29
5
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21995 |
XAP044
|
GluR | Neuroscience |
XAP044 是高效的选择性mGlu7拮抗剂。代谢型谷氨酸受体亚型 7 是哺乳动物 CNS 中神经传递的重要突触前调节剂。它在啮齿动物行为测试中表现出较好的大脑暴露、广谱抗应激、抗抑郁以及抗焦虑作用。 | |||
T19916 |
TRIM
1-(2-Trifluoromethylphenyl)imidazole,1-(2-三氟甲基苯基)咪唑 |
NOS | Immunology/Inflammation |
TRIM (1-(2-Trifluoromethylphenyl)imidazole) 是一氧化氮合酶抑制剂。它在体外能够抑制小鼠小脑 nNOS (IC50:28.2 µM),以及大鼠肺 iNOS (IC50:27.0 µM)。它拥有抗焦虑以及抗抑郁的能力。 | |||
T23007 |
MM 77 dihydrochloride
MM 77二盐酸盐 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
MM 77 dihydrochloride 是一种有效的 5-HT1A 受体突触后拮抗剂,具有抗焦虑样活性。 | |||
T16421 |
p-MPPI hydrochloride
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
p-MPPI hydrochloride 是一种选择性的,具有高亲和力的5-HT1A 受体拮抗剂,能穿过血脑屏障,具有抗抑郁和抗焦虑样作用。 | |||
T23509 |
VU 0285683
|
GluR | Neuroscience |
VU 0285683 是 mGluR5 的特异性负变构调节剂,对 MPEP 结合位点具有高亲和力。 VU 0285683 表现出抗焦虑样活性。 | |||
TP1889 |
MCL0020
MCL 0020 |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
MCL0020 是一种有效的选择性黑素皮质素MC4受体拮抗剂,IC50为 11.63 nM。它剂量依赖性减轻束缚应激诱发的厌食症,在体内表现出抗焦虑样活性。 | |||
T16408 |
Osanetant
SR142801 |
Others | Others |
Osanetant produces anxiolytic- and antidepressant-like effects. Osanetant is a selective NK3 receptor antagonist. It is researched for schizophrenia. | |||
T27744 |
KRM-II-81
KRM-II81,KRM-II 81 |
Others | Others |
KRM-II-81 is a γ-Aminobutyric Acid Type A (GABAA) Receptor Ligand. KRM-II-81 exhibits improved anxiolytic-like effects in a mouse marble burying assay and a rat Vogel conflict test. | |||
T40205 |
Posovolone
Co 134444 |
Others | Others |
Posovolone (Co 134444), an orally active neuroactive steroid with sedative-hypnotic properties, exhibits anticonvulsant and anxiolytic-like activities, alongside ataxic effects. | |||
T13192 |
TPA-023B
|
Others | Others |
TPA-023B is an orally active and high-affinity agonist of the GABAA receptor α2/α3 subtype (Kis: 0.73 nM/2 nM) partial and an antagonist α1 subtype (Ki: 1.8 nM), has non-sedating anxiolytic-like properties. | |||
T70292 |
DDPM-2571 HCl
|
Others | Others |
DDPM-2571 is a highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties. DDPM-2571 was quickly distributed into the brain and was highly effective in the prevention of chemically-induced seizures (pentylenetetrazole and pilocarpine models) and 6-Hz convulsions. It demonstrated significant anxiolytic-like and antidepressant-like properties. DDPM-2571 had antinociceptive properties, both in the hot plate... | |||
T70021 |
Oleanolic acid acrylate
|
Others | Others |
Oleanolic acid acrylate (OAA) is an agonist of the serotonin (5-HT) receptor subtype 5-HT1A and a derivative of oleanolic acid. It is also a selective inhibitor of MAO-A with anti-depressant-like and anxiolytic activities. | |||
T68959 |
Fenobam hydrate
|
Others | Others |
Fenobam hydrate is a noncompetitive antagonist and inverse agonist of metabotropic glutamate receptor 5 (mGluR5). It inhibits intracellular calcium mobilization induced by the glutamate analog quisqualate and inhibits basal activity of mGluR5. Fenobam reduces stress-induced hyperthermia, exhibits anxiolytic-like activity, and may induce analgesia. | |||
