betaamyloid(114),mouse,rat

Beta-Amyloid(1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide. This peptide is amino acids 1 to 14 fragment of Beta-Amyloid peptide.

Adropin (34-76) (human, mouse, rat) 是一种多肽，可减轻肝纤维化和胰岛素抵抗，而不依赖于肥胖或食物摄入。

Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate (Orphan GPCR SP9155 agonist P550 ) 是具有促食欲作用的 RFamide 肽家族的成员。

PACAP-38 (31-38), human, mouse, rat acetate 是 PAC1 受体的激活剂。PACAP-38 (31-38), human, mouse, rat acetate 对交感神经元 NPY 和儿茶酚胺的产生具有强效、有效和持续的刺激作用，可用于神经营养和神经保护研究。

Neuropeptide SF(mouse,rat) acetate (Neuropeptide SF(mouse,rat) acetate (230960-31-3 free base)) 是一种有效的神经肽 FF 受体激动剂，对 NPFF1 和 NPFF2 的 Ki 分别为 48.4 nM 和 12.1 nM。它增加了异源表达的酸感应离子通道 3 (ASIC3) 的持续电流的幅度。

Galanin (1-16), mouse, porcine, rat 是一种有效的甘丙肽受体激动剂，Kd 为 3 nM。

Orexin B, rat, mouse Acetate (Rat orexin B)(202801-92-1 free base) 是 Orexin 受体的内源性激动剂，对 OX1 和 OX2 的 Kis 分别为 420 和 36 nM。

Enterostatin, human, mouse, rat acetate 是一种五肽，主要由分泌的胰腺前脂肪酶在肠道中形成。

Myelin Oligodendrocyte Glycoprotein (MOG) peptide (35-55) , mouse, rat acetate 是MOG peptide (35-55)衍生物。 MOG peptide (35-55)是髓鞘少突胶质细胞糖蛋白 (MOG) 免疫原肽的 一部分。MOG peptide (35-55) 特异性作用于 CD4+ T 细胞，能够给诱导实验性自身免疫性脑脊髓炎 (EAE) 动物模型。MOG peptide (35-55) , mouse, rat acetate(149635-73-4 Free base)是MOG peptide (35-55)衍生物。 MOG peptide (35-55)是髓鞘少突胶质细胞糖蛋白 (MOG) 免疫原肽的 一部分，可用于研究与免疫相关的疾病。

MCH(human, mouse, rat) 是MCH-R 肽激动剂，对 CHO 细胞系中 MCH-2R 高度敏感，激活 MCH-1R 和 MCH-2R 的IC50 值分别为 0.3 和 1.5 nM，EC50值对分别为 3.9 和 0.1 nM。

Angiotensin I (human, mouse, rat) 是血管紧张素Ⅱ的前体物质，在血管紧张素转化酶 (ACE) 的参与下裂解成血管紧张素Ⅱ。

Orphan GPCR SP9155 agonist P550 (mouse, rat) (26RFa (mouse, rat)) is an orphan GPCR with an orexigenic effect belonging to the RFamide peptide family. It acts as the cognate ligand for the mouse orphan receptor GPR103, which is also known as SP9155 or AQ27.

PAR2 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse and rat PAR2. It also corresponds to residues 39-44 and 37-42 of the mouse and rat full-length sequences, respectively. PAR2 (1-6) induces relaxation in precontracted rat arteries in a concentration-dependent manner, an effect that can be reduced by the nitric oxide synthase inhibitor L-NNA . It inhibits keratinocyte growth in the presence and absence of growth factors. PAR2 (1-6) inhibits LPS-induced pulmonary neutrophil influx and increases in matrix metalloproteinase-2 (MMP-2) activity in mice.

MCH (human, mouse, rat) TFA 是一种有效的 MCH-R 的肽激动剂，与 MCH1R 和 MCH2R 结合的 IC50值分别为 0.3 nM 和 1.5 nM。MCH (human, mouse, rat) 对 CHO 细胞系中 MCH-2R 高度敏感，通过 FLIPR 监测细胞内钙动员，显示出功能性激活 MCH-1R 和 MCH-2R 的EC50值对分别为 3.9 nM 和 0.1 nM。

ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) 是ACTH的3-24片段，适用于癌症、免疫疾病、心血管疾病等多种疾病的研究。

Non-selective galanin receptor agonist (Ki values are 0.98, 1.48 and 1.47 nM for GAL1, GAL2 and GAL3 respectively). Anticonvulsant; prevents the occurrence of full kindled seizures in rats.

pTH-Related Protein (1-37) (human, mouse, rat) 为甲状旁腺相关蛋白 (pTHrP) 的肽段，涉及骨形成的生理调控过程。

Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse (MOG (40-54)) 是一种与 H-2Db 关联的CD8+T细胞自身抗原表位，来源于髓鞘少突神经胶质细胞糖蛋白 (MOG)。

Proadrenomedullin N-terminal 12 peptide (PAMP-12) 是一种内源性肽段，源自人体肾上腺髓质，对应人类PAMP-20的9-20氨基酸，涉及降低血压。它是MAS相关G蛋白偶联受体家族成员X2 (MRGPRX2) 的激动剂。在表达人MRGPRX2的CHO细胞中，PAMP-12抑制forskolin诱导的cAMP积累（EC50 = 57.2 nM），特异性诱导表达MRGPRX2的CHO细胞的钙离子动员（EC50 = 41 nM），而在表达MRGPRX1、MRGPRX3或MRGPRX4的细胞中则无此效应（在1 µM浓度下）。PAMP-12还能作为烟碱型乙酰胆碱受体（nAChRs）的拮抗剂，抑制carbachol诱导的儿茶酚胺释放（IC50 = 1.3 µM）及钙和钠的流入（IC50分别为0.39 µM和0.87 µM），但不抑制组胺诱导的儿茶酚胺释放或钙和钠的流入（IC50 >1 µM），在初级牛肾上腺嗜铬细胞中有此表现。当以10至50 nmol/kg剂量给予正常血压大鼠时，PAMP-12能降低平均动脉血压。

Galanin (2-11) amide is a synthetic peptide fragment of the neuropeptide galanin and an agonist of the galanin-2 (GAL2) receptor (EC50= 9.32 nM in a fluorescence imaging plate reader assay).1It selectively binds to the GAL2receptor (IC50= 1.76 nM for the rat receptor) over the GAL1receptor (IC50= 879 nM for the human receptor) but does also bind to the GAL3receptor (Ki= 271 nM for the rat receptor).1,2Intracerebroventricular administration of galanin (2-11) amide (1 nmol/animal) decreases immobility in the forced swim test in rats.3It also reduces the hind paw mechanical pain threshold and increases the hind paw cold sensitivity threshold in rats.1

(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) 是一种有效的 PTH-1R 拮抗剂。

Galanin(1-29)(rat, mouse) TFA 是一种非选择性甘丙肽受体 (galaninreceptor) 激动剂，对 GAL1、GAL2 和 GAL3 的Ki 值分别为 0.98、1.48 和 1.47 nM。具有抗惊厥作用。

Apelin-36(rat, mouse) TFA 是一种内源性孤儿 G 蛋白偶联受体 APJ 激动剂。Apelin-36(rat, mouse) TFA 与 APJ 受体结合，IC50为 5.4 nM，显著抑制 cAMP 的产生，EC50为 0.52 nM。Apelin-36(rat, mouse) TFA 阻断 HIV-1和 HIV-2毒株进入表达 APJ 的 NP-2/CD4 细胞。

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) 是中枢神经鞘的一个次要成分。它能诱导强效的 T 细胞和 B 细胞反应，同时是高度脑源性的。它能够引发复发缓解性神经系统疾病，伴有广泛的斑块样脱髓鞘。

PACAP-38 (31-38), human, mouse, rat (TFA), exhibits potent, efficacious, and sustained stimulatory effects on sympathetic neurons.

pTH-Related Protein (1-34) amide (human, mouse, rat) 为PTHrP的N末端片段，能够诱导高钙血症，适于研究与恶性肿瘤相关的体液性高钙血症。

β-Amyloid (1-38), derived from mice and rats, is a chemical compound comprising 38 amino acids, specifically residues 1-38 of the Aβ peptide. Notably, it serves as the primary constituent of amyloid plaques associated with Alzheimer's disease.

β-Amyloid (1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide. β-Amyloid (1-14),mouse,rat is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. β-Amyloid (1-14),mouse,rat accumulation in the brain is proposed to be an early toxic event in the pathogenesis of Alzheimer’s disease, which is the most common form of dementia associated with plaques and tangles in the brain[1]. [1]. Chen GF, et al. Amyloid beta: structure, biology and structure-based therapeutic development. Acta Pharmacol Sin. 2017 Sep;38(9):1205-1235.

