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Search Results for " asymmetric "

Targets Recommended: TNF

15

抑制剂 & 化合物

3

天然产物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T13951	UCB-9260	TNF	Apoptosis
	UCB-9260 是口服活性小分子，通过稳定三聚体的不对称形式抑制肿瘤坏死因子信号传导。它对肿瘤坏死因子的选择性高于其他超家族成员，并与肿瘤坏死因子结合，其Kd 值为 13 nM。
T70988	Ibulocydine	Others	Others
	Ibulocydine is a potent CDK inhibitor. Ibulocydine has high activity against Cdk7/cyclin H/Mat1 and Cdk9/cyclin T. Ibulocydine inhibited the growth of HCC cells more effectively than other Cdk inhibitors, including olomoucine and roscovitine, whereas ibulocydine as well as the other Cdk inhibitors and BMK-Y101 minimally influenced the growth of normal hepatocyte cells. Ibulocydine induced apoptosis in HCC cells, most likely by inhibiting Cdk7 and Cdk9. In vitro treatment of HCC cells with ibuloc...
T31907	Gamma-Methylleucine L-Neopentylglycine,gamma-Methyl-L-leucine,3-叔丁基-L-丙氨酸,2-Amino-3-tert-butylpropionic acid	Others	Others
	Gamma-Methylleucine (2-Amino-3-tert-butylpropionic acid) 是铜催化的不对称迈克尔反应的辅助剂。
T19941	MBS Crosslinker MBS protein crosslinker,3-Maleimido-benzoic acid-OSu	Others	Others
	MBS Crosslinker (MBS protein crosslinker) 是一种交联剂，可用作不对称间隔基。
T50096	Neramexane HCl 1,3,3,5,5-pentamethylcyclohexan-1-amine HCl	Others	Others
	1,3,3,5,5-pentamethylcyclohexan-1-amine hydrochloride，又称PAC，是一种环胺，通常用作不对称合成中的手性助剂，包括Diels-Alder 反应、羟醛反应和Michael 加成。
T82236	HBED-CC-tris(tert-butyl ester)	Others	Others
	HBED-CC-tris(tert-butyl ester)是HBED-CC的一种单价变体，可用于合成基于非对称 HBED-CC 的放射性化合物，可用于肿瘤成像。
T9897	7-Methoxy-1-naphthaleneacetic acid	Others	Others
	7-Methoxy-1-naphthaleneacetic acid 是植物生长素作用的抑制剂。 7-Methoxy-1-naphthaleneacetic acid 抑制与拟南芥和玉米中生长素不对称分布相关的极性生长素转运和热带反应。 7-Methoxy-1-naphthaleneacetic acid 抑制由酵母中表达的 AUX1、PIN 和 ABCB 蛋白介导的生长素转运。
T25529	IMM-01	GTPase	GPCR/G Protein
	IMM-01 是一类新型的哺乳动物透明 (mDia) 相关形式的小分子激动剂，其作用于 Rho GTPase 下游以组装肌动蛋白丝，并与微丝组织在迁移和不对称分裂过程中建立和维持细胞极性. GTP 结合的 Rho 通过破坏 DID 和 DAD 自动调节结构域之间的相互作用来激活 mDia 家族成员，从而释放 FH2 结构域以调节肌动蛋白和微管动力学。
T33603	Nb-enantride	Others	Others
	Nb-enantride is a novel chiral trialkylborohydride for the asymmetric reduction of ketones.
T36976	SGC 6870	Others	Others
	Potent and selective protein arginine methyltransferase 6 (PRMT6) inhibitor (IC50 = 77 nM). Exhibits selectivity over all other PRMTs and 23 methyltransferases. In HEK293T cells overexpressing PRMT6, inhibits asymmetric dimethylation of H3R2 (IC50 = 0.8 μM) Negative control SGC 6870N (Cat. No. 7184) also available.
T85030	(−)-G-Lactone	Others	Others
	(–)-G-lactone, a bicyclic γ-lactone, serves as a chiral synthon for prostaglandin and a building block. It is formed through an asymmetric Baeyer-Villiger oxidation reaction. Additionally, (–)-G-lactone has been utilized in the synthesis of HIV-1 protease inhibitors.
T83141	Alnuctamab EM901,CC-93269
	Alnuctamab (EM901)为一种不对称双臂人源化IgG T细胞接合器，主要应用于免疫学研究。
T68954	UCB-6876	Others	Others
	UCB-6876 is a novel inhibitor of TNF signalling by stabilising an asymmetric form of the trimer, displaying a concentration-dependent response curve and selectivity over the TNFR1 extracellular domain and control proteins.
T71807	UCB-6786	Others	Others
	UCB-6786 is a novel inhibitor of TNF signalling by stabilising an asymmetric form of the trimer, displaying a concentration-dependent response curve and selectivity over the TNFR1 extracellular domain and control proteins.
T36110	L-Pyrohomoglutamic Acid	Others	Others
	L-Pyrohomoglutamic acid is an amino acid building block.1,2It has been used in the synthesis of ligands for FK506-binding proteins (FKBPs) and histone deacetylase (HDAC) inhibitors. 1.Pomplun, S., Wang, Y., Kirschner, A., et al.Rational design and asymmetric synthesis of potent and neurotrophic ligands for FK506-binding proteins (FKBPs)Angew. Chem. Int. Ed.54(1)345-348(2015) 2.Taddei, M., Cini, E., Giannotti, L., et al.Lactam based 7-amino suberoylamide hydroxamic acids as potent HDAC inhibitors...