T61506 |
NBI-31772 hydrate
|
Others | Others |
NBI-31772 hydrate is a powerful inhibitor of the interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs). It acts as a nonpeptide ligand, effectively releasing bioactive IGF-I from the IGF-I/IGFBP-3 complex (Ki values for all six human subtypes range from 1-24 nM). This compound demonstrates significant anxiolytic and antidepressant-like effects [1] [2] [3]. | |||
T21625 |
BW 723C86 hydrochloride
|
Others | Others |
BW-723C86 是一种有效的选择性5-HT2B 受体激动剂,可导致大鼠食欲过盛和梳理毛发减少。BW-723C86 表现出类抗焦虑作用。 | |||
TP1557 |
Urocortin II, human TFA
|
||
Human urocortin (hUcn) II is a new member of the corticotropin-releasing-factor (CRF) family. It selectively binds to the CRF2 receptor. Human urocortin II exhibits mild motor-suppressive effects and delayed anxiolytic-like effects,suggesting a time-depen | |||
T74413 |
(S)-Osanetant
|
Others | Others |
(S)-Osanetant 是 Osanetant 的S 对映体。Osanetant (SR142801) 是一种选择性的NK3受体拮抗剂。Osanetant 有抗焦虑和抗抑郁的作用,并被研究用于精神分裂症。 | |||
T84898 |
CP 122721 hydrochloride
|
Others | Others |
CP 122721 hydrochloride是一种有效的非肽选择性neurokinin NK1非肽拮抗剂,针对IM-9细胞中表达的人NK1受体展示出9.8的pIC50值,具备抗焦虑和抗抑郁样效应。 | |||
T73568 |
MTEP
|
Others | Others |
MTEP,一种非竞争性且高选择性的mGluR5拮抗剂,具有显著的抗抑郁和抗焦虑效果,亦被用于帕金森疾病的研究。 | |||
T37823 |
M 084 hydrochloride
|
Others | Others |
TRPC4/5 channel blocker (IC50 values are 3.7-10.3 and 8.2 μM, respectively). Also weakly blocks TRPC3 channels. Exhibits rapid antidepressant and anxiolytic effects in vivo. Zhu et al (2015) Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br.J.Pharmacol. 172 3495 PMID:25816897 |Yang et al (2015) Acute treatment with a novel TRPC4/C5 channel inhibitor produces antidepressant and anxiolytic-like effects in mice. PLoS One 10 e0136... | |||
T80423 |
Phoenixin-20
PNX-20 |
Epigenetic Reader Domain | Chromatin/Epigenetic |
Phoenixin-20(PNX-20)为脊椎动物内具激素样生物活性肽,能激活下丘脑-垂体-性腺轴,调控哺乳类生殖过程。该肽通过CREB-PGC-1α途径增进神经元线粒体生物发生。 | |||
T78094 |
Eglumegad hydrochloride
LY354740 hydrochloride,Eglumetad hydrochloride |
Others | Others |
Eglumegad (LY354740) hydrochloride是一种高效且选择性的group II (mGlu2/3) receptor激动剂,其对人mGlu2和mGlu3受体的IC50值分别是5和24 nM。该化合物能够保护神经元不受NMDA毒性影响,并表现出抗焦虑及抗精神病样作用。 | |||
TP2136 |
(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
|
||
Selective vasopressin V1A receptor antagonist. Inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro (IC50 values are 5 and 30 nM respectively). Exhibits potent and prolonged antivasopressor activity and indu | |||
T80424 |
Phoenixin-20 TFA
PNX-20 TFA |
Epigenetic Reader Domain | Chromatin/Epigenetic |
Phoenixin-20 (TFA) (PNX-20 (TFA)) 是一种在脊椎动物中发挥激素作用的生物活性肽,能够激活下丘脑-垂体-性腺轴,从而调控哺乳类动物的生殖机能。此外,该肽通过CREB-PGC-1α途径,增强神经元的线粒体生物生成。 | |||
T75812 |
MMK1 TFA
|
||
MMK1 TFA 是一种有效的选择性人甲酰肽受体样 1 (FPRL-1/FPR2) 激动剂,对 FPRL-1 和 FPR1 的 EC50值分别为 <2 nM 和 >10000 nM。MMK1 TFA 是一种有效的趋化剂和钙动员 (calcium-mobilizing) 激动剂。MMK1 TFA 可有效激活吞噬性白细胞,并可增强人单核细胞对百日咳毒素 敏感的促炎细胞因子 IL-1b 和IL-6的产生。MMK1 TFA 发挥抗焦虑样活性。 | |||
T75832 |
Cyclotraxin B TFA
|
||
