubiquitin to histone H2A in an E3 dependent manner in ...
TMPY-03117	Zinc Alpha 2 Glycoprotein/AZGP1 Protein, Human, Recombinant (His) ZAG,α-2-glycoprotein 1, zinc-binding,Zinc α 2,ZA2G,alpha-2-g...	Human	HEK293 Cells
	Alpha-2-glycoprotein, also known as AZGP1, belongs to the MHC class I family. It can be detected in body fluids such as serum, sweat, and seminal and breast cyst fluids. It has been shown that alpha-2-glycoprotein can stimulate lipolysis by adipocytes in vivo and in vitro. Thus it is believed that alpha-2-glycoprotein plays an important role in the regulation of body weight, and age-dependent changes in genetically influenced obesity, and it also regulates melanin production by normal and malign...

重组蛋白

UBE2B Protein, Human, Recombinant (His)

Cat.No: TMPJ-00033

Species: Human

Expression System: HEK293 Cells

UBE2H Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01047

Species: Human

Expression System: E. coli

Zinc Alpha 2 Glycoprotein/AZGP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03117

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0025	Megestrol Acetate-d3
	Megestrol Acetate-d3 是 Megestrol Acetate 的氘代化合物。Megestrol Acetate 的 CAS 号为 595-33-5。Megestrol acetate 是具有口服活性的合成孕激素。它还具有抗雄激素特性，可用于治疗厌食症和恶病质。

同位素标记化合物

Megestrol Acetate-d3

Cat.No: TMIJ-0025

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