Orexin A (Hypocretin-1) (human, rat, mouse) acetate 是一种具有镇痛特性的下丘脑神经肽 (可透过血脑屏障)。Orexin A (human, rat, mouse) acetate 也是一种OX1R 激动剂，能以时间和剂量依赖性的方式诱导 SH-SY5Y 细胞BDNF 和TH 蛋白的表达。Orexin A (human, rat, mouse) acetate 可用于食欲调节、神经退行性疾病，以及调节伤害性信息传递的研究。

'(Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat)'是用于甲状旁腺激素(PTH)受体的肽类配体。

Enterostatin (human,mouse,rat) TFA, 作为一种五肽，主由胰前脂酶在肠道中裂解生成。它能选择性降低脂肪摄取、体重及体脂。

Neuropeptide SF (mouse,rat) TFA 作为一种高效的 neuropeptide FF receptor 激动剂，对 NPFF1 和 NPFF2 的Ki值分别达到 48.4 nM 和 12.1 nM。该化合物还能够提升异表达的酸感离子通道 3 (ASIC3) 的持续电流幅值。

Pituitary adenylate cyclase-activating peptide (PACAP) (6-27) is a PACAP receptor antagonist with IC50 values of 1,500, 600, and 300 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells. It binds to PACAP receptors on SH-SY5Y and SK-N-MC human neuroblastoma and T47D human breast cancer cells (IC50s = 24.5, 106, and 105 nM, respectively) and inhibits cAMP accumulation induced by PACAP (1-38) (Kis = 457, 102, and 283 nM, respectively, in SH-SY5Y, SK-N-MC, and T47D cells). In vivo, in newborn pigs, PACAP (6-27) (10 μM) inhibits vasodilation of pial arterioles induced by PACAP (1-27) and PACAP (1-38) . It also inhibits PACAP (1-27)-stimulated increases in plasma insulin and glucagon levels and pancreatic venous blood flow in dogs when administered locally to the pancreas at a dose of 500 μg.

Endogenous agonist at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions.

Endothelin-3 (human, mouse, rabbit, rat) is a cyclic 21-amino acid peptide, acting as an endogenous neuropeptide and potent vasoconstrictor.

MOG (92–106), mouse, rat 是一种来自小鼠 大鼠髓磷脂少突胶质细胞糖蛋白的生物活性肽，包含氨基酸片段92至106。在MOG (92–106) 诱导的实验性自身免疫性脑脊髓炎模型中，小鼠会对次级髓磷脂抗原呈现出广泛的B细胞反应性，尽管T细胞反应较弱。该肽段在SJL小鼠、DA大鼠以及恒河猴中均可诱导严重的脑炎。

pTH-Related Protein (7-34) amide (human, mouse, rat) 为一种高效的甲状旁腺激素 (PTH) 拮抗剂。

Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat) (Human PTHrP (107-111) amide) 是一段具有抑制骨吸收作用的C端甲状旁腺激素相关蛋白片段。

pTH-Related Protein (1-40) (human, mouse, rat) 促进大鼠肠细胞通过PTHR1受体和PKCα β信号通路的钙吸收作用。该蛋白增加了甲状旁腺激素1受体（PTHR1）表达，提升了四种跨膜钙转运蛋白—TRPV6、CaBP-D9k、NCX1和PMCA1的水平。

Orexin B, rat, mouse (Rat orexin B) TFA，作为一种内源性促进食欲的(Orexin receptor)激动剂，通过结合并激活两个亲密相关的孤儿G蛋白偶联受体OX1-R和OX2-R，促进食物摄入和能量消耗，并在睡眠-觉醒调节中扮演关键角色。

Enterostatin (human, mouse, rat) is a pentapeptide known to reduce fat intake.

Galanin (1-16), mouse, porcine, rat is a potent agonist of the hippocampal galanin receptor with a Kd of 3 nM, and it exhibits high biological activity on locus coeruleus neurons.

PACAP-38 (16-38), human, mouse, rat, exhibits potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production.

Obestatin(11-23)mouse, rat 是多肽，涉及能量平衡调节，抑制摄食。该化合物能使啮齿类动物食量减少、体重降低、及空肠收缩。

Oxyntomodulin (human, mouse, rat) (Proglucagon (33-69)) 是由胰高血糖素前体产生，融合了完整胰高血糖素序列和C端八肽，含37个氨基酸。

Orexin A (human, rat, mouse) acetate (205640-90-0 Free base) 是一种 33 个氨基酸的兴奋性神经肽，协调多种中枢和外周过程。 Orexin A (human, rat, mouse) acetate 已用于研究其对猪胰岛功能的影响。 Orexin A (human, rat, mouse) acetate 也被用作食欲素受体 1 (OX1R) 激动剂，以研究食欲素系统对依托孕烯对长期代谢性酸中毒呼吸反应的影响。

(Phe13,Tyr19)-MCH (human, mouse, rat) 作为一种高效的 SLC-1 与 S643b 受体配体，可充当这两种受体的激动剂。

Peptide YY (13-36) (canine, mouse, porcine, rat) 是 Y2受体的激动剂。