Cyclotraxin B TFA 是一种环肽,是一种高效且选择性的 TrkB 抑制剂,且不会改变 BDNF 的结合。Cyclotraxin B TFA 非竞争性地抑制 BDNF 诱导的 TrkB 活性,IC50值为 0.30 nM。Cyclotraxin B TFA 可以穿越血脑屏障,并具有止痛和抗焦虑的行为作用。 | |||
T37114 |
SB 242084 dihydrochloride
|
Others | Others |
SB 242084 hydrochloride is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively.IC50 value: 9.0(pKi) [1]Target: 5-HT2C antagonistin vitro: SB 242084 had over 100-fold selectivity over a range of other 5-HT, dopamine and adrenergic receptors. In studies of 5-HT-stimulated phosphatidylinositol hydrolysis using SH-SY5Y cells stably expressing the cloned human 5-HT2C receptor, SB 242084 acted as an antagonist with a pKb of 9.... | |||
T38145 |
Eltoprazine
|
Others | Others |
Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro: The binding of [3H]eltoprazine to whole tissue sections was saturable and revealed an apparent dissociation constant (Kd) of 11 nM. Specific [3H]eltoprazine binding was completely displaced by 5-HT; conversely, unlabelled eltoprazine reduced [3H]5-HT binding to the levels of no... | |||
T37194 |
5α-Androst-16-en-3α-ol
|
Others | Others |
5α-Androst-16-en-3α-ol is a steroid pheromone that has been found in boar testes and human male axillary sweat and has diverse biological activities.1,2It enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50= 0.4 μM).25α-Androst-16-en-3α-ol (0.1-1 μM) increases the amplitude of GABA-activated currents in HEK293 cells expressing human α1β2γ2and α2β2γ2subunit-containing GABAAreceptors.In vivo, 5α-androst-16-en-3α-ol (5-10 mg/kg) decreases immobility time in the forced s... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3886 |
Rosavin
Rosavidin,络塞维 |
P450 | Metabolism |
Rosavin (Rosavidin) 是从R. rosea 中获得的,在小鼠模型中表现出抗抑郁、适应原性和抗焦虑样作用。 | |||
T8014 |
Epoxylinalool
氧化芳樟醇,2-(2-Hydroxy-2-Propyl)-5-Methyl-5-Vinyltetrahydrofuran |
Others | Others |
Epoxylinalool (2-(2-Hydroxy-2-Propyl)-5-Methyl-5-Vinyltetrahydrofuran) 是一种天然存在的单萜醇,广泛用于香水和调味品的生产。 | |||
T6S2227 |
Spinosin
斯皮诺素,Flavoayamenin |
Others | Others |
Spinosin (Flavoayamenin) 是一种具有神经保护作用的 C-糖苷类黄酮,从 Zizyphus jujube 种子分离得到,能够激活 Nrf2/HO-1 通路,并抑制 Aβ1-42的产生和聚合。 | |||
TCS0102 |
Pulegone
胡薄荷酮,(+)-Pulegone,蒲勒酮,胡薄荷酮,长叶薄荷酮 |
Calcium Channel; Endogenous Metabolite; TRP/TRPV Channel | Membrane transporter/Ion channel; Metabolism |
Pulegone ((+)-Pulegone) 是 Calamintha nepeta (L.) Savi 的精油的主要化学成分,也是禽类驱虫剂之一。它在禽类物种中驱避作用的分子靶点是伤害感受性 TRP 锚蛋 1。它刺激鸡感觉神经元中的 TRPM8 和 TRPA1 通道,并在高浓度下抑制前者但不抑制后者。 | |||
TN4322 |
Isopulegol
|
ATPase; Potassium Channel; GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Isopulegol presents depressant- and anxiolytic-like effects, it also has anticonvulsant and bioprotective effects against PTZ-induced convulsions are possibly related to positive modulation of benzodiazepine-sensitive GABAA receptors and to antioxidant properties.Isopulegol presents significant gastroprotective effects in both ethanol- and indomethacin-induced ulcer models, which appear to be mediated, at least in part, by endogenous prostaglandins, K(ATP) channel opening, and antioxidant proper... |