Posovolone

Name: Posovolone
Brand: TargetMol
SKU: T40205
Price: 780 USD
Availability: InStock
Rating: 4.5 (1 reviews)

很棒

产品编号 T40205Cas号 256955-84-7

别名 Co 134444

Posovolone (Co 134444), an orally active neuroactive steroid with sedative-hypnotic properties, exhibits anticonvulsant and anxiolytic-like activities, alongside ataxic effects.

Posovolone

很棒

产品编号 T40205 别名 Co 134444Cas号 256955-84-7

Posovolone (Co 134444), an orally active neuroactive steroid with sedative-hypnotic properties, exhibits anticonvulsant and anxiolytic-like activities, alongside ataxic effects.

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产品介绍

生物活性

产品描述	Posovolone (Co 134444), an orally active neuroactive steroid with sedative-hypnotic properties, exhibits anticonvulsant and anxiolytic-like activities, alongside ataxic effects.
体外活性	In mice, Co 134444 (0.5-10 mg/kg, IP, 15 min; 1-60 mg/kg, PO; 30 min) demonstrates efficacy against pentylenetetrazol (PTZ)-induced seizures with an ED 50 of 3.3 mg/kg after IP administration and 9.8 mg/kg orally. Similarly, protection against maximal electroshock (MES) is observed with an ED 50 of 4.8 mg/kg IP and 20.6 mg/kg PO. In rats, Co134444 (10-40 mg/kg; PO; 30 min) protects against PTZ-induced seizures and MES-induced seizures with an ED 50 of 23.6 mg/kg and 25.3 mg/kg, respectively[1].
别名	Co 134444