化合物

Cat.No: T13951

Target: TNF

Cat.No: T70988

Target: Others

Gamma-Methylleucine

Cat.No: T31907

Synonym: L-Neopentylglycine,gamma-Methyl-L-leucine,3-叔丁基-L-丙氨酸,2-Amino-3-tert-butylpropionic acid

Target: Others

MBS Crosslinker

Cat.No: T19941

Synonym: MBS protein crosslinker,3-Maleimido-benzoic acid-OSu

Target: Others

Cat.No: T50096

Synonym: 1,3,3,5,5-pentamethylcyclohexan-1-amine HCl

Target: Others

HBED-CC-tris(tert-butyl ester)

Cat.No: T82236

Target: Others

7-Methoxy-1-naphthaleneacetic acid

Cat.No: T9897

Target: Others

Cat.No: T25529

Target: GTPase

Cat.No: T33603

Target: Others

Cat.No: T36976

Target: Others

(−)-G-Lactone

Cat.No: T85030

Target: Others

Cat.No: T83141

Synonym: EM901,CC-93269

Cat.No: T68954

Target: Others

Cat.No: T71807

Target: Others

L-Pyrohomoglutamic Acid

Cat.No: T36110

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T7682	Asymmetric dimethylarginine	Endogenous Metabolite; NO Synthase; NOD	Immunology/Inflammation; Metabolism; NF-κB
	Asymmetric dimethylarginine 是内源性一氧化氮合成酶抑制剂，可以作为内皮功能障碍的标志。
T5309	Dimethylamine hydrochloride N,N-Dimethylamine,二甲胺盐酸盐	Others	Others
	Dimethylamine hydrochloride (N,N-Dimethylamine) 大量存在于人类尿液中。
TN3237	7-Isopentenyloxy-gamma-fagarine	Others	Others
	7-Isopentenyloxy-gamma-fagarine has highly cytotoxicity against the MCF-7and Jurkat cell line. It has been used as a precursor for the chemical asymmetric synthesis of the enantiopure alkaloids: evoxine, anhydroevoxine and evodine.

天然产物

Asymmetric dimethylarginine

Cat.No: T7682

Target: Endogenous Metabolite, NO Synthase, NOD

Dimethylamine hydrochloride

Cat.No: T5309

Synonym: N,N-Dimethylamine,二甲胺盐酸盐

Target: Others

7-Isopentenyloxy-gamma-fagarine

Cat.No: TN3237

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02966	UPK2 Protein, Mouse, Recombinant (GST & His) Uroplakin-2,Uroplakin II,Upk2	Mouse	E. coli
	Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM. UPK2 Protein, Mouse, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 40.8 kDa and the accession number is P38575.
TMPH-02967	UPK3A Protein, Mouse, Recombinant (His & Myc) Uroplakin-3a,Upk3a,Uroplakin III	Mouse	E. coli
	Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence. UPK3A Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The pre...
TMPJ-01277	CRT2 Protein, Human, Recombinant CALR3,Calreticulin-3,calreticulin-2,calsperin,CRT2	Human	E. coli
	Calreticulin-3 belongs to the calreticulin family, members of which are calcium binding chaperones localized mainly in the endoplasmic reticulum. It can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. During spermatogenesis process, Calreticulin-3 may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy t...
TMPJ-00657	UPK2 Protein, Human, Recombinant (His) Uroplakin II,Uroplakin-2,UPK2,UP2,UPII	Human	HEK293 Cells
	Uroplakin-2 is a single-pass type I membrane protein that belongs to the uroplakin-2 family. Uroplakin-2 is a component of the asymmetric unit membrane (AUM) and expressed in the ureter, a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. Uroplakin-2 forms heterodimer with UPK1A that is necessary for exiting out of the endoplasmic reticulum (ER). Uroplakin-2 may play an important role in regulating the assembly of the AUM. AUM is believed to strengthen the ...
TMPY-01383	PRMT6 Protein, Human, Recombinant (His & Flag) protein arginine methyltransferase 6,HRMT1L6	Human	HEK293 Cells
	Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly expressed in kidney and testes. PRMT6 is known to catalyze the generation of asymmetric dimethylarginine in polypeptides. It has been implicated in human immunodeficiency virus pathogenesis, DNA repair, and transcriptional regulation. PRMT6 is known to methylate histone H3 Arg-2 (H...
TMPH-01524	KPNA1 Protein, Human, Recombinant (His) Nucleoprotein interactor 1,SRP1-beta,Karyopherin subunit alp...	Human	E. coli
	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta ...
TMPH-02873	RAB10 Protein, Mouse, Recombinant (His & SUMO) Ras-related protein Rab-10,Rab10	Mouse	E. coli
	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, f...

重组蛋白

UPK2 Protein, Mouse, Recombinant (GST & His)

Cat.No: TMPH-02966

Species: Mouse

Expression System: E. coli

UPK3A Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02967

Species: Mouse

Expression System: E. coli

CRT2 Protein, Human, Recombinant

Cat.No: TMPJ-01277

Species: Human

Expression System: E. coli

UPK2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00657

Species: Human

Expression System: HEK293 Cells

PRMT6 Protein, Human, Recombinant (His & Flag)

Cat.No: TMPY-01383

Species: Human

Expression System: HEK293 Cells

KPNA1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01524

Species: Human

Expression System: E. coli

RAB10 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02873

Species: Mouse

Expression System: E. coli

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